Metabolite list (20)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00004632
|
Quercetin 3-methyl ether
/ Quercetin 3-O-methyl ether |
CHEMBL163316
|
32 / 21 / 21 | No. 3 | No. 15 |
|
||
|
C00002460
|
Coumarin
|
CHEMBL6466
|
C030123
|
122 / 60 / 55 | 11 / 7 | No. 1030 | No. 25 |
|
|
C00023624
|
Aflatoxin Q1
|
C033759
|
2 / 0 | No. 1313 |
|
|||
|
C00001551
|
Pyridoxine
|
CHEMBL1364
|
D011736
|
10 / 7 / 8 | 2 / 49 | No. 2457 |
|
|
|
C00001552
|
Riboflavin
|
CHEMBL1534
CHEMBL511565 CHEMBL1397833 |
D012256
|
41 / 57 / 56 | 19 / 13 | No. 2559 |
|
|
|
C00001115
|
Thyminose
/ Deoxyribose / 2-Deoxy-D-arabinose / 2-Deoxy-D-erythro-pentose |
D003855
|
No. 2624 |
|
||||
|
C00002866
|
Ubiquinone-10
|
CHEMBL454801
|
C024989
|
1 / 11 / 10 | 10 / 12 | No. 2805 |
|
|
|
C00000775
|
Thiamin
/ Thiamine / Vitamin B1 |
CHEMBL1547
|
D013831
|
4 / 1 / 0 | 2 / 26 | No. 3404 |
|
|
|
C00001130
|
beta-L-Ribopyranose
|
CHEMBL14343
CHEMBL505348 CHEMBL502135 CHEMBL1159661 CHEMBL1159662 CHEMBL1222249 CHEMBL1357418 CHEMBL1374069 |
8 / 4 / 7 | No. 3572 |
|
|||
|
C00001501
|
Guanine
|
CHEMBL219568
|
D006147
|
3 / 3 / 2 | 1 / 1 | No. 3820 | No. 12 |
|
|
C00001502
|
Hypoxanthine
|
CHEMBL1427
|
D019271
|
2 / 2 / 1 | 6 / 3 | No. 3820 | No. 12 |
|
|
C00001548
|
Nopaline
|
No. 3841 |
|
|||||
|
C00001504
|
Kinetin
|
CHEMBL228792
|
D007701
|
14 / 19 / 48 | No. 4069 |
|
||
|
C00001544
|
Lysopine
|
No. 5217 |
|
|||||
|
C00001549
|
Octopine
|
No. 5217 |
|
|||||
|
C00001553
|
Ruscopine
|
No. 5476 |
|
|||||
|
C00023622
|
Aflatoxin D1
|
C029227
|
No. 6894 |
|
||||
|
C00001352
|
L-Cystine
|
CHEMBL366563
CHEMBL590540 |
D003553
|
3 / 3 / 7 | 5 / 2 | No. 8345 |
|
|
|
C00001498
|
Cytosine
|
CHEMBL15913
|
D003596
|
2 / 1 / 0 | 0 / 2 | No. 8891 |
|
|
|
C00001534
|
Cyanocobalamin
|
D014805
|
9 / 80 | No. 8893 |
|
Human Protein / Gene in interactions
182 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001130 C00001352 C00001504 C00001552 C00004632 | 1 / 2 |
| O00255 | Menin | Unclassified protein | C00001130 C00001352 C00001504 C00001552 C00004632 | 2 / 5 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001504 C00001551 C00001552 C00002460 | 0 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001504 C00001551 C00001552 C00002460 | 1 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001504 C00001551 C00001552 C00002460 | 1 / 1 |
| O75496 | Geminin | Unclassified protein | C00001130 C00001498 C00001504 C00004632 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001504 C00001551 C00001552 C00002460 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001504 C00001551 C00001552 C00002460 | 0 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001551 C00001552 C00004632 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00001552 C00002460 C00004632 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001551 C00001552 C00004632 | 3 / 3 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001130 C00001552 C00004632 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001502 C00001551 C00001552 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00001130 C00002460 C00004632 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001552 C00002460 C00002866 | 11 / 10 |
| P00492 | Hypoxanthine-guanine phosphoribosyltransferase | Enzyme | C00001501 C00001502 | 2 / 1 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00001504 C00001552 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002460 C00004632 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001552 C00004632 | 4 / 3 |
| P10275 | Androgen receptor | NR3C4 | C00001552 C00002460 | 3 / 4 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00001552 C00002460 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00001552 C00002460 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00001552 C00002460 | 0 / 0 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00001552 C00004632 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001352 C00004632 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00001552 C00002460 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00001552 C00004632 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00001552 C00004632 | 1 / 1 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001130 C00001552 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001552 C00002460 | 1 / 1 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00002460 C00004632 | 1 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00001130 C00001498 | 1 / 0 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00002460 C00004632 | 0 / 1 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00001552 C00002460 | 3 / 1 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00001551 C00001552 | 2 / 2 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00002460 | 0 / 0 |
| O00764 | Pyridoxal kinase | Enzyme | C00001551 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001504 | 3 / 2 |
| O15245 | Solute carrier family 22 member 1 | Drug uniporter | C00000775 | 0 / 0 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00001552 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00002460 | 1 / 2 |
| Q8N1Q1 | Carbonic anhydrase 13 | Lyase | C00002460 | 0 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00002460 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00002460 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00002460 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00002460 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00002460 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00002460 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00002460 | 0 / 0 |
| P02768 | Serum albumin | Secreted protein | C00002460 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00002460 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00002460 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00002460 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00002460 | 2 / 2 |
| P04792 | Heat shock protein beta-1 | Unclassified protein | C00004632 | 2 / 1 |
| P54132 | Bloom syndrome protein | Enzyme | C00004632 | 1 / 2 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00001552 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00002460 | 1 / 8 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00001552 | 2 / 3 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00002460 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00002460 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00002460 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00002460 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00002460 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00002460 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00002460 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00002460 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00002460 | 1 / 1 |
| P17538 | Chymotrypsinogen B | S1A | C00002460 | 0 / 0 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00002460 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00002460 | 1 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00002460 | 0 / 0 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | C00002460 | 0 / 0 |
| P68871 | Hemoglobin subunit beta | Secreted protein | C00001552 | 4 / 4 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00002460 | 1 / 2 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00002460 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00001504 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00004632 | 0 / 0 |
| Q99895 | Chymotrypsin-C | S1A | C00001552 | 0 / 2 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00002460 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00004632 | 2 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00002460 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00001552 | 4 / 2 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00002460 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00002460 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00002460 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00002460 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00002460 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00002460 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00002460 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00002460 | 0 / 0 |
| Q9Y2T3 | Guanine deaminase | Enzyme | C00001501 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00002460 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00002460 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00002460 | 1 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00002460 | 0 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00002460 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00002460 | 0 / 0 |
| P29401 | Transketolase | Enzyme | C00000775 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00002460 | 1 / 0 |
| P03956 | Interstitial collagenase | M10A | C00002460 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00002460 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00004632 | 1 / 1 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00002460 | 0 / 0 |
| Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | Electrochemical transporter | C00002460 | 1 / 0 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00004632 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00002460 | 0 / 0 |
| Q9H3S4 | Thiamin pyrophosphokinase 1 | Enzyme | C00000775 | 1 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00002460 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00002460 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00002460 | 0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00002460 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00002460 | 2 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00001552 | 5 / 3 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00002460 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00002460 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00002460 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00002460 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00002460 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00002460 | 0 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00002460 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00002460 | 1 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00004632 | 1 / 1 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00002460 | 2 / 1 |
| P56817 | Beta-secretase 1 | A1A | C00002460 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00001552 | 6 / 4 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00002460 | 0 / 1 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00002460 | 0 / 0 |
| P22234 | Multifunctional protein ADE2 | Enzyme | C00001552 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00004632 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00004632 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00002460 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00002460 | 1 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00002460 | 1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00002460 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00002460 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00001552 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00002460 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00002460 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00002460 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00002460 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00002460 | 0 / 0 |
| Q00796 | Sorbitol dehydrogenase | Enzyme | C00002460 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00001552 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00002460 | 0 / 0 |
| P55210 | Caspase-7 | C14 | C00001552 | 0 / 0 |
| P00491 | Purine nucleoside phosphorylase | Enzyme | C00001501 | 1 / 1 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00002460 | 0 / 0 |
| P08246 | Neutrophil elastase | S1A | C00002460 | 2 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00002460 | 0 / 0 |
| P01375 | Tumor necrosis factor | Secreted protein | C00001552 | 3 / 4 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00004632 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00002460 | 2 / 2 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002460 | 0 / 3 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00002460 | 0 / 0 |
| P07477 | Trypsin-1 | S1A | C00002460 | 1 / 1 |
| Q99700 | Ataxin-2 | Unclassified protein | C00004632 | 1 / 1 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00002460 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00002460 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00002460 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00002460 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00002460 | 1 / 1 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00002460 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00002460 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00002460 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00002460 | 1 / 1 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00002460 | 0 / 0 |
| O14980 | Exportin-1 | Unclassified protein | C00002460 | 0 / 0 |
| Q9BZP6 | Acidic mammalian chitinase | Enzyme | C00001504 | 0 / 0 |
| O15244 | Solute carrier family 22 member 2 | Drug uniporter | C00000775 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00004632 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001552 | 0 / 0 |
| Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | Electrochemical transporter | C00002460 | 1 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00001504 | 4 / 1 |
| Q8IUX4 | DNA dC->dU-editing enzyme APOBEC-3F | Enzyme | C00004632 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00001504 | 7 / 37 |
| P10323 | Acrosin | S1A | C00001130 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002460 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002460 | 1 / 4 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00004632 | 0 / 0 |
| Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | C00004632 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00004632 | 2 / 1 |
59 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00001502
C00001552
C00002460
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00001502
C00001552
C00002460
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00001552
C00002460
|
| 1401 | CRP, PTX1 | C-reactive protein, pentraxin-related |
C00001534
C00001552
|
| 4548 | MTR, HMAG, MS, cblG | 5-methyltetrahydrofolate-homocysteine methyltransferase (EC:2.1.1.13) |
C00001502
C00001534
|
| 10891 | PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
C00001551
C00001552
|
| 116984 | ARAP2, CENTD1, PARX | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
C00002866
|
| 5527 | PPP2R5C, B56G, PR61G | protein phosphatase 2, regulatory subunit B', gamma |
C00002866
|
| 23362 | PSD3, EFA6R, HCA67 | pleckstrin and Sec7 domain containing 3 |
C00002866
|
| 6622 | SNCA, NACP, PARK1, PARK4, PD1 | synuclein, alpha (non A4 component of amyloid precursor) |
C00002866
|
| 374291 | NDUFS7, CI-20, CI-20KD, MY017, PSST | NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) (EC:1.6.5.3 1.6.99.3) |
C00002866
|
| 4712 | NDUFB6, B17, CI | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa (EC:1.6.5.3 1.6.99.3) |
C00002866
|
| 1546 |
C00002460
|
||
| 1553 | CYP2A13, CPAD, CYP2A, CYPIIA13 | cytochrome P450, family 2, subfamily A, polypeptide 13 (EC:1.14.14.1) |
C00002460
|
| 1548 | CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB | cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) |
C00002460
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00002460
|
| 2158 | F9, FIX, HEMB, P19, PTC, THPH8 | coagulation factor IX (EC:3.4.21.22) |
C00002460
|
| 3292 | HSD17B1, EDH17B2, EDHB17, HSD17, SDR28C1 | hydroxysteroid (17-beta) dehydrogenase 1 (EC:1.1.1.62) |
C00002460
|
| 4256 | MGP, MGLAP, NTI | matrix Gla protein |
C00002460
|
| 10499 | NCOA2, GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75 | nuclear receptor coactivator 2 |
C00002866
|
| 79001 | VKORC1, EDTP308, IMAGE3455200, MST134, MST576, VKCFD2, VKOR | vitamin K epoxide reductase complex, subunit 1 (EC:1.1.4.1) |
C00002460
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00023624
|
| 27232 | GNMT | glycine N-methyltransferase (EC:2.1.1.20) |
C00023624
|
| 883 | CCBL1, GTK, KAT1, KATI | cysteine conjugate-beta lyase, cytoplasmic (EC:2.6.1.64 2.6.1.7 4.4.1.13) |
C00001352
|
| 6519 | SLC3A1, ATR1, CSNU1, D2H, NBAT, RBAT | solute carrier family 3 (amino acid transporter heavy chain), member 1 |
C00001352
|
| 6520 | SLC3A2, 4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE | solute carrier family 3 (amino acid transporter heavy chain), member 2 |
C00001352
|
| 23657 | SLC7A11, CCBR1, xCT | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 |
C00001352
|
| 11136 | SLC7A9, BAT1, CSNU3 | solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 |
C00001352
|
| 4255 | MGMT | O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) |
C00001501
|
| 5451 | POU2F1, OCT1, OTF1, oct-1B | POU class 2 homeobox 1 |
C00002866
|
| 6470 | SHMT1, CSHMT, SHMT | serine hydroxymethyltransferase 1 (soluble) (EC:2.1.2.1) |
C00001551
|
| 259266 | ASPM, ASP, Calmbp1, MCPH5 | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) |
C00001552
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00001552
|
| 891 | CCNB1, CCNB | cyclin B1 |
C00001552
|
| 2117 | ETV3, METS, PE-1, PE1, bA110J1.4 | ets variant 3 |
C00002866
|
| 1649 | DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 | DNA-damage-inducible transcript 3 |
C00001552
|
| 2936 | GSR | glutathione reductase (EC:1.8.1.7) |
C00001552
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00001552
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00001552
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00001552
|
| 9493 | KIF23, CHO1, KNSL5, MKLP-1, MKLP1 | kinesin family member 23 |
C00001552
|
| 4524 | MTHFR | methylenetetrahydrofolate reductase (NAD(P)H) (EC:1.5.1.20) |
C00001552
|
| 4609 | MYC, MRTL, MYCC, bHLHe39, c-Myc | v-myc avian myelocytomatosis viral oncogene homolog |
C00001552
|
| 5325 | PLAGL1, LOT1, ZAC, ZAC1 | pleiomorphic adenoma gene-like 1 |
C00001552
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00001552
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00001552
|
| 10560 | SLC19A2, TC1, THMD1, THT1, THTR1, TRMA | solute carrier family 19 (thiamine transporter), member 2 |
C00000775
|
| 80704 | SLC19A3, BBGD, THMD2, THTR2 | solute carrier family 19 (thiamine transporter), member 3 |
C00000775
|
| 5826 | ABCD4, ABC41, EST352188, MAHCJ, P70R, P79R, PMP69, PXMP1L | ATP-binding cassette, sub-family D (ALD), member 4 |
C00001534
|
| 57412 | AS3MT, CYT19 | arsenic (+3 oxidation state) methyltransferase (EC:2.1.1.137) |
C00001534
|
| 2524 | FUT2, B12QTL1, SE, SEC2, Se2, sej | fucosyltransferase 2 (secretor status included) (EC:2.4.1.69) |
C00001534
|
| 3039 | HBA1, CD31, HBH | hemoglobin, alpha 1 |
C00001534
|
| 4129 | MAOB | monoamine oxidase B (EC:1.4.3.4) |
C00001534
|
| 25974 | MMACHC, RP11-291L19.3, cblC | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria |
C00001534
|
| 2060 | EPS15, AF-1P, AF1P, MLLT5 | epidermal growth factor receptor pathway substrate 15 |
C00002866
|
| 6948 | TCN2, D22S676, D22S750, II, TC, TC_II, TC-2, TC2, TCII | transcobalamin II |
C00001534
|
| 248 | ALPI, IAP | alkaline phosphatase, intestinal (EC:3.1.3.1) |
C00001502
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00001502
|
| 7498 | XDH, XO, XOR | xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) |
C00001502
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (120)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #613985 | Beta-thalassemia |
P68871
|
| #603902 | Beta-thalassemia, dominant inclusion body type |
P68871
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| %606641 | Body mass index; bmi |
P37231
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #606595 | Charcot-marie-tooth disease, axonal, type 2f; cmt2f |
P04792
|
| #114500 | Colorectal cancer; crc |
P84022
Q14191 |
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 P37231 |
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #140700 | Heinz body anemias |
P68871
|
| #610424 | Hepatitis b virus, susceptibility to |
P01375
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237450 | Hyperbilirubinemia, rotor type; hblrr |
Q9NPD5
Q9Y6L6 |
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #300323 | Kelley-seegmiller syndrome |
P00492
|
| #300322 | Lesch-nyhan syndrome; lns |
P00492
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 P04637 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #611162 | Malaria, susceptibility to |
P01375
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #159900 | Myoclonic dystonia |
P14416
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #608634 | Neuronopathy, distal hereditary motor, type iib; hmn2b |
P04792
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
P37231 |
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
P38398 |
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #167800 | Pancreatitis, hereditary; pctt |
P07477
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #607507 | Psoriatic arthritis, susceptibility to |
P01375
|
| #613179 | Purine nucleoside phosphorylase deficiency |
P00491
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #603903 | Sickle cell anemia |
P68871
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #614458 | Thiamine metabolism dysfunction syndrome 5 (episodic encephalopathy type); thmd5 |
Q9H3S4
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (112)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P04637 (marker) Q16790 (marker) |
| H00093 | Combined immunodeficiencies (CIDs) |
P00491
(related)
P06239 (related) |
| H00194 | Lesch-Nyhan syndrome |
P00492
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) P04637 (related) P68871 (marker) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) P04637 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00079 | Asthma |
P01375
(related)
P07550 (related) |
| H00080 | Systemic lupus erythematosus |
P01375
(related)
P01375 (marker) |
| H00083 | Allograft rejection |
P01375
(related)
|
| H00084 | Graft-versus-host disease |
P01375
(related)
P01375 (marker) |
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) P04637 (related) Q92731 (marker) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
P04637 (related) P04637 (marker) |
| H00027 | Ovarian cancer |
P04626
(related)
P04637 (related) P38398 (related) |
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) P04637 (related) P38398 (related) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P04637 (related) P35354 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) P68871 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P14780 (related) P35354 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00856 | Distal hereditary motor neuropathies (dHMN) |
P04792
(related)
|
| H00933 | Hereditary pancreatitis |
P07477
(related)
Q99895 (related) |
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
Q99714 (related) |
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
Q14191 (related) |
| H00228 | Thalassemia |
P68871
(related)
|
| H00229 | Sickle cell anemia (SCA) |
P68871
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00932 | Tropical calcific pancreatitis |
Q99895
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
157 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D010523 | Peripheral Nervous System Diseases |
C00001551
C00001552 C00000775 C00001534 |
| D009369 | Neoplasms |
C00001551
C00001552 C00000775 C00001534 |
| D011115 | Polyneuropathies |
C00001551
C00000775 C00001534 |
| D010146 | Pain |
C00001551
C00000775 C00001534 |
| D015362 | Child Nutrition Disorders |
C00001551
C00001552 C00000775 |
| D012871 | Skin Diseases |
C00002460
C00001551 C00001552 |
| D056486 | Drug-Induced Liver Injury |
C00002460
C00001352 C00001534 |
| D002386 | Cataract |
C00001552
C00000775 C00001534 |
| D003072 | Cognition Disorders |
C00002866
C00001534 |
| D018908 | Muscle Weakness |
C00002866
C00001534 |
| D009410 | Nerve Degeneration |
C00002866
C00000775 |
| D020521 | Stroke |
C00001552
C00001534 |
| D012640 | Seizures |
C00001551
C00000775 |
| D015228 | Hypertriglyceridemia |
C00002866
C00001552 |
| D006261 | Headache |
C00001552
C00001534 |
| D009336 | Necrosis |
C00002460
C00001551 |
| D003711 | Demyelinating Diseases |
C00000775
C00001534 |
| D013927 | Thrombosis |
C00002460
C00001534 |
| D006331 | Heart Diseases |
C00002866
C00001534 |
| D003875 | Drug Eruptions |
C00000775
C00001534 |
| D009422 | Nervous System Diseases |
C00001551
C00001534 |
| D004342 | Drug Hypersensitivity |
C00000775
C00001534 |
| D019970 | Cocaine-Related Disorders |
C00001501
C00001502 |
| D000138 | Acidosis |
C00001551
C00000775 |
| D002972 | Cleft Palate |
C00001551
C00000775 |
| D002971 | Cleft Lip |
C00001551
C00000775 |
| D014581 | Urticaria |
C00000775
C00001534 |
| D001714 | Bipolar Disorder |
C00001551
C00000775 |
| D004417 | Dyspnea |
C00001534
|
| D001259 | Ataxia |
C00001551
|
| D001763 | Blepharoptosis |
C00001551
|
| D001766 | Blindness |
C00001551
|
| D002653 | Child Behavior Disorders |
C00001551
|
| D000855 | Anorexia |
C00001551
|
| D000756 | Anemia, Sideroblastic |
C00001551
|
| D000437 | Alcoholism |
C00001551
|
| D003128 | COMA |
C00001551
|
| D003221 | Confusion |
C00001551
|
| D003389 | Cranial Nerve Diseases |
C00001551
|
| D003680 | Deglutition Disorders |
C00001551
|
| D004401 | Dysarthria |
C00001551
|
| D004421 | Dystonia |
C00001551
|
| D004890 | Erythema |
C00001551
|
| D005119 | Extravasation of Diagnostic and Therapeutic Materials |
C00001551
|
| D005155 | Facial Nerve Diseases |
C00001551
|
| D005533 | Foot Dermatoses |
C00001551
|
| D006229 | Hand Dermatoses |
C00001551
|
| D006527 | Hepatolenticular Degeneration |
C00001551
|
| D006948 | Hyperkinesis |
C00001551
|
| D020437 | Hypoglossal Nerve Diseases |
C00001551
|
| D055985 | Latent Tuberculosis |
C00001551
|
| D053609 | Lethargy |
C00001551
|
| D009069 | Movement Disorders |
C00001551
|
| D054198 | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
C00001498
|
| D016393 | Lymphoma, B-Cell |
C00001498
|
| D009886 | Ophthalmoplegia |
C00001551
|
| D012480 | Salmonella Infections |
C00001352
|
| D010292 | Paresthesia |
C00001551
|
| D010300 | Parkinson Disease |
C00001551
|
| D010302 | Parkinson Disease, Secondary |
C00001551
|
| D014689 | Venous Insufficiency |
C00002460
|
| D007674 | Kidney Diseases |
C00002460
|
| D011251 | Pregnancy Complications, Infectious |
C00001551
|
| D011618 | Psychotic Disorders |
C00001551
|
| D012559 | Schizophrenia |
C00001551
|
| D003924 | Diabetes Mellitus, Type 2 |
C00002460
|
| D013226 | Status Epilepticus |
C00001551
|
| D014376 | Tuberculosis |
C00001551
|
| D014397 | Tuberculosis, Pulmonary |
C00001551
|
| D015431 | Weight Loss |
C00001551
|
| D001943 | Breast Neoplasms |
C00001552
|
| D020734 | Parkinsonian Disorders |
C00002866
|
| D015179 | Colorectal Neoplasms |
C00001552
|
| D009120 | Muscle Cramp |
C00002866
|
| D006951 | Hyperlipoproteinemias |
C00001552
|
| D008881 | Migraine Disorders |
C00001552
|
| D019954 | Neurobehavioral Manifestations |
C00001552
|
| D007968 | Leukoencephalopathy, Progressive Multifocal |
C00002866
|
| D000430 | Alcohol Withdrawal Delirium |
C00000775
|
| D001927 | Brain Diseases |
C00000775
|
| D009202 | Cardiomyopathies |
C00000775
|
| D002524 | Cerebellar Ataxia |
C00000775
|
| D006816 | Huntington Disease |
C00002866
|
| D058186 | Acute Kidney Injury |
C00002866
|
| D002375 | Catalepsy |
C00002866
|
| D004660 | Encephalitis |
C00000775
|
| D006333 | Heart Failure |
C00000775
|
| D006501 | Hepatic Encephalopathy |
C00000775
|
| D007855 | Lead Poisoning |
C00000775
|
| D017240 | Mitochondrial Myopathies |
C00000775
|
| D002318 | Cardiovascular Diseases |
C00002866
|
| D014899 | Wernicke Encephalopathy |
C00000775
|
| D000380 | Agranulocytosis |
C00001534
|
| D000544 | Alzheimer Disease |
C00001534
|
| D000707 | Anaphylaxis |
C00001534
|
| D000740 | Anemia |
C00001534
|
| D000748 | Anemia, Macrocytic |
C00001534
|
| D000749 | Anemia, Megaloblastic |
C00001534
|
| D000752 | Anemia, Pernicious |
C00001534
|
| D001044 | Aphonia |
C00001534
|
| D001201 | Ascites |
C00001534
|
| D001284 | Atrophy |
C00001534
|
| D001321 | Autistic Disorder |
C00001534
|
| D001791 | Blood Platelet Disorders |
C00001534
|
| D001925 | Brain Damage, Chronic |
C00001534
|
| D001928 | Brain Diseases, Metabolic |
C00001534
|
| D001986 | Bronchial Spasm |
C00001534
|
| D002279 | Carcinoma 256, Walker |
C00001534
|
| D002446 | Celiac Disease |
C00001534
|
| D002493 | Central Nervous System Diseases |
C00001534
|
| D003161 | Compartment Syndromes |
C00001534
|
| D023903 | Coronary Restenosis |
C00001534
|
| D019965 | Delirium, Dementia, Amnestic, Cognitive Disorders |
C00001534
|
| D003704 | Dementia |
C00001534
|
| D003866 | Depressive Disorder |
C00001534
|
| D003929 | Diabetic Neuropathies |
C00001534
|
| D004244 | Dizziness |
C00001534
|
| D001480 | Basal Ganglia Diseases |
C00001551
|
| D004827 | Epilepsy |
C00001534
|
| D005128 | Eye Diseases |
C00001534
|
| D005234 | Fatty Liver |
C00001534
|
| D005235 | Fatty Liver, Alcoholic |
C00001534
|
| D006330 | Heart Defects, Congenital |
C00001534
|
| D016481 | Helicobacter Infections |
C00001534
|
| D006402 | Hematologic Diseases |
C00001534
|
| D006463 | Hemolytic-Uremic Syndrome |
C00001534
|
| D006712 | Homocystinuria |
C00001534
|
| D020138 | HYPERHOMOCYSTEINEMIA |
C00001534
|
| D007024 | Hypotension, Orthostatic |
C00001534
|
| C538556 | Imerslund-Grasbeck syndrome |
C00001534
|
| D056784 | Leukoencephalopathies |
C00001534
|
| D008106 | Liver Cirrhosis, Experimental |
C00001534
|
| D008107 | Liver Diseases |
C00001534
|
| D008114 | Liver Neoplasms, Experimental |
C00001534
|
| D008180 | Lupus Erythematosus, Systemic |
C00001534
|
| D008661 | Metabolism, Inborn Errors |
C00001534
|
| D009133 | Muscular Atrophy |
C00001534
|
| D009188 | Myelitis, Transverse |
C00001534
|
| D009203 | Myocardial Infarction |
C00001534
|
| D009207 | Myoclonus |
C00001534
|
| D009461 | Neurologic Manifestations |
C00001534
|
| D009902 | Optic Neuritis |
C00001534
|
| D010198 | Pancytopenia |
C00001534
|
| D020335 | Paraparesis |
C00001534
|
| D011602 | Psychophysiologic Disorders |
C00001534
|
| D051437 | Renal Insufficiency |
C00001534
|
| D012393 | Rosacea |
C00001534
|
| D012594 | Scleroderma, Localized |
C00001534
|
| D012851 | Sinus Thrombosis, Intracranial |
C00001534
|
| D013118 | Spinal Cord Diseases |
C00001534
|
| D013182 | Sprue, Tropical |
C00001534
|
| D052879 | Subacute Combined Degeneration |
C00001534
|
| D054556 | Venous Thromboembolism |
C00001534
|
| D014786 | Vision Disorders |
C00001534
|
| D014806 | Vitamin B 12 Deficiency |
C00001534
|
| D005767 | Gastrointestinal Diseases |
C00001502
|
| D011041 | Poisoning |
C00001502
|