KNApSAcK Metabolite C00001551
Metabolite
KNApSAcK Entry
| id | C00001551 |
|---|---|
| Name | Pyridoxine |
| CAS RN | 65-23-6 |
| Standard InChI | InChI=1S/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3 |
| Standard InChI (Main Layer) | InChI=1S/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 2457 |
Link
ChEMBL
| By standard InChI | CHEMBL1364 |
|---|---|
| By standard InChI Main Layer | CHEMBL1364 |
KEGG
| By LinkDB | C00314 |
|---|
CTD
| By CAS RN | D011736 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
Human Protein / Gene in interaction
10 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL1364 |
CHEMBL1741321
(1)
|
1 / 0 |
| O00764 | Pyridoxal kinase | Enzyme | CHEMBL1364 |
CHEMBL1116771
(1)
|
0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL1364 |
CHEMBL1741325
(1)
|
0 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL1364 |
CHEMBL1614458
(1)
|
0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL1364 |
CHEMBL1741322
(1)
|
0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | CHEMBL1364 |
CHEMBL1613910
(1)
|
3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | CHEMBL1364 |
CHEMBL1614038
(1)
|
2 / 2 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL1364 |
CHEMBL1741323
(1)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL1364 |
CHEMBL1741324
(1)
|
0 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL1364 |
CHEMBL1613914
(1)
|
0 / 0 |
CTD interaction (2)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D011736 | 10891 |
PPARGC1A
LEM6 PGC-1(alpha) PGC-1v PGC1 PGC1A PPARGC1 |
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | Pyridoxine results in increased expression of PPARGC1A mRNA |
increases expression
|
mRNA |
23056435
|
| D011736 | 6470 |
SHMT1
CSHMT SHMT |
serine hydroxymethyltransferase 1 (soluble) (EC:2.1.2.1) | Pyridoxine affects the expression of and affects the activity of SHMT1 protein |
affects activity
/ affects expression |
protein |
17482557
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (7)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
KEGG DISEASE (8)
| KEGG | disease name | UniProt |
|---|---|---|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
49 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D000138 | D011736 | Acidosis |
marker/mechanism
|
11423814
|
|
| D000437 | D011736 | Alcoholism |
therapeutic
|
619758
|
|
| D000756 | D011736 | Anemia, Sideroblastic |
therapeutic
|
465361
6054596 7986730 |
|
| D000855 | D011736 | Anorexia |
marker/mechanism
|
6457437
|
|
| D001259 | D011736 | Ataxia |
marker/mechanism
|
6457437
|
|
| D001480 | D011736 | Basal Ganglia Diseases |
marker/mechanism
|
872535
|
|
| D001714 | D011736 | Bipolar Disorder |
marker/mechanism
|
3197022
|
|
| D001763 | D011736 | Blepharoptosis |
therapeutic
|
15838404
16816519 |
|
| D001766 | D011736 | Blindness |
marker/mechanism
|
4059141
|
|
| D002653 | D011736 | Child Behavior Disorders |
therapeutic
|
150790
|
|
| D015362 | D011736 | Child Nutrition Disorders |
therapeutic
|
16153327
|
|
| D002971 | D011736 | Cleft Lip |
therapeutic
|
14991264
|
|
| D002972 | D011736 | Cleft Palate |
therapeutic
|
14991264
|
|
| D003128 | D011736 | COMA |
therapeutic
|
9385305
18807228 |
|
| D003221 | D011736 | Confusion |
therapeutic
|
8477121
9385305 |
|
| D003389 | D011736 | Cranial Nerve Diseases |
therapeutic
|
15838404
17710662 |
|
| D003680 | D011736 | Deglutition Disorders |
therapeutic
|
20167372
|
|
| D004401 | D011736 | Dysarthria |
therapeutic
|
20167372
|
|
| D004421 | D011736 | Dystonia |
therapeutic
|
5467095
|
|
| D004890 | D011736 | Erythema |
therapeutic
|
18191705
19489054 |
|
| D005119 | D011736 | Extravasation of Diagnostic and Therapeutic Materials |
therapeutic
|
3129617
|
|
| D005155 | D011736 | Facial Nerve Diseases |
therapeutic
|
20167372
|
|
| D005533 | D011736 | Foot Dermatoses |
therapeutic
|
2345070
2529807 |
|
| D006229 | D011736 | Hand Dermatoses |
therapeutic
|
2345070
2529807 |
|
| D006527 | D011736 | Hepatolenticular Degeneration |
therapeutic
|
5421930
|
|
| D006948 | D011736 | Hyperkinesis |
therapeutic
|
150790
|
|
| D020437 | D011736 | Hypoglossal Nerve Diseases |
therapeutic
|
20167372
|
|
| D055985 | D011736 | Latent Tuberculosis |
therapeutic
|
11042314
|
|
| D053609 | D011736 | Lethargy |
marker/mechanism
|
4191448
|
|
| D009069 | D011736 | Movement Disorders |
marker/mechanism
|
6457437
|
|
| D009336 | D011736 | Necrosis |
therapeutic
|
3129617
|
|
| D009369 | D011736 | Neoplasms |
marker/mechanism
|
6061664
|
|
| D009422 | D011736 | Nervous System Diseases |
marker/mechanism
therapeutic |
6457438
7283299 8321366 |
|
| D009886 | D011736 | Ophthalmoplegia |
therapeutic
|
16816519
|
|
| D010146 | D011736 | Pain |
therapeutic
|
3129617
11516431 |
|
| D010292 | D011736 | Paresthesia |
marker/mechanism
therapeutic |
2345070
2529807 6293793 14687374 18191705 19489054 |
|
| D010300 | D011736 | Parkinson Disease |
therapeutic
|
818540
|
|
| D010302 | D011736 | Parkinson Disease, Secondary |
therapeutic
|
2269609
|
|
| D010523 | D011736 | Peripheral Nervous System Diseases |
marker/mechanism
therapeutic |
2166360
6269259 16788441 17710662 20216233 |
|
| D011115 | D011736 | Polyneuropathies |
therapeutic
|
15838404
20532679 |
|
| D011251 | D011736 | Pregnancy Complications, Infectious |
therapeutic
|
11042314
|
|
| D011618 | D011736 | Psychotic Disorders |
therapeutic
|
2269609
|
|
| D012559 | D011736 | Schizophrenia |
therapeutic
|
6652165
|
|
| D012640 | D011736 | Seizures |
therapeutic
|
1085609
1257824 5262029 5421930 7310217 8477121 8540225 10708202 11423814 18807228 |
|
| D012871 | D011736 | Skin Diseases |
therapeutic
|
18709164
|
|
| D013226 | D011736 | Status Epilepticus |
therapeutic
|
6866642
18610679 20453796 |
|
| D014376 | D011736 | Tuberculosis |
therapeutic
|
8178358
|
|
| D014397 | D011736 | Tuberculosis, Pulmonary |
therapeutic
|
4059141
|
|
| D015431 | D011736 | Weight Loss |
marker/mechanism
|
6457437
|