PCIDB

KCF-S cluster No. 2457 (3 metabolites)

class name	count
rosids	3
Spermatophyta	1

br08003 Category	# of metabolite

br08003 Category	KEGG ID	KNApSAcK ID

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases
C00007504	Pyridoxamine	CHEMBL593019	D011733	10 / 15 / 16	0 / 5
C00007509	Pyridoxal	CHEMBL102970	D011730	12 / 16 / 20	1 / 1
C00047902	Ginkgotoxin	CHEMBL1076875	C001737	3 / 1 / 1

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
O00764	Pyridoxal kinase	Enzyme	C00007504 C00007509 C00047902	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00007504 C00007509	11 / 10
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00007504 C00007509	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00007504 C00007509	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00007509	2 / 2
P11473	Vitamin D3 receptor	NR1I1	C00007504	2 / 3
P00352	Retinal dehydrogenase 1	Enzyme	C00007509	0 / 0
Q05329	Glutamate decarboxylase 2	Enzyme	C00047902	0 / 0
O75496	Geminin	Unclassified protein	C00007509	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00007504	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00007504	0 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00007504	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00007504	0 / 1
Q99259	Glutamate decarboxylase 1	Enzyme	C00047902	1 / 1
Q06278	Aldehyde oxidase	Enzyme	C00007509	0 / 1
Q9UBT6	DNA polymerase kappa	Enzyme	C00007509	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00007509	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00007504	1 / 0
O00255	Menin	Unclassified protein	C00007509	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00007509	1 / 2

gene	gene name	gene description	KNApSAcK metabolite in interactions
8566	PDXK, C21orf124, C21orf97, PKH, PNK	pyridoxal (pyridoxine, vitamin B6) kinase (EC:2.7.1.35)	C00007509

OMIM	preferred title	UniProt
#115200	Cardiomyopathy, dilated, 1a; cmd1a	P02545
#212112	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	P02545
#603513	Cerebral palsy, spastic quadriplegic, 1; cpsq1	Q99259
#605588	Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1	P02545
#119900	Digital clubbing, isolated congenital	P15428
#609535	Drug metabolism, poor, cyp2c19-related	P33261
#608902	Drug metabolism, poor, cyp2d6-related	P10635
#181350	Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2	P02545
#605130	Hairy elbows, short stature, facial dysmorphism, and developmental delay	Q03164
#610140	Heart-hand syndrome, slovenian type	P02545
#176670	Hutchinson-gilford progeria syndrome; hgps	P02545
#145000	Hyperparathyroidism 1; hrpt1	O00255
#259100	Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1	P15428
#151660	Lipodystrophy, familial partial, type 2; fpld2	P02545
#248370	Mandibuloacral dysplasia with type a lipodystrophy; mada	P02545
#131100	Multiple endocrine neoplasia, type i; men1	O00255
#613205	Muscular dystrophy, congenital, lmna-related	P02545
#159001	Muscular dystrophy, limb-girdle, type 1b; lgmd1b	P02545
#607948	Mycobacterium tuberculosis, susceptibility to	P11473
#275210	Restrictive dermopathy, lethal	P02545
#277440	Vitamin d-dependent rickets, type 2a; vddr2a	P11473

KEGG	name	UniProt
H00033	Adrenal carcinoma	O00255 (related)
H00034	Carcinoid	O00255 (related)
H00045	Malignant islet cell carcinoma	O00255 (related)
H00246	Primary hyperparathyroidism	O00255 (related)
H01102	Pituitary adenomas	O00255 (related)
H00264	Charcot-Marie-Tooth disease (CMT)	P02545 (related)
H00294	Dilated cardiomyopathy (DCM)	P02545 (related)
H00420	Familial partial lipodystrophy (FPL)	P02545 (related)
H00563	Emery-Dreifuss muscular dystrophy	P02545 (related)
H00590	Congenital muscular dystrophies (CMD/MDC)	P02545 (related)
H00593	Limb-girdle muscular dystrophy (LGMD)	P02545 (related)
H00601	Hutchinson-Gilford progeria syndrome	P02545 (related)
H00663	Restrictive dermopathy	P02545 (related)
H00665	Mandibuloacral dysplasia	P02545 (related)
H01216	Left ventricular noncompaction (LVNC)	P02545 (related)
H00036	Osteosarcoma	P08684 (marker)
H00342	Tuberculosis	P11473 (related)
H00784	Localized autosomal recessive hypotrichosis	P11473 (related)
H01143	Vitamin D-dependent rickets	P11473 (related)
H01205	Coumarin resistance	P11712 (related)
H00457	Primary hypertrophic osteoarthropathy (PHO)	P15428 (related)
H01246	Isolated congenital nail clubbing (ICNC)	P15428 (related)
H01171	Poor drug metabolism (PM)	P33261 (related)
H00001	Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)	Q03164 (related) Q03164 (marker)
H00002	Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)	Q03164 (related)
H00192	Xanthinuria	Q06278 (related)
H01097	Cerebral palsy	Q99259 (related)