KCF-S cluster No. 1030 (9 metabolites)
Corresponding Phytochemical cluster No. 25
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| rosids | 60 |
| asterids | 40 |
| eudicotyledons | 4 |
| Liliopsida | 1 |
| Spermatophyta | 1 |
Cumulative family count (Top 20)
| class name | count |
|---|---|
Apiaceae
|
19 |
|
Rutaceae
|
19 |
|
Fabaceae
|
17 |
|
Asteraceae
|
8 |
|
Thymelaeaceae
|
8 |
|
Hydrangeaceae
|
5 |
|
Moraceae
|
5 |
|
Picramniaceae
|
3 |
|
Meliaceae
|
3 |
|
Solanaceae
|
2 |
|
Oleaceae
|
2 |
|
Lamiaceae
|
2 |
|
Euphorbiaceae
|
2 |
|
Caprifoliaceae
|
1 |
|
Xanthorrhoeaceae
|
1 |
|
Hippocastanaceae
|
1 |
|
Plumbaginaceae
|
1 |
|
Pucciniaceae
|
1 |
|
Biebersteiniaceae
|
1 |
|
Cupressaceae
|
1 |
Metabolite list (9)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00002460
|
Coumarin
|
CHEMBL6466
|
C030123
|
122 / 60 / 55 | 11 / 7 |
|
|
C00002462
|
Daphnetin
|
CHEMBL244948
|
C039952
|
40 / 43 / 40 |
|
|
|
C00002471
|
Esculetin
/ Aesculetin / 6,7-Dihydroxycoumarin |
CHEMBL244743
|
C007628
|
40 / 44 / 32 | 19 / 4 |
|
|
C00002503
|
Umbelliferon
/ Umbelliferone / 7-Hydroxycoumarin |
CHEMBL51628
|
C031477
|
39 / 33 / 32 | 9 / 0 |
|
|
C00019143
|
3-Coumarinol
/ 3-Hydroxycoumarin |
CHEMBL150372
|
11 / 5 / 7 |
|
||
|
C00019872
|
6-Formylumbelliferone
|
|
||||
|
C00020030
|
6,7,8-Trihydroxycoumarin
|
|
||||
|
C00029555
|
5,7-Dihydroxycoumarin
|
CHEMBL156000
|
|
|||
|
C00045576
|
5-Hydroxycoumarin
|
CHEMBL452422
|
|
Human Protein / Gene in interactions
173 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P15121 | Aldose reductase | Enzyme | C00002460 C00002471 C00002503 C00019143 | 0 / 0 |
| Q00796 | Sorbitol dehydrogenase | Enzyme | C00002460 C00002471 C00002503 C00019143 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002462 C00002471 C00002503 C00019143 | 2 / 2 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00002462 C00002471 C00002503 C00019143 | 1 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002462 C00002471 C00002503 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002460 C00002462 C00002471 | 1 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00002460 C00002503 C00019143 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002460 C00002462 C00002503 | 1 / 1 |
| P56817 | Beta-secretase 1 | A1A | C00002460 C00002471 C00002503 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002460 C00002462 C00002471 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00002460 C00002503 C00019143 | 0 / 1 |
| O75496 | Geminin | Unclassified protein | C00002462 C00002471 C00002503 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002462 C00002471 C00002503 | 3 / 3 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00002460 C00002503 C00019143 | 1 / 2 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002460 C00002462 C00002471 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002460 C00002462 C00002471 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002460 C00002462 C00002471 | 11 / 10 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00002460 C00002503 C00019143 | 1 / 2 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002460 C00002462 C00002471 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002460 C00002462 C00002471 | 1 / 1 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00002460 C00002462 C00002471 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00002460 C00002471 C00002503 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002462 C00002471 C00002503 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00002462 C00002471 | 0 / 0 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | C00002460 C00002503 | 0 / 0 |
| P55210 | Caspase-7 | C14 | C00002471 C00002503 | 0 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00002460 C00002503 | 1 / 0 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00002471 C00002503 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00002471 C00002503 | 1 / 1 |
| P04062 | Glucosylceramidase | Enzyme | C00002471 C00002503 | 6 / 4 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00002471 C00002503 | 5 / 1 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00002460 C00002462 | 3 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002462 C00002471 | 4 / 3 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00002462 C00002471 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002462 C00002471 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002460 C00002503 | 0 / 3 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00002460 C00002462 | 0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | C00002471 C00002503 | 1 / 1 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00002462 C00002471 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002462 C00002503 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002471 C00002503 | 1 / 1 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00002471 C00002503 | 0 / 0 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00002471 C00002503 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002460 C00002462 | 0 / 1 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002462 C00002503 | 0 / 0 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002460 C00002462 | 1 / 4 |
| P39748 | Flap endonuclease 1 | Enzyme | C00002462 C00002503 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00002460 C00002471 | 1 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00002460 C00002462 | 1 / 8 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002462 C00002471 | 4 / 1 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00002471 C00002503 | 3 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002471 C00002503 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00002460 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00002460 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00002460 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00002460 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00002460 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00002460 | 1 / 1 |
| P17538 | Chymotrypsinogen B | S1A | C00002460 | 0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00002462 | 0 / 0 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00002460 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00002460 | 1 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00002460 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00002460 | 0 / 0 |
| P28845 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Enzyme | C00002503 | 1 / 1 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00002460 | 2 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00002460 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00002471 | 0 / 0 |
| P14920 | D-amino-acid oxidase | Enzyme | C00019143 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00002460 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00002460 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00002460 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00002460 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00002460 | 0 / 0 |
| P18405 | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | Oxidoreductase | C00002503 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00002460 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00002460 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00002460 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00002460 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00002460 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00002460 | 0 / 0 |
| P02768 | Serum albumin | Secreted protein | C00002460 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00002460 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00002460 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00002460 | 1 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00002460 | 0 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00002460 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00002460 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00002460 | 1 / 0 |
| P03956 | Interstitial collagenase | M10A | C00002460 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00002460 | 0 / 0 |
| Q9GZT4 | Serine racemase | Enzyme | C00019143 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00002462 | 1 / 1 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00002460 | 0 / 0 |
| Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | Electrochemical transporter | C00002460 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00002460 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002460 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00002460 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00002460 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00002460 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00002503 | 4 / 2 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00002460 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00002460 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00002460 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00002460 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00002460 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00002460 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00002460 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00002460 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00002460 | 1 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00002460 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00002460 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002460 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00002460 | 2 / 1 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00002460 | 0 / 0 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00002460 | 0 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00002460 | 1 / 1 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00002460 | 0 / 1 |
| Q99489 | D-aspartate oxidase | Enzyme | C00019143 | 0 / 0 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00002462 | 5 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00002462 | 0 / 0 |
| Q8N1Q1 | Carbonic anhydrase 13 | Lyase | C00002460 | 0 / 0 |
| Q9Y4X1 | UDP-glucuronosyltransferase 2A1 | Enzyme | C00002503 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00002460 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00002460 | 1 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00002460 | 1 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00002462 | 0 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00002460 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00002460 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00002460 | 2 / 2 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00002460 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00002460 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00002460 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00002460 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00002460 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00002460 | 0 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00002460 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00002460 | 0 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00002460 | 0 / 0 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00002460 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00002460 | 0 / 0 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00002462 | 1 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00002471 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002462 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00002462 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00002460 | 0 / 0 |
| Q99549 | M-phase phosphoprotein 8 | Unclassified protein | C00002462 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002460 | 0 / 0 |
| P07477 | Trypsin-1 | S1A | C00002460 | 1 / 1 |
| P10275 | Androgen receptor | NR3C4 | C00002460 | 3 / 4 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00002460 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00002460 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00002460 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00002460 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00002460 | 1 / 1 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00002460 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00002460 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00002460 | 0 / 0 |
| P34949 | Mannose-6-phosphate isomerase | Enzyme | C00002471 | 1 / 1 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00002460 | 1 / 1 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00002503 | 1 / 1 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00002460 | 0 / 0 |
| O14980 | Exportin-1 | Unclassified protein | C00002460 | 0 / 0 |
| P08246 | Neutrophil elastase | S1A | C00002460 | 2 / 1 |
| P40225 | Thrombopoietin | Unclassified protein | C00002462 | 1 / 1 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00002460 | 2 / 2 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00002462 | 2 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00002471 | 1 / 0 |
| O00255 | Menin | Unclassified protein | C00002503 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002503 | 1 / 2 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00002460 | 0 / 0 |
| Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | Electrochemical transporter | C00002460 | 1 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00002460 | 0 / 0 |
34 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00002460
C00002471
C00002503
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00002460
C00002503
|
| 1548 | CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB | cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) |
C00002460
C00002503
|
| 7366 | UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 | UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) |
C00002471
C00002503
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00002471
|
| 1312 | COMT | catechol-O-methyltransferase (EC:2.1.1.6) |
C00002471
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00002471
|
| 355 | FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 | Fas cell surface death receptor |
C00002471
|
| 356 | FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 | Fas ligand (TNF superfamily, member 6) |
C00002471
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00002471
|
| 1432 | MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA | mitogen-activated protein kinase 14 (EC:2.7.11.24) |
C00002471
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00002471
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00002471
|
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) |
C00002471
|
| 4780 | NFE2L2, NRF2 | nuclear factor, erythroid 2-like 2 |
C00002471
|
| 1728 | NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 | NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) |
C00002471
|
| 8797 | TNFRSF10A, APO2, CD261, DR4, TRAILR-1, TRAILR1 | tumor necrosis factor receptor superfamily, member 10a |
C00002471
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00002471
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00002471
|
| 637 | BID, FP497 | BH3 interacting domain death agonist |
C00002471
|
| 1546 |
C00002460
|
||
| 1553 | CYP2A13, CPAD, CYP2A, CYPIIA13 | cytochrome P450, family 2, subfamily A, polypeptide 13 (EC:1.14.14.1) |
C00002460
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00002471
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00002460
|
| 2158 | F9, FIX, HEMB, P19, PTC, THPH8 | coagulation factor IX (EC:3.4.21.22) |
C00002460
|
| 3292 | HSD17B1, EDH17B2, EDHB17, HSD17, SDR28C1 | hydroxysteroid (17-beta) dehydrogenase 1 (EC:1.1.1.62) |
C00002460
|
| 4256 | MGP, MGLAP, NTI | matrix Gla protein |
C00002460
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00002460
|
| 79001 | VKORC1, EDTP308, IMAGE3455200, MST134, MST576, VKCFD2, VKOR | vitamin K epoxide reductase complex, subunit 1 (EC:1.1.4.1) |
C00002460
|
| 8644 | AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS | aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) |
C00002503
|
| 8574 | AKR7A2, AFAR, AFAR1, AFB1-AR1, AKR7 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) (EC:1.1.1.n11) |
C00002503
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00002503
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00002503
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00002503
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (108)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #602579 | Congenital disorder of glycosylation, type ib; cdg1b |
P34949
|
| #604931 | Cortisone reductase deficiency 1; cortrd1 |
P28845
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 |
| #232300 | Glycogen storage disease ii |
P10253
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237450 | Hyperbilirubinemia, rotor type; hblrr |
Q9NPD5
Q9Y6L6 |
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #159900 | Myoclonic dystonia |
P14416
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #167800 | Pancreatitis, hereditary; pctt |
P07477
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (85)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
Q16790 (marker) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00933 | Hereditary pancreatitis |
P07477
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01111 | Cortisone reductase deficiency (CRD) |
P28845
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00118 | Congenital disorders of glycosylation (CDG) type I |
P34949
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
Q99714 (related) |
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
10 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D007674 | Kidney Diseases |
C00002471
C00002460 |
| D056486 | Drug-Induced Liver Injury |
C00002460
|
| D003093 | Colitis, Ulcerative |
C00002471
|
| D014693 | Ventricular Fibrillation |
C00002471
|
| D003924 | Diabetes Mellitus, Type 2 |
C00002460
|
| D003967 | Diarrhea |
C00002471
|
| D009336 | Necrosis |
C00002460
|
| D012871 | Skin Diseases |
C00002460
|
| D013927 | Thrombosis |
C00002460
|
| D014689 | Venous Insufficiency |
C00002460
|