PCIDB

KNApSAcK Metabolite C00002503

Metabolite

KNApSAcK Entry

id C00002503
Name Umbelliferon / Umbelliferone / 7-Hydroxycoumarin
CAS RN 93-35-6
Standard InChI InChI=1S/C9H6O3/c10-7-3-1-6-2-4-9(11)12-8(6)5-7/h1-5,10H
Standard InChI (Main Layer) InChI=1S/C9H6O3/c10-7-3-1-6-2-4-9(11)12-8(6)5-7/h1-5,10H

Cluster

Phytochemical cluster No. 25
KCF-S cluster No. 1030

Link

ChEMBL

By standard InChI CHEMBL51628
By standard InChI Main Layer CHEMBL51628

KEGG

By LinkDB C09315

CTD

By CAS RN C031477

Species

Summary

Plant class

class name count
rosids 40
asterids 29
eudicotyledons 2
Spermatophyta 1

Family (Top 10)

family name count
Apiaceae 19
Rutaceae 15
Fabaceae 11
Moraceae 5
Thymelaeaceae 4
Hydrangeaceae 4
Asteraceae 4
Picramniaceae 3
Solanaceae 2
Biebersteiniaceae 1

List (73)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Acacia ehrenbergiana 1179190 Fabaceae rosids Viridiplantae
Achillea biebersteinii 282722 Asteraceae asterids Viridiplantae
Adonis tienschanicus 46984 Ranunculaceae eudicotyledons Viridiplantae
Aegle marmelos 68527 Rutaceae rosids Viridiplantae
Angelica furcijuga KITAGAWA 40948 Apiaceae asterids Viridiplantae
Angelica gigas 85712 Apiaceae asterids Viridiplantae
Apium spp. 4044 Apiaceae asterids Viridiplantae
Artemisia minor 1227633 Asteraceae asterids Viridiplantae
Astragalus brachycarpus 20400 Fabaceae rosids Viridiplantae
Atropa belladonna 33113 Solanaceae asterids Viridiplantae
Biebersteinia orphanidis 74351 Biebersteiniaceae rosids Viridiplantae
Chamaecyparis formosensis 187461 Cupressaceae Spermatophyta Viridiplantae
Citrus grandis 37334 Rutaceae rosids Viridiplantae
Citrus paradisi 37656 Rutaceae rosids Viridiplantae
Citrus sinensis cv.Valencia 2706 Rutaceae rosids Viridiplantae
Clausena anisata 159034 Rutaceae rosids Viridiplantae
Clausena excavata 76959 Rutaceae rosids Viridiplantae
Copaifera langsdorffii 280048 Fabaceae rosids Viridiplantae
Coronilla valentina 118893 Fabaceae rosids Viridiplantae
Daphne odora Thunb. 66679 Thymelaeaceae rosids Viridiplantae
Daphne oleoides ssp. oleoides 66679 Thymelaeaceae rosids Viridiplantae
Dictamnus angustifolius 77005 Rutaceae rosids Viridiplantae
Dorstenia brasiliensis 984796 Moraceae rosids Viridiplantae
Dorstenia turbinata 984821 Moraceae rosids Viridiplantae
Falcaria vulgaris 52469 Apiaceae asterids Viridiplantae
Ferula assa-foetida 52471 Apiaceae asterids Viridiplantae
Ferula diversivittata 371338 Apiaceae asterids Viridiplantae
Ferula spp. 52470 Apiaceae asterids Viridiplantae
Ferula szovitsiana 52470 Apiaceae asterids Viridiplantae
Ficus carica 3494 Moraceae rosids Viridiplantae
Ficus cunninghamii 3487 Moraceae rosids Viridiplantae
Haplophyllum patavinum 452780 Rutaceae rosids Viridiplantae
Heracleum candicans WALL. 40917 Apiaceae asterids Viridiplantae
Heracleum dissectum 380073 Apiaceae asterids Viridiplantae
Heracleum granatense 40917 Apiaceae asterids Viridiplantae
Heracleum spp. 40917 Apiaceae asterids Viridiplantae
Hydrangea chinensis 498914 Hydrangeaceae asterids Viridiplantae
Hydrangea macrophylla Ser.var.thunbergii Makino. 23109 Hydrangeaceae asterids Viridiplantae
Hydrangea paniculata 52833 Hydrangeaceae asterids Viridiplantae
Hydrangea vestita 23109 Hydrangeaceae asterids Viridiplantae
Inula helenium L. 55635 Asteraceae asterids Viridiplantae
Khaya ivorensis 486173 Meliaceae rosids Viridiplantae
Ligusticum multivittatum 49551 Apiaceae asterids Viridiplantae
Mandragora autumnalis 389206 Solanaceae asterids Viridiplantae
Melilotus alba 47082 Fabaceae rosids Viridiplantae
Morus cathayana 226895 Moraceae rosids Viridiplantae
Murraya siamensis 159029 Rutaceae rosids Viridiplantae
Onobrychis kemularia 3881 Fabaceae rosids Viridiplantae
Onobrychis kemulariae 3881 Fabaceae rosids Viridiplantae
Peucedanum bourgaei Lange in Wilk.et Lange. 49562 Apiaceae asterids Viridiplantae
Peucedanum praeruptorum DUNN. 49562 Apiaceae asterids Viridiplantae
Phaseolus vulgaris 3885 Fabaceae rosids Viridiplantae
Phellodendron amurense 68554 Rutaceae rosids Viridiplantae
Phellodendron japonicum MAXIM 68553 Rutaceae rosids Viridiplantae
Phlojodicarpus sibiricus 63026 Apiaceae asterids Viridiplantae
Picramnia antidesma 1129486 Picramniaceae rosids Viridiplantae
Picramnia latifolia 681474 Picramniaceae rosids Viridiplantae
Picramnia teapensis Tul. 85238 Picramniaceae rosids Viridiplantae
Pimpinella spp. 40958 Apiaceae asterids Viridiplantae
Platytaenia dasycarpa
Poncirus trifoliata 37690 Rutaceae rosids Viridiplantae
Ruta chalepensis 452790 Rutaceae rosids Viridiplantae
Saussurea laniceps 254913 Asteraceae asterids Viridiplantae
Securigera elegans 181251 Fabaceae rosids Viridiplantae
Sedum ewersii 3784 Crassulaceae eudicotyledons Viridiplantae
Seseli webbii Cosson. 40951 Apiaceae asterids Viridiplantae
Severinia buxifolia 76974 Rutaceae rosids Viridiplantae
Stellera chamaejasme L. 142737 Thymelaeaceae rosids Viridiplantae
Tordylium apulum 489417 Apiaceae asterids Viridiplantae
Vicia sativa 3908 Fabaceae rosids Viridiplantae
Vigna radiata 157791 Fabaceae rosids Viridiplantae
Wikstroemia elliptica 142693 Thymelaeaceae rosids Viridiplantae
Zanthoxylum wutaiense 697043 Rutaceae rosids Viridiplantae

Human Protein / Gene in interaction

39 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P22310 UDP-glucuronosyltransferase 1-4 Enzyme CHEMBL51628 CHEMBL1908081 (1) CHEMBL1908082 (1)
3 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme CHEMBL51628 CHEMBL1908087 (2)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL51628 CHEMBL2114784 (1)
1 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL51628 CHEMBL1014033 (1)
0 / 3
P04062 Glucosylceramidase Enzyme CHEMBL51628 CHEMBL1613818 (1)
6 / 4
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL51628 CHEMBL1614175 (1)
1 / 1
P29466 Caspase-1 C14 CHEMBL51628 CHEMBL1614158 (1)
0 / 0
P04406 Glyceraldehyde-3-phosphate dehydrogenase Enzyme CHEMBL51628 CHEMBL684062 (1)
0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase CHEMBL51628 CHEMBL892636 (1)
1 / 1
P00918 Carbonic anhydrase 2 Lyase CHEMBL51628 CHEMBL1212359 (1) CHEMBL1290838 (1)
CHEMBL1941822 (1)
1 / 2
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL51628 CHEMBL1614458 (1)
0 / 0
P28845 Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme CHEMBL51628 CHEMBL1656573 (1) CHEMBL1656574 (1)
1 / 1
O43570 Carbonic anhydrase 12 Lyase CHEMBL51628 CHEMBL1212361 (1) CHEMBL1941824 (1)
1 / 2
P39748 Flap endonuclease 1 Enzyme CHEMBL51628 CHEMBL1794486 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL51628 CHEMBL1738606 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL51628 CHEMBL2114843 (1)
0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme CHEMBL51628 CHEMBL1908090 (1)
0 / 0
P18405 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Oxidoreductase CHEMBL51628 CHEMBL816490 (1)
0 / 0
P15121 Aldose reductase Enzyme CHEMBL51628 CHEMBL1260797 (1)
0 / 0
P00915 Carbonic anhydrase 1 Lyase CHEMBL51628 CHEMBL1212358 (1) CHEMBL1290837 (1)
CHEMBL1941821 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL51628 CHEMBL1794401 (1)
0 / 0
P14679 Tyrosinase Oxidoreductase CHEMBL51628 CHEMBL1780390 (1)
4 / 2
P06280 Alpha-galactosidase A Enzyme CHEMBL51628 CHEMBL1614217 (1) CHEMBL1614369 (1)
1 / 1
P56817 Beta-secretase 1 A1A CHEMBL51628 CHEMBL1936881 (1) CHEMBL1936882 (1)
0 / 0
Q16790 Carbonic anhydrase 9 Lyase CHEMBL51628 CHEMBL1212360 (1) CHEMBL1290839 (1)
CHEMBL1941823 (1)
0 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL51628 CHEMBL1613910 (1)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL51628 CHEMBL1614038 (1)
2 / 2
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme CHEMBL51628 CHEMBL1908085 (2)
0 / 0
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme CHEMBL51628 CHEMBL1908088 (1)
0 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL51628 CHEMBL1003053 (1)
1 / 0
Q00796 Sorbitol dehydrogenase Enzyme CHEMBL51628 CHEMBL1260799 (1)
0 / 0
P55210 Caspase-7 C14 CHEMBL51628 CHEMBL1613779 (1)
0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme CHEMBL51628 CHEMBL1908080 (1)
5 / 1
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme CHEMBL51628 CHEMBL1656575 (1) CHEMBL1656576 (1)
1 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL51628 CHEMBL1613914 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL51628 CHEMBL1614364 (1)
1 / 1
O00255 Menin Unclassified protein CHEMBL51628 CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL51628 CHEMBL1614531 (1)
1 / 3
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL51628 CHEMBL2114738 (1)
0 / 0

CTD interaction (12)

compound gene gene name gene description interaction interaction type form reference
pmid
C031477 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) 7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal] decreases reaction
/ increases response to substance
mutant form 22964423
C031477 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) 7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to Hydrogen Peroxide] decreases reaction
/ increases response to substance
mutant form 22964423
C031477 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) 7-hydroxycoumarin results in increased expression of AKR1C3 protein increases expression
protein 22964423
C031477 8574 AKR7A2
AFAR
AFAR1
AFB1-AR1
AKR7
aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) (EC:1.1.1.n11) 7-hydroxycoumarin affects the reaction [AKR7A2 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal] affects reaction
/ increases response to substance
mutant form 22964423
C031477 8574 AKR7A2
AFAR
AFAR1
AFB1-AR1
AKR7
aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) (EC:1.1.1.n11) 7-hydroxycoumarin results in increased expression of AKR7A2 protein increases expression
protein 22964423
C031477 581 BAX
BCL2L4
BCL2-associated X protein 7-hydroxycoumarin results in increased expression of BAX protein increases expression
protein 15964220
C031477 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 7-hydroxycoumarin results in decreased expression of BCL2 protein decreases expression
protein 15964220
C031477 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 7-hydroxycoumarin results in decreased expression of CCND1 protein decreases expression
protein 11679177
C031477 1548 CYP2A6
CPA6
CYP2A
CYP2A3
CYPIIA6
P450C2A
P450PB
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) CYP2A6 protein results in increased chemical synthesis of 7-hydroxycoumarin increases chemical synthesis
protein 11376561
11393269
11927840
12401345
15155557
C031477 6817 SULT1A1
HAST1/HAST2
P-PST
PST
ST1A1
ST1A3
STP
STP1
TSPST1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) SULT1A1 protein results in increased sulfation of 7-hydroxycoumarin increases sulfation
protein 11181495
C031477 54600 UGT1A9
HLUGP4
LUGP4
UDPGT
UDPGT_1-9
UGT-1I
UGT1-09
UGT1-9
UGT1.9
UGT1AI
UGT1I
UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) UGT1A9 protein results in increased glucuronidation of 7-hydroxycoumarin increases glucuronidation
protein 15044611
C031477 7366 UGT2B15
HLUG4
UDPGT_2B8
UDPGT2B15
UDPGTH3
UGT2B8
UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) UGT2B15 protein results in increased metabolism of 7-hydroxycoumarin increases metabolic processing
protein 7835232

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (33)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#218030 Apparent mineralocorticoid excess; ame P80365
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#604931 Cortisone reductase deficiency 1; cortrd1 P28845
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#119900 Digital clubbing, isolated congenital P15428
#301500 Fabry disease P06280
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#143500 Gilbert syndrome P22309
P22310
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#168600 Parkinson disease, late-onset; pd P04062
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (32)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00125 Fabry disease P06280 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00208 Hyperbilirubinemia P22309 (related)
H01111 Cortisone reductase deficiency (CRD) P28845 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00192 Xanthinuria P47989 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)