PCIDB

Clausena excavata

Species

KNApSAcK Entry

Organism name Clausena excavata
Genus Clausena
Family Rutaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Clausena excavata
Linked NCBI taxonomy ID 76959
Linked level species

Family

Family in NCBI taxonomy Rutaceae
ID 23513

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (83)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00013982 External link 512 Myricetin 3',4'-dimethyl ether 3-rhamnoside
/ 3-[(6-Deoxy-alpha-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(3-hydroxy-4,5-dimethoxyphenyl)-4H-1-benzopyran-4-one
No. 2 No. 15
C00000977 External link 512 Liquiritigenin
CHEMBL252642
CHEMBL271939
C083152
5 / 4 / 4 1 / 1 No. 25 No. 14
C00006925 External link 512 Isoliquiritigenin
CHEMBL129795
CHEMBL1395334
C040920
59 / 83 / 90 12 / 3 No. 92 No. 13
C00026896 External link 512 Clausine-P
/ Clausine P
No. 239
C00026897 External link 512 Clausine-Q
/ Clausine Q
No. 239
C00024710 External link 512 Glycozolidal
CHEMBL2036045
No. 239
C00001753 External link 512 Murrayanine
CHEMBL1689802
No. 239
C00025140 External link 512 2-Hydroxy-3-formyl-7-methoxycarbazole
CHEMBL463264
No. 239
C00026902 External link 512 Clausine-V
/ 2,7-Dimethoxycarbazole
/ 2,7-Dimethoxy-9H-carbazole
No. 239
C00024731 External link 512 Murrayafolin A
CHEMBL490667
No. 239
C00039185 External link 512 Excavatin A
/ (+)-Excavatin A
No. 335
C00025172 External link 512 Heptaphylline
CHEMBL1689799
No. 437
C00026899 External link 512 Clausine-S
/ (+)-Clausine S
No. 437
C00030473 External link 512 Heptazoline
No. 437
C00026903 External link 512 Clausenatine A
No. 437
C00002488 External link 512 Osthol
/ Osthole
CHEMBL52229
C046627
12 / 6 / 5 7 / 4 No. 466 No. 25
C00036889 External link 512 Cedrelopsin
No. 466 No. 25
C00039189 External link 512 Excavatin F
No. 590
C00039190 External link 512 Excavatin H
No. 590
C00039191 External link 512 Excavatin I
/ (+)-Excavatin I
No. 590
C00039188 External link 512 Excavatin D
/ (+)-Excavatin D
CHEMBL1348986
4 / 13 / 8 No. 590
C00029988 External link 512 Clauslactone M
No. 590
C00035269 External link 512 Clauslactone E
CHEMBL488603
No. 590
C00030242 External link 512 Excavatin E
No. 590
C00046676 External link 512 Clauslactone I
/ (+)-Clauslactone I
CHEMBL470443
No. 590
C00030243 External link 512 Excavatin G
No. 590
C00039192 External link 512 Excavatin J
/ (+)-Excavatin J
CHEMBL470443
No. 590
C00002505 External link 512 Xanthyletin
CHEMBL303846
C020814
29 / 43 / 58 No. 750 No. 25
C00032520 External link 512 Xanthoxyletin
CHEMBL501358
14 / 5 / 7 No. 750 No. 25
C00038258 External link 512 3-Methylcarbazole
CHEMBL1173768
C110004
1 / 1 / 0 No. 751
C00026895 External link 512 Clausine-O
/ Clausine O
CHEMBL1689804
No. 751
C00024676 External link 512 3-Formylcarbazole
CHEMBL1172392
1 / 1 / 0 No. 751
C00024718 External link 512 Mukonal
CHEMBL1077147
No. 751
C00046678 External link 512 Clauszoline M
No. 751
C00046673 External link 512 Clauslactone F
/ (+)-Clauslactone F
CHEMBL488604
No. 797
C00046677 External link 512 Clauslactone J
/ (+)-Clauslactone J
CHEMBL485784
No. 797
C00039195 External link 512 Excavatin M
/ (+)-Excavatin M
CHEMBL470442
No. 797
C00039193 External link 512 Excavatin K
/ (+)-Excavatin K
No. 797
C00039194 External link 512 Excavatin L
CHEMBL485784
No. 797
C00046675 External link 512 Clauslactone H
/ (+)-Clauslactone H
CHEMBL470442
No. 797
C00029989 External link 512 Clauslactone R
No. 797
C00029990 External link 512 Clauslactone S
/ (+)-Clauslactone S
No. 797
C00038798 External link 512 Clausine R
No. 807
C00029986 External link 512 Clausine L
CHEMBL2037029
No. 807
C00029984 External link 512 Clausine E
/ Clauszoline I
CHEMBL235934
2 / 0 / 0 No. 807
C00029983 External link 512 Clausine C
/ Clauszoline L
CHEMBL1173128
1 / 1 / 0 No. 807
C00026724 External link 512 Mukonidine
CHEMBL1088190
No. 807
C00026898 External link 512 Clausine-R
/ Clausine R
No. 807
C00026818 External link 512 Mukonine
CHEMBL236143
No. 807
C00026893 External link 512 Clausine-M
/ Clausine M
No. 807
C00039755 External link 512 Methyl carbazole-3-carboxylate
CHEMBL446253
1 / 1 / 0 No. 807
C00030835 External link 512 Nordentatin
C052084
No. 953
C00030116 External link 512 Dentatin
CHEMBL552132
No. 953
C00002503 External link 512 Umbelliferon
/ Umbelliferone
/ 7-Hydroxycoumarin
CHEMBL51628
C031477
39 / 33 / 32 9 / 0 No. 1030 No. 25
C00026512 External link 512 Clausamine A
CHEMBL479682
No. 1177
C00026517 External link 512 Clausevatine E
No. 1177
C00026518 External link 512 Clausevatine F
No. 1177
C00026516 External link 512 Clausevatine D
No. 1177
C00029991 External link 512 Clauslactone T
/ (+)-Clauslactone T
No. 1856
C00035268 External link 512 Clauslactone A
CHEMBL485785
No. 1856
C00029987 External link 512 Clauslactone B
/ (+)-Clauslactone B
CHEMBL485786
No. 1856
C00046671 External link 512 Clauslactone C
/ (+)-Clauslactone C
CHEMBL519868
No. 1856
C00046672 External link 512 Clauslactone D
/ (+)-Clauslactone D
CHEMBL488407
No. 1856
C00030796 External link 512 Murrayacoumarin C
No. 1856
C00039233 External link 512 Furoclausine B
/ (-)-Furoclausine B
No. 2135
C00026900 External link 512 Clausine-T
/ (-)-Clausine T
No. 2135
C00026901 External link 512 Clausine-U
/ (-)-Clausine U
No. 2135
C00038800 External link 512 Clausine W
/ (-)-Clausine W
No. 2135
C00019883 External link 512 Hassanidin
/ Claucavatin A
No. 2171
C00029981 External link 512 Clausarin
CHEMBL158198
C052085
No. 2171
C00019943 External link 512 Kinocoumarin
No. 2171
C00038797 External link 512 Claucavatin B
No. 2171
C00038799 External link 512 Clausine F
CHEMBL519276
C076712
No. 2229
C00046674 External link 512 Clauslactone G
/ (+)-Clauslactone G
No. 2977
C00019790 External link 512 Anisocoumarin J
No. 2977
C00029985 External link 512 Clausine K
/ Clauszoline J
CHEMBL1689806
No. 3858
C00026894 External link 512 Clausine-N
/ Clausine N
No. 3858
C00026598 External link 512 Furoclausine-A
No. 3897
C00039186 External link 512 Excavatin B
/ (+)-Excavatin B
No. 5397
C00039187 External link 512 Excavatin C
/ (+)-Excavatin C
No. 5397
C00029982 External link 512 Clausenidin
No. 6250
C00026519 External link 512 Clausevatine G
No. 6588
C00038701 External link 512 Carbazomarine A
/ (-)-Carbazomarine A
No. 8447

Human Protein / Gene in interactions

103 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P83916 Chromobox protein homolog 1 Unclassified protein C00002488 C00002503 C00002505 C00006925 C00032520 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002488 C00002505 C00006925 C00032520 0 / 0
P52732 Kinesin-like protein KIF11 Other cytosolic protein C00024676 C00029983 C00038258 C00039755 1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002503 C00002505 C00032520 C00039188 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002505 C00006925 C00032520 0 / 0
O75496 Geminin Unclassified protein C00002488 C00002503 C00006925 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00002503 C00002505 C00032520 0 / 0
Q99700 Ataxin-2 Unclassified protein C00002503 C00002505 C00006925 1 / 1
P00918 Carbonic anhydrase 2 Lyase C00002503 C00002505 C00032520 1 / 2
P00352 Retinal dehydrogenase 1 Enzyme C00002488 C00002503 C00002505 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002505 C00006925 C00039188 4 / 3
P17405 Sphingomyelin phosphodiesterase Enzyme C00002505 C00032520 C00039188 2 / 2
O43570 Carbonic anhydrase 12 Lyase C00002503 C00002505 C00032520 1 / 2
P56817 Beta-secretase 1 A1A C00002488 C00002503 C00002505 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00002503 C00002505 C00032520 0 / 1
P04062 Glucosylceramidase Enzyme C00002488 C00002503 C00006925 6 / 4
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002505 C00006925 C00032520 0 / 0
P04406 Glyceraldehyde-3-phosphate dehydrogenase Enzyme C00002488 C00002503 C00002505 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002503 C00002505 C00006925 2 / 2
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002503 C00002505 C00006925 3 / 3
P43166 Carbonic anhydrase 7 Lyase C00002505 C00032520 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00000977 C00006925 2 / 2
P22303 Acetylcholinesterase Hydrolase C00002503 C00002505 1 / 0
Q8N1Q1 Carbonic anhydrase 13 Lyase C00002505 C00032520 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002488 C00006925 0 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002488 C00006925 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00002503 C00006925 0 / 3
P05412 Transcription factor AP-1 Transcription Factor C00000977 C00006925 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002503 C00006925 1 / 2
Q04206 Transcription factor p65 Transcription Factor C00000977 C00006925 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00002505 C00039188 7 / 3
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00006925 C00032520 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00002488 C00006925 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00002505 C00006925 7 / 37
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000977 C00006925 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002505 C00006925 1 / 0
O00255 Menin Unclassified protein C00002503 C00006925 2 / 5
P39748 Flap endonuclease 1 Enzyme C00002503 C00006925 0 / 0
P15121 Aldose reductase Enzyme C00002503 C00006925 0 / 0
P37840 Alpha-synuclein Unclassified protein C00002505 C00006925 4 / 2
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00006925 1 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00002505 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00002505 4 / 2
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00002503 0 / 0
P18405 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Oxidoreductase C00002503 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002503 0 / 0
P28845 Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme C00002503 1 / 1
P11473 Vitamin D3 receptor NR1I1 C00006925 2 / 3
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00006925 1 / 8
P54132 Bloom syndrome protein Enzyme C00006925 1 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00006925 0 / 1
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00002503 1 / 1
P11021 78 kDa glucose-regulated protein Unclassified protein C00006925 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00006925 2 / 0
P61586 Transforming protein RhoA Unclassified protein C00029984 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00000977 2 / 2
P14679 Tyrosinase Oxidoreductase C00002503 4 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00006925 5 / 3
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00006925 0 / 0
P06280 Alpha-galactosidase A Enzyme C00002503 1 / 1
P35968 Vascular endothelial growth factor receptor 2 Vegfr C00006925 1 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00006925 2 / 3
P28482 Mitogen-activated protein kinase 1 Erk C00006925 0 / 0
P02545 Prelamin-A/C Unclassified protein C00006925 11 / 10
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00006925 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00006925 0 / 0
Q05655 Protein kinase C delta type Delta C00029984 0 / 0
P29466 Caspase-1 C14 C00002503 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00002505 1 / 1
Q01453 Peripheral myelin protein 22 Unclassified protein C00006925 5 / 2
P10253 Lysosomal alpha-glucosidase Hydrolase C00002503 1 / 1
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00002503 0 / 0
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme C00002503 0 / 0
P21802 Fibroblast growth factor receptor 2 TK tyrosine-protein kinase TLK subfamily C00006925 9 / 3
P11362 Fibroblast growth factor receptor 1 Fgfr C00006925 4 / 5
Q00796 Sorbitol dehydrogenase Enzyme C00002503 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00006925 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00006925 0 / 0
P55210 Caspase-7 C14 C00002503 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00006925 1 / 1
P06746 DNA polymerase beta Enzyme C00002505 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00006925 2 / 2
Q9UNA4 DNA polymerase iota Enzyme C00006925 0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00006925 1 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00006925 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00002503 5 / 1
P21728 D(1A) dopamine receptor Dopamine receptor C00006925 0 / 0
Q99549 M-phase phosphoprotein 8 Unclassified protein C00006925 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00002488 0 / 0
P10721 Mast/stem cell growth factor receptor Kit Pdgfr C00006925 4 / 3
P14618 Pyruvate kinase PKM Enzyme C00006925 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00002503 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00006925 0 / 0
O14980 Exportin-1 Unclassified protein C00002488 0 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00002503 0 / 0
P40225 Thrombopoietin Unclassified protein C00006925 1 / 1
Q16637 Survival motor neuron protein Unclassified protein C00002505 4 / 1
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002503 1 / 1
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00002503 3 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme C00006925 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002503 0 / 0
P51531 Probable global transcription activator SNF2L2 Unclassified protein C00006925 1 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00032520 1 / 1

26 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00002488 C00006925
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00002488 C00006925
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00002503 C00006925
8644 AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) C00002503
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00002503
1548 CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) C00002503
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00002503
581 BAX, BCL2L4 BCL2-associated X protein C00002503
7366 UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) C00002503
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00006925
329 BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 baculoviral IAP repeat containing 2 C00006925
330 BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 baculoviral IAP repeat containing 3 C00006925
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00006925
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00002503
8574 AKR7A2, AFAR, AFAR1, AFB1-AR1, AKR7 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) (EC:1.1.1.n11) C00002503
6513 SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED solute carrier family 2 (facilitated glucose transporter), member 1 C00006925
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00006925
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00006925
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00006925
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00006925
2180 ACSL1, ACS1, FACL1, FACL2, LACS, LACS1, LACS2 acyl-CoA synthetase long-chain family member 1 (EC:6.2.1.3) C00002488
1374 CPT1A, CPT1, CPT1-L, L-CPT1 carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) C00002488
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00002488
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00002488
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00002488
1831 TSC22D3, DIP, DSIPI, GILZ, TSC-22R, hDIP TSC22 domain family, member 3 C00000977

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (123)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#207410 Antley-bixler syndrome without genital anomalies or disordered steroidogenesis; abs2 P21802
#101200 Apert syndrome P21802
#218030 Apparent mineralocorticoid excess; ame P80365
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#123790 Beare-stevenson cutis gyrata syndrome; bstvs P21802
#614592 Bent bone dysplasia syndrome; bbds P21802
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#210900 Bloom syndrome; blm P54132
%606641 Body mass index; bmi P37231
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P84022
#604931 Cortisone reductase deficiency 1; cortrd1 P28845
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#123500 Crouzon syndrome P21802
#127750 Dementia, lewy body; dlb P37840
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#606764 Gastrointestinal stromal tumor; gist P10721
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#143500 Gilbert syndrome P22309
P22310
#137800 Glioma susceptibility 1; glm1 O75874
P37231
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#602089 Hemangioma, capillary infantile P35968
#114550 Hepatocellular carcinoma P08581
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#147950 Hypogonadotropic hypogonadism 2 with or without anosmia; hh2 P11362
#603932 Intervertebral disc disease; idd P14780
#123150 Jackson-weiss syndrome; jws P21802
#149730 Lacrimoauriculodentodigital syndrome; ladd P21802
#601626 Leukemia, acute myeloid; aml P10721
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#152950 Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation; mclmr P52732
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#601358 Nicolaides-baraitser syndrome; ncbrs P51531
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P37231
#166350 Osseous heteroplasia, progressive; poh P63092
#166250 Osteoglophonic dysplasia; ogd P11362
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P04062
P37840
#260540 Parkinson-dementia syndrome P10636
#101600 Pfeiffer syndrome P11362
P21802
#172700 Pick disease of brain P10636
#172800 Piebald trait; pbt P10721
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#275210 Restrictive dermopathy, lethal P02545
#609579 Scaphocephaly, maxillary retrusion, and mental retardation P21802
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#273300 Testicular germ cell tumor; tgct P10721
#187950 Thrombocythemia 1; thcyt1 P40225
#190440 Trigonocephaly 1; trigno1 P11362
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (109)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
P04637 (marker)
P08581 (related)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04637 (related)
P08581 (related)
P21802 (related)
H00022 Bladder cancer P00533 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
P37840 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P08581 (related)
P35354 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00125 Fabry disease P06280 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00003 Acute myeloid leukemia (AML) P10721 (related)
P10721 (marker)
H00170 Piebaldism P10721 (related)
H00023 Testicular cancer P10721 (marker)
H00255 Hypogonadotropic hypogonadism P11362 (related)
H00443 Osteoglophonic dysplasia (OD) P11362 (related)
H00458 Craniosynostosis P11362 (related)
P21802 (related)
H00516 Isolated orofacial clefts P11362 (related)
H01207 Trigonocephaly P11362 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00642 Lacrimo-auriculo-dento-digital syndrome (LADD) P21802 (related)
H00208 Hyperbilirubinemia P22309 (related)
H01111 Cortisone reductase deficiency (CRD) P28845 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00192 Xanthinuria P47989 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

7 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D009120 Muscle Cramp C00006925
C00000977
C538231 Adenocarcinoma of lung C00002488
D009422 Nervous System Diseases C00006925
D001927 Brain Diseases C00006925
D003920 Diabetes Mellitus C00002488
D006943 Hyperglycemia C00002488
D009361 Neoplasm Invasiveness C00002488