KCF-S cluster No. 92 (51 metabolites)
Corresponding Phytochemical cluster No. 13
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| rosids | 115 |
| asterids | 40 |
| Liliopsida | 20 |
| Euphyllophyta | 9 |
| Magnoliophyta | 7 |
| Spermatophyta | 2 |
| eudicotyledons | 1 |
Cumulative family count (Top 20)
| class name | count |
|---|---|
Fabaceae
|
82 |
|
Asteraceae
|
32 |
|
Salicaceae
|
14 |
|
Zingiberaceae
|
9 |
|
Pteridaceae
|
8 |
|
Moraceae
|
6 |
|
Piperaceae
|
4 |
|
Asparagaceae
|
3 |
|
Primulaceae
|
3 |
|
Amaryllidaceae
|
3 |
|
Liliaceae
|
3 |
|
Rutaceae
|
2 |
|
Brassicaceae
|
2 |
|
Solanaceae
|
2 |
|
Lamiaceae
|
2 |
|
Anacardiaceae
|
2 |
|
Meliaceae
|
2 |
|
Lauraceae
|
2 |
|
Myristicaceae
|
1 |
|
Euphorbiaceae
|
1 |
KEGG BRITE br08003
Categories (1)
| br08003 Category | # of metabolite |
|---|---|
| Chalcones | 8 |
metabolites link (10)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|---|---|
| Chalcones | C08650 | C00006925 |
| Chalcones | C15531 | C00006927 |
| Chalcones | C16404 | C00006933 |
| Chalcones | C08578 | C00006941 |
| Chalcones | C08724 | C00006969 |
| Chalcones | C15525 | C00006973 |
| Chalcones | C16405 | C00006974 |
| Chalcones | C06561 | C00007233 |
| Chalcones | C08650 | C00035173 |
| Chalcones | C15531 | C00038229 |
Metabolite list (51)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00006917
|
4'-Methoxychalcone
|
CHEMBL34398
|
9 / 14 / 18 |
|
||
|
C00006918
|
2,2'-Dihydroxychalcone
|
CHEMBL150755
CHEMBL1700548 |
14 / 18 / 10 |
|
||
|
C00006919
|
4,4'-Dihydroxychalcone
|
CHEMBL145927
|
C007423
|
|
||
|
C00006920
|
2',4'-Dihydroxychalcone
|
CHEMBL105310
|
19 / 25 / 22 |
|
||
|
C00006922
|
Echinatin
|
CHEMBL141530
|
2 / 5 / 3 |
|
||
|
C00006924
|
3,4,2'-Trihydroxychalcone
|
CHEMBL339587
|
25 / 18 / 47 |
|
||
|
C00006925
|
Isoliquiritigenin
|
CHEMBL129795
CHEMBL1395334 |
C040920
|
59 / 83 / 90 | 12 / 3 |
|
|
C00006926
|
Isoliquiritigenin 4-methyl ether
|
CHEMBL182653
|
18 / 40 / 65 |
|
||
|
C00006927
|
Isoliquiritigenin 2'-methy ether
/ 4,4'-Dihydroxy-2'-methoxychalcone |
CHEMBL253777
|
7 / 20 / 19 |
|
||
|
C00006928
|
Isoliquiritigenin 4'-methyl ether
|
CHEMBL2333805
|
|
|||
|
C00006930
|
2',5'-Dihydroxy-4-methoxychalcone
|
CHEMBL1528842
CHEMBL1712788 |
27 / 29 / 24 |
|
||
|
C00006931
|
Larrein
|
CHEMBL404034
|
|
|||
|
C00006932
|
Flemichapparin
|
|
||||
|
C00006933
|
2',4',6'-Trihydroxychalcone
|
CHEMBL129371
|
2 / 0 / 3 |
|
||
|
C00006934
|
Pinostrobin chalcone
/ 2',6'-Dihydroxy-4'-methoxychalcone |
CHEMBL317221
CHEMBL1705800 |
3 / 1 / 2 |
|
||
|
C00006935
|
Cardamomin
|
CHEMBL378104
|
13 / 18 / 14 |
|
||
|
C00006938
|
Licochalcone B
|
|
||||
|
C00006940
|
2,4,2',4'-Tetrahydroxychalcone
|
CHEMBL394855
|
1 / 2 / 2 |
|
||
|
C00006941
|
Butein
|
CHEMBL128000
|
C040918
|
17 / 31 / 34 | 8 / 0 |
|
|
C00006942
|
Homobutein
|
CHEMBL144686
|
4 / 6 / 11 |
|
||
|
C00006943
|
3,2',4'-Trihydroxy-4-methoxychalcone
|
C040922
|
|
|||
|
C00006944
|
Sappanchalcone
|
CHEMBL476986
|
C044363
|
7 / 20 / 19 | 8 / 0 |
|
|
C00006945
|
Calythropsin
|
CHEMBL340244
|
|
|||
|
C00006947
|
Pseudosindorin
|
|
||||
|
C00006948
|
4,2',3',4'-Tetrahydroxychalcone
|
|
||||
|
C00006949
|
Kukulkanin B
|
C061637
|
|
|||
|
C00006952
|
2',4',6'-Trihydroxy-4-methoxychalcone
|
CHEMBL133588
|
|
|||
|
C00006953
|
Neosakuranetin
|
|
||||
|
C00006954
|
Helichrysetin
/ 4,2',4'-Trihydroxy-6'-methoxychalcone |
CHEMBL507998
|
C061023
|
|
||
|
C00006968
|
Robtein
|
|
||||
|
C00006969
|
Okanin
|
CHEMBL222557
|
1 / 5 / 5 |
|
||
|
C00006970
|
Lanceoletin
|
|
||||
|
C00006972
|
Neoplathymenin
|
|
||||
|
C00006973
|
3,4,2',4',6'-Pentahydroxychalcone
|
CHEMBL127409
|
2 / 0 / 3 |
|
||
|
C00006974
|
4,2',4',6'-Tetrahydroxy-3-methoxychalcone
|
|
||||
|
C00006975
|
4,2',6'-Trihydroxy-3,4'-dimethoxychalcone
|
|
||||
|
C00006978
|
3,4,2',4',alpha-Pentahydroxychalcone
|
|
||||
|
C00006993
|
2'-beta-Dihydroxychalcone
|
CHEMBL1451434
|
6 / 10 / 7 |
|
||
|
C00007038
|
Isoneobavachalcone
|
|
||||
|
C00007039
|
Neobavachalcone
|
|
||||
|
C00007233
|
Isosalipurpol
/ Chalconaringenin / Naringenin chalcone / trans-2',4,4',6'-Tetrahydroxychalcone / (2E)- 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-2-Propen-1-one |
CHEMBL338066
|
12 / 20 / 21 |
|
||
|
C00014418
|
3,3'-Dihydroxychalcone
|
|
||||
|
C00014420
|
4,2',5'-Trihydroxychalcone
|
|
||||
|
C00014422
|
2,2',4'-Trihydroxy-6'-methoxychalcone
|
|
||||
|
C00014429
|
2',4',4-Trihydroxy-3',3-methoxychalcone
|
|
||||
|
C00014432
|
3,4,3',4'-Tetrahydroxy-2-methoxychalcone
|
|
||||
|
C00031536
|
2',4'-Dihydroxy-6'-methoxychalcone
|
CHEMBL378104
|
13 / 18 / 14 |
|
||
|
C00035173
|
4,2',4'-Trihydroxychalcone
|
CHEMBL129795
CHEMBL1395334 |
59 / 83 / 90 |
|
||
|
C00038229
|
2'-Methoxyisoliquiritigenin
|
CHEMBL253777
|
7 / 20 / 19 |
|
||
|
C00047649
|
2,2',4'-Trihydroxychalcone
|
CHEMBL148472
CHEMBL1976915 |
|
|||
|
C00049932
|
2',3',4',6'-Tetrahydroxychalcone
|
|
Human Protein / Gene in interactions
84 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00006917 C00006920 C00006924 C00006925 C00006926 C00006930 C00006935 C00006941 C00006942 C00007233 C00031536 C00035173 | 1 / 2 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00006917 C00006920 C00006924 C00006925 C00006926 C00006930 C00006935 C00006993 C00007233 C00031536 C00035173 | 4 / 3 |
| O00255 | Menin | Unclassified protein | C00006917 C00006920 C00006925 C00006926 C00006930 C00006935 C00006941 C00006942 C00007233 C00031536 C00035173 | 2 / 5 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00006917 C00006918 C00006920 C00006925 C00006926 C00006930 C00006941 C00006942 C00035173 | 2 / 3 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00006918 C00006924 C00006925 C00006930 C00006935 C00007233 C00031536 C00035173 | 0 / 0 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00006918 C00006920 C00006924 C00006925 C00006930 C00006941 C00035173 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00006918 C00006924 C00006925 C00006930 C00006935 C00031536 C00035173 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00006924 C00006925 C00006933 C00006941 C00006973 C00007233 C00035173 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00006924 C00006925 C00006933 C00006941 C00006973 C00007233 C00035173 | 0 / 3 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00006917 C00006920 C00006925 C00006926 C00006930 C00006993 C00035173 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00006920 C00006925 C00006926 C00006930 C00006993 C00035173 | 2 / 2 |
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00006925 C00006927 C00006941 C00006944 C00035173 C00038229 | 2 / 3 |
| Q99700 | Ataxin-2 | Unclassified protein | C00006918 C00006924 C00006925 C00006935 C00031536 C00035173 | 1 / 1 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00006920 C00006924 C00006925 C00006926 C00006930 C00035173 | 0 / 0 |
| P11362 | Fibroblast growth factor receptor 1 | Fgfr | C00006925 C00006927 C00006941 C00006944 C00035173 C00038229 | 4 / 5 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00006925 C00006927 C00006941 C00006944 C00035173 C00038229 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00006920 C00006925 C00006926 C00006993 C00007233 C00035173 | 0 / 1 |
| P35968 | Vascular endothelial growth factor receptor 2 | Vegfr | C00006925 C00006927 C00006941 C00006944 C00035173 C00038229 | 1 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00006925 C00006927 C00006941 C00006944 C00035173 C00038229 | 1 / 8 |
| P10721 | Mast/stem cell growth factor receptor Kit | Pdgfr | C00006925 C00006927 C00006941 C00006944 C00035173 C00038229 | 4 / 3 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00006917 C00006918 C00006924 C00006925 C00006930 C00035173 | 0 / 0 |
| P21802 | Fibroblast growth factor receptor 2 | TK tyrosine-protein kinase TLK subfamily | C00006925 C00006927 C00006941 C00006944 C00035173 C00038229 | 9 / 3 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00006925 C00006934 C00006941 C00007233 C00035173 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00006918 C00006924 C00006930 C00006935 C00031536 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00006918 C00006924 C00006925 C00006930 C00035173 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00006918 C00006925 C00006935 C00031536 C00035173 | 2 / 0 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00006924 C00006925 C00006935 C00031536 C00035173 | 1 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00006920 C00006925 C00006926 C00006930 C00035173 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00006918 C00006930 C00006935 C00007233 C00031536 | 7 / 3 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00006918 C00006924 C00006925 C00006930 C00035173 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00006920 C00006925 C00006926 C00006930 C00035173 | 3 / 3 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00006920 C00006924 C00006930 C00006993 | 0 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00006922 C00006925 C00006926 C00035173 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00006924 C00006925 C00006926 C00035173 | 7 / 37 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00006917 C00006920 C00006926 C00006930 | 0 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00006922 C00006925 C00006926 C00035173 | 5 / 3 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00006918 C00006925 C00006930 C00035173 | 1 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00006925 C00006941 C00007233 C00035173 | 6 / 4 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00006920 C00006930 C00006942 | 1 / 1 |
| P37840 | Alpha-synuclein | Unclassified protein | C00006918 C00006925 C00035173 | 4 / 2 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00006930 C00006935 C00031536 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00006925 C00006934 C00035173 | 0 / 1 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00006918 C00006924 C00006930 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00006924 C00006925 C00035173 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00006925 C00006926 C00035173 | 11 / 10 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00006924 C00006935 C00031536 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00006920 C00006930 C00006993 | 4 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00006925 C00006941 C00035173 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00006925 C00006934 C00035173 | 1 / 1 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00006924 C00006930 C00007233 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00006924 C00006925 C00035173 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00006925 C00035173 | 1 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00006925 C00035173 | 0 / 0 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00006925 C00035173 | 5 / 2 |
| P51531 | Probable global transcription activator SNF2L2 | Unclassified protein | C00006925 C00035173 | 1 / 0 |
| P42345 | Serine/threonine-protein kinase mTOR | Enzyme | C00006925 C00035173 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00006925 C00035173 | 0 / 0 |
| Q04206 | Transcription factor p65 | Transcription Factor | C00006925 C00035173 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00006925 C00035173 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00006925 C00035173 | 0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00006930 C00007233 | 0 / 0 |
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00006920 C00006926 | 0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00006925 C00035173 | 1 / 2 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00006920 C00006926 | 2 / 0 |
| P14618 | Pyruvate kinase PKM | Enzyme | C00006925 C00035173 | 0 / 0 |
| Q99549 | M-phase phosphoprotein 8 | Unclassified protein | C00006925 C00035173 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00006920 C00006926 | 1 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00006925 C00035173 | 0 / 0 |
| P22001 | Potassium voltage-gated channel subfamily A member 3 | KCNA, Kv1.x (Shaker) | C00006935 C00031536 | 0 / 0 |
| P05412 | Transcription factor AP-1 | Transcription Factor | C00006925 C00035173 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00006925 C00035173 | 2 / 2 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00006925 C00035173 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00006925 C00035173 | 2 / 2 |
| P40225 | Thrombopoietin | Unclassified protein | C00006925 C00035173 | 1 / 1 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00006924 C00006930 | 1 / 1 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00006924 | 1 / 1 |
| O14746 | Telomerase reverse transcriptase | Enzyme | C00006969 | 5 / 5 |
| Q8IUX4 | DNA dC->dU-editing enzyme APOBEC-3F | Enzyme | C00006924 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00006917 | 3 / 4 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00006941 | 0 / 0 |
| P19438 | Tumor necrosis factor receptor superfamily member 1A | Membrane receptor | C00006917 | 2 / 1 |
| P11308 | Transcriptional regulator ERG | Unclassified protein | C00006924 | 1 / 2 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00006940 | 2 / 2 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00006920 | 3 / 1 |
24 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00006925
C00006941
C00006944
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00006925
C00006944
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00006925
C00006944
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00006941
|
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00006941
|
| 23411 | SIRT1, SIR2L1 | sirtuin 1 |
C00006941
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00006941
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00006941
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00006925
|
| 329 | BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 | baculoviral IAP repeat containing 2 |
C00006925
|
| 330 | BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 | baculoviral IAP repeat containing 3 |
C00006925
|
| 1734 | DIO2, 5DII, D2, DIOII, SelY, TXDI2 | deiodinase, iodothyronine, type II (EC:1.97.1.10) |
C00006941
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00006941
|
| 6513 | SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED | solute carrier family 2 (facilitated glucose transporter), member 1 |
C00006925
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00006925
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00006925
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00006925
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00006925
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00006925
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00006944
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00006944
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00006944
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00006944
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00006944
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (117)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #207410 | Antley-bixler syndrome without genital anomalies or disordered steroidogenesis; abs2 |
P21802
|
| #101200 | Apert syndrome |
P21802
|
| #609135 | Aplastic anemia |
O14746
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #123790 | Beare-stevenson cutis gyrata syndrome; bstvs |
P21802
|
| #614592 | Bent bone dysplasia syndrome; bbds |
P21802
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #210900 | Bloom syndrome; blm |
P54132
|
| %606641 | Body mass index; bmi |
P37231
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #123500 | Crouzon syndrome |
P21802
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #613989 | Dyskeratosis congenita, autosomal dominant, 2; dkca2 |
O14746
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
|
| #612219 | Ewing sarcoma; es |
P11308
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #606764 | Gastrointestinal stromal tumor; gist |
P10721
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P37231 |
| #232300 | Glycogen storage disease ii |
P10253
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #602089 | Hemangioma, capillary infantile |
P35968
|
| #114550 | Hepatocellular carcinoma |
P08581
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #147950 | Hypogonadotropic hypogonadism 2 with or without anosmia; hh2 |
P11362
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #123150 | Jackson-weiss syndrome; jws |
P21802
|
| #149730 | Lacrimoauriculodentodigital syndrome; ladd |
P21802
|
| #601626 | Leukemia, acute myeloid; aml |
P10721
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04637 |
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #615134 | Melanoma, cutaneous malignant, susceptibility to, 9; cmm9 |
O14746
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #614810 | Multiple sclerosis, susceptibility to, 5; ms5 |
P19438
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #601358 | Nicolaides-baraitser syndrome; ncbrs |
P51531
|
| #601665 | Obesity |
P37231
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #166250 | Osteoglophonic dysplasia; ogd |
P11362
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
P37840 |
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #142680 | Periodic fever, familial, autosomal dominant |
P19438
|
| #101600 | Pfeiffer syndrome |
P11362
P21802 |
| #172700 | Pick disease of brain |
P10636
|
| #172800 | Piebald trait; pbt |
P10721
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #614742 | Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1; pfbmft1 |
O14746
|
| #178500 | Pulmonary fibrosis, idiopathic; ipf |
O14746
|
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #609579 | Scaphocephaly, maxillary retrusion, and mental retardation |
P21802
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #273300 | Testicular germ cell tumor; tgct |
P10721
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #190440 | Trigonocephaly 1; trigno1 |
P11362
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (108)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00764 | Cri du chat syndrome |
O14746
(related)
|
| H01132 | Aplastic anemia (AA) |
O14746
(related)
|
| H01299 | Idiopathic pulmonary fibrosis |
O14746
(related)
|
| H00022 | Bladder cancer |
O14746
(marker)
P00533 (related) P04637 (related) |
| H00024 | Prostate cancer |
O14746
(marker)
P10275 (related) P11308 (related) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04637 (related) P08581 (related) P21802 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P04637 (related) |
| H00030 | Cervical cancer |
P00533
(related)
|
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
P37840 (related) |
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P14780 (related) P35354 (related) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P08581 (related) P35354 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
P08581 (related) |
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P10721
(related)
P10721 (marker) |
| H00170 | Piebaldism |
P10721
(related)
|
| H00023 | Testicular cancer |
P10721
(marker)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00035 | Ewing's sarcoma |
P11308
(related)
|
| H00255 | Hypogonadotropic hypogonadism |
P11362
(related)
|
| H00443 | Osteoglophonic dysplasia (OD) |
P11362
(related)
|
| H00458 | Craniosynostosis |
P11362
(related)
P21802 (related) |
| H00516 | Isolated orofacial clefts |
P11362
(related)
|
| H01207 | Trigonocephaly |
P11362
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00912 | Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) |
P19438
(related)
|
| H00642 | Lacrimo-auriculo-dento-digital syndrome (LADD) |
P21802
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|