PCIDB

KNApSAcK Metabolite C00006944

Metabolite

KNApSAcK Entry

id C00006944
Name Sappanchalcone
CAS RN 94344-54-4
Standard InChI InChI=1S/C16H14O5/c1-21-16-9-11(17)4-5-12(16)13(18)6-2-10-3-7-14(19)15(20)8-10/h2-9,17,19-20H,1H3/b6-2+
Standard InChI (Main Layer) InChI=1S/C16H14O5/c1-21-16-9-11(17)4-5-12(16)13(18)6-2-10-3-7-14(19)15(20)8-10/h2-9,17,19-20H,1H3

Cluster

Phytochemical cluster No. 13
KCF-S cluster No. 92

Link

ChEMBL

By standard InChI CHEMBL476986
By standard InChI Main Layer CHEMBL476986

KEGG

By LinkDB

CTD

By CAS RN C044363

Species

Summary

Plant class

class name count
rosids 2

Family

family name count
Fabaceae 2

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Caesalpinia japonica 53845 Fabaceae rosids Viridiplantae
Caesalpinia sappan 483143 Fabaceae rosids Viridiplantae

Human Protein / Gene in interaction

7 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P21802 Fibroblast growth factor receptor 2 TK tyrosine-protein kinase TLK subfamily CHEMBL476986 CHEMBL986526 (1)
9 / 3
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL476986 CHEMBL986517 (1)
1 / 11
P12931 Proto-oncogene tyrosine-protein kinase Src Src CHEMBL476986 CHEMBL986511 (1)
0 / 0
P35968 Vascular endothelial growth factor receptor 2 Vegfr CHEMBL476986 CHEMBL986515 (1)
1 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily CHEMBL476986 CHEMBL986512 (1)
2 / 3
P11362 Fibroblast growth factor receptor 1 Fgfr CHEMBL476986 CHEMBL986513 (1)
4 / 5
P10721 Mast/stem cell growth factor receptor Kit Pdgfr CHEMBL476986 CHEMBL986519 (1)
4 / 4

CTD interaction (8)

compound gene gene name gene description interaction interaction type form reference
pmid
C044363 581 BAX
BCL2L4
BCL2-associated X protein sappanchalcone results in increased expression of BAX protein increases expression
protein 21963806
C044363 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 sappanchalcone results in decreased expression of BCL2 protein decreases expression
protein 21963806
C044363 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) sappanchalcone results in increased activity of CASP3 protein increases activity
protein 21963806
C044363 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) sappanchalcone results in increased activity of CASP9 protein increases activity
protein 21963806
C044363 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) sappanchalcone results in increased phosphorylation of MAPK8 protein increases phosphorylation
protein 21963806
C044363 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha sappanchalcone results in increased degradation of and results in increased phosphorylation of NFKBIA protein increases degradation
/ increases phosphorylation
protein 21963806
C044363 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A sappanchalcone affects the localization of RELA protein affects localization
protein 21963806
C044363 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 sappanchalcone results in increased expression of TP53 protein increases expression
protein 21963806

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (20)

OMIM preferred title UniProt
#207410 Antley-bixler syndrome without genital anomalies or disordered steroidogenesis; abs2 P21802
#101200 Apert syndrome P21802
#123790 Beare-stevenson cutis gyrata syndrome; bstvs P21802
#614592 Bent bone dysplasia syndrome; bbds P21802
#123500 Crouzon syndrome P21802
#606764 Gastrointestinal stromal tumor; gist P10721
#602089 Hemangioma, capillary infantile P35968
#114550 Hepatocellular carcinoma P08581
#147950 Hypogonadotropic hypogonadism 2 with or without anosmia; hh2 P11362
#123150 Jackson-weiss syndrome; jws P21802
#149730 Lacrimoauriculodentodigital syndrome; ladd P21802
#601626 Leukemia, acute myeloid; aml P10721
#211980 Lung cancer P00533
#166250 Osteoglophonic dysplasia; ogd P11362
#101600 Pfeiffer syndrome P11362
P21802
#172800 Piebald trait; pbt P10721
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#609579 Scaphocephaly, maxillary retrusion, and mental retardation P21802
#273300 Testicular germ cell tumor; tgct P10721
#190440 Trigonocephaly 1; trigno1 P11362

KEGG DISEASE (19)

KEGG disease name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
H00018 Gastric cancer P00533 (related)
P08581 (related)
P21802 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00021 Renal cell carcinoma P08581 (related)
H00046 Cholangiocarcinoma P08581 (related)
H00003 Acute myeloid leukemia (AML) P10721 (related)
P10721 (marker)
H00170 Piebaldism P10721 (related)
H00023 Testicular cancer P10721 (marker)
H00255 Hypogonadotropic hypogonadism P11362 (related)
H00443 Osteoglophonic dysplasia (OD) P11362 (related)
H00458 Craniosynostosis P11362 (related)
P21802 (related)
H00516 Isolated orofacial clefts P11362 (related)
H01207 Trigonocephaly P11362 (related)
H00642 Lacrimo-auriculo-dento-digital syndrome (LADD) P21802 (related)