PCIDB

KNApSAcK Metabolite C00006941

Metabolite

KNApSAcK Entry

id C00006941
Name Butein
CAS RN 487-52-5
Standard InChI InChI=1S/C15H12O5/c16-10-3-4-11(14(19)8-10)12(17)5-1-9-2-6-13(18)15(20)7-9/h1-8,16,18-20H/b5-1+
Standard InChI (Main Layer) InChI=1S/C15H12O5/c16-10-3-4-11(14(19)8-10)12(17)5-1-9-2-6-13(18)15(20)7-9/h1-8,16,18-20H

Cluster

Phytochemical cluster No. 13
KCF-S cluster No. 92

Link

ChEMBL

By standard InChI CHEMBL128000
By standard InChI Main Layer CHEMBL128000

KEGG

By LinkDB C08578

CTD

By CAS RN C040918

Human Protein / Gene in interaction

17 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P21802 Fibroblast growth factor receptor 2 TK tyrosine-protein kinase TLK subfamily CHEMBL128000 CHEMBL986526 (1)
9 / 3
P04062 Glucosylceramidase Enzyme CHEMBL128000 CHEMBL1613818 (1)
6 / 4
P24941 Cyclin-dependent kinase 2 Cdc2 CHEMBL128000 CHEMBL1003092 (1)
0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL128000 CHEMBL986517 (1) CHEMBL1003093 (1)
CHEMBL970971 (1)
1 / 11
P11473 Vitamin D3 receptor NR1I1 CHEMBL128000 CHEMBL1794311 (1)
2 / 3
P11021 78 kDa glucose-regulated protein Unclassified protein CHEMBL128000 CHEMBL1963893 (1)
0 / 0
P12931 Proto-oncogene tyrosine-protein kinase Src Src CHEMBL128000 CHEMBL986511 (1) CHEMBL1003141 (1)
CHEMBL970972 (1)
0 / 0
P35968 Vascular endothelial growth factor receptor 2 Vegfr CHEMBL128000 CHEMBL986515 (1)
1 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily CHEMBL128000 CHEMBL986512 (1)
2 / 3
P11362 Fibroblast growth factor receptor 1 Fgfr CHEMBL128000 CHEMBL986513 (1)
4 / 5
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL128000 CHEMBL1614211 (1)
0 / 0
P10721 Mast/stem cell growth factor receptor Kit Pdgfr CHEMBL128000 CHEMBL986519 (1)
4 / 4
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL128000 CHEMBL1794536 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL128000 CHEMBL1614257 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL128000 CHEMBL1614257 (1)
1 / 3
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL128000 CHEMBL763067 (1)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL128000 CHEMBL763067 (1)
0 / 3

CTD interaction (15)

compound gene gene name gene description interaction interaction type form reference
pmid
C040918 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) butein results in decreased phosphorylation of AKT1 protein decreases phosphorylation
protein 20696233
C040918 1734 DIO2
5DII
D2
DIOII
SelY
TXDI2
deiodinase, iodothyronine, type II (EC:1.97.1.10) butein results in decreased activity of DIO2 protein decreases activity
protein 17327447
C040918 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [butein results in decreased expression of MMP9 protein] decreases expression
/ increases reaction
protein 20696233
C040918 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [butein results in decreased expression of MMP9 protein] decreases expression
/ increases reaction
protein 20696233
C040918 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) bortezomib promotes the reaction [butein results in decreased expression of MMP9 protein] decreases expression
/ increases reaction
protein 20696233
C040918 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) butein inhibits the reaction [TNF protein results in increased expression of MMP9 protein] decreases reaction
/ increases expression
protein 20696233
C040918 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) butein results in decreased expression of MMP9 mRNA decreases expression
mRNA 20696233
C040918 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) butein results in decreased expression of MMP9 protein decreases expression
protein 20696233
C040918 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) prolinedithiocarbamate promotes the reaction [butein results in decreased expression of MMP9 protein] decreases expression
/ increases reaction
protein 20696233
C040918 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 butein affects the localization of NFKB1 protein affects localization
protein 20696233
C040918 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A butein affects the localization of RELA protein affects localization
protein 20696233
C040918 23411 SIRT1
SIR2L1
sirtuin 1 butein results in increased activity of SIRT1 protein increases activity
protein 17327447
C040918 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor butein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF protein] decreases reaction
/ increases expression
protein 20696233
C040918 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor butein inhibits the reaction [TNF protein results in increased expression of MMP9 protein] decreases reaction
/ increases expression
protein 20696233
C040918 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A butein results in decreased expression of VEGFA mRNA decreases expression
mRNA 20696233

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (31)

OMIM preferred title UniProt
#207410 Antley-bixler syndrome without genital anomalies or disordered steroidogenesis; abs2 P21802
#101200 Apert syndrome P21802
#123790 Beare-stevenson cutis gyrata syndrome; bstvs P21802
#614592 Bent bone dysplasia syndrome; bbds P21802
#123500 Crouzon syndrome P21802
#606764 Gastrointestinal stromal tumor; gist P10721
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#602089 Hemangioma, capillary infantile P35968
#114550 Hepatocellular carcinoma P08581
#145000 Hyperparathyroidism 1; hrpt1 O00255
#147950 Hypogonadotropic hypogonadism 2 with or without anosmia; hh2 P11362
#123150 Jackson-weiss syndrome; jws P21802
#149730 Lacrimoauriculodentodigital syndrome; ladd P21802
#601626 Leukemia, acute myeloid; aml P10721
#211980 Lung cancer P00533
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#166250 Osteoglophonic dysplasia; ogd P11362
#168600 Parkinson disease, late-onset; pd P04062
#101600 Pfeiffer syndrome P11362
P21802
#172800 Piebald trait; pbt P10721
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#609579 Scaphocephaly, maxillary retrusion, and mental retardation P21802
#273300 Testicular germ cell tumor; tgct P10721
#190440 Trigonocephaly 1; trigno1 P11362
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (34)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P08581 (related)
P21802 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00021 Renal cell carcinoma P08581 (related)
H00046 Cholangiocarcinoma P08581 (related)
P35354 (related)
H00003 Acute myeloid leukemia (AML) P10721 (related)
P10721 (marker)
H00170 Piebaldism P10721 (related)
H00023 Testicular cancer P10721 (marker)
H00255 Hypogonadotropic hypogonadism P11362 (related)
H00443 Osteoglophonic dysplasia (OD) P11362 (related)
H00458 Craniosynostosis P11362 (related)
P21802 (related)
H00516 Isolated orofacial clefts P11362 (related)
H01207 Trigonocephaly P11362 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00642 Lacrimo-auriculo-dento-digital syndrome (LADD) P21802 (related)
H00025 Penile cancer P35354 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)