Species

KNApSAcK Entry

Organism name Coreopsis maritima
Genus Coreopsis
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Coreopsis maritima
Linked NCBI taxonomy ID 159671
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00008050 External link 512 Maritimein
CHEMBL1454040
CHEMBL2165570
8 / 3 / 7 No. 36 No. 13
C00007893 External link 512 Marein
CHEMBL490510
6 / 5 / 13 No. 36 No. 13
C00007218 External link 512 Coreopsin
No. 36 No. 13
C00006969 External link 512 Okanin
CHEMBL222557
1 / 5 / 5 No. 92 No. 13
C00006941 External link 512 Butein
CHEMBL128000
C040918
17 / 31 / 34 8 / 0 No. 92 No. 13

Human Protein / Gene in interactions

24 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9UBT6 DNA polymerase kappa Enzyme C00006941 C00007893 C00008050 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00006941 C00007893 C00008050 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00006941 C00007893 1 / 8
O00255 Menin Unclassified protein C00006941 C00008050 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00006941 C00008050 1 / 2
P11473 Vitamin D3 receptor NR1I1 C00006941 C00007893 2 / 3
P11362 Fibroblast growth factor receptor 1 Fgfr C00006941 4 / 5
P39748 Flap endonuclease 1 Enzyme C00008050 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00006941 0 / 0
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00006941 0 / 0
P35968 Vascular endothelial growth factor receptor 2 Vegfr C00006941 1 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00006941 2 / 3
P21802 Fibroblast growth factor receptor 2 TK tyrosine-protein kinase TLK subfamily C00006941 9 / 3
Q9UNA4 DNA polymerase iota Enzyme C00008050 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00008050 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00006941 0 / 0
P10721 Mast/stem cell growth factor receptor Kit Pdgfr C00006941 4 / 3
O14746 Telomerase reverse transcriptase Enzyme C00006969 5 / 5
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00008050 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00007893 1 / 1
P10253 Lysosomal alpha-glucosidase Hydrolase C00007893 1 / 1
P04062 Glucosylceramidase Enzyme C00006941 6 / 4
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00006941 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00006941 0 / 3

8 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00006941
1734 DIO2, 5DII, D2, DIOII, SelY, TXDI2 deiodinase, iodothyronine, type II (EC:1.97.1.10) C00006941
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00006941
4790 NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 C00006941
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00006941
23411 SIRT1, SIR2L1 sirtuin 1 C00006941
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00006941
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00006941

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (38)

OMIM preferred title UniProt
#207410 Antley-bixler syndrome without genital anomalies or disordered steroidogenesis; abs2 P21802
#101200 Apert syndrome P21802
#609135 Aplastic anemia O14746
#123790 Beare-stevenson cutis gyrata syndrome; bstvs P21802
#614592 Bent bone dysplasia syndrome; bbds P21802
#123500 Crouzon syndrome P21802
#613989 Dyskeratosis congenita, autosomal dominant, 2; dkca2 O14746
#606764 Gastrointestinal stromal tumor; gist P10721
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#602089 Hemangioma, capillary infantile P35968
#114550 Hepatocellular carcinoma P08581
#145000 Hyperparathyroidism 1; hrpt1 O00255
#147950 Hypogonadotropic hypogonadism 2 with or without anosmia; hh2 P11362
#123150 Jackson-weiss syndrome; jws P21802
#149730 Lacrimoauriculodentodigital syndrome; ladd P21802
#601626 Leukemia, acute myeloid; aml P10721
#211980 Lung cancer P00533
#615134 Melanoma, cutaneous malignant, susceptibility to, 9; cmm9 O14746
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#166250 Osteoglophonic dysplasia; ogd P11362
#168600 Parkinson disease, late-onset; pd P04062
#101600 Pfeiffer syndrome P11362
P21802
#172800 Piebald trait; pbt P10721
#614742 Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1; pfbmft1 O14746
#178500 Pulmonary fibrosis, idiopathic; ipf O14746
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#609579 Scaphocephaly, maxillary retrusion, and mental retardation P21802
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#273300 Testicular germ cell tumor; tgct P10721
#190440 Trigonocephaly 1; trigno1 P11362
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (40)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00764 Cri du chat syndrome O14746 (related)
H01132 Aplastic anemia (AA) O14746 (related)
H01299 Idiopathic pulmonary fibrosis O14746 (related)
H00022 Bladder cancer O14746 (marker)
P00533 (related)
H00024 Prostate cancer O14746 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P08581 (related)
P21802 (related)
H00028 Choriocarcinoma P00533 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00021 Renal cell carcinoma P08581 (related)
H00046 Cholangiocarcinoma P08581 (related)
P35354 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00003 Acute myeloid leukemia (AML) P10721 (related)
P10721 (marker)
H00170 Piebaldism P10721 (related)
H00023 Testicular cancer P10721 (marker)
H00255 Hypogonadotropic hypogonadism P11362 (related)
H00443 Osteoglophonic dysplasia (OD) P11362 (related)
H00458 Craniosynostosis P11362 (related)
P21802 (related)
H00516 Isolated orofacial clefts P11362 (related)
H01207 Trigonocephaly P11362 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00642 Lacrimo-auriculo-dento-digital syndrome (LADD) P21802 (related)
H00025 Penile cancer P35354 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)