KCF-S cluster No. 25 (120 metabolites)
Corresponding Phytochemical cluster No. 14
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| rosids | 212 |
| asterids | 129 |
| Liliopsida | 33 |
| Magnoliophyta | 29 |
| Euphyllophyta | 20 |
| Spermatophyta | 17 |
| eudicotyledons | 14 |
Cumulative family count (Top 20)
| class name | count |
|---|---|
Fabaceae
|
136 |
|
Asteraceae
|
78 |
|
Lamiaceae
|
30 |
|
Pinaceae
|
16 |
|
Zingiberaceae
|
15 |
|
Piperaceae
|
13 |
|
Moraceae
|
12 |
|
Myrtaceae
|
12 |
|
Annonaceae
|
11 |
|
Pteridaceae
|
11 |
|
Rosaceae
|
10 |
|
Ericaceae
|
7 |
|
Rutaceae
|
6 |
|
Betulaceae
|
6 |
|
Dryopteridaceae
|
5 |
|
Myricaceae
|
5 |
|
Acanthaceae
|
5 |
|
Iridaceae
|
5 |
|
Poaceae
|
3 |
|
Petiveriaceae
|
3 |
KEGG BRITE br08003
Categories (1)
| br08003 Category | # of metabolite |
|---|---|
| Flavanones | 12 |
metabolites link (12)
Metabolite list (120)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00000945
|
Butin
/ 7,3',4'-Trihydroxyflavanone |
CHEMBL451168
|
C051437
|
|
||
|
C00000960
|
Eriodictyol
|
CHEMBL8996
CHEMBL307893 CHEMBL1975989 |
C007619
|
32 / 29 / 55 | 5 / 0 |
|
|
C00000968
|
Hesperetin
|
CHEMBL88169
CHEMBL399121 CHEMBL1589200 |
C013015
|
42 / 50 / 65 | 18 / 3 |
|
|
C00000969
|
Homoeriodictyol
|
CHEMBL398282
CHEMBL490170 |
4 / 4 / 4 |
|
||
|
C00000973
|
Isosakuranetin
/ 5,7-Dihydroxy-4'-methoxyflavanone |
CHEMBL470266
|
3 / 4 / 4 |
|
||
|
C00000977
|
Liquiritigenin
|
CHEMBL252642
CHEMBL271939 |
C083152
|
5 / 4 / 4 | 1 / 1 |
|
|
C00000982
|
Naringenin
/ (-)-Naringenin |
CHEMBL9352
CHEMBL32571 |
C005273
|
57 / 46 / 40 | 35 / 10 |
|
|
C00000992
|
Pinocembrin
|
CHEMBL70518
CHEMBL399910 CHEMBL399249 |
C016063
|
18 / 23 / 23 | 5 / 0 |
|
|
C00000999
|
Sakuranetin
/ Naringenin 7-O-methyl ether / 5,4'-Dihydroxy-7-methoxyflavanone |
CHEMBL74852
CHEMBL448297 |
C099724
|
19 / 20 / 20 |
|
|
|
C00001006
|
Strobopinin
|
CHEMBL227611
CHEMBL1556958 |
12 / 5 / 3 |
|
||
|
C00008126
|
7-Hydroxyflavanone
|
CHEMBL97542
CHEMBL402744 |
C059353
|
9 / 18 / 45 | 1 / 0 |
|
|
C00008127
|
7-Methoxyflavanone
|
CHEMBL9687
|
5 / 6 / 7 |
|
||
|
C00008128
|
7-Hydroxy-8-methoxyflavanone
|
|
||||
|
C00008130
|
7,8-Dimethoxyflavanone
|
|
||||
|
C00008143
|
Alpinetin
/ (-)-Alpinetin |
CHEMBL427218
CHEMBL254825 |
|
|||
|
C00008144
|
Pinostrobin
/ (-)-Pinostrobin / (2S)-Pinocembrin / (-)-(2S)-Pinocembrin |
CHEMBL254613
|
1 / 2 / 0 |
|
||
|
C00008145
|
Pinocembrin 5,7-dimethyl ether
|
CHEMBL107131
CHEMBL1253912 |
9 / 14 / 11 |
|
||
|
C00008146
|
Dihydrobaicalein
|
CHEMBL402227
|
|
|||
|
C00008148
|
Dihydrooroxylin A
/ 5,7-Dihydroxy-6-methoxyflavanone |
CHEMBL253465
CHEMBL1517942 |
5 / 1 / 1 |
|
||
|
C00008149
|
Onysilin
/ 5-Hydroxy-6,7-dimethoxyflavanone |
|
||||
|
C00008150
|
6-Hydroxy-5,7-dimethoxyflavanone
|
|
||||
|
C00008151
|
Dihydronorwogonin
|
|
||||
|
C00008154
|
5-Hydroxy-7,8-dimethoxyflavanone
|
CHEMBL1082119
CHEMBL1253998 |
1 / 5 / 5 |
|
||
|
C00008155
|
8-Hydroxy-5,7-dimethoxyflavanone
|
CHEMBL1350188
|
21 / 16 / 18 |
|
||
|
C00008156
|
Dihydrowogonin
|
|
||||
|
C00008158
|
5,7,8-Trimethoxyflavanone
|
|
||||
|
C00008164
|
Comptonin
|
|
||||
|
C00008165
|
7-O-Methylstrobopinin
|
CHEMBL1685067
|
2 / 3 / 0 |
|
||
|
C00008166
|
Cryptostrobin
|
CHEMBL1269161
|
|
|||
|
C00008167
|
5-Hydroxy-7-methoxy-8-C-methylflavanone
|
|
||||
|
C00008168
|
Desmethoxymatteucinol
|
CHEMBL53439
|
5 / 1 / 4 |
|
||
|
C00008169
|
5-Hydroxy-7-methoxy-6,8-di-C-methylflavanone
|
CHEMBL53343
CHEMBL1986306 |
|
|||
|
C00008170
|
Lawinal
|
CHEMBL53757
|
C061398
|
|
||
|
C00008180
|
(+)-6,8-Di-C-methylpinocembrin 5-methyl ether
|
|
||||
|
C00008192
|
7,8,4'-Trihydroxyflavanone
|
|
||||
|
C00008198
|
Methyl-liquiritigenin
|
CHEMBL402970
|
1 / 2 / 2 |
|
||
|
C00008199
|
7,4'-Dimethoxy-6-C-methylflavanone
|
|
||||
|
C00008225
|
Naringenin 5-methyl ether
/ Naringenin 5-O-methyl ether / 7,4'-Dihydroxy-5-methoxyflavanone / (-)-7,4'-Dihydroxy-5-methoxyflavanone |
CHEMBL255035
CHEMBL501251 |
|
|||
|
C00008226
|
Naringenin 7,4'-dimethyl ether
|
CHEMBL462909
CHEMBL2164944 |
|
|||
|
C00008227
|
Naringenin 5,7-dimethyl ether
|
|
||||
|
C00008229
|
Naringenin trimethyl ether
|
CHEMBL483550
|
|
|||
|
C00008230
|
Carthamidin
|
C012808
|
|
|||
|
C00008232
|
Isocarthamidin
|
|
||||
|
C00008233
|
5,7,4'-Trihydroxy-6-methoxyflavanone
|
|
||||
|
C00008237
|
Poriol
|
CHEMBL484640
|
20 / 14 / 14 |
|
||
|
C00008239
|
Farrerol
/ (-)-Farrerol |
CHEMBL507611
CHEMBL1224582 |
C015881
|
|
||
|
C00008242
|
Angophorol
|
|
||||
|
C00008243
|
Matteucinol
|
CHEMBL1224711
|
C049059
|
|
||
|
C00008252
|
5,4'-Dihydroxy-6,7-dimethoxyflavanone
|
CHEMBL210692
CHEMBL502359 |
1 / 0 / 0 |
|
||
|
C00008254
|
5,4'-Dihydroxy-7,8-dimethoxyflavanone
|
|
||||
|
C00008259
|
5,7-Dihydroxy-8,2'-dimethoxyflavanone
|
|
||||
|
C00008275
|
6,3',4'-Trimethoxyflavanone
|
CHEMBL483549
|
|
|||
|
C00008280
|
Plathymenin
|
|
||||
|
C00008281
|
Isookanin
|
CHEMBL1505816
|
22 / 13 / 12 |
|
||
|
C00008284
|
8-Methoxybutin
|
|
||||
|
C00008299
|
Eriodictyol 7,3'-dimethyl ether
|
|
||||
|
C00008300
|
Persicogenin
|
|
||||
|
C00008304
|
Sternbin
|
C079930
|
|
|||
|
C00008306
|
5,7,4'-Trihydroxy-8,3'-dimethoxyflavanone
|
|
||||
|
C00008315
|
5,7,4'-Trihydroxy-3'-methoxy-6,8-di-C-methylflavanone
|
|
||||
|
C00008337
|
5,7,2',5'-Tetrahydroxy-6-methoxyflavanone
|
|
||||
|
C00008338
|
5,7,2',6'-Tetrahydroxyflavanone
|
CHEMBL465691
|
|
|||
|
C00008339
|
7,2',6'-Trihydroxy-5-methoxyflavanone
|
|
||||
|
C00008342
|
5,7,3',4',5'-Pentahydroxyflavanone
|
|
||||
|
C00008344
|
Dihydrotricetin 7,3'-dimethyl ether
|
|
||||
|
C00008345
|
5,7,3'-Trihydroxy-4',5'-dimethoxy-6,8-di-C-methylflavanone
|
|
||||
|
C00008352
|
Cyrtominetin
|
CHEMBL1224646
|
C068573
|
|
||
|
C00008354
|
5,7,2',5'-Tetrahydroxyflavanone
/ (2S)-5,7,2',5'-Tetrahydroxyflavanone |
|
||||
|
C00008362
|
Artocarpanone
|
CHEMBL467194
|
|
|||
|
C00008367
|
Steppogenin
/ Norartocarpanone / 5,7,2',4'-Tetrahydroxyflavanone |
CHEMBL458395
CHEMBL465194 |
3 / 2 / 5 |
|
||
|
C00008391
|
5,6-Dihydroxy-4'-methoxyflavanone
|
|
||||
|
C00008392
|
5,8,4'-Trihydroxyflavanone
|
|
||||
|
C00008411
|
5,2',5'-Trihydroxy-7,8-dimethoxyflavanone
|
|
||||
|
C00008412
|
Scutamoenin
|
C067160
|
|
|||
|
C00008415
|
6-Methoxyeriodictyol
|
|
||||
|
C00008420
|
5,7-Dimethoxy-6-C-methylflavanone
|
|
||||
|
C00008429
|
4'-Methylliquiritigenin
|
CHEMBL549474
|
|
|||
|
C00008436
|
Tsugafolin
/ 7-Hydroxy-5,4'-dimethoxyflavanone |
CHEMBL233063
CHEMBL537954 |
|
|||
|
C00008444
|
5,8-Dihydroxy-7-methoxyflavanone
|
|
||||
|
C00008445
|
5,7,4'-Trihydroxy-8-methoxyflavanone
|
|
||||
|
C00008446
|
5,8,2'-Trihydroxy-7-methoxyflavanone
|
|
||||
|
C00008447
|
8-Methoxyeriodictyol
|
|
||||
|
C00008478
|
5,7,2'-Trihydroxyflavanone
/ (2S)-5,7,2'-Trihydroxyflavanone |
CHEMBL1083820
|
|
|||
|
C00008479
|
5,7,3'-Trihydroxyflavanone
|
|
||||
|
C00008481
|
Leridal
|
CHEMBL1271363
|
|
|||
|
C00008482
|
Leridol
|
|
||||
|
C00008483
|
5-O-Methylleridol
|
|
||||
|
C00014114
|
Dihydroechioidinin
/ 5,2'-Dihydroxy-7-methoxyflavanone |
|
||||
|
C00014115
|
5,2'-Dihydroxy-6,7-methylenedioxyflavanone
|
|
||||
|
C00014116
|
5,7,8-Trihydroxy-4'-methoxyflavanone
|
|
||||
|
C00014117
|
Alysifolinone
/ 5,7,3'-Trihydroxy-5'-methoxyflavanone |
|
||||
|
C00014118
|
5,2',3'-Trihydroxy-7-methoxyflavanone
|
|
||||
|
C00014119
|
Oresbiusin
/ 6,7,8-Trihydroxy-5-methoxyflavanone |
|
||||
|
C00014121
|
5,7-Dihydroxy-8,4'-dimethoxyflavanone
|
|
||||
|
C00014122
|
Dihydroskullcap flavone I
/ 5,2'-Dihydroxy-7,8-dimethoxyflavanone |
|
||||
|
C00014123
|
5,2'-Dihydroxy-7,4'-dimethoxyflavanone
|
|
||||
|
C00014124
|
5,2'-Dihydroxy-7,5'-dimethoxyflavanone
|
|
||||
|
C00014125
|
5,3'-Dihydroxy-7,2'-dimethoxyflavanone
|
|
||||
|
C00014126
|
7,8-Dihydroxy-6,4'-dimethoxyflavanone
|
|
||||
|
C00014127
|
7,4'-Dihydroxy-8,3'-dimethoxyflavanone
|
|
||||
|
C00014131
|
5,2',3'-Trihydroxy-6,7-methylenedioxyflavanone
|
CHEMBL1807889
|
|
|||
|
C00014132
|
8-Hydroxyhesperetin
/ 5,7,8,3'-Tetrahydroxy-4'-methoxyflavanone |
|
||||
|
C00014133
|
Dioclein
/ 5,2',5'-Trihydroxy-6,7-dimethoxyflavanone |
|
||||
|
C00014146
|
5,7-Dihydroxy-4'-methoxy-8-methylflavanone
|
|
||||
|
C00014147
|
(2R)-5,4'-Dihydroxy-7-methoxy-6-methylflavanone
|
|
||||
|
C00014148
|
5,4'-Dihydroxy-7-methoxy-8-methylflavanone
|
|
||||
|
C00014149
|
5,7,3',5'-Tetrahydroxy-6-methylflavanone
|
|
||||
|
C00014151
|
Isomatteucinol
/ 5,7-Dihydroxy-3'-methoxy-6,8-dimethylflavanone |
|
||||
|
C00014152
|
2'-Hydroxymatteucinol
/ 5,7,2'-Trihydroxy-4'-methoxy-6,8-dimethylflavanone |
C085277
|
|
|||
|
C00014153
|
Desmosflavanone II
/ 7-Hydroxy-5-methoxy-6-methyl-8-formylflavanone |
CHEMBL54105
|
|
|||
|
C00029518
|
4',5,7-Trihydroxyflavanone
/ 5,7,4'-Trihydroxyflavanone |
CHEMBL9352
CHEMBL32571 |
57 / 46 / 40 |
|
||
|
C00030750
|
Methoxymatteucin
|
|
||||
|
C00034930
|
Artomunoflavanone
/ (+)-Artomunoflavanone |
|
||||
|
C00035826
|
(-)-
/ Dihydroskullcapflavone I |
|
||||
|
C00036584
|
5,3'-Dihydroxy-7-4'-dimethoxyflavanone
|
|
||||
|
C00036598
|
5-Hydroxy-7,8-dimethoxyflavanone
|
CHEMBL1082119
CHEMBL1253998 |
1 / 5 / 5 |
|
||
|
C00038060
|
(-)-Pinocembrin
|
CHEMBL70518
CHEMBL399910 CHEMBL399249 |
18 / 23 / 23 |
|
||
|
C00039356
|
Heliannone B
/ (+)-Heliannone B |
|
||||
|
C00044462
|
5-Hydroxyflavanone
|
|
||||
|
C00048239
|
(+)-Naringenin
|
CHEMBL9352
CHEMBL32571 |
57 / 46 / 40 |
|
Human Protein / Gene in interactions
127 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000960 C00000968 C00000982 C00001006 C00008155 C00008168 C00008237 C00008281 C00029518 C00048239 | 0 / 0 |
| Q16678 | Cytochrome P450 1B1 | Cytochrome P450 1B1 | C00000960 C00000968 C00000969 C00000973 C00000982 C00000992 C00029518 C00038060 C00048239 | 4 / 4 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000960 C00000968 C00000969 C00000973 C00000982 C00000992 C00029518 C00038060 C00048239 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00000960 C00000968 C00000982 C00000999 C00001006 C00008155 C00008281 C00029518 C00048239 | 0 / 0 |
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00000960 C00000968 C00000969 C00000973 C00000982 C00000992 C00029518 C00038060 C00048239 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000960 C00000968 C00000982 C00000992 C00008145 C00029518 C00038060 C00048239 | 3 / 3 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00000968 C00000982 C00001006 C00008144 C00008145 C00008165 C00029518 C00048239 | 2 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00000977 C00000982 C00008126 C00008127 C00008198 C00008367 C00029518 C00048239 | 2 / 2 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000960 C00000968 C00000982 C00000992 C00008145 C00029518 C00038060 C00048239 | 0 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000960 C00000992 C00001006 C00008148 C00008155 C00008237 C00008281 C00038060 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000968 C00000992 C00000999 C00001006 C00008168 C00008281 C00038060 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000982 C00000992 C00008155 C00008237 C00029518 C00038060 C00048239 | 1 / 2 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000960 C00000968 C00000992 C00000999 C00008155 C00008281 C00038060 | 4 / 3 |
| O00255 | Menin | Unclassified protein | C00000982 C00000992 C00008155 C00008237 C00029518 C00038060 C00048239 | 2 / 5 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000968 C00000982 C00000992 C00029518 C00038060 C00048239 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000968 C00000982 C00000992 C00029518 C00038060 C00048239 | 1 / 1 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000982 C00001006 C00008168 C00008367 C00029518 C00048239 | 0 / 3 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00000968 C00000992 C00000999 C00008237 C00008281 C00038060 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00000960 C00000969 C00001006 C00008155 C00008237 C00008281 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000968 C00000982 C00000992 C00029518 C00038060 C00048239 | 1 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00000982 C00008126 C00008127 C00029518 C00048239 | 0 / 1 |
| P22303 | Acetylcholinesterase | Hydrolase | C00000960 C00000968 C00000982 C00029518 C00048239 | 1 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00000982 C00008126 C00008127 C00029518 C00048239 | 3 / 4 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00000960 C00000999 C00008155 C00008237 C00008281 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00000968 C00000992 C00000999 C00008148 C00038060 | 0 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00000968 C00000982 C00029518 C00048239 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00000968 C00000982 C00029518 C00048239 | 0 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00000977 C00000982 C00029518 C00048239 | 0 / 0 |
| P04745 | Alpha-amylase 1 | Enzyme | C00000968 C00000982 C00029518 C00048239 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000960 C00008155 C00008237 C00008281 | 0 / 0 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00000968 C00000982 C00029518 C00048239 | 0 / 0 |
| P14061 | Estradiol 17-beta-dehydrogenase 1 | Enzyme | C00000968 C00000982 C00029518 C00048239 | 0 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00000968 C00000982 C00029518 C00048239 | 5 / 3 |
| P08183 | Multidrug resistance protein 1 | drug | C00000982 C00008165 C00029518 C00048239 | 1 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000960 C00008155 C00008237 C00008281 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00000982 C00000999 C00029518 C00048239 | 6 / 4 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00000968 C00000982 C00029518 C00048239 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00000960 C00008155 C00008237 C00008281 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000982 C00000999 C00029518 C00048239 | 1 / 1 |
| P37059 | Estradiol 17-beta-dehydrogenase 2 | Enzyme | C00000968 C00000982 C00029518 C00048239 | 0 / 0 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00000960 C00000982 C00029518 C00048239 | 1 / 1 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00000960 C00008155 C00008237 C00008281 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000960 C00000968 C00000999 C00008145 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00000968 C00000982 C00029518 C00048239 | 0 / 0 |
| Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | Electrochemical transporter | C00000982 C00029518 C00048239 | 1 / 0 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00000982 C00029518 C00048239 | 0 / 0 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00000982 C00029518 C00048239 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000999 C00008155 C00008237 | 2 / 3 |
| P04278 | Sex hormone-binding globulin | Secreted protein | C00000982 C00029518 C00048239 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00000968 C00000999 C00008168 | 1 / 1 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00000982 C00029518 C00048239 | 5 / 1 |
| O75828 | Carbonyl reductase [NADPH] 3 | Enzyme | C00000982 C00029518 C00048239 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00001006 C00008168 C00008367 | 0 / 0 |
| P16152 | Carbonyl reductase [NADPH] 1 | Enzyme | C00000982 C00029518 C00048239 | 0 / 0 |
| P24864 | G1/S-specific cyclin-E1 | Other cytosolic protein | C00000982 C00029518 C00048239 | 0 / 2 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00000960 C00008155 C00008281 | 2 / 1 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00000982 C00029518 C00048239 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00000982 C00029518 C00048239 | 1 / 1 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00000982 C00029518 C00048239 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000960 C00008145 C00008281 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00000982 C00029518 C00048239 | 0 / 1 |
| P15121 | Aldose reductase | Enzyme | C00000982 C00029518 C00048239 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00000982 C00029518 C00048239 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00000960 C00000968 C00008126 | 7 / 37 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00000982 C00029518 C00048239 | 0 / 0 |
| Q04760 | Lactoylglutathione lyase | Enzyme | C00000982 C00029518 C00048239 | 0 / 0 |
| P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00000960 C00008155 C00008281 | 0 / 0 |
| P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00000960 C00008155 C00008281 | 3 / 1 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00000982 C00029518 C00048239 | 1 / 1 |
| O14746 | Telomerase reverse transcriptase | Enzyme | C00008145 C00008154 C00036598 | 5 / 5 |
| Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | Electrochemical transporter | C00000982 C00029518 C00048239 | 1 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000960 C00000968 C00008145 | 2 / 2 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000982 C00029518 C00048239 | 0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00000992 C00008148 C00038060 | 0 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00000982 C00029518 C00048239 | 3 / 0 |
| P62158 | Calmodulin | Unclassified protein | C00000982 C00029518 C00048239 | 1 / 0 |
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00000982 C00029518 C00048239 | 0 / 0 |
| Q13315 | Serine-protein kinase ATM | Atypical serine/threonine protein kinase PIKK subfamily | C00000968 C00000999 C00008281 | 1 / 4 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00000982 C00029518 C00048239 | 2 / 0 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00000982 C00029518 C00048239 | 1 / 1 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000960 C00000968 C00008145 | 0 / 0 |
| P10696 | Alkaline phosphatase, placental-like | Enzyme | C00000960 C00008155 C00008281 | 0 / 1 |
| P49888 | Estrogen sulfotransferase | Enzyme | C00000982 C00029518 C00048239 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00000960 C00008155 C00008281 | 1 / 1 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00000992 C00008237 C00038060 | 7 / 3 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00008126 C00008127 | 1 / 1 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00000960 C00001006 | 0 / 0 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00000968 C00008148 | 1 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00008155 C00008237 | 0 / 0 |
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | C00008237 C00008281 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00008237 C00008281 | 0 / 0 |
| P59538 | Taste receptor type 2 member 31 | Taste receptor (taste family GPCR) | C00000999 C00008252 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00000968 C00008126 | 4 / 2 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00000968 C00008148 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000999 C00001006 | 2 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00000968 C00001006 | 1 / 0 |
| P14618 | Pyruvate kinase PKM | Enzyme | C00000960 C00000968 | 0 / 0 |
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | C00008126 C00008127 | 0 / 0 |
| P11309 | Serine/threonine-protein kinase pim-1 | Pim | C00000992 C00038060 | 0 / 0 |
| Q13133 | Oxysterols receptor LXR-alpha | NR1H3 | C00000968 | 0 / 0 |
| Q9GZU7 | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 | Enzyme | C00008237 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00008237 | 1 / 0 |
| Q15056 | Eukaryotic translation initiation factor 4H | Unclassified protein | C00008155 | 0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00008281 | 1 / 2 |
| P11940 | Polyadenylate-binding protein 1 | Unclassified protein | C00008155 | 0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00000960 | 0 / 0 |
| Q9Y3R4 | Sialidase-2 | Enzyme | C00000999 | 0 / 0 |
| P05412 | Transcription factor AP-1 | Transcription Factor | C00000977 | 0 / 0 |
| P05091 | Aldehyde dehydrogenase, mitochondrial | Oxidoreductase | C00008126 | 1 / 1 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000968 | 3 / 2 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00000977 | 2 / 2 |
| P37173 | TGF-beta receptor type-2 | TKL dual-specificity kinase STKR type 2 subfamily | C00000968 | 4 / 3 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00000999 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00000968 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001006 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00008145 | 2 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00000960 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00008126 | 0 / 0 |
| P02647 | Apolipoprotein A-I | Unclassified protein | C00000968 | 3 / 2 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00000968 | 4 / 1 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00000999 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00000999 | 1 / 4 |
| Q02410 | Amyloid beta A4 precursor protein-binding family A member 1 | Unclassified protein | C00008237 | 0 / 0 |
| Q00975 | Voltage-dependent N-type calcium channel subunit alpha-1B | N-TYPE | C00008237 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00000960 | 0 / 0 |
| Q04206 | Transcription factor p65 | Transcription Factor | C00000977 | 0 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00000999 | 1 / 1 |
52 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00000960
C00000968
C00000982
|
| 1588 | CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM | cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00000968
C00000982
C00008126
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00000968
C00000982
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00000968
C00000982
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00000968
C00000982
|
| 10057 | ABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 |
C00000968
C00000982
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00000982
C00000992
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00000968
C00000982
|
| 10257 | ABCC4, EST170205, MOAT-B, MOATB, MRP4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 |
C00000968
C00000982
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00000968
C00000982
|
| 6818 | SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) |
C00000982
C00000992
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00000982
|
| 405 | ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 | aryl hydrocarbon receptor nuclear translocator |
C00000982
|
| 249 | ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP | alkaline phosphatase, liver/bone/kidney (EC:3.1.3.1) |
C00000982
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00000982
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00000982
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00000982
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00000982
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00000982
|
| 2100 | ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 (ER beta) |
C00000982
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00000982
|
| 3757 | KCNH2, ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1 | potassium voltage-gated channel, subfamily H (eag-related), member 2 |
C00000982
|
| 5444 | PON1, ESA, MVCD5, PON | paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) |
C00000982
|
| 6566 | SLC16A1, HHF7, MCT, MCT1 | solute carrier family 16 (monocarboxylate transporter), member 1 |
C00000982
|
| 6513 | SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED | solute carrier family 2 (facilitated glucose transporter), member 1 |
C00000982
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00000982
|
| 8644 | AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS | aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) |
C00000982
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00000982
|
| 1645 | AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB | aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) |
C00000982
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00000982
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00000982
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00000982
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00000982
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00000982
|
| 7366 | UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 | UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) |
C00000982
|
| 2950 | GSTP1, DFN7, FAEES3, GST3, GSTP, PI | glutathione S-transferase pi 1 (EC:2.5.1.18) |
C00000960
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00000960
|
| 4780 | NFE2L2, NRF2 | nuclear factor, erythroid 2-like 2 |
C00000960
|
| 29110 | TBK1, NAK, T2K | TANK-binding kinase 1 (EC:2.7.11.1) |
C00000960
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00000968
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00000968
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00000968
|
| 1017 | CDK2, p33(CDK2) | cyclin-dependent kinase 2 (EC:2.7.11.22) |
C00000968
|
| 1019 | CDK4, CMM3, PSK-J3 | cyclin-dependent kinase 4 (EC:2.7.11.22) |
C00000968
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00000968
|
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00000968
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00000968
|
| 7402 | UTRN, DMDL, DRP, DRP1 | utrophin |
C00000968
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00000992
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00000992
|
| 7052 | TGM2, G-ALPHA-h, GNAH, TG2, TGC | transglutaminase 2 (EC:2.3.2.13) |
C00000992
|
| 1831 | TSC22D3, DIP, DSIPI, GILZ, TSC-22R, hDIP | TSC22 domain family, member 3 |
C00000977
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (109)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #610251 | Alcohol sensitivity, acute |
P05091
|
| #105200 | Amyloidosis, familial visceral |
P02647
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #609135 | Aplastic anemia |
O14746
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #208900 | Ataxia-telangiectasia; at |
Q13315
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #210900 | Bloom syndrome; blm |
P54132
|
| %606641 | Body mass index; bmi |
P37231
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #300615 | Brunner syndrome |
P21397
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #614331 | Colorectal cancer, hereditary nonpolyposis, type 6; hnpcc6 |
P37173
|
| #114500 | Colorectal cancer; crc |
P18054
P84022 Q14191 |
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #613989 | Dyskeratosis congenita, autosomal dominant, 2; dkca2 |
O14746
|
| #133239 | Esophageal cancer |
P04637
P18054 P37173 |
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137750 | Glaucoma 1, open angle, a; glc1a |
Q16678
|
| #231300 | Glaucoma 3, primary congenital, a; glc3a |
Q16678
|
| #137760 | Glaucoma, primary open angle; poag |
Q16678
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P37231 |
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #237450 | Hyperbilirubinemia, rotor type; hblrr |
Q9NPD5
Q9Y6L6 |
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #604091 | Hypoalphalipoproteinemia, primary |
P02647
|
| #146300 | Hypophosphatasia, adult |
P05186
|
| #241510 | Hypophosphatasia, childhood |
P05186
|
| #241500 | Hypophosphatasia, infantile |
P05186
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #601626 | Leukemia, acute myeloid; aml |
P36888
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #610168 | Loeys-dietz syndrome, type 1b; lds1b |
P37173
|
| #610380 | Loeys-dietz syndrome, type 2b; lds2b |
P37173
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #615134 | Melanoma, cutaneous malignant, susceptibility to, 9; cmm9 |
O14746
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601665 | Obesity |
P37231
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #604229 | Peters anomaly |
Q16678
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #614742 | Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1; pfbmft1 |
O14746
|
| #178500 | Pulmonary fibrosis, idiopathic; ipf |
O14746
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #205400 | Tangier disease; tgd |
P02647
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #614916 | Ventricular tachycardia, catecholaminergic polymorphic, 4; cpvt4 |
P62158
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (102)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00764 | Cri du chat syndrome |
O14746
(related)
|
| H01132 | Aplastic anemia (AA) |
O14746
(related)
|
| H01299 | Idiopathic pulmonary fibrosis |
O14746
(related)
|
| H00022 | Bladder cancer |
O14746
(marker)
P04637 (related) |
| H00024 | Prostate cancer |
O14746
(marker)
P10275 (related) |
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00845 | Familial amyloidosis |
P02647
(related)
|
| H00930 | Hypoalphalipoproteinemia |
P02647
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) Q92731 (marker) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
P11511 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
Q13315 (related) |
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P04637
(related)
P24864 (related) |
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) P37173 (related) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P14780 (related) P35354 (related) |
| H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P35354 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) P24864 (related) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H01071 | Acute alcohol sensitivity |
P05091
(related)
|
| H00213 | Hypophosphatasia |
P05186
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00023 | Testicular cancer |
P10696
(marker)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
Q92887 (related) |
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
Q01196 (related) Q01196 (marker) Q13951 (marker) |
| H00800 | Loeys-Dietz syndrome (LDS) |
P37173
(related)
|
| H00801 | Familial thoracic aortic aneurysm and dissection (TAAD) |
P37173
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
Q13315 (related) |
| H00296 | Defects in RecQ helicases |
P54132
(related)
Q14191 (related) |
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00064 | Ataxia telangiectasia (AT) |
Q13315
(related)
|
| H00848 | Ataxia with ocular apraxia (AOA) |
Q13315
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00612 | Primary open angle glaucoma |
Q16678
(related)
|
| H01075 | Peters anomaly |
Q16678
(related)
|
| H01159 | Anterior segment dysgenesis (ASD) |
Q16678
(related)
|
| H01203 | Primary congenital glaucoma (PCG) |
Q16678
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
13 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D056486 | Drug-Induced Liver Injury |
C00000982
C00000968 |
| D008106 | Liver Cirrhosis, Experimental |
C00000982
|
| D009202 | Cardiomyopathies |
C00000982
|
| D000647 | Amnesia |
C00000982
|
| D064420 | Drug-Related Side Effects and Adverse Reactions |
C00000982
|
| D007674 | Kidney Diseases |
C00000982
|
| D001932 | Brain Neoplasms |
C00000982
|
| D008107 | Liver Diseases |
C00000982
|
| D009369 | Neoplasms |
C00000982
|
| D009374 | Neoplasms, Experimental |
C00000982
|
| D000230 | Adenocarcinoma |
C00000968
|
| D003110 | Colonic Neoplasms |
C00000968
|
| D009120 | Muscle Cramp |
C00000977
|