PCIDB

KNApSAcK Metabolite C00000999

Metabolite

KNApSAcK Entry

id C00000999
Name Sakuranetin / Naringenin 7-O-methyl ether / 5,4'-Dihydroxy-7-methoxyflavanone
CAS RN 2957-21-3
Standard InChI InChI=1S/C16H14O5/c1-20-11-6-12(18)16-13(19)8-14(21-15(16)7-11)9-2-4-10(17)5-3-9/h2-7,14,17-18H,8H2,1H3/t14-/m0/s1
Standard InChI (Main Layer) InChI=1S/C16H14O5/c1-20-11-6-12(18)16-13(19)8-14(21-15(16)7-11)9-2-4-10(17)5-3-9/h2-7,14,17-18H,8H2,1H3

Cluster

Phytochemical cluster No. 14
KCF-S cluster No. 25

Link

ChEMBL

By standard InChI CHEMBL448297
By standard InChI Main Layer CHEMBL74852 CHEMBL448297

KEGG

By LinkDB C09833

CTD

By CAS RN C099724

Human Protein / Gene in interaction

19 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q99700 Ataxin-2 Unclassified protein CHEMBL74852 CHEMBL2114784 (1)
1 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL74852 CHEMBL638578 (1) CHEMBL641515 (1)
CHEMBL649050 (1)
0 / 0
P04062 Glucosylceramidase Enzyme CHEMBL74852 CHEMBL1613818 (1)
6 / 4
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL74852 CHEMBL1794585 (1)
0 / 0
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily CHEMBL74852 CHEMBL1614153 (1)
1 / 4
P11473 Vitamin D3 receptor NR1I1 CHEMBL74852 CHEMBL1794311 (1)
2 / 3
Q9Y3R4 Sialidase-2 Enzyme CHEMBL448297 CHEMBL1100507 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL74852 CHEMBL1614458 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL74852 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL74852 CHEMBL2114843 (1)
0 / 0
Q9Y253 DNA polymerase eta Enzyme CHEMBL74852 CHEMBL1794569 (1)
1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL74852 CHEMBL1794401 (1)
0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL74852 CHEMBL1738317 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL74852 CHEMBL1614421 (1)
4 / 3
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL74852 CHEMBL1614364 (1)
1 / 1
P59538 Taste receptor type 2 member 31 Taste receptor (taste family GPCR) CHEMBL448297 CHEMBL2039382 (1)
0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL74852 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL74852 CHEMBL1613933 (1)
1 / 6
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL74852 CHEMBL2354287 (1)
1 / 1

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (20)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#208900 Ataxia-telangiectasia; at Q13315
#114500 Colorectal cancer; crc P84022
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (20)

KEGG disease name UniProt
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) Q13315 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00094 DNA repair defects Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)