Microtropis japonica
Species
KNApSAcK Entry
| Organism name | Microtropis japonica |
|---|---|
| Genus | Microtropis |
| Family | Celastraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Microtropis japonica |
|---|---|
| Linked NCBI taxonomy ID | 1089418 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Celastraceae |
|---|---|
| ID | 4305 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (24)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00000999
|
Sakuranetin
/ Naringenin 7-O-methyl ether / 5,4'-Dihydroxy-7-methoxyflavanone |
CHEMBL74852
CHEMBL448297 |
C099724
|
19 / 20 / 20 | No. 25 | No. 14 |
|
|
|
C00029821
|
Sitostenone
/ beta-Sitostenone / Stigmast-4-en-3-one / Stigmast-4-ene-3-one |
CHEMBL66926
|
No. 53 | No. 11 |
|
|||
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00032208
|
Stigmasta-4,22-dien-3-one
/ (+)-Stigmasta-4,22-dien-3-one |
No. 53 | No. 11 |
|
||||
|
C00038331
|
8-Benzoyloxymutangin
|
CHEMBL509087
|
No. 168 |
|
||||
|
C00039218
|
Fokienagarofuran A
|
CHEMBL504778
|
No. 168 |
|
||||
|
C00039219
|
Fokienagarofuran D
/ (+)-Fokienagarofuran D |
CHEMBL487597
|
No. 168 |
|
||||
|
C00038185
|
1alpha,2alpha-Diacetoxy-6beta,9beta,15-tribenzoyloxy-beta-dihydroagarofuran
/ (+)-1alpha,2alpha-Diacetoxy-6beta,9beta,15-tribenzoyloxy-beta-dihydroagarofuran |
CHEMBL373768
|
No. 168 |
|
||||
|
C00038166
|
15-Acetoxyorbiculin G
|
CHEMBL450650
|
No. 168 |
|
||||
|
C00040183
|
Salasol A
|
CHEMBL489050
|
No. 173 |
|
||||
|
C00038716
|
Celahin C
|
CHEMBL507495
|
No. 173 |
|
||||
|
C00029633
|
Ursolic acid
/ Acetylursolic acid |
CHEMBL55086
CHEMBL410525 |
4 / 2 / 2 | No. 177 |
|
|||
|
C00002728
|
Coniferaldehyde
/ Coniferyl aldehyde / 4-Hydroxy-3-methoxycinnamaldehyde |
CHEMBL242529
CHEMBL1956165 |
C075384
|
1 / 1 / 1 | No. 310 | No. 6 |
|
|
|
C00007558
|
Syringaldehyde
/ 4-Hydroxy-3,5-dimethoxybenzaldehyde |
CHEMBL225303
|
C069665
|
No. 856 |
|
|||
|
C00002498
|
Scoparone
/ 6,7-Dimethoxycoumarin / Aesculetin dimethyl ether |
CHEMBL325864
|
C018145
|
4 / 2 / 2 | 6 / 0 | No. 864 | No. 25 |
|
|
C00002683
|
Vanillin
|
CHEMBL13883
|
18 / 8 / 9 | No. 1003 |
|
|||
|
C00002682
|
Vanillic acid
/ 3-Methoxy-4-hydroxybenzoic acid |
CHEMBL120568
|
D014641
|
5 / 3 / 3 | 5 / 0 | No. 1073 |
|
|
|
C00038335
|
9,9'-O-di-(E)-feruloyl-(-)-secoisolariciresinol
|
CHEMBL447988
CHEMBL451903 |
No. 1214 |
|
||||
|
C00038336
|
9,9'-O-di-(Z)-feruloyl-(-)-secoisolariciresinol
|
CHEMBL447988
CHEMBL451903 |
No. 1214 |
|
||||
|
C00033844
|
Evofolin B
/ (-)-Evofolin B |
CHEMBL448601
CHEMBL602133 |
No. 2211 |
|
||||
|
C00038293
|
5'-Methoxyevofolin B
/ (-)-5'-Methoxyevofolin B |
CHEMBL486902
|
No. 2211 |
|
||||
|
C00029477
|
beta-Hydroxypropiovanillone
/ omega-Hydroxypropioguaiacone / 3,4'-Dihydroxy-3'-methoxypropiophenone / 3-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-1-propanone |
CHEMBL485875
|
No. 2959 |
|
||||
|
C00038233
|
2-Pyrrolidone
|
CHEMBL276849
|
C028537
|
No. 5191 |
|
|||
|
C00039855
|
N-Methyl-2-pyrrolidone
|
CHEMBL12543
|
C063153
|
5 / 1 / 1 | No. 5808 |
|
Human Protein / Gene in interactions
68 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000999 C00002683 C00003672 | 1 / 1 |
| P03372 | Estrogen receptor | NR3A1 | C00002682 C00003672 | 1 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00003672 C00029633 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000999 C00002683 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00029633 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00000999 | 1 / 1 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 | 2 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00000999 | 0 / 0 |
| P78527 | DNA-dependent protein kinase catalytic subunit | Atypical serine/threonine protein kinase PIKK subfamily | C00002683 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003672 | 1 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00000999 | 6 / 4 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00000999 | 0 / 0 |
| Q13315 | Serine-protein kinase ATM | Atypical serine/threonine protein kinase PIKK subfamily | C00000999 | 1 / 4 |
| Q92793 | CREB-binding protein | Enzyme | C00039855 | 1 / 1 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003672 | 3 / 2 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00002728 | 1 / 1 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00002683 | 0 / 0 |
| P51649 | Succinate-semialdehyde dehydrogenase, mitochondrial | Oxidoreductase | C00002683 | 1 / 1 |
| P05091 | Aldehyde dehydrogenase, mitochondrial | Oxidoreductase | C00002498 | 1 / 1 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00002683 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00003672 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003672 | 0 / 1 |
| Q9HAW7 | UDP-glucuronosyltransferase 1-7 | Enzyme | C00002683 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000999 | 2 / 3 |
| Q9Y3R4 | Sialidase-2 | Enzyme | C00000999 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00039855 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00002682 | 1 / 1 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000999 | 2 / 0 |
| O75496 | Geminin | Unclassified protein | C00000999 | 0 / 0 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00002683 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00002682 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 | 0 / 0 |
| O00519 | Fatty-acid amide hydrolase 1 | Enzyme | C00002683 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00000999 | 1 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000999 | 0 / 0 |
| P00734 | Prothrombin | S1A | C00003672 | 4 / 2 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00029633 | 2 / 2 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 | 4 / 2 |
| P80404 | 4-aminobutyrate aminotransferase, mitochondrial | Transferase | C00002683 | 1 / 1 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00002683 | 0 / 0 |
| P56817 | Beta-secretase 1 | A1A | C00002498 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003672 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002683 | 2 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00000999 | 0 / 0 |
| Q9Y4X1 | UDP-glucuronosyltransferase 2A1 | Enzyme | C00002683 | 0 / 0 |
| P25440 | Bromodomain-containing protein 2 | Unclassified protein | C00039855 | 0 / 0 |
| P51580 | Thiopurine S-methyltransferase | Enzyme | C00002682 | 1 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003672 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003672 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002682 | 0 / 0 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00002683 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000999 | 4 / 3 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00002683 | 0 / 0 |
| Q15059 | Bromodomain-containing protein 3 | Unclassified protein | C00039855 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002683 | 0 / 0 |
| O60885 | Bromodomain-containing protein 4 | Unclassified protein | C00039855 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00002683 | 3 / 4 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00029633 | 0 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003672 | 0 / 0 |
| P59538 | Taste receptor type 2 member 31 | Taste receptor (taste family GPCR) | C00000999 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00000999 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00000999 | 1 / 4 |
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | C00002498 | 0 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00002498 | 1 / 1 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002683 | 0 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00000999 | 1 / 1 |
11 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00002498
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00002498
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00002498
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00002498
|
| 5966 | REL, C-Rel | v-rel avian reticuloendotheliosis viral oncogene homolog |
C00002498
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00002498
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00002682
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002682
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00002682
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002682
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002682
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (53)
| OMIM | preferred title | UniProt |
|---|---|---|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #610251 | Alcohol sensitivity, acute |
P05091
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #208900 | Ataxia-telangiectasia; at |
Q13315
|
| #300615 | Brunner syndrome |
P21397
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613163 | Gaba-transaminase deficiency |
P80404
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #143100 | Huntington disease; hd |
P42858
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #180849 | Rubinstein-taybi syndrome 1; rsts1 |
Q92793
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601367 | Stroke, ischemic |
P00734
|
| #271980 | Succinic semialdehyde dehydrogenase deficiency; ssadhd |
P51649
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #610460 | Thiopurine s-methyltransferase deficiency |
P51580
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (47)
| KEGG | name | UniProt |
|---|---|---|
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H01071 | Acute alcohol sensitivity |
P05091
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00964 | Thiopurine S-methyltransferase deficiency (TPMT deficiency) |
P51580
(related)
|
| H00835 | Succinic semialdehyde dehydrogenase (SSADH) deficiency |
P51649
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H01257 | GABA-transaminase deficiency |
P80404
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
Q13315
(related)
|
| H00064 | Ataxia telangiectasia (AT) |
Q13315
(related)
|
| H00094 | DNA repair defects |
Q13315
(related)
|
| H00848 | Ataxia with ocular apraxia (AOA) |
Q13315
(related)
|
| H00504 | Rubinstein-Taybi syndrome |
Q92793
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|