KCF-S cluster No. 864 (10 metabolites)

Corresponding Phytochemical cluster No. 25

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (10)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	89
asterids	77
eudicotyledons	4
Liliopsida	3
Magnoliophyta	1

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Cumulative family count (Top 20)

class name	count
Asteraceae	31
Fabaceae	26
Rutaceae	26
Rubiaceae	14
Apiaceae	12
Meliaceae	7
Euphorbiaceae	7
Solanaceae	5
Malvaceae	5
Convolvulaceae	3
Hydrangeaceae	3
Caryophyllaceae	2
Hippocastanaceae	2
Rosaceae	2
Apocynaceae	2
Oleaceae	2
Orchidaceae	2
Aceraceae	2
Amaranthaceae	2
Moraceae	2

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Coumarins	4

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metabolites link (4)

br08003 Category	KEGG ID	KNApSAcK ID
Coumarins	C09265	C00002473
Coumarins	C09268	C00002476
Coumarins	C09311	C00002498
Coumarins	C01752	C00002499

Metabolite list (10)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002473	Fraxetin	CHEMBL54909	C105671	32 / 21 / 23	6 / 0
C00002476	Herniarin / 7-Methoxycoumarin	CHEMBL49732	C007929	23 / 10 / 12
C00002498	Scoparone / 6,7-Dimethoxycoumarin / Aesculetin dimethyl ether	CHEMBL325864	C018145	4 / 2 / 2	6 / 0
C00002499	Scopoletin	CHEMBL71851	D012603	48 / 37 / 34	9 / 0
C00019843	6,8-Dihydroxy-7-methoxycoumarin
C00031439	Yunngnin B
C00037597	Paniculal
C00039442	Isofraxetin
C00039452	Isoscopoletin	CHEMBL390320		12 / 3 / 8
C00045589	7-Hydroxy-8-methoxycoumarin	CHEMBL2331585		6 / 2 / 4

Human Protein / Gene in interactions

74 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P43166	Carbonic anhydrase 7	Lyase	C00002473 C00002476 C00002499 C00039452 C00045589	0 / 0
O43570	Carbonic anhydrase 12	Lyase	C00002473 C00002476 C00002499 C00039452 C00045589	1 / 2
Q16790	Carbonic anhydrase 9	Lyase	C00002473 C00002476 C00002499 C00039452 C00045589	0 / 1
P00918	Carbonic anhydrase 2	Lyase	C00002473 C00002476 C00002499 C00039452 C00045589	1 / 2
P00915	Carbonic anhydrase 1	Lyase	C00002473 C00002476 C00002499 C00039452 C00045589	0 / 0
Q8N1Q1	Carbonic anhydrase 13	Lyase	C00002473 C00002499 C00039452 C00045589	0 / 0
P15121	Aldose reductase	Enzyme	C00002476 C00002499 C00039452	0 / 0
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00002473 C00002499 C00039452	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00002473 C00002476 C00039452	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00002473 C00002476 C00002499	0 / 0
Q00796	Sorbitol dehydrogenase	Enzyme	C00002476 C00002499 C00039452	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00002473 C00002476 C00002499	2 / 2
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00002473 C00002476 C00002499	3 / 3
P00352	Retinal dehydrogenase 1	Enzyme	C00002473 C00002476 C00002499	0 / 0
P29466	Caspase-1	C14	C00002473 C00002499	0 / 0
P55210	Caspase-7	C14	C00002473 C00002499	0 / 0
P56817	Beta-secretase 1	A1A	C00002476 C00002498	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00002499 C00039452	0 / 3
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00002473 C00002499	1 / 1
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00002499 C00039452	1 / 1
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00002473 C00002476	0 / 0
O00255	Menin	Unclassified protein	C00002473 C00002499	2 / 5
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00002473 C00002499	0 / 1
O75496	Geminin	Unclassified protein	C00002473 C00002499	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002473 C00002499	1 / 2
Q99700	Ataxin-2	Unclassified protein	C00002473 C00002499	1 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00002473	0 / 0
P28845	Corticosteroid 11-beta-dehydrogenase isozyme 1	Enzyme	C00002476	1 / 1
P23280	Carbonic anhydrase 6	Lyase	C00002476	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00002499	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00002473	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00002499	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00002473	0 / 0
O60656	UDP-glucuronosyltransferase 1-9	Enzyme	C00002499	0 / 0
P54855	UDP-glucuronosyltransferase 2B15	Enzyme	C00002499	0 / 0
P05091	Aldehyde dehydrogenase, mitochondrial	Oxidoreductase	C00002498	1 / 1
P55789	FAD-linked sulfhydryl oxidase ALR	Enzyme	C00002499	1 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00002473	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00002499	7 / 3
Q04206	Transcription factor p65	Transcription Factor	C00002499	0 / 0
P06280	Alpha-galactosidase A	Enzyme	C00002499	1 / 1
P28482	Mitogen-activated protein kinase 1	Erk	C00002473	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00002499	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00002499	0 / 0
P04406	Glyceraldehyde-3-phosphate dehydrogenase	Enzyme	C00002499	0 / 0
P35218	Carbonic anhydrase 5A, mitochondrial	Lyase	C00002476	0 / 0
Q9Y2D0	Carbonic anhydrase 5B, mitochondrial	Lyase	C00002476	0 / 0
Q9HAW9	UDP-glucuronosyltransferase 1-8	Enzyme	C00002499	0 / 0
Q9Y4X1	UDP-glucuronosyltransferase 2A1	Enzyme	C00002499	0 / 0
P22303	Acetylcholinesterase	Hydrolase	C00002499	1 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00002499	1 / 1
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00002473	0 / 0
P04062	Glucosylceramidase	Enzyme	C00002499	6 / 4
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002499	1 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002499	0 / 1
Q9ULX7	Carbonic anhydrase 14	Lyase	C00002476	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00002473	0 / 0
Q9HAW8	UDP-glucuronosyltransferase 1-10	Enzyme	C00002499	0 / 0
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00002499	5 / 1
P10636	Microtubule-associated protein tau	Unclassified protein	C00002473	4 / 3
P07451	Carbonic anhydrase 3	Lyase	C00002476	0 / 0
P22748	Carbonic anhydrase 4	Lyase	C00002476	1 / 1
P80365	Corticosteroid 11-beta-dehydrogenase isozyme 2	Enzyme	C00002476	1 / 1
Q16637	Survival motor neuron protein	Unclassified protein	C00002473	4 / 1
O14980	Exportin-1	Unclassified protein	C00002476	0 / 0
O75795	UDP-glucuronosyltransferase 2B17	Enzyme	C00002499	1 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00002499	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00002499	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00002473	1 / 1
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00002499	0 / 0
P22310	UDP-glucuronosyltransferase 1-4	Enzyme	C00002499	3 / 0
P27338	Amine oxidase [flavin-containing] B	Oxidoreductase	C00002498	0 / 0
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00002498	1 / 1
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00002473	0 / 0

21 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00002498
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00002498
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00002498
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00002498
5966	REL, C-Rel	v-rel avian reticuloendotheliosis viral oncogene homolog	C00002498
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002498
581	BAX, BCL2L4	BCL2-associated X protein	C00002473
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00002473
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00002473
847	CAT	catalase (EC:1.11.1.6)	C00002473
54205	CYCS, CYC, HCS, THC4	cytochrome c, somatic	C00002473
6648	SOD2, IPOB, MNSOD, MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	C00002473
54658	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A	UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)	C00002499
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00002499
54659	UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C	UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17)	C00002499
54578	UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT_1-6, UGT1, UGT1A6S, UGT1F	UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17)	C00002499
54577	UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G	UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17)	C00002499
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00002499
54600	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I	UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17)	C00002499
7366	UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8	UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17)	C00002499
7508	XPC, RAD4, XP3, XPCC	xeroderma pigmentosum, complementation group C	C00002499

Related Diseases

Diseases related to proteins in ChEMBL interactions