PCIDB

KNApSAcK Metabolite C00002473

Metabolite

KNApSAcK Entry

id C00002473
Name Fraxetin
CAS RN 574-84-5
Standard InChI InChI=1S/C10H8O5/c1-14-6-4-5-2-3-7(11)15-10(5)9(13)8(6)12/h2-4,12-13H,1H3
Standard InChI (Main Layer) InChI=1S/C10H8O5/c1-14-6-4-5-2-3-7(11)15-10(5)9(13)8(6)12/h2-4,12-13H,1H3

Cluster

Phytochemical cluster No. 25
KCF-S cluster No. 864

Link

ChEMBL

By standard InChI CHEMBL54909
By standard InChI Main Layer CHEMBL54909

KEGG

By LinkDB C09265

CTD

By CAS RN C105671

Human Protein / Gene in interaction

32 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q16637 Survival motor neuron protein Unclassified protein CHEMBL54909 CHEMBL1613842 (1)
4 / 2
Q99700 Ataxin-2 Unclassified protein CHEMBL54909 CHEMBL2114784 (1)
1 / 1
P09917 Arachidonate 5-lipoxygenase Oxidoreductase CHEMBL54909 CHEMBL950605 (1)
0 / 0
P43166 Carbonic anhydrase 7 Lyase CHEMBL54909 CHEMBL2341285 (1)
0 / 0
P29466 Caspase-1 C14 CHEMBL54909 CHEMBL1614158 (2)
0 / 0
Q8N1Q1 Carbonic anhydrase 13 Lyase CHEMBL54909 CHEMBL2341282 (1)
0 / 0
P00918 Carbonic anhydrase 2 Lyase CHEMBL54909 CHEMBL2341286 (1)
1 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL54909 CHEMBL1614027 (1)
0 / 1
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL54909 CHEMBL1008496 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL54909 CHEMBL1614458 (2)
0 / 0
O43570 Carbonic anhydrase 12 Lyase CHEMBL54909 CHEMBL2341283 (1)
1 / 2
P39748 Flap endonuclease 1 Enzyme CHEMBL54909 CHEMBL1794486 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL54909 CHEMBL2114780 (1)
0 / 0
P00915 Carbonic anhydrase 1 Lyase CHEMBL54909 CHEMBL2341287 (1)
0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL54909 CHEMBL2114788 (1)
0 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL54909 CHEMBL1613808 (2)
0 / 0
Q16790 Carbonic anhydrase 9 Lyase CHEMBL54909 CHEMBL2341284 (1)
0 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL54909 CHEMBL1613910 (2) CHEMBL1614227 (1)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL54909 CHEMBL1614038 (2)
2 / 2
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL54909 CHEMBL1614240 (1)
0 / 0
P55210 Caspase-7 C14 CHEMBL54909 CHEMBL1613779 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL54909 CHEMBL1613777 (1)
1 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL54909 CHEMBL1794483 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL54909 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL54909 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL54909 CHEMBL1614250 (1) CHEMBL1614421 (2)
4 / 3
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL54909 CHEMBL1794536 (3)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL54909 CHEMBL1613914 (2)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL54909 CHEMBL1614364 (1)
1 / 1
O00255 Menin Unclassified protein CHEMBL54909 CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL54909 CHEMBL1614531 (1)
1 / 3
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL54909 CHEMBL2114738 (1)
0 / 0

CTD interaction (6)

compound gene gene name gene description interaction interaction type form reference
pmid
C105671 581 BAX
BCL2L4
BCL2-associated X protein fraxetin results in decreased expression of BAX protein decreases expression
protein 15996779
C105671 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) fraxetin results in decreased activity of CASP3 protein decreases activity
protein 15996779
C105671 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) fraxetin results in decreased activity of CASP9 protein decreases activity
protein 15996779
C105671 847 CAT
catalase (EC:1.11.1.6) fraxetin inhibits the reaction [Rotenone results in increased expression of and results in increased activity of CAT protein] decreases reaction
/ increases activity
/ increases expression
protein 15904944
C105671 54205 CYCS
CYC
HCS
THC4
cytochrome c, somatic fraxetin affects the localization of CYCS protein affects localization
protein 15996779
C105671 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) fraxetin inhibits the reaction [Rotenone results in increased expression of and results in increased activity of SOD2 protein] decreases reaction
/ increases activity
/ increases expression
protein 15904944

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (21)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (23)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)