KCF-S cluster No. 1003 (8 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (8)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	18
Magnoliophyta	13
asterids	13
Liliopsida	9
eudicotyledons	6
Spermatophyta	4
Euphyllophyta	1

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Cumulative family count (Top 20)

class name	count
Lauraceae	6
Asteraceae	5
Apiaceae	4
Rutaceae	3
Orchidaceae	3
Pinaceae	2
Asparagaceae	2
Viscaceae	2
Aristolochiaceae	2
Myrtaceae	2
Annonaceae	2
Fabaceae	2
Zygophyllaceae	1
Lamiaceae	1
Pleurotaceae	1
Brassicaceae	1
Hydrangeaceae	1
Amaranthaceae	1
Bovidae	1
Rosaceae	1

KEGG BRITE br08003

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Categories (0)

br08003 Category	# of metabolite

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metabolites link (0)

br08003 Category	KEGG ID	KNApSAcK ID

Metabolite list (8)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002636	Anisaldehyde / p-Anisaldehyde	CHEMBL161598	C024896	11 / 18 / 13	1 / 0
C00002683	Vanillin	CHEMBL13883		18 / 8 / 9
C00029531	Vanillic aldehyde / 4-Hydroxy-3-methoxybenzaldehyde	CHEMBL13883	C100058	18 / 8 / 9	33 / 1
C00036597	5-Hydroxy-2-methoxy benzaldehyde	CHEMBL1988977
C00044431	2-Hydroxy-5-methoxybenzaldehyde
C00044826	Isovanillin	CHEMBL275563	C093382	7 / 8 / 4
C00047056	Isovanillin	CHEMBL275563	C093382	7 / 8 / 4
C00049046	Isovanillin	CHEMBL275563	C093382	7 / 8 / 4

Human Protein / Gene in interactions

29 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P00352	Retinal dehydrogenase 1	Enzyme	C00002636 C00002683 C00029531 C00044826 C00047056 C00049046	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00002683 C00029531 C00044826 C00047056 C00049046	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00002636 C00044826 C00047056 C00049046	0 / 0
P51649	Succinate-semialdehyde dehydrogenase, mitochondrial	Oxidoreductase	C00002636 C00002683 C00029531	1 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00044826 C00047056 C00049046	0 / 0
P10275	Androgen receptor	NR3C4	C00002636 C00002683 C00029531	3 / 4
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00044826 C00047056 C00049046	1 / 1
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00044826 C00047056 C00049046	7 / 3
P80404	4-aminobutyrate aminotransferase, mitochondrial	Transferase	C00002636 C00002683 C00029531	1 / 1
Q06278	Aldehyde oxidase	Enzyme	C00044826 C00047056 C00049046	0 / 1
O00519	Fatty-acid amide hydrolase 1	Enzyme	C00002683 C00029531	0 / 0
O60656	UDP-glucuronosyltransferase 1-9	Enzyme	C00002683 C00029531	0 / 0
Q9HAW7	UDP-glucuronosyltransferase 1-7	Enzyme	C00002683 C00029531	0 / 0
P34969	5-hydroxytryptamine receptor 7	Serotonin receptor	C00002683 C00029531	0 / 0
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00002683 C00029531	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00002683 C00029531	1 / 1
P78527	DNA-dependent protein kinase catalytic subunit	Atypical serine/threonine protein kinase PIKK subfamily	C00002683 C00029531	0 / 0
Q96RI1	Bile acid receptor	NR1H4	C00002683 C00029531	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002683 C00029531	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00002683 C00029531	2 / 2
Q9Y4X1	UDP-glucuronosyltransferase 2A1	Enzyme	C00002683 C00029531	0 / 0
P19224	UDP-glucuronosyltransferase 1-6	Enzyme	C00002683 C00029531	0 / 0
Q9HAW8	UDP-glucuronosyltransferase 1-10	Enzyme	C00002683 C00029531	0 / 0
P03372	Estrogen receptor	NR3A1	C00002636	1 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00002636	0 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00002636	5 / 3
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00002636	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00002636	3 / 1
P14679	Tyrosinase	Oxidoreductase	C00002636	4 / 2

34 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
8989	TRPA1, ANKTM1, FEPS	transient receptor potential cation channel, subfamily A, member 1	C00002636
1646	AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8	aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357)	C00029531
759	CA1, CA-I, CAB, Car1	carbonic anhydrase I (EC:4.2.1.1)	C00029531
760	CA2, CA-II, CAC, CAII, Car2	carbonic anhydrase II (EC:4.2.1.1)	C00029531
1196	CLK2, hCLK2	CDC-like kinase 2 (EC:2.7.12.1)	C00029531
1490	CTGF, CCN2, HCS24, IGFBP8, NOV2	connective tissue growth factor	C00029531
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00029531
54541	DDIT4, Dig2, REDD-1, REDD1	DNA-damage-inducible transcript 4	C00029531
1789	DNMT3B, ICF, ICF1, M.HsaIIIB	DNA (cytosine-5-)-methyltransferase 3 beta (EC:2.1.1.37)	C00029531
1848	DUSP6, HH19, MKP3, PYST1	dual specificity phosphatase 6 (EC:3.1.3.16 3.1.3.48)	C00029531
2263	FGFR2, BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25	fibroblast growth factor receptor 2 (EC:2.7.10.1)	C00029531
2535	FZD2, Fz2, fz-2, fzE2, hFz2	frizzled family receptor 2	C00029531
2729	GCLC, GCL, GCS, GLCL, GLCLC	glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2)	C00029531
2730	GCLM, GLCLR	glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2)	C00029531
3162	HMOX1, HMOX1D, HO-1, HSP32, bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	C00029531
3251	HPRT1, HGPRT, HPRT	hypoxanthine phosphoribosyltransferase 1 (EC:2.4.2.8)	C00029531
3304	HSPA1B, HSP70-1B, HSP70-2	heat shock 70kDa protein 1B	C00029531
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00029531
3638	INSIG1, CL-6, CL6	insulin induced gene 1	C00029531
3727	JUND, AP-1	jun D proto-oncogene	C00029531
5605	MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2	mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)	C00029531
57787	MARK4, MARK4L, MARK4S, MARKL1, MARKL1L, PAR-1D	MAP/microtubule affinity-regulating kinase 4 (EC:2.7.11.1)	C00029531
4502	MT2A, MT2	metallothionein 2A	C00029531
5514	PPP1R10, CAT53, FB19, PNUTS, PP1R10, R111, p99	protein phosphatase 1, regulatory subunit 10	C00029531
11046	SLC35D2, HFRC1, SQV7L, UGTrel8, hfrc	solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2	C00029531
23657	SLC7A11, CCBR1, xCT	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11	C00029531
7041	TGFB1I1, ARA55, HIC-5, HIC5, TSC-5	transforming growth factor beta 1 induced transcript 1	C00029531
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00029531
10626	TRIM16, EBBP	tripartite motif containing 16	C00029531
7360	UGP2, UDPG, UDPGP, UDPGP2, UGP1, UGPP1, UGPP2, pHC379	UDP-glucose pyrophosphorylase 2 (EC:2.7.7.9)	C00029531
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00029531
54659	UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C	UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17)	C00029531
54577	UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G	UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17)	C00029531
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00029531

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions