PCIDB

KNApSAcK Metabolite C00000982

Metabolite

KNApSAcK Entry

id C00000982
Name Naringenin / (-)-Naringenin
CAS RN 480-41-1
Standard InChI InChI=1S/C15H12O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-6,13,16-18H,7H2/t13-/m0/s1
Standard InChI (Main Layer) InChI=1S/C15H12O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-6,13,16-18H,7H2

Cluster

Phytochemical cluster No. 14
KCF-S cluster No. 25

Link

ChEMBL

By standard InChI CHEMBL9352
By standard InChI Main Layer CHEMBL9352 CHEMBL32571

KEGG

By LinkDB C00509

CTD

By CAS RN C005273

Species

Summary

Plant class

class name count
rosids 30
asterids 14
Liliopsida 4
Spermatophyta 2
Magnoliophyta 2
eudicotyledons 1

Family (Top 10)

family name count
Fabaceae 20
Asteraceae 12
Moraceae 3
Poaceae 2
Nymphaeaceae 1
Lamiaceae 1
Podocarpaceae 1
Viscaceae 1
Gesneriaceae 1
Orchidaceae 1

List (55)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Acacia dealbata 205042 Fabaceae rosids Viridiplantae
Acacia longifolia 139010 Fabaceae rosids Viridiplantae
Aeschynanthus bracteatus 175969 Gesneriaceae asterids Viridiplantae
Arabidopsis thaliana 3702 Brassicaceae rosids Viridiplantae
Artemisia campestris ssp.maritima 4219 Asteraceae asterids Viridiplantae
Artemisia glutinosa 4219 Asteraceae asterids Viridiplantae
Artemisia spp. 4219 Asteraceae asterids Viridiplantae
Baccharis spp. 41487 Asteraceae asterids Viridiplantae
Bauhinia guianensis 508984 Fabaceae rosids Viridiplantae
Broussonetia papyrifera 172644 Moraceae rosids Viridiplantae
Centaurea spp. 41503 Asteraceae asterids Viridiplantae
Chrysothamnus humilis 217578 Asteraceae asterids Viridiplantae
Chrysothamnus viscidiflorus 72914 Asteraceae asterids Viridiplantae
Citrus spp. 2706 Rutaceae rosids Viridiplantae
Cochlospermum gillivraei 66674 Bixaceae rosids Viridiplantae
Crotalaria assamica 671522 Fabaceae rosids Viridiplantae
Crotalaria pallida 3830 Fabaceae rosids Viridiplantae
Cudrania cochinchinensis var. gerontogea 3495 Moraceae rosids Viridiplantae
Curcuma mangga 379528 Zingiberaceae Liliopsida Viridiplantae
Dahlia spp. 4210 Asteraceae asterids Viridiplantae
Dalbergia stevensonii 53862 Fabaceae rosids Viridiplantae
Dendrobium densiflorum Lindl.ex.Wall. 37818 Orchidaceae Liliopsida Viridiplantae
Equsetum arvense
Flemingia stricta 520842 Fabaceae rosids Viridiplantae
Garcinia multiflora 1009474 Clusiaceae rosids Viridiplantae
Glycine max 3847 Fabaceae rosids Viridiplantae
Glycyrrhiza glabra 49827 Fabaceae rosids Viridiplantae
Glycyrrhiza uralensis 74613 Fabaceae rosids Viridiplantae
Gynerium sagittatum 42053 Poaceae Liliopsida Viridiplantae
Helichrysum arenarium 261776 Asteraceae asterids Viridiplantae
Helichrysum bracteatum (Vent.)Andr. 59430 Asteraceae asterids Viridiplantae
Helichrysum graveolen 59430 Asteraceae asterids Viridiplantae
Intsia bijuga 162812 Fabaceae rosids Viridiplantae
Lespedeza cyrtobotrya 701533 Fabaceae rosids Viridiplantae
Lupinus subcarnosus 3869 Fabaceae rosids Viridiplantae
Lupinus texensis 28959 Fabaceae rosids Viridiplantae
Maclura tinctoria 681456 Moraceae rosids Viridiplantae
Medicago truncatula 3880 Fabaceae rosids Viridiplantae
Millettia brandisiana 53625 Fabaceae rosids Viridiplantae
Mimosa hostilis 21013 Fabaceae rosids Viridiplantae
Moghania philippinensis
Nymphaea caerulea 49506 Nymphaeaceae Magnoliophyta Viridiplantae
Oryza sativa 4530 Poaceae Liliopsida Viridiplantae
Phlomis caucasica 316257 Lamiaceae asterids Viridiplantae
Phyllanthus emblica 296036 Phyllanthaceae rosids Viridiplantae
Piper crassinervium Kunth 538253 Piperaceae Magnoliophyta Viridiplantae
Podocarpus fasciculus 120615 Podocarpaceae Spermatophyta Viridiplantae
Polymnia fruticosa 183069 Asteraceae asterids Viridiplantae
Prunus persica 3760 Rosaceae rosids Viridiplantae
Pseudotsuga wilsoniana 71408 Pinaceae Spermatophyta Viridiplantae
Pterocarpus marsupium 1071187 Fabaceae rosids Viridiplantae
Rhynchosia beddomei 1378005 Fabaceae rosids Viridiplantae
Swartzia polyphylla 450104 Fabaceae rosids Viridiplantae
Viscum coloratum 3971 Viscaceae eudicotyledons Viridiplantae
Xanthoceras sorbifolia 99658 Xanthoceraceae rosids Viridiplantae

Human Protein / Gene in interaction

57 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL9352 CHEMBL1741321 (1)
1 / 0
P14061 Estradiol 17-beta-dehydrogenase 1 Enzyme CHEMBL9352 CHEMBL957998 (1) CHEMBL957999 (1)
0 / 0
P33527 Multidrug resistance-associated protein 1 drugs CHEMBL9352 CHEMBL1062294 (1) CHEMBL2076527 (1)
0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme CHEMBL9352 CHEMBL1908081 (1) CHEMBL1908082 (1)
3 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr CHEMBL9352 CHEMBL995832 (1)
0 / 0
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter CHEMBL9352 CHEMBL2169429 (1)
1 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein CHEMBL9352 CHEMBL2076048 (1) CHEMBL2076049 (1)
CHEMBL2169431 (1)
0 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme CHEMBL9352 CHEMBL1908087 (1)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL9352 CHEMBL1014033 (1) CHEMBL1008495 (1)
0 / 3
P04062 Glucosylceramidase Enzyme CHEMBL32571 CHEMBL1613818 (2)
6 / 4
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL9352 CHEMBL2341203 (1) CHEMBL2341207 (1)
0 / 0
P62158 Calmodulin Unclassified protein CHEMBL9352 CHEMBL1647727 (2) CHEMBL1647728 (1)
1 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase CHEMBL9352 CHEMBL1023248 (1)
1 / 1
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 CHEMBL9352 CHEMBL1225717 (1)
0 / 0
P08183 Multidrug resistance protein 1 drug CHEMBL9352 CHEMBL2075378 (1) CHEMBL2077302 (1)
CHEMBL2075425 (1) CHEMBL2078579 (1)
1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL9352 CHEMBL1614027 (1) CHEMBL1741325 (1)
0 / 1
P24941 Cyclin-dependent kinase 2 Cdc2 CHEMBL32571 CHEMBL2318159 (1)
0 / 0
P24864 G1/S-specific cyclin-E1 Other cytosolic protein CHEMBL32571 CHEMBL2318159 (1)
0 / 2
O75828 Carbonyl reductase [NADPH] 3 Enzyme CHEMBL9352 CHEMBL1004501 (1) CHEMBL1004502 (1)
CHEMBL1004503 (1)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL9352 CHEMBL926465 (1)
0 / 0
P04278 Sex hormone-binding globulin Secreted protein CHEMBL9352 CHEMBL922711 (2)
0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr CHEMBL9352 CHEMBL2342404 (1)
1 / 1
P16152 Carbonyl reductase [NADPH] 1 Enzyme CHEMBL9352 CHEMBL1004498 (1) CHEMBL1004499 (1)
CHEMBL1004500 (1) CHEMBL1004504 (1)
CHEMBL1004505 (2)
0 / 0
O75496 Geminin Unclassified protein CHEMBL9352 CHEMBL32571 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme CHEMBL9352 CHEMBL1908090 (1)
0 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL9352 CHEMBL926467 (1)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL9352 CHEMBL909844 (1) CHEMBL909845 (1)
0 / 1
P15121 Aldose reductase Enzyme CHEMBL9352 CHEMBL1942674 (1)
0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter CHEMBL9352 CHEMBL2169430 (1)
1 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL9352 CHEMBL1794467 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL9352 CHEMBL1052489 (1) CHEMBL1052500 (1)
0 / 1
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 CHEMBL9352 CHEMBL949646 (1) CHEMBL1105634 (1)
CHEMBL1918238 (1) CHEMBL1941245 (1)
CHEMBL2213354 (1)
2 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL9352 CHEMBL1059360 (1) CHEMBL1059361 (1)
5 / 3
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 CHEMBL9352 CHEMBL1225718 (1)
4 / 4
P04745 Alpha-amylase 1 Enzyme CHEMBL9352 CHEMBL964479 (2)
0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme CHEMBL32571 CHEMBL1614252 (1)
2 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL9352 CHEMBL1225716 (1) CHEMBL1741322 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL9352 CHEMBL1614227 (1)
3 / 3
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette CHEMBL9352 CHEMBL2076473 (1) CHEMBL2076243 (1)
CHEMBL2076820 (1) CHEMBL2076835 (1)
CHEMBL2078552 (1)
2 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein CHEMBL9352 CHEMBL1006005 (1)
1 / 1
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme CHEMBL9352 CHEMBL1908085 (2)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL9352 CHEMBL998835 (1)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL9352 CHEMBL909843 (1) CHEMBL909845 (1)
1 / 1
P22303 Acetylcholinesterase Hydrolase CHEMBL9352 CHEMBL2014392 (1) CHEMBL2014393 (1)
1 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL9352 CHEMBL926466 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL9352 CHEMBL1613777 (2) CHEMBL1741323 (1)
1 / 1
P37059 Estradiol 17-beta-dehydrogenase 2 Enzyme CHEMBL9352 CHEMBL958788 (1) CHEMBL958789 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL9352 CHEMBL32571 CHEMBL1614108 (3) CHEMBL1613886 (3)
CHEMBL1741324 (1)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL32571 CHEMBL1794483 (1)
0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme CHEMBL9352 CHEMBL1908080 (2)
5 / 1
P10275 Androgen receptor NR3C4 CHEMBL9352 CHEMBL1052499 (1)
3 / 4
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 CHEMBL9352 CHEMBL1059364 (1) CHEMBL1059365 (1)
0 / 0
Q04760 Lactoylglutathione lyase Enzyme CHEMBL9352 CHEMBL684310 (1) CHEMBL967535 (1)
0 / 0
P49888 Estrogen sulfotransferase Enzyme CHEMBL9352 CHEMBL1743309 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL9352 CHEMBL1614364 (1)
1 / 1
O00255 Menin Unclassified protein CHEMBL32571 CHEMBL1614257 (2)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL32571 CHEMBL1614257 (2)
1 / 3

CTD interaction (63)

compound gene gene name gene description interaction interaction type form reference
pmid
C005273 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 naringenin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide] decreases reaction
/ decreases response to substance
protein 16156793
C005273 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 naringenin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione] decreases reaction
/ increases export
protein 16156793
C005273 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 naringenin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate] increases hydrolysis
/ increases reaction
protein 16156793
C005273 10257 ABCC4
EST170205
MOAT-B
MOATB
MRP4
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 naringenin inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP] decreases reaction
/ increases export
protein 16156793
C005273 10257 ABCC4
EST170205
MOAT-B
MOATB
MRP4
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 naringenin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate] increases hydrolysis
/ increases reaction
protein 16156793
C005273 10057 ABCC5
ABC33
EST277145
MOAT-C
MOATC
MRP5
SMRP
pABC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 5 naringenin inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine] decreases reaction
/ decreases response to substance
protein 16156793
C005273 10057 ABCC5
ABC33
EST277145
MOAT-C
MOATC
MRP5
SMRP
pABC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 5 naringenin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] decreases reaction
/ increases export
protein 16156793
C005273 196 AHR
bHLHe76
aryl hydrocarbon receptor naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein] decreases reaction
/ increases phosphorylation
protein 20450880
C005273 1645 AKR1C1
2-ALPHA-HSD
20-ALPHA-HSD
C9
DD1
DD1/DD2
DDH
DDH1
H-37
HAKRC
HBAB
MBAB
aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) naringenin binds to and results in decreased activity of AKR1C1 protein affects binding
/ decreases activity
protein 16962702
C005273 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) naringenin results in decreased activity of AKR1C3 protein decreases activity
protein 19007764
C005273 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) naringenin inhibits the reaction [bisphenol A results in increased activity of AKT1 protein] decreases reaction
/ increases activity
protein 22692793
C005273 249 ALPL
AP-TNAP
APTNAP
HOPS
TNAP
TNSALP
alkaline phosphatase, liver/bone/kidney (EC:3.1.3.1) fulvestrant inhibits the reaction [[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein] affects binding
/ decreases reaction
/ increases activity
protein 12650720
C005273 249 ALPL
AP-TNAP
APTNAP
HOPS
TNAP
TNSALP
alkaline phosphatase, liver/bone/kidney (EC:3.1.3.1) [naringenin binds to ESR1 protein] which results in increased activity of ALPL protein affects binding
/ increases activity
protein 12650720
C005273 405 ARNT
HIF-1-beta
HIF-1beta
HIF1-beta
HIF1B
HIF1BETA
TANGO
bHLHe2
aryl hydrocarbon receptor nuclear translocator naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein] decreases reaction
/ increases phosphorylation
protein 20450880
C005273 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 BCL2 protein results in decreased susceptibility to naringenin decreases response to substance
protein 19124070
C005273 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate inhibits the reaction [BCL2 protein results in decreased susceptibility to naringenin] decreases reaction
/ decreases response to substance
protein 19124070
C005273 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) naringenin results in increased activity of CASP3 protein increases activity
protein 19124070
22692793
C005273 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) naringenin results in increased activity of CASP9 protein increases activity
protein 19124070
C005273 1588 CYP19A1
ARO
ARO1
CPV1
CYAR
CYP19
CYPXIX
P-450AROM
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) naringenin binds to and results in decreased activity of CYP19A1 protein affects binding
/ decreases activity
protein 9435150
C005273 1588 CYP19A1
ARO
ARO1
CPV1
CYAR
CYP19
CYPXIX
P-450AROM
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) naringenin results in decreased activity of CYP19A1 protein decreases activity
protein 15319488
C005273 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) naringenin binds to and results in decreased activity of CYP1A1 protein affects binding
/ decreases activity
protein 11454723
C005273 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] decreases reaction
/ increases expression
mRNA 11454723
C005273 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) naringenin results in decreased activity of CYP1A1 protein decreases activity
protein 21053930
C005273 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) naringenin results in decreased activity of CYP1A2 protein decreases activity
protein 21053930
C005273 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) naringenin binds to and results in decreased activity of CYP1B1 protein affects binding
/ decreases activity
protein 21053930
C005273 1559 CYP2C9
CPC9
CYP2C
CYP2C10
CYPIIC9
P450IIC9
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) naringenin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen] decreases reaction
/ increases hydroxylation
protein 21053930
C005273 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) naringenin results in decreased activity of CYP3A4 protein decreases activity
protein 21053930
C005273 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 fulvestrant inhibits the reaction [[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein] affects binding
/ decreases reaction
/ increases activity
protein 12650720
C005273 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 naringenin affects the activity of ESR1 protein affects activity
protein 15185748
C005273 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 naringenin binds to and results in increased activity of ESR1 protein affects binding
/ increases activity
protein 9751507
10397250
C005273 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 naringenin binds to ESR1 protein affects binding
protein 19913605
22692793
C005273 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 [naringenin binds to ESR1 protein] which results in increased activity of ALPL protein affects binding
/ increases activity
protein 12650720
C005273 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 naringenin promotes the reaction [ESR1 protein binds to ESR1 protein] affects binding
/ increases reaction
protein 15713566
C005273 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 naringenin results in increased activity of ESR1 protein increases activity
protein 10854714
16118406
C005273 2100 ESR2
ER-BETA
ESR-BETA
ESRB
ESTRB
Erb
NR3A2
estrogen receptor 2 (ER beta) naringenin binds to and results in increased activity of ESR2 protein affects binding
/ increases activity
protein 9751507
C005273 2100 ESR2
ER-BETA
ESR-BETA
ESRB
ESTRB
Erb
NR3A2
estrogen receptor 2 (ER beta) naringenin binds to ESR2 protein affects binding
protein 12224631
16566672
19913605
C005273 2100 ESR2
ER-BETA
ESR-BETA
ESRB
ESTRB
Erb
NR3A2
estrogen receptor 2 (ER beta) naringenin inhibits the reaction [Estradiol binds to ESR2 protein] affects binding
/ decreases reaction
protein 9751507
16566672
C005273 2100 ESR2
ER-BETA
ESR-BETA
ESRB
ESTRB
Erb
NR3A2
estrogen receptor 2 (ER beta) naringenin results in increased activity of ESR2 protein increases activity
protein 16118406
C005273 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL8 protein] decreases reaction
/ increases secretion
protein 19135038
C005273 3757 KCNH2
ERG1
HERG
HERG1
Kv11.1
LQT2
SQT1
potassium voltage-gated channel, subfamily H (eag-related), member 2 Amiodarone promotes the reaction [naringenin results in decreased activity of KCNH2 protein] decreases activity
/ increases reaction
protein 18057881
C005273 3757 KCNH2
ERG1
HERG
HERG1
Kv11.1
LQT2
SQT1
potassium voltage-gated channel, subfamily H (eag-related), member 2 azimilide promotes the reaction [naringenin results in decreased activity of KCNH2 protein] decreases activity
/ increases reaction
protein 18057881
C005273 3757 KCNH2
ERG1
HERG
HERG1
Kv11.1
LQT2
SQT1
potassium voltage-gated channel, subfamily H (eag-related), member 2 dofetilide promotes the reaction [naringenin results in decreased activity of KCNH2 protein] decreases activity
/ increases reaction
protein 18057881
C005273 3757 KCNH2
ERG1
HERG
HERG1
Kv11.1
LQT2
SQT1
potassium voltage-gated channel, subfamily H (eag-related), member 2 naringenin promotes the reaction [Amiodarone results in decreased activity of KCNH2 protein] decreases activity
/ increases reaction
protein 18057881
C005273 3757 KCNH2
ERG1
HERG
HERG1
Kv11.1
LQT2
SQT1
potassium voltage-gated channel, subfamily H (eag-related), member 2 naringenin promotes the reaction [azimilide results in decreased activity of KCNH2 protein] decreases activity
/ increases reaction
protein 18057881
C005273 3757 KCNH2
ERG1
HERG
HERG1
Kv11.1
LQT2
SQT1
potassium voltage-gated channel, subfamily H (eag-related), member 2 naringenin promotes the reaction [dofetilide results in decreased activity of KCNH2 protein] decreases activity
/ increases reaction
protein 18057881
C005273 3757 KCNH2
ERG1
HERG
HERG1
Kv11.1
LQT2
SQT1
potassium voltage-gated channel, subfamily H (eag-related), member 2 naringenin promotes the reaction [Quinidine results in decreased activity of KCNH2 protein] decreases activity
/ increases reaction
protein 18057881
C005273 3757 KCNH2
ERG1
HERG
HERG1
Kv11.1
LQT2
SQT1
potassium voltage-gated channel, subfamily H (eag-related), member 2 naringenin results in decreased activity of KCNH2 protein decreases activity
protein 18057881
C005273 3757 KCNH2
ERG1
HERG
HERG1
Kv11.1
LQT2
SQT1
potassium voltage-gated channel, subfamily H (eag-related), member 2 Quinidine promotes the reaction [naringenin results in decreased activity of KCNH2 protein] decreases activity
/ increases reaction
protein 18057881
C005273 5444 PON1
ESA
MVCD5
PON
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) naringenin results in increased expression of PON1 mRNA increases expression
mRNA 15169886
C005273 6566 SLC16A1
HHF7
MCT
MCT1
solute carrier family 16 (monocarboxylate transporter), member 1 naringenin inhibits the reaction [SLC16A1 protein results in increased uptake of Benzoic Acid] decreases reaction
/ increases uptake
protein 17976262
C005273 6513 SLC2A1
DYT17
DYT18
DYT9
EIG12
GLUT
GLUT1
GLUT1DS
HTLVR
PED
solute carrier family 2 (facilitated glucose transporter), member 1 naringenin inhibits the reaction [SLC2A1 protein affects the transport of Glucose] affects transport
/ decreases reaction
protein 14642735
C005273 6513 SLC2A1
DYT17
DYT18
DYT9
EIG12
GLUT
GLUT1
GLUT1DS
HTLVR
PED
solute carrier family 2 (facilitated glucose transporter), member 1 naringenin results in decreased activity of SLC2A1 protein decreases activity
protein 14642735
C005273 6817 SULT1A1
HAST1/HAST2
P-PST
PST
ST1A1
ST1A3
STP
STP1
TSPST1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of naringenin] decreases reaction
/ increases sulfation
protein 11181495
C005273 6818 SULT1A3
HAST
HAST3
M-PST
ST1A3/ST1A4
ST1A5
STM
TL-PST
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) SULT1A3 protein results in increased sulfation of naringenin increases sulfation
protein 11181495
C005273 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein] decreases reaction
/ increases secretion
protein 19135038
C005273 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 naringenin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of TP53 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15795422
C005273 54658 UGT1A1
BILIQTL1
GNT1
HUG-BR1
UDPGT
UDPGT_1-1
UGT1
UGT1A
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) UGT1A1 protein results in increased glucuronidation of naringenin increases glucuronidation
protein 14557274
C005273 54575 UGT1A10
UDPGT
UGT-1J
UGT1-10
UGT1.10
UGT1J
UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) UGT1A10 protein results in increased glucuronidation of naringenin increases glucuronidation
protein 14557274
C005273 54577 UGT1A7
UDPGT
UDPGT_1-7
UGT-1G
UGT1-07
UGT1.7
UGT1G
UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) UGT1A7 protein results in increased glucuronidation of naringenin increases glucuronidation
protein 14557274
C005273 54576 UGT1A8
UDPGT
UDPGT_1-8
UGT-1H
UGT1-08
UGT1.8
UGT1A8S
UGT1H
UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) UGT1A8 protein results in increased glucuronidation of naringenin increases glucuronidation
protein 14557274
C005273 54600 UGT1A9
HLUGP4
LUGP4
UDPGT
UDPGT_1-9
UGT-1I
UGT1-09
UGT1-9
UGT1.9
UGT1AI
UGT1I
UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) UGT1A9 protein results in increased glucuronidation of naringenin increases glucuronidation
protein 14557274
18816295
C005273 7366 UGT2B15
HLUG4
UDPGT_2B8
UDPGT2B15
UDPGTH3
UGT2B8
UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) UGT2B15 protein results in increased metabolism of naringenin increases metabolic processing
protein 7835232
C005273 7366 UGT2B15
HLUG4
UDPGT_2B8
UDPGT2B15
UDPGTH3
UGT2B8
UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) UGT2B15 protein SNP results in increased metabolism of naringenin increases metabolic processing
protein 12386133

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (46)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#614490 Blood group, junior system; jr Q9UNQ0
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#114500 Colorectal cancer; crc P18054
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#133239 Esophageal cancer P18054
#615363 Estrogen resistance; estrr P03372
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#143500 Gilbert syndrome P22309
P22310
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#145000 Hyperparathyroidism 1; hrpt1 O00255
#612244 Inflammatory bowel disease 13; ibd13 P08183
#601626 Leukemia, acute myeloid; aml P36888
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#601665 Obesity P37231
#168600 Parkinson disease, late-onset; pd P04062
#604229 Peters anomaly Q16678
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#614916 Ventricular tachycardia, catecholaminergic polymorphic, 4; cpvt4 P62158
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (40)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00026 Endometrial Cancer P03372 (marker)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00208 Hyperbilirubinemia P22309 (related)
Q92887 (related)
H00018 Gastric cancer P24864 (related)
H00055 Laryngeal cancer P24864 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

10 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000647 C005273 Amnesia therapeutic
14739537
15030205
D001932 C005273 Brain Neoplasms therapeutic
20932960
D009202 C005273 Cardiomyopathies therapeutic
16444662
D056486 C005273 Drug-Induced Liver Injury therapeutic
19409769
D064420 C005273 Drug-Related Side Effects and Adverse Reactions therapeutic
17102822
D007674 C005273 Kidney Diseases therapeutic
19063931
D008106 C005273 Liver Cirrhosis, Experimental therapeutic
14709902
D008107 C005273 Liver Diseases therapeutic
16945181
D009369 C005273 Neoplasms therapeutic
15185748
D009374 C005273 Neoplasms, Experimental therapeutic
20932960