PCIDB

Phlomis caucasica

Species

KNApSAcK Entry

Organism name Phlomis caucasica
Genus Phlomis
Family Labiatae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Phlomis
Linked NCBI taxonomy ID 316257
Linked level genus

Family

Family in NCBI taxonomy Lamiaceae
ID 4136

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00005413 External link 512 Rutin
/ Birutan
/ 3-Rutinosylquercetin
/ Quercetin 3-O-rutinoside
/ (+)-Quercetin 3-O-rutinoside
/ Quercetin 3-O-beta-rutinoside
/ (+)-Quercetin 3-O-beta-rutinoside
/ 3,3',4',5,7-Pentahydroxyflavone 3-rutinoside
/ Quercetin 3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside
CHEMBL32579
CHEMBL310754
CHEMBL182108
CHEMBL226335
CHEMBL502782
CHEMBL1436093
CHEMBL1532989
D012431
25 / 18 / 16 29 / 8 No. 1 No. 15
C00005138 External link 512 Astragalin
/ Kaempferol 3-glucoside
/ Kaempferol 3-O-beta-D-glucoside
/ Kaempferol 3-O-beta-D-glucopyranoside
CHEMBL233930
CHEMBL453290
CHEMBL1572115
C001579
10 / 6 / 7 0 / 1 No. 2 No. 15
C00004338 External link 512 Chrysoeriol 7-glucoside
/ Luteolin 3'-methyl ether-7-glucoside
/ Luteolin 3'-methyl ether 7-glucoside
/ 5,7,4'-Trihydroxy-3'-methoxyflavone 7-beta-D-glucopyranoside
CHEMBL486391
No. 2 No. 15
C00000982 External link 512 Naringenin
/ (-)-Naringenin
CHEMBL9352
CHEMBL32571
C005273
57 / 46 / 40 35 / 10 No. 25 No. 14
C00002783 External link 512 Kusaginin
/ Acteoside
/ Verbascoside
CHEMBL231853
CHEMBL444478
CHEMBL1364101
C058956
12 / 1 / 1 34 / 3 No. 33
C00030317 External link 512 Forsythoside B
CHEMBL393292
1 / 0 / 3 No. 33

Human Protein / Gene in interactions

86 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9UNA4 DNA polymerase iota Enzyme C00000982 C00002783 C00005138 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000982 C00005413 C00030317 0 / 3
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00000982 C00005413 2 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00005138 C00005413 0 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00000982 C00005413 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000982 C00005413 0 / 1
P22303 Acetylcholinesterase Hydrolase C00000982 C00005413 1 / 0
P03372 Estrogen receptor NR3A1 C00000982 C00005413 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00002783 C00005413 0 / 0
Q99700 Ataxin-2 Unclassified protein C00002783 C00005138 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002783 C00005413 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000982 C00005413 3 / 3
P14679 Tyrosinase Oxidoreductase C00005138 C00005413 4 / 2
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000982 C00005413 0 / 0
P15121 Aldose reductase Enzyme C00000982 C00005138 0 / 0
O75496 Geminin Unclassified protein C00000982 C00002783 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000982 C00005413 1 / 1
P35372 Mu-type opioid receptor Opioid receptor C00000982 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00005138 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00005413 0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00000982 0 / 0
P08183 Multidrug resistance protein 1 drug C00000982 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000982 0 / 1
P24941 Cyclin-dependent kinase 2 Cdc2 C00000982 0 / 0
P24864 G1/S-specific cyclin-E1 Other cytosolic protein C00000982 0 / 2
P07237 Protein disulfide-isomerase Enzyme C00005138 0 / 0
O75828 Carbonyl reductase [NADPH] 3 Enzyme C00000982 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00005413 1 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00005413 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000982 0 / 0
P04278 Sex hormone-binding globulin Secreted protein C00000982 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00000982 1 / 1
P39748 Flap endonuclease 1 Enzyme C00002783 0 / 0
P16152 Carbonyl reductase [NADPH] 1 Enzyme C00000982 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00000982 0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00000982 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00005413 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000982 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00000982 0 / 1
P17252 Protein kinase C alpha type Alpha C00002783 0 / 0
P27487 Dipeptidyl peptidase 4 S9B C00005413 0 / 1
Q9Y253 DNA polymerase eta Enzyme C00005138 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00002783 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00002783 0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter C00000982 1 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00005413 1 / 1
P04150 Glucocorticoid receptor NR3C1 C00000982 0 / 1
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00000982 2 / 2
P04062 Glucosylceramidase Enzyme C00000982 6 / 4
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00000982 5 / 3
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00000982 4 / 4
P06276 Cholinesterase Hydrolase C00005413 0 / 0
P04745 Alpha-amylase 1 Enzyme C00000982 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00000982 2 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00005413 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000982 0 / 0
P06746 DNA polymerase beta Enzyme C00005413 0 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00000982 0 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00000982 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00005138 0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00000982 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00000982 0 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00000982 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00002783 0 / 0
P62158 Calmodulin Unclassified protein C00000982 1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000982 1 / 1
P37059 Estradiol 17-beta-dehydrogenase 2 Enzyme C00000982 0 / 0
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00000982 1 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000982 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00002783 0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00000982 3 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00000982 5 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00005413 4 / 3
P10275 Androgen receptor NR3C4 C00000982 3 / 4
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00000982 0 / 0
Q04760 Lactoylglutathione lyase Enzyme C00000982 0 / 0
P48147 Prolyl endopeptidase S9A C00005413 0 / 0
P49888 Estrogen sulfotransferase Enzyme C00000982 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000982 1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00005413 0 / 0
P14061 Estradiol 17-beta-dehydrogenase 1 Enzyme C00000982 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000982 1 / 1
O00255 Menin Unclassified protein C00000982 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000982 1 / 2
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002783 0 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein C00005138 0 / 3

75 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
196 AHR, bHLHe76 aryl hydrocarbon receptor C00000982 C00002783 C00005413
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000982 C00002783 C00005413
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000982 C00002783 C00005413
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00000982 C00002783 C00005413
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00000982 C00002783 C00005413
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00002783 C00005413
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00002783 C00005413
3458 IFNG, IFG, IFI interferon, gamma C00002783 C00005413
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00002783 C00005413
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00002783 C00005413
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000982 C00005413
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00002783 C00005413
3627 CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 chemokine (C-X-C motif) ligand 10 C00002783 C00005413
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00002783 C00005413
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00002783 C00005413
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00000982 C00005413
7039 TGFA, TFGA transforming growth factor, alpha C00002783 C00005413
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000982 C00005413
894 CCND2, KIAK0002 cyclin D2 C00002783
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00000982
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00000982
3757 KCNH2, ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1 potassium voltage-gated channel, subfamily H (eag-related), member 2 C00000982
5444 PON1, ESA, MVCD5, PON paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) C00000982
6566 SLC16A1, HHF7, MCT, MCT1 solute carrier family 16 (monocarboxylate transporter), member 1 C00000982
6513 SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED solute carrier family 2 (facilitated glucose transporter), member 1 C00000982
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00000982
6818 SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) C00000982
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00000982
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00000982
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00000982
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00000982
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00000982
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00000982
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00000982
7366 UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) C00000982
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00000982
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00002783
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00000982
896 CCND3 cyclin D3 C00002783
898 CCNE1, CCNE cyclin E1 C00002783
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00002783
1019 CDK4, CMM3, PSK-J3 cyclin-dependent kinase 4 (EC:2.7.11.22) C00002783
1021 CDK6, PLSTIRE cyclin-dependent kinase 6 (EC:2.7.11.22) C00002783
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00002783
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00002783
1588 CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000982
1869 E2F1, E2F-1, RBAP1, RBBP3, RBP3 E2F transcription factor 1 C00002783
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00000982
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00002783
249 ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP alkaline phosphatase, liver/bone/kidney (EC:3.1.3.1) C00000982
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00000982
3689 ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) C00002783
8644 AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) C00000982
1645 AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) C00000982
27035 NOX1, GP91-2, MOX1, NOH-1, NOH1 NADPH oxidase 1 C00002783
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00000982
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00002783
10057 ABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 C00000982
4087 SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2 SMAD family member 2 C00002783
4088 SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3 SMAD family member 3 C00002783
6648 SOD2, IPOB, MNSOD, MVCD6 superoxide dismutase 2, mitochondrial (EC:1.15.1.1) C00002783
10257 ABCC4, EST170205, MOAT-B, MOATB, MRP4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 C00000982
7040 TGFB1, CED, DPD1, LAP, TGFB, TGFbeta transforming growth factor, beta 1 C00002783
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00002783
177 AGER, RAGE advanced glycosylation end product-specific receptor C00005413
581 BAX, BCL2L4 BCL2-associated X protein C00005413
847 CAT catalase (EC:1.11.1.6) C00005413
873 CBR1, CBR, SDR21C1, hCBR1 carbonyl reductase 1 (EC:1.1.1.189 1.1.1.197 1.1.1.184) C00005413
2936 GSR glutathione reductase (EC:1.8.1.7) C00005413
3480 IGF1R, CD221, IGFIR, IGFR, JTK13 insulin-like growth factor 1 receptor (EC:2.7.10.1) C00005413
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00005413
3667 IRS1, HIRS-1 insulin receptor substrate 1 C00005413
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00005413
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00005413
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00005413

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (58)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#614490 Blood group, junior system; jr Q9UNQ0
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#114500 Colorectal cancer; crc P18054
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#133239 Esophageal cancer P18054
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#143500 Gilbert syndrome P22309
P22310
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 P37231
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#145000 Hyperparathyroidism 1; hrpt1 O00255
#612244 Inflammatory bowel disease 13; ibd13 P08183
#601626 Leukemia, acute myeloid; aml P36888
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#601665 Obesity P37231
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#614916 Ventricular tachycardia, catecholaminergic polymorphic, 4; cpvt4 P62158
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (50)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00026 Endometrial Cancer P03372 (marker)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00208 Hyperbilirubinemia P22309 (related)
Q92887 (related)
H00018 Gastric cancer P24864 (related)
H00055 Laryngeal cancer P24864 (related)
H00032 Thyroid cancer P27487 (marker)
P37231 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

21 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D007674 Kidney Diseases C00000982
C00005413
D009374 Neoplasms, Experimental C00000982
D001932 Brain Neoplasms C00000982
D009202 Cardiomyopathies C00000982
D056486 Drug-Induced Liver Injury C00000982
D064420 Drug-Related Side Effects and Adverse Reactions C00000982
D003876 Dermatitis, Atopic C00005138
D008106 Liver Cirrhosis, Experimental C00000982
D008107 Liver Diseases C00000982
D009369 Neoplasms C00000982
D000647 Amnesia C00000982
D007249 Inflammation C00002783
D007938 Leukemia C00002783
D014947 Wounds and Injuries C00002783
D001424 Bacterial Infections C00005413
D003092 Colitis C00005413
D004409 Dyskinesia, Drug-Induced C00005413
D015212 Inflammatory Bowel Diseases C00005413
D028361 Mitochondrial Diseases C00005413
D010243 Paralysis C00005413
D013276 Stomach Ulcer C00005413