PCIDB

KNApSAcK Metabolite C00005413

Metabolite

KNApSAcK Entry

id C00005413
Name Rutin / Birutan / 3-Rutinosylquercetin / Quercetin 3-O-rutinoside / (+)-Quercetin 3-O-rutinoside / Quercetin 3-O-beta-rutinoside / (+)-Quercetin 3-O-beta-rutinoside / 3,3',4',5,7-Pentahydroxyflavone 3-rutinoside / Quercetin 3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside
CAS RN 153-18-4
Standard InChI InChI=1S/C27H30O16/c1-8-17(32)20(35)22(37)26(40-8)39-7-15-18(33)21(36)23(38)27(42-15)43-25-19(34)16-13(31)5-10(28)6-14(16)41-24(25)9-2-3-11(29)12(30)4-9/h2-6,8,15,17-18,20-23,26-33,35-38H,7H2,1H3/t8?,15?,17-,18+,20-,21?,22?,23?,26+,27-/m0/s1
Standard InChI (Main Layer) InChI=1S/C27H30O16/c1-8-17(32)20(35)22(37)26(40-8)39-7-15-18(33)21(36)23(38)27(42-15)43-25-19(34)16-13(31)5-10(28)6-14(16)41-24(25)9-2-3-11(29)12(30)4-9/h2-6,8,15,17-18,20-23,26-33,35-38H,7H2,1H3

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 1

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL32579 CHEMBL310754 CHEMBL182108 CHEMBL226335 CHEMBL502782 CHEMBL1436093 CHEMBL1532989

KEGG

By LinkDB C05625

CTD

By CAS RN D012431

Species

Summary

Plant class

class name count
rosids 43
asterids 39
eudicotyledons 7
Magnoliophyta 3
Spermatophyta 2
Liliopsida 1

Family (Top 10)

family name count
Asteraceae 15
Fabaceae 14
Euphorbiaceae 6
Rosaceae 4
Polygonaceae 4
Lamiaceae 4
Moraceae 3
Oleaceae 3
Araliaceae 3
Solanaceae 3

List (98)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Achillea alexandri-regis Bornm.& Rudski 13328 Asteraceae asterids Viridiplantae
Achillea millefolium 13329 Asteraceae asterids Viridiplantae
Aganosma caryophyllata
Ajuga remota 38595 Lamiaceae asterids Viridiplantae
Alkanna orientalis 543563 Boraginaceae asterids Viridiplantae
Amaranthus spinosus 124765 Amaranthaceae eudicotyledons Viridiplantae
Aristolochia kaempferi 158550 Aristolochiaceae Magnoliophyta Viridiplantae
Baccharis gaudichaudiana DC 41487 Asteraceae asterids Viridiplantae
Bellis perennis 41492 Asteraceae asterids Viridiplantae
Betula nigra 3508 Betulaceae rosids Viridiplantae
Boehmeria holosericea 83905 Urticaceae rosids Viridiplantae
Boehmeria tricuspis 644073 Urticaceae rosids Viridiplantae
Bruguiera sexangula var.rhynchopetala 39983 Rhizophoraceae rosids Viridiplantae
Bupleurum rotundifolium L. 90446 Apiaceae asterids Viridiplantae
Caesalpinia pulcherrima 53846 Fabaceae rosids Viridiplantae
Calendula officinalis 41496 Asteraceae asterids Viridiplantae
Campanula glomerata L. 82281 Campanulaceae asterids Viridiplantae
Capparis spinosa L. 65558 Capparaceae rosids Viridiplantae
Cassia hirsuta 162906 Fabaceae rosids Viridiplantae
Cassytha filiformis 121073 Lauraceae Magnoliophyta Viridiplantae
Centranthus longiflorus ssp. longiflorus 42331 Caprifoliaceae asterids Viridiplantae
Clitoria ternatea 43366 Fabaceae rosids Viridiplantae
Colubrina asiatica 106664 Rhamnaceae rosids Viridiplantae
Conyza filaginoides 41552 Asteraceae asterids Viridiplantae
Crataegus monogyna L. 23159 Rosaceae rosids Viridiplantae
Cruciata taurica 715653 Rubiaceae asterids Viridiplantae
Cussonia bojeri SEEM 46390 Araliaceae asterids Viridiplantae
Cussonia racemosa 46390 Araliaceae asterids Viridiplantae
Cussonia vantsilana Baker 46390 Araliaceae asterids Viridiplantae
Dichrocephala bicolor 648857 Asteraceae asterids Viridiplantae
Echinop ritro
Eucalyptus globulus 34317 Myrtaceae rosids Viridiplantae
Eucommia ulmoides Oliv. 4391 Eucommiaceae asterids Viridiplantae
Eupatorium microphyllum 13516 Asteraceae asterids Viridiplantae
Euphorbia hirta 318062 Euphorbiaceae rosids Viridiplantae
Euphorbia larica 1031526 Euphorbiaceae rosids Viridiplantae
Euphorbia magalanta 3977 Euphorbiaceae rosids Viridiplantae
Euphorbia tinctoria 3977 Euphorbiaceae rosids Viridiplantae
Euphorbia virgata 526204 Euphorbiaceae rosids Viridiplantae
Fagopyrum esculentum 3617 Polygonaceae eudicotyledons Viridiplantae
Fagopyrum homotropicum 85475 Polygonaceae eudicotyledons Viridiplantae
Ficus carica 3494 Moraceae rosids Viridiplantae
Ficus pumila 66386 Moraceae rosids Viridiplantae
Ficus ruficaulis Merr.var.antaoensis 3487 Moraceae rosids Viridiplantae
Forsythia suspensa 126418 Oleaceae asterids Viridiplantae
Fraxinus oxycarba 38871 Oleaceae asterids Viridiplantae
Fuchsia fulgens 253484 Onagraceae rosids Viridiplantae
Galanthus caucasicus 4669 Amaryllidaceae Liliopsida Viridiplantae
Ginkgo biloba 3311 Ginkgoaceae Spermatophyta Viridiplantae
Glycyrrhiza glabra L. 49827 Fabaceae rosids Viridiplantae
Gynostemma cardiospermum 182083 Cucurbitaceae rosids Viridiplantae
Hypericum perforatum var.angustifolium 55962 Hypericaceae rosids Viridiplantae
Lactuca indica 75953 Asteraceae asterids Viridiplantae
Lycopersicon sculentum 49274 Solanaceae asterids Viridiplantae
Macaranga tanarius 109849 Euphorbiaceae rosids Viridiplantae
Malus doumeri varl formosana 3749 Rosaceae rosids Viridiplantae
Marsypianthes chamaedrys 986255 Lamiaceae asterids Viridiplantae
Menyanthes trifoliata L. 28525 Menyanthaceae asterids Viridiplantae
Morinda citrifolia 43522 Rubiaceae asterids Viridiplantae
Nerium oleander 63479 Apocynaceae asterids Viridiplantae
Onobrychis amoena 1233737 Fabaceae rosids Viridiplantae
Onobrychis bobrovi 3881 Fabaceae rosids Viridiplantae
Onobrychis chlorassanica 3881 Fabaceae rosids Viridiplantae
Onobrychis echidna 3881 Fabaceae rosids Viridiplantae
Onobrychis ferganica 3881 Fabaceae rosids Viridiplantae
Onobrychis grandis 3881 Fabaceae rosids Viridiplantae
Onobrychis seravschanica 3881 Fabaceae rosids Viridiplantae
Opunitia dillenii HAW.
Oryctes nevadensis 304124 Solanaceae asterids Viridiplantae
Parageum montanum 3745 Rosaceae rosids Viridiplantae
Pelargonium reniforme 59871 Geraniaceae rosids Viridiplantae
Peltophorum africanum 321567 Fabaceae rosids Viridiplantae
Phlomis caucasica 316257 Lamiaceae asterids Viridiplantae
Phyllanthus emblica 296036 Phyllanthaceae rosids Viridiplantae
Phyllanthus niruri 296034 Phyllanthaceae rosids Viridiplantae
Piper umbellatum 130418 Piperaceae Magnoliophyta Viridiplantae
Podocarpus fasciculus 120615 Podocarpaceae Spermatophyta Viridiplantae
Polygonum spp. 46786 Polygonaceae eudicotyledons Viridiplantae
Prunus mume 102107 Rosaceae rosids Viridiplantae
Pulicaria salviifolia 557703 Asteraceae asterids Viridiplantae
Rumex japonicus 174651 Polygonaceae eudicotyledons Viridiplantae
Ruta graveolens 37565 Rutaceae rosids Viridiplantae
Salix songorica 40685 Salicaceae rosids Viridiplantae
Scurrula atropurpurea 1146880 Loranthaceae eudicotyledons Viridiplantae
Sedum ewersii 3784 Crassulaceae eudicotyledons Viridiplantae
Senecio nemorensis 189242 Asteraceae asterids Viridiplantae
Senecio viravira 18794 Asteraceae asterids Viridiplantae
Senecio yegua 18794 Asteraceae asterids Viridiplantae
Silphium perfoliatum L. 53588 Asteraceae asterids Viridiplantae
Solanum tuberosum L. 4113 Solanaceae asterids Viridiplantae
Solidago altissima 59294 Asteraceae asterids Viridiplantae
Sophora japonica 3897 Fabaceae rosids Viridiplantae
Spermacoce laevis Roxb. 35916 Rubiaceae asterids Viridiplantae
Stachys palustris L. 1060938 Lamiaceae asterids Viridiplantae
Styphnolobium japonicum 3897 Fabaceae rosids Viridiplantae
Syringa vulgaris L. 24208 Oleaceae asterids Viridiplantae
Tordylium apulum 489417 Apiaceae asterids Viridiplantae
Tribulus terrestris 210369 Zygophyllaceae rosids Viridiplantae

Human Protein / Gene in interaction

25 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P33527 Multidrug resistance-associated protein 1 drugs CHEMBL226335 CHEMBL2045961 (1)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL226335 CHEMBL1014033 (1)
0 / 3
P06746 DNA polymerase beta Enzyme CHEMBL226335 CHEMBL1614079 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL226335 CHEMBL1614076 (1)
1 / 1
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase CHEMBL226335 CHEMBL1023248 (1)
1 / 1
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL226335 CHEMBL1120976 (1)
0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL226335 CHEMBL1614166 (1) CHEMBL1738096 (1)
CHEMBL1738622 (1)
1 / 0
P11388 DNA topoisomerase 2-alpha Isomerase CHEMBL226335 CHEMBL1014691 (1)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL226335 CHEMBL1120977 (1)
0 / 0
P27487 Dipeptidyl peptidase 4 S9B CHEMBL502782 CHEMBL974554 (1)
0 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL1532989 CHEMBL1794467 (1)
0 / 0
P14679 Tyrosinase Oxidoreductase CHEMBL226335 CHEMBL814346 (1)
4 / 2
P06276 Cholinesterase Hydrolase CHEMBL226335 CHEMBL1045780 (1)
0 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL226335 CHEMBL1614521 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL1436093 CHEMBL1614227 (1)
3 / 3
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette CHEMBL226335 CHEMBL2045959 (1) CHEMBL2045960 (1)
2 / 0
P03372 Estrogen receptor NR3A1 CHEMBL226335 CHEMBL999944 (1) CHEMBL1941568 (1)
CHEMBL1941569 (1)
1 / 1
P22303 Acetylcholinesterase Hydrolase CHEMBL226335 CHEMBL1045781 (1)
1 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL32579 CHEMBL226335 CHEMBL972070 (1) CHEMBL1614108 (1)
CHEMBL1613886 (1)
0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL32579 CHEMBL226335 CHEMBL1614211 (2)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL32579 CHEMBL226335 CHEMBL1614421 (2)
4 / 3
P48147 Prolyl endopeptidase S9A CHEMBL502782 CHEMBL974553 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL32579 CHEMBL226335 CHEMBL1532989 CHEMBL1794536 (3)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL32579 CHEMBL226335 CHEMBL1532989 CHEMBL1613914 (3)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL226335 CHEMBL1738442 (1)
0 / 0

CTD interaction (74)

compound gene gene name gene description interaction interaction type form reference
pmid
D012431 177 AGER
RAGE
advanced glycosylation end product-specific receptor Rutin inhibits the reaction [Glucose results in increased expression of AGER mRNA] decreases reaction
/ increases expression
mRNA 19557821
D012431 196 AHR
bHLHe76
aryl hydrocarbon receptor Rutin promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of AHR protein] increases localization
/ increases reaction
protein 21756928
D012431 196 AHR
bHLHe76
aryl hydrocarbon receptor Rutin results in decreased localization of AHR protein decreases localization
protein 21756928
D012431 405 ARNT
HIF-1-beta
HIF-1beta
HIF1-beta
HIF1B
HIF1BETA
TANGO
bHLHe2
aryl hydrocarbon receptor nuclear translocator Rutin results in increased localization of ARNT protein increases localization
protein 21756928
D012431 581 BAX
BCL2L4
BCL2-associated X protein Rutin affects the expression of BAX protein affects expression
protein 15975156
D012431 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Rutin affects the expression of BCL2 protein affects expression
protein 15975156
D012431 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Rutin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of BCL2 protein] decreases expression
/ decreases reaction
/ increases degradation
protein 19557821
D012431 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Rutin affects the cleavage of CASP3 protein affects cleavage
protein 15975156
D012431 847 CAT
catalase (EC:1.11.1.6) Rutin inhibits the reaction [bifenthrin results in decreased activity of CAT protein] decreases activity
/ decreases reaction
protein 19833193
D012431 873 CBR1
CBR
SDR21C1
hCBR1
carbonyl reductase 1 (EC:1.1.1.189 1.1.1.197 1.1.1.184) Rutin binds to and results in decreased activity of CBR1 protein affects binding
/ decreases activity
protein 18579125
D012431 873 CBR1
CBR
SDR21C1
hCBR1
carbonyl reductase 1 (EC:1.1.1.189 1.1.1.197 1.1.1.184) Rutin inhibits the reaction [CBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] decreases reaction
/ increases metabolic processing
protein 11306090
D012431 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Rutin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA] decreases reaction
/ increases expression
mRNA 21756928
D012431 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Rutin results in decreased expression of CCL2 mRNA decreases expression
mRNA 21756928
21967610
D012431 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Rutin results in decreased secretion of CCL2 protein decreases secretion
protein 21967610
D012431 3627 CXCL10
C7
IFI10
INP10
IP-10
SCYB10
crg-2
gIP-10
mob-1
chemokine (C-X-C motif) ligand 10 Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein] affects cotreatment
/ decreases reaction
/ increases secretion
protein 21756928
D012431 3627 CXCL10
C7
IFI10
INP10
IP-10
SCYB10
crg-2
gIP-10
mob-1
chemokine (C-X-C motif) ligand 10 Rutin results in decreased expression of CXCL10 mRNA decreases expression
mRNA 21756928
21967610
D012431 3627 CXCL10
C7
IFI10
INP10
IP-10
SCYB10
crg-2
gIP-10
mob-1
chemokine (C-X-C motif) ligand 10 Rutin results in decreased secretion of CXCL10 protein decreases secretion
protein 21756928
21967610
D012431 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Rutin results in increased expression of CYP1A1 mRNA increases expression
mRNA 21756928
D012431 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) Rutin results in decreased activity of CYP1B1 protein decreases activity
protein 16271822
D012431 1956 EGFR
ERBB
ERBB1
HER1
PIG61
mENA
epidermal growth factor receptor (EC:2.7.10.1) Rutin inhibits the reaction [TGFA protein affects the localization of EGFR protein] affects localization
/ decreases reaction
protein 21967610
D012431 2936 GSR
glutathione reductase (EC:1.8.1.7) Rutin results in decreased activity of GSR protein decreases activity
protein 15782287
D012431 3458 IFNG
IFG
IFI
interferon, gamma Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21756928
D012431 3458 IFNG
IFG
IFI
interferon, gamma Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21756928
D012431 3458 IFNG
IFG
IFI
interferon, gamma Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21756928
D012431 3458 IFNG
IFG
IFI
interferon, gamma Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein] affects cotreatment
/ decreases reaction
/ increases secretion
protein 21756928
D012431 3458 IFNG
IFG
IFI
interferon, gamma Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of IL8 protein] affects cotreatment
/ decreases reaction
/ increases secretion
protein 21756928
D012431 3480 IGF1R
CD221
IGFIR
IGFR
JTK13
insulin-like growth factor 1 receptor (EC:2.7.10.1) Rutin results in increased susceptibility to [Vitamin E results in decreased expression of IGF1R protein] decreases expression
/ increases response to substance
protein 20015448
D012431 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Rutin inhibits the reaction [Glucose results in increased expression of IL1B mRNA] decreases reaction
/ increases expression
mRNA 19557821
D012431 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Rutin inhibits the reaction [Glucose results in increased expression of IL1B protein] decreases reaction
/ increases expression
protein 19557821
D012431 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 18958421
D012431 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL1B protein] affects cotreatment
/ decreases reaction
/ increases secretion
protein 18958421
D012431 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Rutin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA] decreases reaction
/ increases expression
mRNA 21756928
D012431 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 18958421
D012431 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL6 protein] affects cotreatment
/ decreases reaction
/ increases secretion
protein 18958421
D012431 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Rutin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 21756928
D012431 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL8 mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 18958421
D012431 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL8 protein] affects cotreatment
/ decreases reaction
/ increases secretion
protein 18958421
D012431 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of IL8 protein] affects cotreatment
/ decreases reaction
/ increases secretion
protein 21756928
D012431 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Rutin results in decreased secretion of IL8 protein decreases secretion
protein 21756928
21967610
D012431 3667 IRS1
HIRS-1
insulin receptor substrate 1 Rutin results in decreased expression of IRS1 protein decreases expression
protein 20015448
D012431 3667 IRS1
HIRS-1
insulin receptor substrate 1 Rutin results in increased susceptibility to [Vitamin E results in decreased expression of IRS1 protein] decreases expression
/ increases response to substance
protein 20015448
D012431 3667 IRS1
HIRS-1
insulin receptor substrate 1 Vitamin E results in increased susceptibility to [Rutin results in decreased expression of IRS1 protein] decreases expression
/ increases response to substance
protein 20015448
D012431 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Rutin results in decreased expression of JUN protein decreases expression
protein 20015448
D012431 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Rutin results in increased susceptibility to [Vitamin E results in decreased expression of JUN protein] decreases expression
/ increases response to substance
protein 20015448
D012431 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Vitamin E results in increased susceptibility to [Rutin results in decreased expression of JUN protein] decreases expression
/ increases response to substance
protein 20015448
D012431 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Rutin inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 19557821
D012431 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21756928
D012431 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Rutin results in decreased phosphorylation of MAPK1 protein decreases phosphorylation
protein 21756928
D012431 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Rutin inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 19557821
D012431 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21756928
D012431 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Rutin results in decreased phosphorylation of MAPK3 protein decreases phosphorylation
protein 21756928
D012431 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Rutin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of NFKBIA protein] decreases expression
/ decreases reaction
/ increases degradation
protein 19557821
D012431 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) [Rutin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTGS2 mRNA affects cotreatment
/ decreases expression
mRNA 21756928
D012431 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Rutin inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA] decreases reaction
/ increases expression
mRNA 19557821
D012431 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Rutin inhibits the reaction [Glucose results in increased expression of PTGS2 protein] decreases reaction
/ increases expression
protein 19557821
D012431 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Rutin inhibits the reaction [Glucose affects the localization of RELA protein] affects localization
/ decreases reaction
protein 19557821
D012431 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Rutin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein] decreases reaction
/ increases phosphorylation
protein 21756928
D012431 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21756928
D012431 7039 TGFA
TFGA
transforming growth factor, alpha Rutin inhibits the reaction [TGFA protein affects the localization of EGFR protein] affects localization
/ decreases reaction
protein 21967610
D012431 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Rutin inhibits the reaction [Glucose results in increased expression of TNF mRNA] decreases reaction
/ increases expression
mRNA 19557821
D012431 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Rutin inhibits the reaction [Glucose results in increased expression of TNF protein] decreases reaction
/ increases expression
protein 19557821
D012431 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA] affects cotreatment
/ decreases reaction
/ increases expression
mRNA 18958421
D012431 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of TNF protein] affects cotreatment
/ decreases reaction
/ increases secretion
protein 18958421
D012431 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21756928
D012431 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21756928
D012431 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 21756928
D012431 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein] affects cotreatment
/ decreases reaction
/ increases secretion
protein 21756928
D012431 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of IL8 protein] affects cotreatment
/ decreases reaction
/ increases secretion
protein 21756928
D012431 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Rutin results in decreased expression of VEGFA mRNA decreases expression
mRNA 20015448
D012431 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Rutin results in decreased secretion of and results in decreased expression of VEGFA protein decreases expression
/ decreases secretion
protein 20015448
D012431 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Rutin results in increased susceptibility to [Vitamin E results in decreased expression of VEGFA mRNA] decreases expression
/ increases response to substance
mRNA 20015448
D012431 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Rutin results in increased susceptibility to [Vitamin E results in decreased secretion of and results in decreased expression of VEGFA protein] decreases expression
/ decreases secretion
/ increases response to substance
protein 20015448
D012431 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Vitamin E results in increased susceptibility to [Rutin results in decreased expression of VEGFA mRNA] decreases expression
/ increases response to substance
mRNA 20015448
D012431 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Vitamin E results in increased susceptibility to [Rutin results in decreased secretion of and results in decreased expression of VEGFA protein] decreases expression
/ decreases secretion
/ increases response to substance
protein 20015448

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (18)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#614490 Blood group, junior system; jr Q9UNQ0
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (16)

KEGG disease name UniProt
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00032 Thyroid cancer P27487 (marker)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00192 Xanthinuria P47989 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

8 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D001424 D012431 Bacterial Infections therapeutic
12669766
D003092 D012431 Colitis therapeutic
15652231
D004409 D012431 Dyskinesia, Drug-Induced therapeutic
17868205
D015212 D012431 Inflammatory Bowel Diseases therapeutic
15652231
D007674 D012431 Kidney Diseases therapeutic
21605616
D028361 D012431 Mitochondrial Diseases therapeutic
22214982
D010243 D012431 Paralysis therapeutic
3582421
D013276 D012431 Stomach Ulcer therapeutic
20374237