Pelargonium reniforme
Species
KNApSAcK Entry
| Organism name | Pelargonium reniforme |
|---|---|
| Genus | Pelargonium |
| Family | Geraniaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Pelargonium reniforme |
|---|---|
| Linked NCBI taxonomy ID | 59871 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Geraniaceae |
|---|---|
| ID | 4027 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (30)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00005413
|
Rutin
/ Birutan / 3-Rutinosylquercetin / Quercetin 3-O-rutinoside / (+)-Quercetin 3-O-rutinoside / Quercetin 3-O-beta-rutinoside / (+)-Quercetin 3-O-beta-rutinoside / 3,3',4',5,7-Pentahydroxyflavone 3-rutinoside / Quercetin 3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside |
CHEMBL32579
CHEMBL310754 CHEMBL182108 CHEMBL226335 CHEMBL502782 CHEMBL1436093 CHEMBL1532989 |
D012431
|
25 / 18 / 16 | 29 / 8 | No. 1 | No. 15 |
|
|
C00005169
|
Nicotiflorin
/ Nicotifloroside / Kaempferol 3-O-rutinoside / Kaempferol 3-O-(alpha-L-rhamnopyranosyl(1->6)-beta-D-glucopyranoside / (-)-Kaempferol 3-O-(alpha-L-rhamnopyranosyl(1->6)-beta-D-glucopyranoside |
CHEMBL431610
CHEMBL79790 CHEMBL255020 CHEMBL501550 CHEMBL498879 CHEMBL1419228 CHEMBL1875691 |
22 / 10 / 12 | No. 1 | No. 15 |
|
||
|
C00005373
|
Hirsutrin
/ Isoquercetin / Isoquercetrin / (-)-Isoquercetrin / Quercetin 3-glucoside / Quercetin 3-O-beta-D-glucoside / Quercetin-3-O-beta-D-glucopyranoside / Quercetin 3-O-beta-D-glucopyranoside / (-)-Quercetin-3-O-beta-D-glucopyranoside |
CHEMBL33027
CHEMBL309323 CHEMBL250450 CHEMBL251254 CHEMBL457304 CHEMBL1098724 CHEMBL2337335 CHEMBL2337336 |
38 / 43 / 34 | No. 2 | No. 15 |
|
||
|
C00005138
|
Astragalin
/ Kaempferol 3-glucoside / Kaempferol 3-O-beta-D-glucoside / Kaempferol 3-O-beta-D-glucopyranoside |
CHEMBL233930
CHEMBL453290 CHEMBL1572115 |
C001579
|
10 / 6 / 7 | 0 / 1 | No. 2 | No. 15 |
|
|
C00005729
|
Myricetin 3-glucoside
/ Myricetin 3-O-beta-D-glucoside / Myricetin 3-O-beta-D-glucopyranoside |
CHEMBL462244
CHEMBL1221722 |
No. 2 | No. 15 |
|
|||
|
C00005149
|
Populnin
/ Kaempferol 7-glucoside |
CHEMBL469441
CHEMBL1159471 |
No. 2 | No. 15 |
|
|||
|
C00005137
|
Trifolin
/ Kaempferol 3-O-beta-D-galactopyranoside |
CHEMBL233930
CHEMBL453290 CHEMBL1572115 |
C066407
|
10 / 6 / 7 | 1 / 1 | No. 2 | No. 15 |
|
|
C00014083
|
Isovitexin 2''-O-(6'''-(E)-feruloyl)glucoside 4'-O-glucoside
|
No. 7 | No. 15 |
|
||||
|
C00008709
|
Taxifolin 7-glucoside
/ Taxifolin 7-O-beta-D-glucopyranoside / 3,5,7,3',4'-Pentahydroxyflavanone 7-beta-D-glucopyranoside |
No. 12 | No. 14 |
|
||||
|
C00001055
|
Isoorientin
/ Homoorientin / Lespecapitioside / Luteolin 6-C-beta-D-glucopyranoside / 2-(3,4-Dihydroxyphenyl)-6-beta-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one |
CHEMBL239559
CHEMBL1302308 |
C057912
|
23 / 14 / 17 | 0 / 1 | No. 22 | No. 15 |
|
|
C00001110
|
Vitexin
/ Apigenin 8-C-glucoside / 8-D-Glucosyl-4',5,7-trihydroxyflavone / 8-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL487417
CHEMBL1332209 CHEMBL1357921 |
16 / 4 / 8 | No. 22 | No. 15 |
|
||
|
C00001078
|
Lutexin
/ Orientin / Luteolin 8-C-beta-D-glucopyranoside / 8-beta-D-Glucopyranosyl-3',4',5,7-tetrahydroxyflavone |
CHEMBL520866
CHEMBL1468796 |
C065886
|
20 / 15 / 14 | No. 22 | No. 15 |
|
|
|
C00001059
|
Isovitexin
/ Saponaretin / Homovitexin / 6-C-beta-D-Glucopyranosylapigenin / 6-beta-D-Glucopyranosyl-4',5,7-trihydroxyflavone / 6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL465360
CHEMBL1601394 |
C049772
|
28 / 20 / 19 | No. 22 | No. 15 |
|
|
|
C00014104
|
Orientin 2''-O-gallate
|
No. 30 | No. 15 |
|
||||
|
C00014088
|
Vitexin 2''-O-gallate
|
No. 30 | No. 15 |
|
||||
|
C00014084
|
2''-O-Galloylisovitexin
|
No. 30 | No. 15 |
|
||||
|
C00014098
|
Isoorientin 2''-O-gallate
|
No. 30 | No. 15 |
|
||||
|
C00000677
|
Distylin
/ Dihydroquercetin / (2R,3R)-Taxifolin |
CHEMBL66
CHEMBL9249 CHEMBL337309 CHEMBL1492383 |
C003377
|
65 / 41 / 37 | 29 / 1 | No. 42 | No. 14 |
|
|
C00007234
|
Katuranin
/ (+)-Aromadendrin / (+)-Dihydrokaempferol / (2R,3R)-2,3-Dihydro-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL9323
CHEMBL1933859 |
C080220
|
4 / 3 / 3 | No. 42 | No. 14 |
|
|
|
C00037605
|
Pelargoniin A
|
No. 226 | No. 81 |
|
||||
|
C00002501
|
5,6,7-Trimethoxycoumarin
|
CHEMBL607537
|
No. 364 | No. 25 |
|
|||
|
C00033581
|
6-O-Galloylsalidroside
/ 6'-O-Galloylsalidroside / (+)-6-O-Galloylsalidroside |
CHEMBL1770695
|
No. 532 |
|
||||
|
C00002915
|
Corilagin
|
CHEMBL449392
CHEMBL1425538 |
C049096
|
44 / 45 / 33 | No. 818 | No. 81 |
|
|
|
C00035393
|
Strictinin
|
CHEMBL504212
|
No. 818 | No. 81 |
|
|||
|
C00035668
|
Isostrictinin
|
No. 818 | No. 81 |
|
||||
|
C00037606
|
Pelargoniin B
/ (-)-Pelargoniin B |
No. 2287 |
|
|||||
|
C00037607
|
Pelargoniin D
|
No. 2287 |
|
|||||
|
C00037622
|
Phyllanthusiin E
|
No. 5838 |
|
|||||
|
C00036839
|
Brevifolincarboxylic acid
|
No. 6107 |
|
|||||
|
C00034195
|
Reniformin
/ (+)-Reniformin |
No. 7612 |
|
Human Protein / Gene in interactions
120 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000677 C00001055 C00001059 C00001078 C00001110 C00002915 C00005137 C00005138 C00005169 C00005373 C00005413 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000677 C00001055 C00001059 C00001078 C00001110 C00002915 C00005137 C00005138 C00005169 C00005373 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00000677 C00001055 C00001059 C00001078 C00001110 C00002915 C00005137 C00005138 C00005169 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00000677 C00001055 C00001059 C00001078 C00001110 C00005137 C00005138 C00005169 C00005373 | 1 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000677 C00001055 C00001059 C00001078 C00001110 C00005169 C00005373 C00005413 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00000677 C00001055 C00001059 C00001078 C00002915 C00005169 C00005373 C00005413 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00000677 C00001055 C00001059 C00001078 C00002915 C00005169 C00005373 C00005413 | 1 / 1 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00000677 C00001055 C00001059 C00001078 C00002915 C00005169 C00005373 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00000677 C00001055 C00001059 C00001110 C00002915 C00005169 C00005373 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00000677 C00001055 C00001059 C00001110 C00002915 C00005169 C00005373 | 1 / 4 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000677 C00001055 C00001078 C00002915 C00005373 C00005413 | 4 / 3 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00001055 C00001059 C00001078 C00001110 C00002915 C00005169 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00000677 C00001055 C00001059 C00002915 C00005169 C00005373 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00001055 C00001059 C00001078 C00005169 C00005373 C00005413 | 1 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000677 C00001055 C00001059 C00001078 C00005373 C00005413 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00001055 C00001059 C00001078 C00002915 C00005169 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00000677 C00001110 C00005169 C00005373 C00007234 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000677 C00001078 C00002915 C00005373 C00005413 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001055 C00001059 C00001110 C00005169 C00005373 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000677 C00001055 C00001059 C00001078 C00002915 | 1 / 2 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00001055 C00001059 C00002915 C00005169 | 2 / 1 |
| P15121 | Aldose reductase | Enzyme | C00001110 C00005137 C00005138 C00005373 | 0 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00000677 C00005169 C00005373 C00005413 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00000677 C00001055 C00001059 C00001078 | 2 / 5 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001055 C00001059 C00005137 C00005138 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00001078 C00005137 C00005138 C00005169 | 1 / 1 |
| P07237 | Protein disulfide-isomerase | Enzyme | C00005137 C00005138 C00005169 C00005373 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00005137 C00005138 C00005373 C00005413 | 4 / 2 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001055 C00001059 C00001078 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000677 C00001110 C00005413 | 0 / 1 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000677 C00005373 C00005413 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000677 C00001059 C00005169 | 0 / 0 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00000677 C00005373 C00007234 | 1 / 1 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00000677 C00005373 | 0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00001059 C00002915 | 2 / 2 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001059 C00001078 | 0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00000677 C00002915 | 1 / 2 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000677 C00001110 | 0 / 1 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00005373 C00005413 | 0 / 0 |
| Q05513 | Protein kinase C zeta type | Iota | C00000677 C00002915 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002915 C00005373 | 11 / 10 |
| Q04759 | Protein kinase C theta type | Delta | C00000677 C00002915 | 0 / 1 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00000677 C00005373 | 0 / 0 |
| Q02156 | Protein kinase C epsilon type | Eta | C00000677 C00002915 | 0 / 0 |
| O94806 | Serine/threonine-protein kinase D3 | Pkd | C00000677 C00002915 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000677 C00001110 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00001059 C00002915 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00000677 C00002915 | 0 / 0 |
| Q05655 | Protein kinase C delta type | Delta | C00000677 C00002915 | 0 / 0 |
| P05129 | Protein kinase C gamma type | Alpha | C00000677 C00002915 | 1 / 1 |
| P05771 | Protein kinase C beta type | Alpha | C00000677 C00002915 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00005373 C00005413 | 0 / 3 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000677 C00007234 | 0 / 0 |
| P24723 | Protein kinase C eta type | Eta | C00000677 C00002915 | 1 / 0 |
| P41743 | Protein kinase C iota type | Iota | C00000677 C00002915 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00000677 C00002915 | 2 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000677 C00001110 | 1 / 1 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00000677 C00005373 | 4 / 1 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00000677 C00005373 | 0 / 0 |
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00000677 C00002915 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000677 C00002915 | 2 / 2 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00005373 C00005413 | 2 / 0 |
| P01215 | Glycoprotein hormones alpha chain | Unclassified protein | C00005137 C00005138 | 0 / 3 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000677 C00005413 | 3 / 3 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000677 C00001110 | 1 / 0 |
| P56817 | Beta-secretase 1 | A1A | C00000677 | 0 / 0 |
| P08253 | 72 kDa type IV collagenase | M10A | C00000677 | 1 / 3 |
| P10696 | Alkaline phosphatase, placental-like | Enzyme | C00005373 | 0 / 1 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00000677 | 2 / 0 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00000677 | 1 / 1 |
| P45452 | Collagenase 3 | M10A | C00000677 | 1 / 1 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00000677 | 5 / 2 |
| P06280 | Alpha-galactosidase A | Enzyme | C00005373 | 1 / 1 |
| P03372 | Estrogen receptor | NR3A1 | C00005413 | 1 / 1 |
| P12821 | Angiotensin-converting enzyme | M2 | C00002915 | 4 / 2 |
| P22303 | Acetylcholinesterase | Hydrolase | C00005413 | 1 / 0 |
| P06276 | Cholinesterase | Hydrolase | C00005413 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00000677 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00000677 | 0 / 0 |
| P30989 | Neurotensin receptor type 1 | Neurotensin receptor | C00001059 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00007234 | 2 / 2 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00005413 | 0 / 0 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00000677 | 0 / 0 |
| P98073 | Enteropeptidase | Enzyme | C00002915 | 1 / 1 |
| P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00005373 | 3 / 1 |
| P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00005373 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00001059 | 7 / 3 |
| P08908 | 5-hydroxytryptamine receptor 1A | Serotonin receptor | C00005373 | 1 / 0 |
| P08254 | Stromelysin-1 | M10A | C00000677 | 1 / 0 |
| P34949 | Mannose-6-phosphate isomerase | Enzyme | C00005373 | 1 / 1 |
| P03956 | Interstitial collagenase | M10A | C00000677 | 0 / 1 |
| P27487 | Dipeptidyl peptidase 4 | S9B | C00005413 | 0 / 1 |
| P24298 | Alanine aminotransferase 1 | Enzyme | C00000677 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00005413 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00002915 | 2 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002915 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00000677 | 0 / 0 |
| P55072 | Transitional endoplasmic reticulum ATPase | Unclassified protein | C00002915 | 2 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00001059 | 1 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00005169 | 2 / 3 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00005413 | 0 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00002915 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00001078 | 3 / 1 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00002915 | 0 / 0 |
| P28907 | ADP-ribosyl cyclase 1 | Enzyme | C00000677 | 0 / 1 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00000677 | 2 / 2 |
| P39900 | Macrophage metalloelastase | M10A | C00000677 | 0 / 0 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | C00002915 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00005373 | 6 / 4 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00000677 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00000677 | 0 / 0 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00000677 | 0 / 0 |
| Q9NPH5 | NADPH oxidase 4 | Enzyme | C00005373 | 0 / 0 |
| P19429 | Troponin I, cardiac muscle | Unclassified protein | C00002915 | 4 / 4 |
| P45379 | Troponin T, cardiac muscle | Unclassified protein | C00002915 | 3 / 5 |
| P63316 | Troponin C, slow skeletal and cardiac muscles | Other cytosolic protein | C00002915 | 2 / 2 |
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | C00002915 | 0 / 0 |
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00005413 | 0 / 0 |
| Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | C00001055 | 0 / 0 |
| P48147 | Prolyl endopeptidase | S9A | C00005413 | 0 / 0 |
57 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 3458 | IFNG, IFG, IFI | interferon, gamma |
C00000677
C00005413
|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00000677
C00005413
|
| 7518 | XRCC4 | X-ray repair complementing defective repair in Chinese hamster cells 4 |
C00000677
|
| 8900 | CCNA1 | cyclin A1 |
C00000677
|
| 993 | CDC25A, CDC25A2 | cell division cycle 25A (EC:3.1.3.48) |
C00000677
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00000677
|
| 1630 | DCC, CRC18, CRCR1, IGDCC1, MRMV1 | deleted in colorectal carcinoma |
C00000677
|
| 1950 | EGF, HOMG4, URG | epidermal growth factor |
C00000677
|
| 8817 | FGF18, FGF-18, ZFGF5 | fibroblast growth factor 18 |
C00000677
|
| 2248 | FGF3, HBGF-3, INT2 | fibroblast growth factor 3 |
C00000677
|
| 2621 | GAS6, AXLLG, AXSF | growth arrest-specific 6 |
C00000677
|
| 9518 | GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB | growth differentiation factor 15 |
C00000677
|
| 2944 | GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1 | glutathione S-transferase mu 1 (EC:2.5.1.18) |
C00000677
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00000677
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00000677
|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00000677
|
| 335 | APOA1 | apolipoprotein A-I |
C00000677
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00000677
|
| 4547 | MTTP, ABL, MTP | microsomal triglyceride transfer protein |
C00000677
|
| 4780 | NFE2L2, NRF2 | nuclear factor, erythroid 2-like 2 |
C00000677
|
| 1728 | NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 | NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) |
C00000677
|
| 5155 | PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis | platelet-derived growth factor beta polypeptide |
C00000677
|
| 5921 | RASA1, CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120GAP, p120RASGAP | RAS p21 protein activator (GTPase activating protein) 1 |
C00000677
|
| 6772 | STAT1, CANDF7, ISGF-3, STAT91 | signal transducer and activator of transcription 1, 91kDa |
C00000677
|
| 7187 | TRAF3, CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1 | TNF receptor-associated factor 3 |
C00000677
|
| 7296 | TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR | thioredoxin reductase 1 (EC:1.8.1.9) |
C00000677
|
| 7498 | XDH, XO, XOR | xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) |
C00000677
|
| 7507 | XPA, XP1, XPAC | xeroderma pigmentosum, complementation group A |
C00000677
|
| 338 | APOB, FLDB, LDLCQ4 | apolipoprotein B |
C00000677
|
| 5320 | PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2 | phospholipase A2, group IIA (platelets, synovial fluid) (EC:3.1.1.4) |
C00005137
|
| 177 | AGER, RAGE | advanced glycosylation end product-specific receptor |
C00005413
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00005413
|
| 405 | ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 | aryl hydrocarbon receptor nuclear translocator |
C00005413
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00005413
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00005413
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00005413
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00005413
|
| 873 | CBR1, CBR, SDR21C1, hCBR1 | carbonyl reductase 1 (EC:1.1.1.189 1.1.1.197 1.1.1.184) |
C00005413
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00005413
|
| 3627 | CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 | chemokine (C-X-C motif) ligand 10 |
C00005413
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00005413
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00005413
|
| 1956 | EGFR, ERBB, ERBB1, HER1, PIG61, mENA | epidermal growth factor receptor (EC:2.7.10.1) |
C00005413
|
| 2936 | GSR | glutathione reductase (EC:1.8.1.7) |
C00005413
|
| 3480 | IGF1R, CD221, IGFIR, IGFR, JTK13 | insulin-like growth factor 1 receptor (EC:2.7.10.1) |
C00005413
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00005413
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00005413
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00005413
|
| 3667 | IRS1, HIRS-1 | insulin receptor substrate 1 |
C00005413
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00005413
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00005413
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00005413
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00005413
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00005413
|
| 7039 | TGFA, TFGA | transforming growth factor, alpha |
C00005413
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00005413
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00005413
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (109)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #613954 | Amyotrophic lateral sclerosis 14, with or without frontotemporal dementia; als14 |
P55072
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #601494 | Cardiomyopathy, dilated, 1d; cmd1d |
P45379
|
| #613286 | Cardiomyopathy, dilated, 1ff; cmd1ff |
P19429
|
| #611879 | Cardiomyopathy, dilated, 1z; cmd1z |
P63316
|
| #611880 | Cardiomyopathy, dilated, 2a; cmd2a |
P19429
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #613243 | Cardiomyopathy, familial hypertrophic, 13; cmh13 |
P63316
|
| #115195 | Cardiomyopathy, familial hypertrophic, 2; cmh2 |
P45379
|
| #613690 | Cardiomyopathy, familial hypertrophic, 7; cmh7 |
P19429
|
| #115210 | Cardiomyopathy, familial restrictive, 1; rcm1 |
P19429
|
| #612422 | Cardiomyopathy, familial restrictive, 3; rcm3 |
P45379
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #114500 | Colorectal cancer; crc |
P18054
P84022 Q14191 |
| #602579 | Congenital disorder of glycosylation, type ib; cdg1b |
P34949
|
| #614466 | Coronary heart disease, susceptibility to, 6; chds6 |
P08254
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #226200 | Enterokinase deficiency |
P98073
|
| #133239 | Esophageal cancer |
P18054
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #614519 | Hemorrhage, intracerebral, susceptibility to; ich |
P12821
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #146300 | Hypophosphatasia, adult |
P05186
|
| #241510 | Hypophosphatasia, childhood |
P05186
|
| #241500 | Hypophosphatasia, infantile |
P05186
|
| #167320 | Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1; ibmpfd1 |
P55072
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #601626 | Leukemia, acute myeloid; aml |
P36888
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #612624 | Microvascular complications of diabetes, susceptibility to, 3; mvcd3 |
P12821
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #614674 | Periodic fever, menstrual cycle-dependent |
P08908
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #267430 | Renal tubular dysgenesis; rtd |
P12821
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #602111 | Spondyloepimetaphyseal dysplasia, missouri type |
P45452
|
| #601367 | Stroke, ischemic |
P12821
P24723 |
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (80)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00081 | Hashimoto's thyroiditis |
P01215
(marker)
|
| H00082 | Graves' disease |
P01215
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P01215
(marker)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
P19429 (related) P45379 (related) P63316 (related) |
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
P45379 (related) |
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00028 | Choriocarcinoma |
P03956
(related)
P08253 (related) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
Q99700 (related) Q9NUW8 (related) |
| H00213 | Hypophosphatasia |
P05186
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00025 | Penile cancer |
P08253
(related)
P14780 (related) P35354 (related) |
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
P55072 (related) |
| H00023 | Testicular cancer |
P10696
(marker)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00083 | Allograft rejection |
P12821
(related)
|
| H00575 | Renal tubular dysgenesis |
P12821
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
P45452 (related) |
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00292 | Hypertrophic cardiomyopathy (HCM) |
P19429
(related)
P45379 (related) P63316 (related) |
| H01219 | Restrictive cardiomyopathy (RCM) |
P19429
(related)
P45379 (related) |
| H00295 | Viral myocarditis |
P19429
(marker)
P45379 (marker) |
| H00032 | Thyroid cancer |
P27487
(marker)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P28907
(marker)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00118 | Congenital disorders of glycosylation (CDG) type I |
P34949
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
Q01196 (related) Q01196 (marker) Q13951 (marker) |
| H00192 | Xanthinuria |
P47989
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
Q14191 (related) |
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00988 | Enterokinase deficiency |
P98073
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00408 | Type I diabetes mellitus |
Q04759
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00208 | Hyperbilirubinemia |
Q92887
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
12 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D003876 | Dermatitis, Atopic |
C00005138
|
| D006461 | Hemolysis |
C00000677
|
| D008104 | Liver Cirrhosis, Alcoholic |
C00001055
|
| D004487 | Edema |
C00005137
|
| D001424 | Bacterial Infections |
C00005413
|
| D003092 | Colitis |
C00005413
|
| D004409 | Dyskinesia, Drug-Induced |
C00005413
|
| D015212 | Inflammatory Bowel Diseases |
C00005413
|
| D007674 | Kidney Diseases |
C00005413
|
| D028361 | Mitochondrial Diseases |
C00005413
|
| D010243 | Paralysis |
C00005413
|
| D013276 | Stomach Ulcer |
C00005413
|