PCIDB

KNApSAcK Metabolite C00002915

Metabolite

KNApSAcK Entry

id C00002915
Name Corilagin
CAS RN 23094-69-1
Standard InChI InChI=1S/C27H22O18/c28-9-1-6(2-10(29)16(9)32)24(39)45-27-22(38)23-19(35)13(43-27)5-42-25(40)7-3-11(30)17(33)20(36)14(7)15-8(26(41)44-23)4-12(31)18(34)21(15)37/h1-4,13,19,22-23,27-38H,5H2/t13-,19+,22?,23?,27-/m0/s1
Standard InChI (Main Layer) InChI=1S/C27H22O18/c28-9-1-6(2-10(29)16(9)32)24(39)45-27-22(38)23-19(35)13(43-27)5-42-25(40)7-3-11(30)17(33)20(36)14(7)15-8(26(41)44-23)4-12(31)18(34)21(15)37/h1-4,13,19,22-23,27-38H,5H2

Cluster

Phytochemical cluster No. 81
KCF-S cluster No. 818

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL449392 CHEMBL1425538

KEGG

By LinkDB C10219

CTD

By CAS RN C049096

Human Protein / Gene in interaction

44 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein CHEMBL1425538 CHEMBL1614529 (1)
0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL1425538 CHEMBL1738312 (1)
0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL1425538 CHEMBL1794499 (1)
2 / 0
P06746 DNA polymerase beta Enzyme CHEMBL1425538 CHEMBL1614079 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL1425538 CHEMBL1614076 (1)
1 / 1
P04406 Glyceraldehyde-3-phosphate dehydrogenase Enzyme CHEMBL1425538 CHEMBL1613955 (1)
0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL1425538 CHEMBL1794585 (1)
0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL1425538 CHEMBL1614474 (1) CHEMBL1738493 (1)
CHEMBL1738375 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL1425538 CHEMBL1614544 (1)
11 / 10
P54132 Bloom syndrome protein Enzyme CHEMBL1425538 CHEMBL1614067 (1)
1 / 2
P11387 DNA topoisomerase 1 Isomerase CHEMBL449392 CHEMBL956189 (1)
0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme CHEMBL1425538 CHEMBL1794495 (1)
2 / 2
P39748 Flap endonuclease 1 Enzyme CHEMBL1425538 CHEMBL1794486 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL1425538 CHEMBL1738606 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL1425538 CHEMBL1794584 (1)
2 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein CHEMBL1425538 CHEMBL1614280 (1)
0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL1425538 CHEMBL1614410 (1)
1 / 3
P98073 Enteropeptidase Enzyme CHEMBL1425538 CHEMBL1738398 (1)
1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL1425538 CHEMBL1614038 (1)
2 / 2
P12821 Angiotensin-converting enzyme M2 CHEMBL449392 CHEMBL1015636 (1)
4 / 2
Q9UNA4 DNA polymerase iota Enzyme CHEMBL1425538 CHEMBL1794483 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL1425538 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL1425538 CHEMBL1614466 (1) CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1425538 CHEMBL1614250 (1) CHEMBL1614421 (1)
CHEMBL1614502 (1)
4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL1425538 CHEMBL1738184 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL1425538 CHEMBL1738442 (1)
0 / 0
P55072 Transitional endoplasmic reticulum ATPase Unclassified protein CHEMBL1425538 CHEMBL1614506 (1) CHEMBL1614140 (1)
2 / 1
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL1425538 CHEMBL1738090 (1) CHEMBL1737904 (1)
CHEMBL1738444 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL1425538 CHEMBL1738090 (1) CHEMBL1737904 (1)
CHEMBL1738444 (1)
1 / 6
Q05513 Protein kinase C zeta type Iota CHEMBL449392 CHEMBL769344 (1)
0 / 0
Q04759 Protein kinase C theta type Delta CHEMBL449392 CHEMBL769344 (1) CHEMBL768505 (1)
0 / 1
Q02156 Protein kinase C epsilon type Eta CHEMBL449392 CHEMBL769344 (1) CHEMBL768505 (1)
0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd CHEMBL449392 CHEMBL769344 (1) CHEMBL768505 (1)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL449392 CHEMBL769344 (1) CHEMBL768505 (1)
0 / 0
Q05655 Protein kinase C delta type Delta CHEMBL449392 CHEMBL769344 (1) CHEMBL768505 (1)
0 / 0
P05129 Protein kinase C gamma type Alpha CHEMBL449392 CHEMBL769344 (1) CHEMBL768505 (1)
1 / 1
P05771 Protein kinase C beta type Alpha CHEMBL449392 CHEMBL769344 (1) CHEMBL768505 (1)
0 / 0
P24723 Protein kinase C eta type Eta CHEMBL449392 CHEMBL769344 (1) CHEMBL768505 (1)
1 / 0
P41743 Protein kinase C iota type Iota CHEMBL449392 CHEMBL769344 (1)
0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd CHEMBL449392 CHEMBL769344 (1) CHEMBL768505 (1)
0 / 0
P19429 Troponin I, cardiac muscle Unclassified protein CHEMBL1425538 CHEMBL1738244 (1)
4 / 4
P45379 Troponin T, cardiac muscle Unclassified protein CHEMBL1425538 CHEMBL1738244 (1)
3 / 5
P63316 Troponin C, slow skeletal and cardiac muscles Other cytosolic protein CHEMBL1425538 CHEMBL1738244 (1)
2 / 2
Q14191 Werner syndrome ATP-dependent helicase Enzyme CHEMBL1425538 CHEMBL2114796 (1)
2 / 1

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (45)

OMIM preferred title UniProt
#613954 Amyotrophic lateral sclerosis 14, with or without frontotemporal dementia; als14 P55072
#210900 Bloom syndrome; blm P54132
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#601494 Cardiomyopathy, dilated, 1d; cmd1d P45379
#613286 Cardiomyopathy, dilated, 1ff; cmd1ff P19429
#611879 Cardiomyopathy, dilated, 1z; cmd1z P63316
#611880 Cardiomyopathy, dilated, 2a; cmd2a P19429
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#613243 Cardiomyopathy, familial hypertrophic, 13; cmh13 P63316
#115195 Cardiomyopathy, familial hypertrophic, 2; cmh2 P45379
#613690 Cardiomyopathy, familial hypertrophic, 7; cmh7 P19429
#115210 Cardiomyopathy, familial restrictive, 1; rcm1 P19429
#612422 Cardiomyopathy, familial restrictive, 3; rcm3 P45379
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
Q14191
#119900 Digital clubbing, isolated congenital P15428
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#226200 Enterokinase deficiency P98073
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#614519 Hemorrhage, intracerebral, susceptibility to; ich P12821
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#167320 Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1; ibmpfd1 P55072
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#612624 Microvascular complications of diabetes, susceptibility to, 3; mvcd3 P12821
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#267430 Renal tubular dysgenesis; rtd P12821
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#605361 Spinocerebellar ataxia 14; sca14 P05129
#601367 Stroke, ischemic P12821
P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191

KEGG DISEASE (33)

KEGG disease name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
P19429 (related)
P45379 (related)
P63316 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
P45379 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
P55072 (related)
H00083 Allograft rejection P12821 (related)
H00575 Renal tubular dysgenesis P12821 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00292 Hypertrophic cardiomyopathy (HCM) P19429 (related)
P45379 (related)
P63316 (related)
H01219 Restrictive cardiomyopathy (RCM) P19429 (related)
P45379 (related)
H00295 Viral myocarditis P19429 (marker)
P45379 (marker)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00988 Enterokinase deficiency P98073 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)