KCF-S cluster (7)

KCF-S ID # of metabolite
No. 126 40
No. 226 26
No. 302 22
No. 448 17
No. 818 11
No. 817 11
No. 2068 5

Metabolite list (132)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
figure
C00035327 External link 512 Chebulinic acid
CHEMBL501154
CHEMBL1159459
CHEMBL1391063
C103481
29 / 15 / 14 6 / 0 No. 126
C00035326 External link 512 Pedunculagin
CHEMBL292719
CHEMBL506204
1 / 1 / 0 No. 126
C00035325 External link 512 Casuariin
CHEMBL509562
CHEMBL488110
1 / 1 / 0 No. 126
C00035428 External link 512 Pentagalloyl-beta-D-glucose
/ 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose
/ (+)-1,2,3,4,6-Penta-O-galloyl-beta-D-glucose
CHEMBL127911
CHEMBL262173
CHEMBL206710
CHEMBL207164
CHEMBL382408
CHEMBL377052
CHEMBL425946
CHEMBL383306
CHEMBL207014
CHEMBL1224764
CHEMBL1500249
C013185
46 / 53 / 44 5 / 0 No. 126
C00035427 External link 512 Pentagalloylglucose
/ Penta-O-galloyl-beta-D-glucose
CHEMBL127911
CHEMBL262173
CHEMBL206710
CHEMBL207164
CHEMBL382408
CHEMBL377052
CHEMBL425946
CHEMBL383306
CHEMBL207014
CHEMBL1224764
CHEMBL1500249
C058187
46 / 53 / 44 No. 126
C00035426 External link 512 Remurin A
No. 126
C00048494 External link 512 4',6'-O-(S)-hexahydroxydiphenoylsalicin
No. 126
C00002907 External link 512 Nilotinin D1
No. 126
C00035320 External link 512 Mallotusinin
No. 126
C00035319 External link 512 Casuarictin
CHEMBL305099
CHEMBL446979
C073064
No. 126
C00035275 External link 512 Pterocarinin A
No. 126
C00035274 External link 512 Vescalagin
CHEMBL288949
CHEMBL288273
CHEMBL504485
CHEMBL607711
C084709
11 / 2 / 2 No. 126
C00035272 External link 512 Castalagin
CHEMBL288949
CHEMBL288273
CHEMBL504485
CHEMBL607711
11 / 2 / 2 No. 126
C00002914 External link 512 Cocciferin D1
No. 126
C00048493 External link 512 Balanophotannin B
/ (+)-Balanophotannin B
No. 126
C00048492 External link 512 1-O-p-(E)-Coumaroyl-4,6-(S)-HHDP-beta-D-glucopyranose
No. 126
C00044996 External link 512 6-Hydroxysalicylic acid
/ 2,6-Dihydroxybenzoic acid
CHEMBL454808
C412605
12 / 6 / 8 No. 126
C00002925 External link 512 Gemin B
No. 126
C00035256 External link 512 Paeonianin E
No. 126
C00035254 External link 512 Casuarinin
CHEMBL79244
CHEMBL507387
11 / 2 / 2 No. 126
C00035345 External link 512 Acalyphidin M1
No. 126
C00035347 External link 512 Stenophynin B
No. 126
C00035388 External link 512 Eugeniin
CHEMBL450745
CHEMBL510512
C110634
1 / 1 / 0 No. 126
C00002937 External link 512 Hirtellin B
No. 126
C00035387 External link 512 Tellimagrandin II
CHEMBL450745
CHEMBL510512
1 / 1 / 0 No. 126
C00035348 External link 512 Tellimagrandin I
CHEMBL450376
C087926
7 / 0 No. 126
C00040859 External link 512 Monacanthin B
No. 126
C00035703 External link 512 3-O-(E)-Caffeoyl-1,4-di-O-galloyl-beta-D-glucopyranose
No. 126
C00040953 External link 512 Prunasin 2',3',6'-tri-O-gallate
/ (+)-Prunasin 2',3',6'-tri-O-gallate
No. 126
C00035356 External link 512 Praecoxin B
No. 126
C00035354 External link 512 Balanophotannin A
/ (+)-Balanophotannin A
No. 126
C00045266 External link 512 Strictinin
CHEMBL504212
No. 126
C00040954 External link 512 Prunasin 3',4',6'-tri-O-gallate
No. 126
C00044998 External link 512 Saligel
/ Salonil
/ Salicylic acid
/ 2-Carboxyphenol
/ o-Hydroxybenzoic acid
CHEMBL424
D020156
124 / 50 / 42 15 / 12 No. 126
C00035330 External link 512 Isoterchebin
No. 126
C00035350 External link 512 Nobotanin D
No. 126
C00044997 External link 512 Gallic acid
CHEMBL288114
D005707
42 / 53 / 68 52 / 16 No. 126
C00035349 External link 512 Tercatain
No. 126
C00044995 External link 512 Pyrocatechuic acid
/ o-Pyrocatechuic acid
/ 2,3-Dihydroxybenzoic acid
CHEMBL1432
C009135
12 / 6 / 5 1 / 4 No. 126
C00035404 External link 512 Pterocaryanin C
No. 126
C00032196 External link 512 Euphorbin B
No. 226
C00043104 External link 512 Gentisic acid
/ 2,5-Dihydroxybenzoic acid
CHEMBL1461
C010925
15 / 6 / 8 2 / 1 No. 226
C00042346 External link 512 3,5-Di-galloyl-4-O-digalloylquinic acid
C061725
No. 226
C00031107 External link 512 Coriariin A
CHEMBL505639
No. 226
C00044999 External link 512 3-Hydroxybenzoic acid
CHEMBL65369
9 / 2 / 4 No. 226
C00046303 External link 512 Phyllanemblinin B
No. 226
C00040861 External link 512 Geponin
No. 226
C00035366 External link 512 Mallorepanin
No. 226
C00035367 External link 512 Mallotinic acid
CHEMBL448796
No. 226
C00035368 External link 512 Balanophotannin C
/ (+)-Balanophotannin C
No. 226
C00002932 External link 512 Cornusiin A
CHEMBL2304261
C062123
No. 226
C00002931 External link 512 Hirtellin G
No. 226
C00037605 External link 512 1,2,3,6-Tetra-O-galloyl-beta-D-glucose
CHEMBL449947
CHEMBL1159463
C060475
11 / 2 / 2 No. 226
C00002928 External link 512 Nilotinin D2
No. 226
C00002926 External link 512 Gemin C
No. 226
C00002912 External link 512 Woodfordin A
No. 226
C00002911 External link 512 Paeonianin C
No. 226
C00002910 External link 512 Paeonianin D
No. 226
C00002909 External link 512 Paeonianin B
No. 226
C00002908 External link 512 Paeonianin A
No. 226
C00035321 External link 512 Alnusiin
No. 226
C00035322 External link 512 5'-Desgalloylstachyurin
CHEMBL509562
CHEMBL488110
1 / 1 / 0 No. 226
C00049290 External link 512 3,3',4-Tri-O-methylflavellagic acid
CHEMBL509184
No. 226
C00049958 External link 512 Gallogen
/ Ellagic acid
/ Elagostasine
/ Alizarin yellow
CHEMBL6246
D004610
104 / 97 / 100 77 / 9 No. 226
C00050033 External link 512 3-O-Methylellagic acid
CHEMBL564351
No. 226
C00041050 External link 512 Prunasin 2',3',4',6'-tetra-O-gallate
/ (+)-Prunasin 2',3',4',6'-tetra-O-gallate
No. 226
C00035172 External link 512 Mallotusinic acid
No. 302
C00035171 External link 512 Carpinerin B
/ Rhoipteleanin H
No. 302
C00037615 External link 512 1,2,4,6-Tetra-O-galloyl-beta-D-glucose
CHEMBL449495
No. 302
C00031620 External link 512 Euphorbin A
No. 302
C00031618 External link 512 Nobotanin H
No. 302
C00014626 External link 512 Isorugosin D
No. 302
C00014625 External link 512 Agrimoniin
CHEMBL524674
C052420
No. 302
C00046334 External link 512 Phyllanemblinin A
/ (-)-Phyllanemblinin A
No. 302
C00009377 External link 512 Nobotanin F
No. 302
C00046458 External link 512 Gemin D
No. 302
C00035373 External link 512 Nilotinin M1
No. 302
C00035376 External link 512 Remurin B
No. 302
C00002938 External link 512 Rugosin F
No. 302
C00002933 External link 512 Oenothein B
C080077
No. 302
C00037508 External link 512 1,4,6-tri-O-Galloyl-beta-D-glucose
CHEMBL450636
CHEMBL1159462
11 / 2 / 2 No. 302
C00002920 External link 512 Brediatin B
No. 302
C00048495 External link 512 Castalin
No. 302
C00048525 External link 512 3,3'-Dimethoxyellagic acid
/ 3,3'-di-O-Methylellagic acid
CHEMBL487203
C050401
10 / 11 / 15 No. 302
C00048526 External link 512 Nasutin B
/ 3,3',4'-tri-O-methylellagic acid
CHEMBL451476
No. 302
C00036226 External link 512 1,3-Di-O-(E)-Caffeoyl-4-O-galloyl-beta-D-glucopyranose
No. 302
C00035704 External link 512 1-O-(E)-Caffeoyl-4,6-(S)-HHDP-beta-D-glucopyranose
No. 302
C00040860 External link 512 6-O-(E)-Caffeoyl-1,3,4-tri-O-galloyl-beta-D-glucopyranose
No. 302
C00045029 External link 512 5-Carboxyresorcinol
/ alpha-Resorcylic acid
/ 3,5-Dihydroxybenzoic acid
/ 3,5-Dihydroxy-benzoic acid
CHEMBL95308
C076950
10 / 2 / 4 No. 448
C00035455 External link 512 Thonningianin B
CHEMBL319853
CHEMBL509123
No. 448
C00035453 External link 512 Thonningianin A
CHEMBL510229
No. 448
C00035452 External link 512 Monacanthin A
No. 448
C00045028 External link 512 4-Hydroxybenzoic acid
/ p-Hydroxybenzoic acid
CHEMBL441343
C038193
21 / 7 / 16 2 / 1 No. 448
C00045027 External link 512 m-Hydroxybenzoic acid
CHEMBL65369
C032948
9 / 2 / 4 No. 448
C00037509 External link 512 1,4,6-Trigalloylglucose
CHEMBL450636
CHEMBL1159462
11 / 2 / 2 No. 448
C00035191 External link 512 Stachyurin
CHEMBL79244
CHEMBL507387
11 / 2 / 2 No. 448
C00024209 External link 512 Cornusiin E
No. 448
C00002940 External link 512 Gemin A
No. 448
C00032670 External link 512 Phyllanthusiin D
No. 448
C00032577 External link 512 Acalyphidin D1
No. 448
C00032652 External link 512 Geraniinic acid C
No. 448
C00032589 External link 512 Phyllanthusiin B
No. 448
C00032609 External link 512 Phyllanemblinin C
CHEMBL501660
No. 448
C00032611 External link 512 Acalyphidin M2
No. 448
C00002916 External link 512 Nobotanin R
No. 448
C00002668 External link 512 Camelliin B
C063356
No. 817
C00002669 External link 512 Woodfordin C
C065469
No. 817
C00048480 External link 512 1-O-(E)-Caffeoyl-3-O-galloyl-beta-D-glucopyranose
No. 817
C00032618 External link 512 Geraniinic acid B
No. 817
C00002648 External link 512 Woodfordin B
No. 817
C00040822 External link 512 1,2,3,4-Tetragalloyl-alpha-D-glucose
CHEMBL206385
No. 817
C00016318 External link 512 Rugosin D
CHEMBL454004
No. 817
C00033542 External link 512 Geraniin
CHEMBL506069
C024603
1 / 4 / 2 0 / 1 No. 817
C00002647 External link 512 Nilotinin D3
No. 817
C00000856 External link 512 Rugosin E
C106155
No. 817
C00000206 External link 512 Cornusiin D
No. 817
C00031619 External link 512 Nobotanin I
C063355
No. 818
C00046301 External link 512 Corilagin
CHEMBL449392
CHEMBL1425538
C049096
44 / 45 / 33 No. 818
C00046302 External link 512 Isostrictinin
No. 818
C00035668 External link 512 1-O-(E)-Caffeoyl-3,4-di-O-galloyl-beta-D-glucopyranose
No. 818
C00037173 External link 512 1,2,6-tri-O-Galloyl-beta-D-glucose
CHEMBL447974
11 / 2 / 2 No. 818
C00035393 External link 512 Punicafolin
CHEMBL507308
11 / 2 / 2 No. 818
C00032655 External link 512 Phyllanthusiin A
No. 818
C00042347 External link 512 beta-Resorcylic acid
/ 2,4-Dihydroxybenzoic acid
CHEMBL328910
C017704
23 / 17 / 17 No. 818
C00032610 External link 512 Chebulagic acid
CHEMBL525240
CHEMBL1970427
C076178
12 / 2 / 2 No. 818
C00032614 External link 512 Pelargoniin A
No. 818
C00002915 External link 512 Nobotanin G
No. 818
C00002678 External link 512 Tamarixinin A
No. 2068
C00044433 External link 512 Protocatechuic acid
/ 3,4-Dihydroxybenzoic acid
CHEMBL37537
C009091
33 / 19 / 19 2 / 0 No. 2068
C00029474 External link 512 Hirtellin A
No. 2068
C00011153 External link 512 Nobotanin B
C075603
No. 2068
C00011154 External link 512 Nobotanin B
C075603
No. 2068

Human Protein / Gene in interactions

260 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P17252 Protein kinase C alpha type Alpha C00000206 C00002910 C00002911 C00002912 C00002915 C00002933 C00032196 C00032577 C00035191 C00035453 C00035455 C00037615 C00042346 C00043104 C00046334 0 / 0
P05771 Protein kinase C beta type Alpha C00002910 C00002911 C00002912 C00002915 C00002933 C00032196 C00032577 C00035191 C00035453 C00035455 C00037615 C00042346 C00043104 C00046334 0 / 0
Q05513 Protein kinase C zeta type Iota C00002910 C00002911 C00002912 C00002915 C00002933 C00032196 C00032577 C00035191 C00035453 C00035455 C00037615 C00042346 C00043104 C00046334 0 / 0
Q02156 Protein kinase C epsilon type Eta C00002910 C00002911 C00002912 C00002915 C00002933 C00032196 C00032577 C00035191 C00035453 C00035455 C00037615 C00042346 C00043104 C00046334 0 / 0
Q05655 Protein kinase C delta type Delta C00002910 C00002911 C00002912 C00002915 C00002933 C00032196 C00032577 C00035191 C00035453 C00035455 C00037615 C00042346 C00043104 C00046334 0 / 0
P05129 Protein kinase C gamma type Alpha C00002910 C00002911 C00002912 C00002915 C00002933 C00032196 C00032577 C00035191 C00035453 C00035455 C00037615 C00042346 C00043104 C00046334 1 / 1
Q04759 Protein kinase C theta type Delta C00002910 C00002911 C00002912 C00002915 C00002933 C00032196 C00032577 C00035191 C00035453 C00035455 C00037615 C00042346 C00043104 C00046334 0 / 1
Q15139 Serine/threonine-protein kinase D1 Pkd C00002910 C00002911 C00002912 C00002915 C00002933 C00032196 C00032577 C00035191 C00035453 C00035455 C00037615 C00042346 C00043104 C00046334 0 / 0
P24723 Protein kinase C eta type Eta C00002910 C00002911 C00002912 C00002915 C00002933 C00032196 C00032577 C00035191 C00035453 C00035455 C00037615 C00042346 C00043104 C00046334 1 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00002910 C00002911 C00002912 C00002915 C00002933 C00032196 C00032577 C00035191 C00035453 C00035455 C00037615 C00042346 C00043104 C00046334 0 / 0
P41743 Protein kinase C iota type Iota C00002910 C00002911 C00002912 C00002915 C00002933 C00032196 C00032577 C00035191 C00035453 C00035455 C00037615 C00042346 C00043104 C00046334 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00000206 C00000856 C00002647 C00002648 C00002668 C00011153 C00016318 C00032618 C00033542 C00040822 C00048480 1 / 2
P00918 Carbonic anhydrase 2 Lyase C00000206 C00000856 C00002647 C00002648 C00002668 C00011153 C00016318 C00032618 C00033542 C00040822 C00048480 1 / 2
Q16790 Carbonic anhydrase 9 Lyase C00000206 C00000856 C00002647 C00002648 C00002668 C00011153 C00016318 C00032618 C00033542 C00040822 C00048480 0 / 1
P00915 Carbonic anhydrase 1 Lyase C00000206 C00000856 C00002647 C00002648 C00002668 C00011153 C00016318 C00032618 C00033542 C00040822 C00048480 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00000206 C00000856 C00002647 C00002648 C00002668 C00011153 C00016318 C00032618 C00033542 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00000206 C00000856 C00002647 C00002648 C00002668 C00011153 C00016318 C00032618 C00033542 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002647 C00002668 C00002912 C00002915 C00002933 C00011153 C00029474 C00037615 4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000206 C00002647 C00002668 C00002912 C00002933 C00011153 C00029474 C00037615 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000206 C00002648 C00002933 C00016318 C00037615 C00040822 C00048480 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00000206 C00000856 C00002647 C00002668 C00011153 C00040822 C00048480 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002647 C00002912 C00002915 C00002933 C00011153 C00029474 C00037615 0 / 0
P00742 Coagulation factor X S1A C00002920 C00002932 C00002933 C00036226 C00037615 C00049958 C00050033 1 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000206 C00002647 C00002915 C00002933 C00011153 C00029474 C00037615 2 / 2
Q01196 Runt-related transcription factor 1 Unclassified protein C00002668 C00002912 C00002915 C00002933 C00011153 C00037615 1 / 4
P08253 72 kDa type IV collagenase M10A C00000206 C00002648 C00002668 C00002669 C00032618 C00033542 1 / 3
P10253 Lysosomal alpha-glucosidase Hydrolase C00002668 C00002912 C00002915 C00002933 C00011153 C00037615 1 / 1
P22894 Neutrophil collagenase M10A C00000206 C00002648 C00002668 C00002669 C00032618 C00033542 0 / 0
P54132 Bloom syndrome protein Enzyme C00002912 C00002915 C00002933 C00011153 C00029474 C00037615 1 / 2
P06746 DNA polymerase beta Enzyme C00002668 C00002912 C00002915 C00002933 C00011153 C00037615 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00000206 C00002647 C00002915 C00002933 C00011153 C00037615 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00002668 C00002912 C00002915 C00002933 C00011153 C00037615 0 / 1
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00000206 C00002648 C00002668 C00002669 C00032618 C00033542 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002912 C00002915 C00002933 C00011153 C00029474 C00037615 1 / 2
P14780 Matrix metalloproteinase-9 M10A C00000206 C00002648 C00002668 C00002669 C00032618 C00033542 2 / 2
P08254 Stromelysin-1 M10A C00000206 C00002648 C00002668 C00002669 C00032618 C00033542 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000206 C00002647 C00002912 C00002933 C00011153 C00037615 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002647 C00002912 C00002933 C00011153 C00029474 C00037615 1 / 1
O75496 Geminin Unclassified protein C00000206 C00002668 C00002933 C00011153 C00033542 C00037615 0 / 0
P03956 Interstitial collagenase M10A C00000206 C00002648 C00002668 C00002669 C00032618 C00033542 0 / 1
P02545 Prelamin-A/C Unclassified protein C00002647 C00002915 C00002933 C00011153 C00037615 11 / 10
P22748 Carbonic anhydrase 4 Lyase C00000206 C00000856 C00002647 C00002668 C00011153 1 / 1
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00002912 C00002915 C00002933 C00011153 C00037615 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002647 C00002915 C00002933 C00011153 C00037615 0 / 0
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein C00002912 C00002915 C00002933 C00011153 C00037615 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00002912 C00002915 C00002933 C00011153 C00037615 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00002912 C00002933 C00011153 C00029474 C00037615 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00002912 C00002933 C00011153 C00037615 3 / 1
Q16637 Survival motor neuron protein Unclassified protein C00000206 C00002647 C00002933 C00037615 4 / 1
P07451 Carbonic anhydrase 3 Lyase C00000206 C00000856 C00002647 C00011153 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00002668 C00002915 C00002933 C00037615 0 / 0
O00255 Menin Unclassified protein C00002933 C00011153 C00029474 C00037615 2 / 5
P00352 Retinal dehydrogenase 1 Enzyme C00000206 C00002647 C00029474 C00033542 0 / 0
P15121 Aldose reductase Enzyme C00000206 C00002647 C00002668 C00011153 0 / 0
P02768 Serum albumin Secreted protein C00000206 C00002668 C00002669 C00016318 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00002648 C00002668 C00002915 C00011153 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002647 C00002668 C00011153 C00033542 0 / 0
P12821 Angiotensin-converting enzyme M2 C00002647 C00002915 C00002926 C00011153 4 / 2
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000206 C00000856 C00002647 C00011153 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000206 C00000856 C00002647 C00011153 0 / 0
Q9UQ49 Sialidase-3 Enzyme C00000856 C00040822 C00048480 0 / 0
P14151 L-selectin Adhesion C00002647 C00002668 C00002669 0 / 0
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00016318 C00040822 C00048480 0 / 0
P03372 Estrogen receptor NR3A1 C00000206 C00002647 C00002668 1 / 1
P16581 E-selectin Adhesion C00002647 C00002668 C00002669 0 / 0
P16109 P-selectin Adhesion C00002647 C00002668 C00002669 1 / 0
Q9BXC0 Hydroxycarboxylic acid receptor 1 Hydroxycarboxylic acid receptor C00016318 C00040822 C00048480 0 / 0
P04406 Glyceraldehyde-3-phosphate dehydrogenase Enzyme C00002647 C00002915 C00011153 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000206 C00000856 C00011153 1 / 8
P06213 Insulin receptor TK tyrosine-protein kinase INSR subfamily C00002933 C00011153 C00037615 5 / 4
O75164 Lysine-specific demethylase 4A Enzyme C00002669 C00002915 C00011153 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002647 C00002915 C00033542 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00002648 C00011153 C00033542 0 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00002647 C00011153 2 / 3
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00002912 C00011153 1 / 0
P11387 DNA topoisomerase 1 Isomerase C00002911 C00002915 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00002647 C00011153 2 / 3
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00002933 C00037615 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00000206 C00011153 5 / 9
P56817 Beta-secretase 1 A1A C00002933 C00037615 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00000206 C00002647 0 / 1
P03951 Coagulation factor XI S1A C00002933 C00037615 1 / 1
Q4U2R8 Solute carrier family 22 member 6 Antiporter C00000206 C00011153 0 / 0
P17706 Tyrosine-protein phosphatase non-receptor type 2 Tyr C00002933 C00037615 0 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00002647 C00011153 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00011153 C00033542 1 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00002915 C00011153 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000206 C00011153 1 / 1
Q06124 Tyrosine-protein phosphatase non-receptor type 11 Tyr C00002933 C00037615 4 / 2
P04062 Glucosylceramidase Enzyme C00002933 C00037615 6 / 4
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002647 C00011153 3 / 3
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00002647 C00002668 3 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000206 C00002647 0 / 3
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000206 C00011153 0 / 1
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00000206 C00000856 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00002915 C00011153 2 / 0
Q9NSA0 Solute carrier family 22 member 11 Transporter C00000206 C00011153 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00002915 C00011153 2 / 0
P42858 Huntingtin Unclassified protein C00002933 C00037615 1 / 1
P10586 Receptor-type tyrosine-protein phosphatase F Receptor tyrosine-protein phosphatase C00002933 C00037615 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00002647 C00011153 7 / 37
P39748 Flap endonuclease 1 Enzyme C00002915 C00011153 0 / 0
P11142 Heat shock cognate 71 kDa protein Unclassified protein C00011153 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000206 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00011153 1 / 1
P17405 Sphingomyelin phosphodiesterase Enzyme C00002915 2 / 2
Q8TCC7 Solute carrier family 22 member 8 Antiporter C00000206 0 / 0
P68871 Hemoglobin subunit beta Secreted protein C00011153 4 / 4
P41968 Melanocortin receptor 3 Melanocortin receptor C00000206 1 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00000206 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00000206 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00000206 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00000206 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00000206 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000206 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00000206 0 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00000206 0 / 0
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00000206 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00011153 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00000206 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00000206 0 / 0
P10145 Interleukin-8 Secreted protein C00002647 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00000206 1 / 0
O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta Other serine/threonine protein kinase C00000206 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00011153 0 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00000206 0 / 0
P08311 Cathepsin G S1A C00000206 0 / 0
P07711 Cathepsin L1 C1A C00002668 0 / 0
Q05397 Focal adhesion kinase 1 Fak C00011153 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00000206 1 / 0
P09211 Glutathione S-transferase P Enzyme C00011153 0 / 1
Q02763 Angiopoietin-1 receptor Tie C00011153 1 / 1
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00000206 1 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00000206 0 / 0
P15056 Serine/threonine-protein kinase B-raf Raf C00011153 6 / 3
P08107 Heat shock 70 kDa protein 1A/1B Unclassified protein C00011153 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00011153 1 / 1
O60285 NUAK family SNF1-like kinase 1 CAMK serine/threonine protein kinase NUAK subfamily C00011153 0 / 0
P05067 Amyloid beta A4 protein Membrane receptor C00000206 2 / 2
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00000206 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00000206 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00000206 0 / 0
P98073 Enteropeptidase Enzyme C00002915 1 / 1
P11021 78 kDa glucose-regulated protein Unclassified protein C00011153 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00011153 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000206 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00000206 0 / 0
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00000206 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00000206 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00000206 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00000206 2 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00033542 5 / 3
P80404 4-aminobutyrate aminotransferase, mitochondrial Transferase C00000856 1 / 1
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000206 0 / 0
P09619 Platelet-derived growth factor receptor beta Pdgfr C00011153 5 / 1
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00000206 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00000206 0 / 0
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00011153 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00000206 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00000206 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00000206 0 / 0
Q96GD4 Aurora kinase B Aur C00011153 0 / 0
P35968 Vascular endothelial growth factor receptor 2 Vegfr C00011153 1 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00000206 2 / 0
Q9HAW7 UDP-glucuronosyltransferase 1-7 Enzyme C00000856 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00000206 1 / 0
Q9HC97 G-protein coupled receptor 35 Kynurenic acid receptor C00011153 0 / 0
P35916 Vascular endothelial growth factor receptor 3 Vegfr C00011153 2 / 1
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00000206 2 / 1
Q9GZT9 Egl nine homolog 1 Enzyme C00002668 1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000206 0 / 0
P00390 Glutathione reductase, mitochondrial Oxidoreductase C00011153 0 / 0
P24385 G1/S-specific cyclin-D1 Other cytosolic protein C00011153 1 / 8
P11802 Cyclin-dependent kinase 4 CMGC serine/threonine protein kinase family C00011153 1 / 3
P41279 Mitogen-activated protein kinase kinase kinase 8 Ste11 C00011153 0 / 0
O00444 Serine/threonine-protein kinase PLK4 PLK serine/threonine protein kinase subfamily C00011153 0 / 0
P08236 Beta-glucuronidase Enzyme C00000206 1 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00033542 0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00000856 0 / 0
P06133 UDP-glucuronosyltransferase 2B4 Enzyme C00000206 0 / 0
P36537 UDP-glucuronosyltransferase 2B10 Enzyme C00000206 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00000206 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00000206 0 / 0
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00000206 1 / 0
P06241 Tyrosine-protein kinase Fyn Src C00000206 0 / 0
P22303 Acetylcholinesterase Hydrolase C00000206 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00000206 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00000206 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00000206 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00000206 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00000206 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00000206 0 / 0
P53350 Serine/threonine-protein kinase PLK1 PLK serine/threonine protein kinase subfamily C00011153 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00000206 0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00011153 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00011153 0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt C00011153 4 / 1
P51580 Thiopurine S-methyltransferase Enzyme C00000856 1 / 1
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00000206 0 / 0
P78536 Disintegrin and metalloproteinase domain-containing protein 17 M12B C00002647 1 / 0
P08183 Multidrug resistance protein 1 drug C00000206 1 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000206 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00000206 0 / 0
P07949 Proto-oncogene tyrosine-protein kinase receptor Ret Ret C00011153 9 / 4
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00011153 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00000206 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00000206 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00002647 5 / 1
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00000206 0 / 0
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00000856 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00000206 1 / 0
P10275 Androgen receptor NR3C4 C00033542 3 / 4
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00000206 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00000206 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00000206 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00000206 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00000206 1 / 1
P35367 Histamine H1 receptor Histamine receptor C00000206 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00000206 0 / 1
P25021 Histamine H2 receptor Histamine receptor C00000206 0 / 0
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00000206 0 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00000206 1 / 1
Q13627 Dual specificity tyrosine-phosphorylation-regulated kinase 1A CMGC dual-specificity kinase DYRK1 C00011153 1 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00000206 0 / 1
P68400 Casein kinase II subunit alpha Ck2 C00011153 0 / 0
Q9UHC3 Acid-sensing ion channel 3 Unclassified protein C00000206 0 / 0
P54760 Ephrin type-B receptor 4 Eph C00011153 0 / 0
P51649 Succinate-semialdehyde dehydrogenase, mitochondrial Oxidoreductase C00000856 1 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00033542 3 / 2
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily C00011153 1 / 4
O14965 Aurora kinase A Aur C00011153 0 / 0
P55072 Transitional endoplasmic reticulum ATPase Unclassified protein C00002915 2 / 1
Q8N1Q1 Carbonic anhydrase 13 Lyase C00011153 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00033542 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00000206 0 / 0
P29466 Caspase-1 C14 C00000206 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00000206 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00000206 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00000206 0 / 0
P08246 Neutrophil elastase S1A C00000206 2 / 1
P08069 Insulin-like growth factor 1 receptor TK tyrosine-protein kinase INSR subfamily C00011153 1 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000206 2 / 2
P21728 D(1A) dopamine receptor Dopamine receptor C00000206 0 / 0
P14618 Pyruvate kinase PKM Enzyme C00002912 0 / 0
Q99700 Ataxin-2 Unclassified protein C00002669 1 / 1
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00000856 0 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00000206 0 / 0
P20248 Cyclin-A2 Other cytosolic protein C00011153 0 / 0
P78396 Cyclin-A1 Other cytosolic protein C00011153 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00011153 0 / 0
P22694 cAMP-dependent protein kinase catalytic subunit beta Pka C00011153 0 / 0
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka C00011153 0 / 0
P22612 cAMP-dependent protein kinase catalytic subunit gamma Pka C00011153 0 / 0
P19429 Troponin I, cardiac muscle Unclassified protein C00002915 4 / 4
P45379 Troponin T, cardiac muscle Unclassified protein C00002915 3 / 5
P63316 Troponin C, slow skeletal and cardiac muscles Other cytosolic protein C00002915 2 / 2
Q9UM73 ALK tyrosine kinase receptor TKL serine/threonine protein kinase STKR type 1 subfamily C00011153 1 / 1
P06748 Nucleophosmin Other nuclear protein C00011153 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000206 1 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00002915 2 / 1

152 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00002647 C00002669 C00011153
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00000856 C00002647 C00002648
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00002647 C00002933 C00011153
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00002647 C00011153
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00002647 C00011153
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00002933 C00011153
4778 NFE2, NF-E2, p45 nuclear factor, erythroid 2 C00002912 C00002938
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00002647 C00011153
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00002647 C00002933
3145 HMBS, PBG-D, PBGD, PORC, UPS hydroxymethylbilane synthase (EC:2.5.1.61) C00002912 C00002938
2993 GYPA, CD235a, GPA, GPErik, GPSAT, HGpMiV, HGpMiXI, HGpSta(C), MN, MNS, PAS-2 glycophorin A (MNS blood group) C00002912 C00002938
43 ACHE, ACEE, ARACHE, N-ACHE, YT acetylcholinesterase (EC:3.1.1.7) C00002912 C00002938
2623 GATA1, ERYF1, GATA-1, GF-1, GF1, NF-E1, NFE1, XLANP, XLTDA, XLTT GATA binding protein 1 (globin transcription factor 1) C00002912 C00002938
2624 GATA2, DCML, MONOMAC, NFE1B GATA binding protein 2 C00002912 C00002938
5604 MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) C00002647
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00002933
3690 ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) C00002938
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00002933
55 ACPP, 5'-NT, ACP-3, ACP3, PAP acid phosphatase, prostate (EC:3.1.3.2 3.1.3.5) C00011153
213 ALB, PRO0883, PRO0903, PRO1341 albumin C00011153
317 APAF1, APAF-1, CED4 apoptotic peptidase activating factor 1 C00011153
429 ASCL1, ASH1, HASH1, MASH1, bHLHa46 achaete-scute family bHLH transcription factor 1 C00011153
440 ASNS, TS11 asparagine synthetase (glutamine-hydrolyzing) (EC:6.3.5.4) C00011153
467 ATF3 activating transcription factor 3 C00011153
9474 ATG5, APG5, APG5-LIKE, APG5L, ASP, hAPG5 autophagy related 5 C00011153
2539 G6PD, G6PD1 glucose-6-phosphate dehydrogenase (EC:1.1.1.49) C00002648
654 BMP6, VGR, VGR1 bone morphogenetic protein 6 C00011153
2972 BRF1, BRF, BRF-1, GTF3B, TAF3B2, TAF3C, TAFIII90, TF3B90, TFIIIB90, hBRF BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit C00011153
811 CALR, CRT, RO, SSA, cC1qR calreticulin C00011153
1312 COMT catechol-O-methyltransferase (EC:2.1.1.6) C00002668
929 CD14 CD14 molecule C00011153
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00011153
1616 DAXX, BING2, DAP6, EAP1 death-domain associated protein C00011153
1676 DFFA, DFF-45, DFF1, ICAD DNA fragmentation factor, 45kDa, alpha polypeptide C00011153
1877 E4F1, E4F E4F transcription factor 1 C00011153
1960 EGR3, EGR-3, PILOT early growth response 3 C00011153
2033 EP300, KAT3B, RSTS2, p300 E1A binding protein p300 (EC:2.3.1.48) C00011153
2060 EPS15, AF-1P, AF1P, MLLT5 epidermal growth factor receptor pathway substrate 15 C00011153
2145 EZH1, KMT6B enhancer of zeste homolog 1 (Drosophila) (EC:2.1.1.43) C00011153
2161 F12, HAE3, HAEX, HAF coagulation factor XII (Hageman factor) (EC:3.4.21.38) C00011153
2260 FGFR1, BFGFR, CD331, CEK, FGFBR, FGFR-1, FLG, FLT-2, FLT2, HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD, bFGF-R-1 fibroblast growth factor receptor 1 (EC:2.7.10.1) C00011153
2316 FLNA, ABP-280, ABPX, CSBS, CVD1, FLN, FLN-A, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2, XLVD, XMVD filamin A, alpha C00011153
2822 GPLD1, GPIPLD, GPIPLDM, PIGPLD, PIGPLD1 glycosylphosphatidylinositol specific phospholipase D1 (EC:3.1.4.50) C00011153
2941 GSTA4, GSTA4-4, GTA4 glutathione S-transferase alpha 4 (EC:2.5.1.18) C00011153
2961 GTF2E2, FE, TF2E2, TFIIE-B general transcription factor IIE, polypeptide 2, beta 34kDa C00011153
2968 GTF2H4, P52, TFB2, TFIIH general transcription factor IIH, polypeptide 4, 52kDa C00011153
3091 HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) C00011153
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00011153
9592 IER2, ETR101 immediate early response 2 C00011153
3485 IGFBP2, IBP2, IGF-BP53 insulin-like growth factor binding protein 2, 36kDa C00011153
3487 IGFBP4, BP-4, HT29-IGFBP, IBP4, IGFBP-4 insulin-like growth factor binding protein 4 C00011153
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00011153
3554 IL1R1, CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80 interleukin 1 receptor, type I C00011153
2023 ENO1, ENO1L1, MPB1, NNE, PPH enolase 1, (alpha) (EC:4.2.1.11) C00002668
3635 INPP5D, SHIP, SHIP-1, SHIP1, SIP-145, hp51CN inositol polyphosphate-5-phosphatase, 145kDa (EC:3.1.3.86) C00011153
10788 IQGAP2 IQ motif containing GTPase activating protein 2 C00011153
10379 IRF9, IRF-9, ISGF3, ISGF3G, p48 interferon regulatory factor 9 C00011153
354 KLK3, APS, KLK2A1, PSA, hK3 kallikrein-related peptidase 3 (EC:3.4.21.77) C00011153
9516 LITAF, PIG7, SIMPLE, TP53I7 lipopolysaccharide-induced TNF factor C00011153
4130 MAP1A, MAP1L, MTAP1A microtubule-associated protein 1A C00011153
23531 MMD, MMA, MMD1, PAQR11 monocyte to macrophage differentiation-associated C00011153
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00011153
4791 NFKB2, H2TF1, LYT-10, LYT10, NF-kB2, p105, p52 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) C00011153
4826 NNAT, Peg5 neuronatin C00011153
10528 NOP56, NOL5A, SCA36 NOP56 ribonucleoprotein C00011153
4862 NPAS2, MOP4, PASD4, bHLHe9 neuronal PAS domain protein 2 C00011153
9970 NR1I3, CAR, CAR1, MB67 nuclear receptor subfamily 1, group I, member 3 C00011153
8505 PARG, PARG99 poly (ADP-ribose) glycohydrolase (EC:3.2.1.143) C00011153
5320 PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2 phospholipase A2, group IIA (platelets, synovial fluid) (EC:3.1.1.4) C00011153
5355 PLP2, A4, A4LSB proteolipid protein 2 (colonic epithelium-enriched) C00011153
5371 PML, MYL, PP8675, RNF71, TRIM19 promyelocytic leukemia C00011153
5467 PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB peroxisome proliferator-activated receptor delta C00011153
5592 PRKG1, 1, AAT8, PKG, PRKG1B, PRKGR1B, cGK, cGK_1, cGK1, cGKI, cGKI-BETA, cGKI-alpha protein kinase, cGMP-dependent, type I (EC:2.7.11.12) C00011153
5764 PTN, HARP, HBGF8, HBNF, NEGF1 pleiotrophin C00011153
5799 PTPRN2, IA-2beta, IAR, ICAAR, PTPRP, R-PTP-N2 protein tyrosine phosphatase, receptor type, N polypeptide 2 (EC:3.1.3.48) C00011153
5901 RAN, ARA24, Gsp1, TC4 RAN, member RAS oncogene family C00011153
8434 RECK, ST15 reversion-inducing-cysteine-rich protein with kazal motifs C00011153
8490 RGS5, MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129 regulator of G-protein signaling 5 C00011153
6319 SCD, FADS5, MSTP008, SCD1, SCDOS stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) C00011153
4735 SEPT2, DIFF6, NEDD-5, NEDD5, Pnutl3, hNedd5 septin 2 C00011153
6649 SOD3, EC-SOD superoxide dismutase 3, extracellular (EC:1.15.1.1) C00011153
6774 STAT3, APRF, HIES signal transducer and activator of transcription 3 (acute-phase response factor) C00011153
9013 TAF1C, MGC:39976, SL1, TAFI110, TAFI95 TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa C00011153
6938 TCF12, CRS3, HEB, HTF4, HsT17266, bHLHb20 transcription factor 12 C00011153
7015 TERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT telomerase reverse transcriptase (EC:2.7.7.49) C00011153
7019 TFAM, MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3 transcription factor A, mitochondrial C00011153
7040 TGFB1, CED, DPD1, LAP, TGFB, TGFbeta transforming growth factor, beta 1 C00011153
7360 UGP2, UDPG, UDPGP, UDPGP2, UGP1, UGPP1, UGPP2, pHC379 UDP-glucose pyrophosphorylase 2 (EC:2.7.7.9) C00011153
7375 USP4, UNP, Unph ubiquitin specific peptidase 4 (proto-oncogene) (EC:3.4.19.12) C00011153
7453 WARS, GAMMA-2, IFI53, IFP53 tryptophanyl-tRNA synthetase (EC:6.1.1.2) C00011153
7704 ZBTB16, PLZF, ZNF145 zinc finger and BTB domain containing 16 C00011153
7750 ZMYM2, FIM, MYM, RAMP, SCLL, ZNF198 zinc finger, MYM-type 2 C00011153
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00002647
25 ABL1, ABL, JTK7, bcr/abl, c-ABL, p150, v-abl c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) C00002647
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00002647
338 APOB, FLDB, LDLCQ4 apolipoprotein B C00002647
472 ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 ataxia telangiectasia mutated (EC:2.7.11.1) C00002647
545 ATR, FCTCS, FRP1, MEC1, SCKL, SCKL1 ataxia telangiectasia and Rad3 related (EC:2.7.11.1) C00002647
581 BAX, BCL2L4 BCL2-associated X protein C00002647
613 BCR, ALL, BCR1, CML, D22S11, D22S662, PHL breakpoint cluster region (EC:2.7.11.1) C00002647
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00002647
898 CCNE1, CCNE cyclin E1 C00002647
998 CDC42, CDC42Hs, G25K cell division cycle 42 C00002647
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00002647
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00002647
1147 CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16 conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) C00002647
7852 CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM chemokine (C-X-C motif) receptor 4 C00002647
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00002647
356 FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 Fas ligand (TNF superfamily, member 6) C00002647
2551 GABPA, E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07 GA binding protein transcription factor, alpha subunit 60kDa C00002647
2885 GRB2, ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2 growth factor receptor-bound protein 2 C00002647
3551 IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) C00002647
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00002647
3949 LDLR, FH, FHC, LDLCQ2 low density lipoprotein receptor C00002647
3952 LEP, LEPD, OB, OBS leptin C00000856
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00002647
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00002647
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00002647
5601 MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK mitogen-activated protein kinase 9 (EC:2.7.11.24) C00002647
4255 MGMT O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) C00002647
4316 MMP7, MMP-7, MPSL1, PUMP-1 matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23) C00002647
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00002647
4793 NFKBIB, IKBB, TRIP9 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta C00002647
5578 PRKCA, AAG6, PKC-alpha, PKCA, PRKACA protein kinase C, alpha (EC:2.7.11.13) C00002647
5591 PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350 protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1) C00002647
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00002647
5879 RAC1, Rac-1, TC-25, p21-Rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) C00002647
19412 C00002647
387 RHOA, ARH12, ARHA, RHO12, RHOH12 ras homolog family member A C00002647
388 RHOB, ARH6, ARHB, MST081, MSTP081, RHOH6 ras homolog family member B C00002647
6195 RPS6KA1, HU-1, MAPKAPK1A, RSK, RSK1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 (EC:2.7.11.1) C00002647
9252 RPS6KA5, MSK1, MSPK1, RLPK ribosomal protein S6 kinase, 90kDa, polypeptide 5 (EC:2.7.11.1) C00002647
6622 SNCA, NACP, PARK1, PARK4, PD1 synuclein, alpha (non A4 component of amyloid precursor) C00002647
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00002647
7224 TRPC5, TRP5 transient receptor potential cation channel, subfamily C, member 5 C00002647
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00002647
331 XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 X-linked inhibitor of apoptosis C00002647
1645 AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) C00000206
1646 AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8 aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) C00000206
8644 AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) C00000206
3565 IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 interleukin 4 C00000206
23764 MAFF, U-MAF, hMafF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F C00000206
4489 MT1A, MT1, MT1S, MTC metallothionein 1A C00000206
55867 SLC22A11, OAT4, hOAT4 solute carrier family 22 (organic anion/urate transporter), member 11 C00000206
9356 SLC22A6, HOAT1, OAT1, PAHT, ROAT1 solute carrier family 22 (organic anion transporter), member 6 C00000206
10864 SLC22A7, NLT, OAT2 solute carrier family 22 (organic anion transporter), member 7 C00000206
114571 SLC22A9, HOAT4, OAT4, OAT7, UST3H, ust3 solute carrier family 22 (organic anion transporter), member 9 C00000206
7295 TXN, TRDX, TRX, TRX1 thioredoxin C00000206
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00000206
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00000206
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00000206
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00000206

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (187)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103780 Alcohol dependence P08172
P14416
P31645
#104300 Alzheimer disease; ad P05067
#613954 Amyotrophic lateral sclerosis 14, with or without frontotemporal dementia; als14 P55072
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#600807 Asthma, susceptibility to Q13093
#208900 Ataxia-telangiectasia; at Q13315
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#615007 Basal ganglia calcification, idiopathic, 4; ibgc4 P09619
#613985 Beta-thalassemia P68871
#603902 Beta-thalassemia, dominant inclusion body type P68871
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#210900 Bloom syndrome; blm P54132
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
%606641 Body mass index; bmi P37231
#114480 Breast cancer P31749
#300615 Brunner syndrome P21397
#115150 Cardiofaciocutaneous syndrome 1; cfc1 P15056
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#601494 Cardiomyopathy, dilated, 1d; cmd1d P45379
#613286 Cardiomyopathy, dilated, 1ff; cmd1ff P19429
#611879 Cardiomyopathy, dilated, 1z; cmd1z P63316
#611880 Cardiomyopathy, dilated, 2a; cmd2a P19429
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#613243 Cardiomyopathy, familial hypertrophic, 13; cmh13 P63316
#115195 Cardiomyopathy, familial hypertrophic, 2; cmh2 P45379
#613690 Cardiomyopathy, familial hypertrophic, 7; cmh7 P19429
#115210 Cardiomyopathy, familial restrictive, 1; rcm1 P19429
#612422 Cardiomyopathy, familial restrictive, 3; rcm3 P45379
#609338 Carotid intimal medial thickness 1 P37231
#209880 Central hypoventilation syndrome, congenital; cchs P07949
#605714 Cerebral amyloid angiopathy, app-related P05067
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P07949
P15056
P18054
P31749
P84022
Q14191
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#615109 Cowden syndrome 6; cws6 P31749
#218800 Crigler-najjar syndrome, type i P22309
#606785 Crigler-najjar syndrome, type ii P22309
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#610549 Diabetes mellitus, insulin-resistant, with acanthosis nigricans P06213
#125853 Diabetes mellitus, noninsulin-dependent; niddm P06213
#119900 Digital clubbing, isolated congenital P15428
#246200 Donohue syndrome P06213
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#226200 Enterokinase deficiency P98073
#609820 Erythrocytosis, familial, 3; ecyt3 Q9GZT9
#133239 Esophageal cancer P04637
P18054
#615363 Estrogen resistance; estrr P03372
#227600 Factor x deficiency P00742
#612416 Factor xi deficiency P03951
#600274 Frontotemporal dementia; ftd P10636
#613163 Gaba-transaminase deficiency P80404
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22309
#137800 Glioma susceptibility 1; glm1 O75874
P04626
P37231
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#140700 Heinz body anemias P68871
#602089 Hemangioma, capillary infantile P35916
P35968
#614519 Hemorrhage, intracerebral, susceptibility to; ich P12821
#114550 Hepatocellular carcinoma P08581
#142623 Hirschsprung disease, susceptibility to, 1; hscr1 P07949
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#609968 Hyperinsulinemic hypoglycemia, familial, 5; hhf5 P06213
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#167320 Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1; ibmpfd1 P55072
#612244 Inflammatory bowel disease 13; ibd13 P08183
#614328 Inflammatory skin and bowel disease, neonatal; nisbd P78536
#270450 Insulin-like growth factor i, resistance to P08069
#603932 Intervertebral disc disease; idd P14780
#607785 Juvenile myelomonocytic leukemia; jmml P09619
Q06124
#151100 Leopard syndrome 1 Q06124
#613707 Leopard syndrome 3 P15056
#601626 Leukemia, acute myeloid; aml P09619
P36888
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
P15056
#153100 Lymphedema, hereditary, ia P35916
#605027 Lymphoma, non-hodgkin, familial P15056
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#609048 Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 P11802
#614104 Mental retardation, autosomal dominant 7; mrd7 Q13627
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#156250 Metachondromatosis; metcds Q06124
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#612624 Microvascular complications of diabetes, susceptibility to, 3; mvcd3 P12821
#253220 Mucopolysaccharidosis, type vii; mps7 P08236
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#171400 Multiple endocrine neoplasia, type iia; men2a P07949
#162300 Multiple endocrine neoplasia, type iib; men2b P07949
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#254500 Myeloma, multiple P24385
#131440 Myeloproliferative disorder, chronic, with eosinophilia P09619
#159900 Myoclonic dystonia P14416
#228550 Myofibromatosis, infantile, 1; imf1 P09619
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#613014 Neuroblastoma, susceptibility to, 3; nblst3 Q9UM73
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#163950 Noonan syndrome 1; ns1 Q06124
#613706 Noonan syndrome 7; ns7 P15056
#601665 Obesity P32245
P37231
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#171300 Pheochromocytoma P07949
#172700 Pick disease of brain P10636
#262190 Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities P06213
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#176920 Proteus syndrome P31749
#191830 Renal adysplasia P07949
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#267430 Renal tubular dysgenesis; rtd P12821
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#603903 Sickle cell anemia P68871
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#605361 Spinocerebellar ataxia 14; sca14 P05129
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P12821
P16109
P24723
#271980 Succinic semialdehyde dehydrogenase deficiency; ssadhd P51649
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#610460 Thiopurine s-methyltransferase deficiency P51580
#155240 Thyroid carcinoma, familial medullary; mtc P07949
#188550 Thyroid carcinoma, papillary P07949
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#600195 Venous malformations, multiple cutaneous and mucosal; vmcm Q02763
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#610379 West nile virus, susceptibility to P51681
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (142)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
P04637 (marker)
P08581 (related)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
P24385 (related)
P24385 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P24385 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
P08581 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
P68871 (marker)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
P08253 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
P11802 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
P09619 (related)
P11802 (related)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
P24385 (related)
P24385 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
P19429 (related)
P45379 (related)
P63316 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
P45379 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00938 Factor XI deficiency P03951 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
P24385 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P08581 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
Q13315 (related)
H00006 Hairy-cell leukemia P04637 (related)
P24385 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
P24385 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
Q9UM73 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
P08069 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
P68871 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P08253 (related)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P07949 (related)
P07949 (marker)
P15056 (related)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
P11802 (related)
P15056 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
P24385 (marker)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00056 Alzheimer's disease (AD) P05067 (related)
H01185 Cerebral amyloid angiopathy (CAA) P05067 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q99700 (related)
Q9NUW8 (related)
H00719 Leprechaunism P06213 (related)
H00942 Rabson-Mendenhall syndrome P06213 (related)
H01228 Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) P06213 (related)
H01267 Familial hyperinsulinemic hypoglycemia (HHF) P06213 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00822 Renal agenesis and Renal adysplasia P07949 (related)
H00910 Hirschsprung disease (HD) P07949 (related)
H00916 Congenital central hypoventilation syndrome (CCHS) P07949 (related)
H00050 Synovial sarcoma P08069 (related)
H01274 Growth delay due to insulin-like growth factor I resistance P08069 (related)
H00132 Mucopolysaccharidosis type VII (MPS7) P08236 (related)
H00421 Mucopolysaccharidosis (MPS) P08236 (related)
H00100 Neutropenic disorders P08246 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00024 Prostate cancer P09211 (related)
P09211 (marker)
P10275 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
P55072 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00083 Allograft rejection P12821 (related)
H00575 Renal tubular dysgenesis P12821 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00523 Noonan syndrome and related disorders P15056 (related)
Q06124 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00408 Type I diabetes mellitus P17706 (related)
Q04759 (related)
H00292 Hypertrophic cardiomyopathy (HCM) P19429 (related)
P45379 (related)
P63316 (related)
H01219 Restrictive cardiomyopathy (RCM) P19429 (related)
P45379 (related)
H00295 Viral myocarditis P19429 (marker)
P45379 (marker)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00559 von Hippel-Lindau syndrome P24385 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00535 Lymphedemas P35916 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00409 Type II diabetes mellitus P37231 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00964 Thiopurine S-methyltransferase deficiency (TPMT deficiency) P51580 (related)
H00835 Succinic semialdehyde dehydrogenase (SSADH) deficiency P51649 (related)
H00094 DNA repair defects P54132 (related)
Q13315 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00228 Thalassemia P68871 (related)
H00229 Sickle cell anemia (SCA) P68871 (related)
H01257 GABA-transaminase deficiency P80404 (related)
H00988 Enterokinase deficiency P98073 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00531 Venous malformations Q02763 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H01018 Metachondromatosis Q06124 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00236 Congenital polycythemia Q9GZT9 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

41 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D034381 Hearing Loss C00002669
C00000206
D009203 Myocardial Infarction C00011153
C00002647
D012878 Skin Neoplasms C00002926
C00011153
D006943 Hyperglycemia C00002647
D006461 Hemolysis C00002648
D007674 Kidney Diseases C00002669
D012220 Rhinitis C00000856
D000014 Abnormalities, Drug-Induced C00011153
D002471 Cell Transformation, Neoplastic C00011153
D006965 Hyperplasia C00011153
D007248 Infertility, Male C00011153
D058186 Acute Kidney Injury C00002669
D015427 Reperfusion Injury C00011153
D013471 Sunburn C00011153
D013733 Testicular Diseases C00011153
D003921 Diabetes Mellitus, Experimental C00002647
D050171 Dyslipidemias C00002647
D005234 Fatty Liver C00002647
D018149 Glucose Intolerance C00002647
D006937 Hypercholesterolemia C00002647
D015837 Vestibular Diseases C00002669
D006949 Hyperlipidemias C00002647
D015228 Hypertriglyceridemia C00002647
D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive C00002647
D008546 Melanoma, Experimental C00002647
D009069 Movement Disorders C00002647
D009361 Neoplasm Invasiveness C00002647
D009362 Neoplasm Metastasis C00002647
D012516 Osteosarcoma C00002647
D010182 Pancreatic Diseases C00002647
D001249 Asthma C00000206
D003128 COMA C00000206
D004342 Drug Hypersensitivity C00000206
D006685 Hoarseness C00000206
D007819 Laryngeal Edema C00000206
D009668 Nose Diseases C00000206
D049188 Prenatal Injuries C00000206
D012640 Seizures C00000206
D014012 Tinnitus C00000206
D014581 Urticaria C00000206
D014860 Warts C00000206