PCIDB

KCF-S cluster No. 817 (11 metabolites)

Corresponding Phytochemical cluster No. 81

KEGG BRITE br08003 External link 512

Categories (1)

br08003 Category # of metabolite
Galloyl derivatives 1

metabolites link (1)

br08003 Category KEGG ID KNApSAcK ID
Galloyl derivatives C01424 C00002647

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		figure
C00000206 External link 512 Saligel
/ Salonil
/ Salicylic acid
/ 2-Carboxyphenol
/ o-Hydroxybenzoic acid
CHEMBL424
D020156
124 / 50 / 42 15 / 12
C00000856 External link 512 4-Hydroxybenzoic acid
/ p-Hydroxybenzoic acid
CHEMBL441343
C038193
21 / 7 / 16 2 / 1
C00002647 External link 512 Gallic acid
CHEMBL288114
D005707
42 / 53 / 68 52 / 16
C00002648 External link 512 Gentisic acid
/ 2,5-Dihydroxybenzoic acid
CHEMBL1461
C010925
15 / 6 / 8 2 / 1
C00002668 External link 512 Protocatechuic acid
/ 3,4-Dihydroxybenzoic acid
CHEMBL37537
C009091
33 / 19 / 19 2 / 0
C00002669 External link 512 Pyrocatechuic acid
/ o-Pyrocatechuic acid
/ 2,3-Dihydroxybenzoic acid
CHEMBL1432
C009135
12 / 6 / 5 1 / 4
C00016318 External link 512 5-Carboxyresorcinol
/ alpha-Resorcylic acid
/ 3,5-Dihydroxybenzoic acid
/ 3,5-Dihydroxy-benzoic acid
CHEMBL95308
C076950
10 / 2 / 4
C00032618 External link 512 6-Hydroxysalicylic acid
/ 2,6-Dihydroxybenzoic acid
CHEMBL454808
C412605
12 / 6 / 8
C00033542 External link 512 beta-Resorcylic acid
/ 2,4-Dihydroxybenzoic acid
CHEMBL328910
C017704
23 / 17 / 17
C00040822 External link 512 3-Hydroxybenzoic acid
CHEMBL65369
9 / 2 / 4
C00048480 External link 512 m-Hydroxybenzoic acid
CHEMBL65369
C032948
9 / 2 / 4

Human Protein / Gene in interactions

172 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q16790 Carbonic anhydrase 9 Lyase C00000206 C00000856 C00002647 C00002648 C00002668 C00016318 C00032618 C00033542 C00040822 C00048480 0 / 1
P00915 Carbonic anhydrase 1 Lyase C00000206 C00000856 C00002647 C00002648 C00002668 C00016318 C00032618 C00033542 C00040822 C00048480 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00000206 C00000856 C00002647 C00002648 C00002668 C00016318 C00032618 C00033542 C00040822 C00048480 1 / 2
O43570 Carbonic anhydrase 12 Lyase C00000206 C00000856 C00002647 C00002648 C00002668 C00016318 C00032618 C00033542 C00040822 C00048480 1 / 2
P43166 Carbonic anhydrase 7 Lyase C00000206 C00000856 C00002647 C00002648 C00002668 C00016318 C00032618 C00033542 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00000206 C00000856 C00002647 C00002648 C00002668 C00016318 C00032618 C00033542 0 / 0
P08253 72 kDa type IV collagenase M10A C00000206 C00002648 C00002668 C00002669 C00032618 C00033542 1 / 3
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00000206 C00002648 C00002668 C00002669 C00032618 C00033542 0 / 0
P08254 Stromelysin-1 M10A C00000206 C00002648 C00002668 C00002669 C00032618 C00033542 1 / 0
P23280 Carbonic anhydrase 6 Lyase C00000206 C00000856 C00002647 C00002668 C00040822 C00048480 0 / 0
P22894 Neutrophil collagenase M10A C00000206 C00002648 C00002668 C00002669 C00032618 C00033542 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00000206 C00002648 C00002668 C00002669 C00032618 C00033542 2 / 2
P03956 Interstitial collagenase M10A C00000206 C00002648 C00002668 C00002669 C00032618 C00033542 0 / 1
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000206 C00002648 C00016318 C00040822 C00048480 0 / 0
P02768 Serum albumin Secreted protein C00000206 C00002668 C00002669 C00016318 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00000206 C00000856 C00002647 C00002668 1 / 1
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002647 C00002668 C00033542 0 / 0
P03372 Estrogen receptor NR3A1 C00000206 C00002647 C00002668 1 / 1
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000206 C00000856 C00002647 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000206 C00000856 C00002647 0 / 0
P14151 L-selectin Adhesion C00002647 C00002668 C00002669 0 / 0
Q9UQ49 Sialidase-3 Enzyme C00000856 C00040822 C00048480 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000206 C00002647 C00002668 0 / 0
P07451 Carbonic anhydrase 3 Lyase C00000206 C00000856 C00002647 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000206 C00002647 C00033542 0 / 0
P16581 E-selectin Adhesion C00002647 C00002668 C00002669 0 / 0
P16109 P-selectin Adhesion C00002647 C00002668 C00002669 1 / 0
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00016318 C00040822 C00048480 0 / 0
O75496 Geminin Unclassified protein C00000206 C00002668 C00033542 0 / 0
P15121 Aldose reductase Enzyme C00000206 C00002647 C00002668 0 / 0
Q9BXC0 Hydroxycarboxylic acid receptor 1 Hydroxycarboxylic acid receptor C00016318 C00040822 C00048480 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000206 C00002647 0 / 3
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00000206 C00000856 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002647 C00002668 4 / 3
Q92830 Histone acetyltransferase KAT2A Enzyme C00000206 C00002647 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00002648 C00002668 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002647 C00033542 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00002648 C00033542 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00000206 C00002647 0 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00000206 C00002647 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00000206 C00002647 4 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000206 C00002647 2 / 2
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000206 C00000856 1 / 8
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00002647 C00002668 3 / 0
P12821 Angiotensin-converting enzyme M2 C00002647 4 / 2
P06241 Tyrosine-protein kinase Fyn Src C00000206 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00000206 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000206 0 / 1
P08236 Beta-glucuronidase Enzyme C00000206 1 / 2
Q9GZT9 Egl nine homolog 1 Enzyme C00002668 1 / 1
Q9HAW7 UDP-glucuronosyltransferase 1-7 Enzyme C00000856 0 / 0
P78536 Disintegrin and metalloproteinase domain-containing protein 17 M12B C00002647 1 / 0
P11473 Vitamin D3 receptor NR1I1 C00002647 2 / 3
P14416 D(2) dopamine receptor Dopamine receptor C00000206 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000206 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00000206 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000206 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00000206 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00000206 0 / 0
P08183 Multidrug resistance protein 1 drug C00000206 1 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00000206 0 / 0
P05067 Amyloid beta A4 protein Membrane receptor C00000206 2 / 2
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00000206 1 / 1
O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta Other serine/threonine protein kinase C00000206 0 / 0
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00000206 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00000206 1 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00000206 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00000206 0 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00000206 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00000206 1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000206 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00000206 0 / 0
P25021 Histamine H2 receptor Histamine receptor C00000206 0 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00000206 1 / 1
Q8TCC7 Solute carrier family 22 member 8 Antiporter C00000206 0 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00000206 0 / 1
P51649 Succinate-semialdehyde dehydrogenase, mitochondrial Oxidoreductase C00000856 1 / 1
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00000206 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00000206 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00000206 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00000206 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00000206 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000206 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00000206 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00000206 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00033542 3 / 2
P25101 Endothelin-1 receptor Endothelin receptor C00000206 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00000206 0 / 0
P10145 Interleukin-8 Secreted protein C00002647 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00000206 1 / 0
P02545 Prelamin-A/C Unclassified protein C00002647 11 / 10
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00000206 0 / 0
P08311 Cathepsin G S1A C00000206 0 / 0
P07711 Cathepsin L1 C1A C00002668 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00000206 1 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00033542 0 / 0
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00000206 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00002668 0 / 0
Q4U2R8 Solute carrier family 22 member 6 Antiporter C00000206 0 / 0
P04406 Glyceraldehyde-3-phosphate dehydrogenase Enzyme C00002647 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00000206 0 / 0
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00000206 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00000206 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00000206 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00000206 2 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00033542 5 / 3
P80404 4-aminobutyrate aminotransferase, mitochondrial Transferase C00000856 1 / 1
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00000206 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00000206 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00000206 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00000206 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00000206 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00000206 0 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00002647 2 / 3
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00000206 1 / 0
P17252 Protein kinase C alpha type Alpha C00000206 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00000206 2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000206 0 / 0
P29466 Caspase-1 C14 C00000206 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00002668 1 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002647 3 / 3
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00000206 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00033542 0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00000856 0 / 0
P06133 UDP-glucuronosyltransferase 2B4 Enzyme C00000206 0 / 0
P36537 UDP-glucuronosyltransferase 2B10 Enzyme C00000206 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00000206 0 / 0
P06746 DNA polymerase beta Enzyme C00002668 0 / 0
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00000206 1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00000206 0 / 0
P22303 Acetylcholinesterase Hydrolase C00000206 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00000206 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00000206 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00000206 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00000206 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00000206 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00000206 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00000206 0 / 0
P51580 Thiopurine S-methyltransferase Enzyme C00000856 1 / 1
Q16539 Mitogen-activated protein kinase 14 p38 C00000206 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00000206 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000206 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000206 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00000206 0 / 0
P08246 Neutrophil elastase S1A C00000206 2 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00002669 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002647 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00002647 5 / 1
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000206 2 / 2
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00000856 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00000206 0 / 0
P10275 Androgen receptor NR3C4 C00033542 3 / 4
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00000206 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00000206 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00000206 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00000206 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00000206 1 / 1
Q99700 Ataxin-2 Unclassified protein C00002669 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00000206 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00000206 0 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00000856 0 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00000206 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00002647 0 / 0
Q9UHC3 Acid-sensing ion channel 3 Unclassified protein C00000206 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00002647 7 / 37
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002647 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002647 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00033542 1 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00002668 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00002668 1 / 4
Q9NSA0 Solute carrier family 22 member 11 Transporter C00000206 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000206 1 / 0

71 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00000856 C00002647 C00002648
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00002647 C00002669
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00002647
2539 G6PD, G6PD1 glucose-6-phosphate dehydrogenase (EC:1.1.1.49) C00002648
2023 ENO1, ENO1L1, MPB1, NNE, PPH enolase 1, (alpha) (EC:4.2.1.11) C00002668
3952 LEP, LEPD, OB, OBS leptin C00000856
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00002647
25 ABL1, ABL, JTK7, bcr/abl, c-ABL, p150, v-abl c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) C00002647
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00002647
338 APOB, FLDB, LDLCQ4 apolipoprotein B C00002647
472 ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 ataxia telangiectasia mutated (EC:2.7.11.1) C00002647
545 ATR, FCTCS, FRP1, MEC1, SCKL, SCKL1 ataxia telangiectasia and Rad3 related (EC:2.7.11.1) C00002647
581 BAX, BCL2L4 BCL2-associated X protein C00002647
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00002647
613 BCR, ALL, BCR1, CML, D22S11, D22S662, PHL breakpoint cluster region (EC:2.7.11.1) C00002647
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00002647
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00002647
898 CCNE1, CCNE cyclin E1 C00002647
998 CDC42, CDC42Hs, G25K cell division cycle 42 C00002647
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00002647
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00002647
1147 CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16 conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) C00002647
7852 CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM chemokine (C-X-C motif) receptor 4 C00002647
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00002647
356 FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 Fas ligand (TNF superfamily, member 6) C00002647
2551 GABPA, E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07 GA binding protein transcription factor, alpha subunit 60kDa C00002647
2885 GRB2, ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2 growth factor receptor-bound protein 2 C00002647
3551 IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) C00002647
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00002647
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00002647
3949 LDLR, FH, FHC, LDLCQ2 low density lipoprotein receptor C00002647
5604 MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) C00002647
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00002647
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00002647
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00002647
5601 MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK mitogen-activated protein kinase 9 (EC:2.7.11.24) C00002647
4255 MGMT O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) C00002647
4316 MMP7, MMP-7, MPSL1, PUMP-1 matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23) C00002647
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00002647
4793 NFKBIB, IKBB, TRIP9 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta C00002647
5578 PRKCA, AAG6, PKC-alpha, PKCA, PRKACA protein kinase C, alpha (EC:2.7.11.13) C00002647
5591 PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350 protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1) C00002647
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00002647
5879 RAC1, Rac-1, TC-25, p21-Rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) C00002647
19412 C00002647
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00002647
387 RHOA, ARH12, ARHA, RHO12, RHOH12 ras homolog family member A C00002647
388 RHOB, ARH6, ARHB, MST081, MSTP081, RHOH6 ras homolog family member B C00002647
6195 RPS6KA1, HU-1, MAPKAPK1A, RSK, RSK1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 (EC:2.7.11.1) C00002647
9252 RPS6KA5, MSK1, MSPK1, RLPK ribosomal protein S6 kinase, 90kDa, polypeptide 5 (EC:2.7.11.1) C00002647
6622 SNCA, NACP, PARK1, PARK4, PD1 synuclein, alpha (non A4 component of amyloid precursor) C00002647
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00002647
1312 COMT catechol-O-methyltransferase (EC:2.1.1.6) C00002668
7224 TRPC5, TRP5 transient receptor potential cation channel, subfamily C, member 5 C00002647
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00002647
331 XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 X-linked inhibitor of apoptosis C00002647
1645 AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) C00000206
1646 AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8 aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) C00000206
8644 AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) C00000206
3565 IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 interleukin 4 C00000206
23764 MAFF, U-MAF, hMafF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F C00000206
4489 MT1A, MT1, MT1S, MTC metallothionein 1A C00000206
55867 SLC22A11, OAT4, hOAT4 solute carrier family 22 (organic anion/urate transporter), member 11 C00000206
9356 SLC22A6, HOAT1, OAT1, PAHT, ROAT1 solute carrier family 22 (organic anion transporter), member 6 C00000206
10864 SLC22A7, NLT, OAT2 solute carrier family 22 (organic anion transporter), member 7 C00000206
114571 SLC22A9, HOAT4, OAT4, OAT7, UST3H, ust3 solute carrier family 22 (organic anion transporter), member 9 C00000206
7295 TXN, TRDX, TRX, TRX1 thioredoxin C00000206
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00000206
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00000206
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00000206
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00000206

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (108)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103780 Alcohol dependence P08172
P14416
P31645
#104300 Alzheimer disease; ad P05067
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#600807 Asthma, susceptibility to Q13093
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
%606641 Body mass index; bmi P37231
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605714 Cerebral amyloid angiopathy, app-related P05067
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#218800 Crigler-najjar syndrome, type i P22309
#606785 Crigler-najjar syndrome, type ii P22309
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#609820 Erythrocytosis, familial, 3; ecyt3 Q9GZT9
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613163 Gaba-transaminase deficiency P80404
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22309
#137800 Glioma susceptibility 1; glm1 O75874
P04626
P37231
#232300 Glycogen storage disease ii P10253
#610140 Heart-hand syndrome, slovenian type P02545
#614519 Hemorrhage, intracerebral, susceptibility to; ich P12821
#114550 Hepatocellular carcinoma P08581
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#612244 Inflammatory bowel disease 13; ibd13 P08183
#614328 Inflammatory skin and bowel disease, neonatal; nisbd P78536
#603932 Intervertebral disc disease; idd P14780
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#612624 Microvascular complications of diabetes, susceptibility to, 3; mvcd3 P12821
#253220 Mucopolysaccharidosis, type vii; mps7 P08236
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
P37231
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#267430 Renal tubular dysgenesis; rtd P12821
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P12821
P16109
#271980 Succinic semialdehyde dehydrogenase deficiency; ssadhd P51649
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#610460 Thiopurine s-methyltransferase deficiency P51580
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (101)

KEGG name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
P04637 (marker)
P08581 (related)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
P08581 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
P08253 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P08581 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P08253 (related)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00056 Alzheimer's disease (AD) P05067 (related)
H01185 Cerebral amyloid angiopathy (CAA) P05067 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00132 Mucopolysaccharidosis type VII (MPS7) P08236 (related)
H00421 Mucopolysaccharidosis (MPS) P08236 (related)
H00100 Neutropenic disorders P08246 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00083 Allograft rejection P12821 (related)
H00575 Renal tubular dysgenesis P12821 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00964 Thiopurine S-methyltransferase deficiency (TPMT deficiency) P51580 (related)
H00835 Succinic semialdehyde dehydrogenase (SSADH) deficiency P51649 (related)
H01257 GABA-transaminase deficiency P80404 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00236 Congenital polycythemia Q9GZT9 (related)

Diseases related to CTD interactions

33 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D034381 Hearing Loss C00002669
C00000206
D009069 Movement Disorders C00002647
D007674 Kidney Diseases C00002669
D015837 Vestibular Diseases C00002669
D006461 Hemolysis C00002648
D012220 Rhinitis C00000856
D003921 Diabetes Mellitus, Experimental C00002647
D050171 Dyslipidemias C00002647
D005234 Fatty Liver C00002647
D018149 Glucose Intolerance C00002647
D006937 Hypercholesterolemia C00002647
D006943 Hyperglycemia C00002647
D006949 Hyperlipidemias C00002647
D015228 Hypertriglyceridemia C00002647
D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive C00002647
D008546 Melanoma, Experimental C00002647
D058186 Acute Kidney Injury C00002669
D009203 Myocardial Infarction C00002647
D009361 Neoplasm Invasiveness C00002647
D009362 Neoplasm Metastasis C00002647
D012516 Osteosarcoma C00002647
D010182 Pancreatic Diseases C00002647
D001249 Asthma C00000206
D003128 COMA C00000206
D004342 Drug Hypersensitivity C00000206
D006685 Hoarseness C00000206
D007819 Laryngeal Edema C00000206
D009668 Nose Diseases C00000206
D049188 Prenatal Injuries C00000206
D012640 Seizures C00000206
D014012 Tinnitus C00000206
D014581 Urticaria C00000206
D014860 Warts C00000206