Metabolite

KNApSAcK Entry

id C00002648
Name Gentisic acid / 2,5-Dihydroxybenzoic acid
CAS RN 490-79-9
Standard InChI InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)
Standard InChI (Main Layer) InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)

Cluster

Phytochemical cluster No. 81
KCF-S cluster No. 817

Link

ChEMBL

By standard InChI CHEMBL1461
By standard InChI Main Layer CHEMBL1461

KEGG

By LinkDB C00628

CTD

By CAS RN C010925

Human Protein / Gene in interaction

15 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr CHEMBL1461 CHEMBL1826221 (1)
0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase CHEMBL1461 CHEMBL1664429 (1) CHEMBL1664439 (1)
0 / 0
P43166 Carbonic anhydrase 7 Lyase CHEMBL1461 CHEMBL2340802 (1)
0 / 0
P22894 Neutrophil collagenase M10A CHEMBL1461 CHEMBL1664434 (1)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL1461 CHEMBL1664435 (1)
2 / 2
P00918 Carbonic anhydrase 2 Lyase CHEMBL1461 CHEMBL2340803 (1)
1 / 2
Q9ULX7 Carbonic anhydrase 14 Lyase CHEMBL1461 CHEMBL2340799 (1)
0 / 0
O43570 Carbonic anhydrase 12 Lyase CHEMBL1461 CHEMBL2340800 (1)
1 / 2
P00915 Carbonic anhydrase 1 Lyase CHEMBL1461 CHEMBL2340804 (1)
0 / 0
P03956 Interstitial collagenase M10A CHEMBL1461 CHEMBL1664431 (1)
0 / 1
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL1461 CHEMBL1794401 (1)
0 / 0
Q16790 Carbonic anhydrase 9 Lyase CHEMBL1461 CHEMBL2340801 (1)
0 / 1
P08253 72 kDa type IV collagenase M10A CHEMBL1461 CHEMBL1664432 (1)
1 / 3
Q9UNA4 DNA polymerase iota Enzyme CHEMBL1461 CHEMBL1794483 (1)
0 / 0
P08254 Stromelysin-1 M10A CHEMBL1461 CHEMBL1664433 (1)
1 / 0

CTD interaction (2)

compound gene gene name gene description interaction interaction type form reference
pmid
C010925 2539 G6PD
G6PD1
glucose-6-phosphate dehydrogenase (EC:1.1.1.49) 2,5-dihydroxybenzoic acid results in decreased activity of G6PD protein mutant form decreases activity
protein 5432368
C010925 6817 SULT1A1
HAST1/HAST2
P-PST
PST
ST1A1
ST1A3
STP
STP1
TSPST1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) 2,5-dihydroxybenzoic acid results in increased activity of SULT1A1 protein increases activity
protein 16308312

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (6)

OMIM preferred title UniProt
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#143860 Hyperchlorhidrosis, isolated O43570
#603932 Intervertebral disc disease; idd P14780
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918

KEGG DISEASE (8)

KEGG disease name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00479 Metaphyseal dysplasias P14780 (related)

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D006461 C010925 Hemolysis marker/mechanism
5432368