id | C00002648 |
---|---|
Name | Gentisic acid / 2,5-Dihydroxybenzoic acid |
CAS RN | 490-79-9 |
Standard InChI | InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11) |
Standard InChI (Main Layer) | InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11) |
Phytochemical cluster | No. 81 |
---|---|
KCF-S cluster | No. 817 |
By standard InChI | CHEMBL1461 |
---|---|
By standard InChI Main Layer | CHEMBL1461 |
By LinkDB | C00628 |
---|
By CAS RN | C010925 |
---|
class name | count |
---|---|
rosids | 7 |
asterids | 4 |
Spermatophyta | 1 |
family name | count |
---|---|
Asteraceae | 2 |
Sarcolaenaceae | 2 |
Gentianaceae | 1 |
Rutaceae | 1 |
Myrtaceae | 1 |
Pedaliaceae | 1 |
Vitaceae | 1 |
Fabaceae | 1 |
Aspergillaceae | 1 |
Rhamnaceae | 1 |
accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
---|---|---|---|---|---|
P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | CHEMBL1461 |
CHEMBL1826221
(1)
|
0 / 0 |
P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | CHEMBL1461 |
CHEMBL1664429
(1)
CHEMBL1664439
(1)
|
0 / 0 |
P43166 | Carbonic anhydrase 7 | Lyase | CHEMBL1461 |
CHEMBL2340802
(1)
|
0 / 0 |
P22894 | Neutrophil collagenase | M10A | CHEMBL1461 |
CHEMBL1664434
(1)
|
0 / 0 |
P14780 | Matrix metalloproteinase-9 | M10A | CHEMBL1461 |
CHEMBL1664435
(1)
|
2 / 2 |
P00918 | Carbonic anhydrase 2 | Lyase | CHEMBL1461 |
CHEMBL2340803
(1)
|
1 / 2 |
Q9ULX7 | Carbonic anhydrase 14 | Lyase | CHEMBL1461 |
CHEMBL2340799
(1)
|
0 / 0 |
O43570 | Carbonic anhydrase 12 | Lyase | CHEMBL1461 |
CHEMBL2340800
(1)
|
1 / 2 |
P00915 | Carbonic anhydrase 1 | Lyase | CHEMBL1461 |
CHEMBL2340804
(1)
|
0 / 0 |
P03956 | Interstitial collagenase | M10A | CHEMBL1461 |
CHEMBL1664431
(1)
|
0 / 1 |
P83916 | Chromobox protein homolog 1 | Unclassified protein | CHEMBL1461 |
CHEMBL1794401
(1)
|
0 / 0 |
Q16790 | Carbonic anhydrase 9 | Lyase | CHEMBL1461 |
CHEMBL2340801
(1)
|
0 / 1 |
P08253 | 72 kDa type IV collagenase | M10A | CHEMBL1461 |
CHEMBL1664432
(1)
|
1 / 3 |
Q9UNA4 | DNA polymerase iota | Enzyme | CHEMBL1461 |
CHEMBL1794483
(1)
|
0 / 0 |
P08254 | Stromelysin-1 | M10A | CHEMBL1461 |
CHEMBL1664433
(1)
|
1 / 0 |
compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
---|---|---|---|---|---|---|---|
C010925 | 2539 |
G6PD
G6PD1 |
glucose-6-phosphate dehydrogenase (EC:1.1.1.49) | 2,5-dihydroxybenzoic acid results in decreased activity of G6PD protein mutant form |
decreases activity
|
protein |
5432368
|
C010925 | 6817 |
SULT1A1
HAST1/HAST2 P-PST PST ST1A1 ST1A3 STP STP1 TSPST1 |
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) | 2,5-dihydroxybenzoic acid results in increased activity of SULT1A1 protein |
increases activity
|
protein |
16308312
|
OMIM | preferred title | UniProt |
---|---|---|
#614466 | Coronary heart disease, susceptibility to, 6; chds6 |
P08254
|
#143860 | Hyperchlorhidrosis, isolated |
O43570
|
#603932 | Intervertebral disc disease; idd |
P14780
|
#613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
#259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
#259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
KEGG | disease name | UniProt |
---|---|---|
H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
H00021 | Renal cell carcinoma |
O43570
(marker)
Q16790 (marker) |
H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
H00436 | Osteopetrosis |
P00918
(related)
|
H00028 | Choriocarcinoma |
P03956
(related)
P08253 (related) |
H00025 | Penile cancer |
P08253
(related)
P14780 (related) |
H00472 | Torg-Winchester syndrome |
P08253
(related)
|
H00479 | Metaphyseal dysplasias |
P14780
(related)
|