Species

KNApSAcK Entry

Organism name Helianthus tuberosus
Genus Helianthus
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Helianthus tuberosus
Linked NCBI taxonomy ID 4233
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00000235 External link 512 Heliangine
CHEMBL483867
CHEMBL517148
CHEMBL463123
No. 94 No. 38
C00011866 External link 512 Tagitinin E
C012565
No. 687 No. 38
C00000218 External link 512 Jasmonic acid
/ trans-Jasmonic acid
/ 3-Oxo-2-(2Z-pentenyl)cyclotentylacetic acid
CHEMBL445499
CHEMBL449572
C011006
4 / 1 / 0 No. 707 No. 70
C00002648 External link 512 Gentisic acid
/ 2,5-Dihydroxybenzoic acid
CHEMBL1461
C010925
15 / 6 / 8 2 / 1 No. 817 No. 81
C00000170 External link 512 trans-Cinnamate
/ trans-Cinnamic acid
CHEMBL27246
5 / 2 / 2 No. 904 No. 6
C00000580 External link 512 trans-p-Coumaric acid
/ trans-p-Hydroxycinnamic acid
CHEMBL66879
CHEMBL2336752
23 / 13 / 18 No. 904 No. 6
C00000091 External link 512 trans-Zeatin
CHEMBL525239
D015026
2 / 3 / 2 0 / 1 No. 2879
C00011637 External link 512 Helianthol A
/ [R-(E)]-2-Methyl-6-(4-methyl-3-cyclohexen-1-yl)-4,6-heptadien-2-ol
No. 3871

Human Protein / Gene in interactions

35 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000170 C00002648 0 / 0
P17516 Aldo-keto reductase family 1 member C4 Enzyme C00000218 C00000580 1 / 0
P52895 Aldo-keto reductase family 1 member C2 Enzyme C00000218 C00000580 1 / 0
P03372 Estrogen receptor NR3A1 C00000170 C00000580 1 / 1
Q04828 Aldo-keto reductase family 1 member C1 Enzyme C00000218 C00000580 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00000580 C00002648 0 / 1
P00915 Carbonic anhydrase 1 Lyase C00000580 C00002648 0 / 0
P15121 Aldose reductase Enzyme C00000170 C00000580 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00000580 C00002648 0 / 0
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00000170 C00000580 0 / 0
P42330 Aldo-keto reductase family 1 member C3 Enzyme C00000218 C00000580 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00000580 C00002648 1 / 2
Q9ULX7 Carbonic anhydrase 14 Lyase C00000580 C00002648 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00000580 C00002648 1 / 2
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000580 1 / 8
P23280 Carbonic anhydrase 6 Lyase C00000580 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000170 1 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00000091 3 / 2
P14780 Matrix metalloproteinase-9 M10A C00002648 2 / 2
P22894 Neutrophil collagenase M10A C00002648 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000580 0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000580 0 / 0
P03956 Interstitial collagenase M10A C00002648 0 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00002648 0 / 0
P14679 Tyrosinase Oxidoreductase C00000580 4 / 2
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00000580 3 / 0
P08253 72 kDa type IV collagenase M10A C00002648 1 / 3
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000580 0 / 3
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00002648 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00002648 0 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00000580 0 / 0
P07451 Carbonic anhydrase 3 Lyase C00000580 0 / 0
P08254 Stromelysin-1 M10A C00002648 1 / 0
P22748 Carbonic anhydrase 4 Lyase C00000580 1 / 1
P46063 ATP-dependent DNA helicase Q1 Enzyme C00000091 0 / 0

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
2539 G6PD, G6PD1 glucose-6-phosphate dehydrogenase (EC:1.1.1.49) C00002648
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00002648

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (21)

OMIM preferred title UniProt
#614279 46,xy sex reversal 8; srxy8 P17516
P52895
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#600807 Asthma, susceptibility to Q13093
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#615363 Estrogen resistance; estrr P03372
#143860 Hyperchlorhidrosis, isolated O43570
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#603932 Intervertebral disc disease; idd P14780
#211980 Lung cancer P00533
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#600852 Retinitis pigmentosa 17; rp17 P22748
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#278300 Xanthinuria, type i P47989

KEGG DISEASE (23)

KEGG name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P08253 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
H00025 Penile cancer P08253 (related)
P14780 (related)
P35354 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00192 Xanthinuria P47989 (related)

Diseases related to CTD interactions

2 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006461 Hemolysis C00002648
D000647 Amnesia C00000091