PCIDB

Sesamum indicum

Species

KNApSAcK Entry

Organism name Sesamum indicum
Genus Sesamum
Family Pedaliaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Sesamum indicum
Linked NCBI taxonomy ID 4182
Linked level species

Family

Family in NCBI taxonomy Pedaliaceae
ID 4180

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Natural Activity

List (106)

Species Activity
Sesamum indicum L. Abortifacient
Sesamum indicum L. Alopecia
Sesamum indicum L. Amenorrhea
Sesamum indicum L. Aneuria
Sesamum indicum L. Antiabortive
Sesamum indicum L. Anticonvulsant
Sesamum indicum L. Antiedemic
Sesamum indicum L. Antiinflammatory
Sesamum indicum L. Antioxidant
Sesamum indicum L. Aphrodisiac
Sesamum indicum L. Arthrosis
Sesamum indicum L. Asthma
Sesamum indicum L. Astringent
Sesamum indicum L. Bacteria
Sesamum indicum L. Bleeding
Sesamum indicum L. Boil
Sesamum indicum L. Bronchosis
Sesamum indicum L. Burn
Sesamum indicum L. Cachexia
Sesamum indicum L. Cacoethes
Sesamum indicum L. Cancer
Sesamum indicum L. Cancer, abdomen
Sesamum indicum L. Cancer, breast
Sesamum indicum L. Cancer, colon
Sesamum indicum L. Cancer, eye
Sesamum indicum L. Cancer, stomach
Sesamum indicum L. Caries
Sesamum indicum L. Catarrh
Sesamum indicum L. Cholera
Sesamum indicum L. Cold
Sesamum indicum L. Condylomata
Sesamum indicum L. Conjunctivosis
Sesamum indicum L. Constipation
Sesamum indicum L. Cough
Sesamum indicum L. Cramp
Sesamum indicum L. Cystosis
Sesamum indicum L. Demulcent
Sesamum indicum L. Dentifrice
Sesamum indicum L. Dermatosis
Sesamum indicum L. Diabetes
Sesamum indicum L. Diarrhea
Sesamum indicum L. Diuretic
Sesamum indicum L. Dizziness
Sesamum indicum L. Dyschezia
Sesamum indicum L. Dysentery
Sesamum indicum L. Dysmenorrhea
Sesamum indicum L. Dysuria
Sesamum indicum L. Edema
Sesamum indicum L. Emmenagogue
Sesamum indicum L. Emollient
Sesamum indicum L. Enterosis
Sesamum indicum L. Fungus
Sesamum indicum L. Gastrosis
Sesamum indicum L. Gout
Sesamum indicum L. Gray Hair
Sesamum indicum L. Headache
Sesamum indicum L. Hemorrhoid
Sesamum indicum L. Hepatosis
Sesamum indicum L. High Blood Pressure
Sesamum indicum L. HIV
Sesamum indicum L. Immunodepression
Sesamum indicum L. Immunosuppressant
Sesamum indicum L. Impotence
Sesamum indicum L. Induration
Sesamum indicum L. Infection
Sesamum indicum L. Inflammation
Sesamum indicum L. Lactagogue
Sesamum indicum L. Laxative
Sesamum indicum L. Laxative
Sesamum indicum L. Malaria
Sesamum indicum L. Mastosis
Sesamum indicum L. Menorrhagia
Sesamum indicum L. Migraine
Sesamum indicum L. Nephrosis
Sesamum indicum L. Neuroparalysis
Sesamum indicum L. Neurosis
Sesamum indicum L. Neurotonic
Sesamum indicum L. Ophthalmia
Sesamum indicum L. Osteoporosis
Sesamum indicum L. Otorrhea
Sesamum indicum L. Pain
Sesamum indicum L. Proctorrhagia
Sesamum indicum L. Propecic
Sesamum indicum L. Pulmonosis
Sesamum indicum L. Respirosis
Sesamum indicum L. Rheumatosis
Sesamum indicum L. Scab
Sesamum indicum L. Scabies
Sesamum indicum L. Smallpox
Sesamum indicum L. Snakebite
Sesamum indicum L. Sore
Sesamum indicum L. Sore Throat
Sesamum indicum L. Splenosis
Sesamum indicum L. Strangury
Sesamum indicum L. Swelling
Sesamum indicum L. Syphilis
Sesamum indicum L. Tinnitus
Sesamum indicum L. Tonic
Sesamum indicum L. Tumor
Sesamum indicum L. Urethrosis
Sesamum indicum L. Uterorrhagia
Sesamum indicum L. Uterosis
Sesamum indicum L. VD
Sesamum indicum L. Vertigo
Sesamum indicum L. Virus
Sesamum indicum L. Wart

Metabolite list (15)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00003886 External link 512 Pedalitin
/ 6-Hydroxyluteolin 6-methyl ether
/ 3',4',5,6-Tetrahydroxy-7-methoxyflavone
/ 2-(3,4-Dihydroxyphenyl)-5,6-dihydroxy-7-methoxy-4H-1-benzopyran-4-one
CHEMBL476314
No. 3 No. 15
C00000638 External link 512 (+)-Piperitol
CHEMBL1688935
CHEMBL1688938
CHEMBL2011539
CHEMBL2011540
CHEMBL2136585
7 / 13 / 7 No. 38 No. 21
C00007190 External link 512 (+)-Pinoresinol
CHEMBL267963
CHEMBL487611
CHEMBL460862
C103298
7 / 5 / 6 No. 38 No. 21
C00000601 External link 512 (+)-Sesamin
CHEMBL43469
CHEMBL252915
CHEMBL1572261
CHEMBL1591714
CHEMBL1708854
CHEMBL1904496
CHEMBL1968861
C054125
20 / 24 / 15 0 / 5 No. 621 No. 21
C00000639 External link 512 (+)-Sesamolin
CHEMBL2059646
C054124
No. 621 No. 21
C00002626 External link 512 Sesamolinol
No. 621 No. 21
C00002648 External link 512 Gentisic acid
/ 2,5-Dihydroxybenzoic acid
CHEMBL1461
C010925
15 / 6 / 8 2 / 1 No. 817 No. 81
C00001148 External link 512 Sesamose
No. 1212
C00036899 External link 512 Chlorosesamone
No. 2968 No. 80
C00002673 External link 512 Sesamol
CHEMBL1517998
C025583
3 / 8 / 8 0 / 1 No. 4093
C00036039 External link 512 Anthrasesamone C
No. 4146
C00036038 External link 512 Anthrasesamone B
No. 4146
C00036037 External link 512 Anthrasesamone A
No. 4146
C00001348 External link 512 L-Citrulline
CHEMBL444814
No. 4388
C00001400 External link 512 Agmatine
CHEMBL58343
D000376
11 / 2 / 3 0 / 9 No. 7327 No. 78

Human Protein / Gene in interactions

46 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000601 C00001400 C00002673 0 / 1
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00000638 C00002673 C00007190 5 / 3
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00000601 C00007190 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00000601 C00002648 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00002648 C00007190 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000601 C00001400 1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000601 C00001400 1 / 1
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00000638 C00007190 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00000638 C00007190 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00000601 C00000638 1 / 1
O75496 Geminin Unclassified protein C00000601 C00000638 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00000601 C00000638 7 / 3
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000601 C00001400 0 / 1
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000601 C00000638 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00000601 C00002648 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00002648 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00002648 1 / 2
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000601 2 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00000601 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00002648 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00000601 2 / 3
P03956 Interstitial collagenase M10A C00002648 0 / 1
P00918 Carbonic anhydrase 2 Lyase C00002648 1 / 2
O15245 Solute carrier family 22 member 1 Drug uniporter C00001400 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000601 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00002648 2 / 2
P28482 Mitogen-activated protein kinase 1 Erk C00000601 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001400 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00002648 0 / 1
P08253 72 kDa type IV collagenase M10A C00002648 1 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000601 2 / 2
P22894 Neutrophil collagenase M10A C00002648 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00001400 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00001400 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00002648 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00007190 0 / 3
O15244 Solute carrier family 22 member 2 Drug uniporter C00001400 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000601 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000601 0 / 0
P10275 Androgen receptor NR3C4 C00002673 3 / 4
Q16637 Survival motor neuron protein Unclassified protein C00000601 4 / 1
P08254 Stromelysin-1 M10A C00002648 1 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001400 0 / 0
O75751 Solute carrier family 22 member 3 Unclassified protein C00001400 0 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00007190 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00002648 0 / 0

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
2539 G6PD, G6PD1 glucose-6-phosphate dehydrogenase (EC:1.1.1.49) C00002648
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00002648

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (38)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#114500 Colorectal cancer; crc P84022
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 P37231
#143860 Hyperchlorhidrosis, isolated O43570
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#603932 Intervertebral disc disease; idd P14780
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#601665 Obesity P37231
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (32)

KEGG name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
P35354 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)

Diseases related to CTD interactions

16 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006461 Hemolysis C00002648
D009203 Myocardial Infarction C00002673
D001930 Brain Injuries C00000601
D002375 Catalepsy C00000601
D018476 Hypokinesia C00000601
D020244 Infarction, Middle Cerebral Artery C00000601
D020734 Parkinsonian Disorders C00000601
D001919 Bradycardia C00001400
D006930 Hyperalgesia C00001400
D006973 Hypertension C00001400
D007022 Hypotension C00001400
D009021 Morphine Dependence C00001400
D009293 Opioid-Related Disorders C00001400
D010146 Pain C00001400
D013375 Substance Withdrawal Syndrome C00001400
D013610 Tachycardia C00001400