phytochemical cluster No. 80 (25 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• KCF-S cluster (5)
• Metabolite list (25)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	81
eudicotyledons	31
rosids	13
Liliopsida	3
Magnoliophyta	1

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Cumulative family count (Top 20)

class name	count
Ebenaceae	55
Ancistrocladaceae	9
Bignoniaceae	9
Boraginaceae	7
Droseraceae	7
Juglandaceae	6
Plumbaginaceae	5
Ericaceae	4
Lamiaceae	3
Iridaceae	3
Dioncophyllaceae	3
Nepenthaceae	3
Proteaceae	3
Fabaceae	2
Staphylococcaceae	2
Malvaceae	2
Balsaminaceae	2
Lythraceae	2
Peraceae	1
Aristolochiaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
alpha-Naphthoquinones	7

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metabolites link (7)

br08003 Category	KEGG ID	KNApSAcK ID
alpha-Naphthoquinones	C03840	C00000144
alpha-Naphthoquinones	C17412	C00000859
alpha-Naphthoquinones	C10325	C00002813
alpha-Naphthoquinones	C10335	C00002818
alpha-Naphthoquinones	C10366	C00002835
alpha-Naphthoquinones	C10368	C00002837
alpha-Naphthoquinones	C10398	C00002859

KCF-S cluster (5)

KCF-S ID	# of metabolite
No. 1119	9
No. 1047	7
No. 2968	4
No. 4183	3
No. 4286	2

Metabolite list (25)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	figure
C00000144	3-Methoxyjuglone / 5-Hydroxy-3-methoxy-1,4-naphthoquinone	CHEMBL2204407				No. 1047
C00043720	Ramentaceone / 7-Methyljuglone	CHEMBL430853				No. 1047
C00043194	Deoxylapachol	CHEMBL32570	C044416			No. 1047
C00002837	Ancistroquinone C	CHEMBL1915220				No. 1047
C00002852	Aristolindiquinone					No. 1047
C00002846	Ancistroquinone D					No. 1047
C00049940	Chimaphilin	CHEMBL495277	C057774			No. 1047
C00002818	Ancistroquinone					No. 1119
C00036542	Alkannin beta,beta-dimethylacrylate	CHEMBL267024 CHEMBL513640	C032573	1 / 0 / 0		No. 1119
C00034050	Chlorosesamone					No. 1119
C00033640	Alkannin	CHEMBL9470 CHEMBL29285 CHEMBL28457		16 / 14 / 12		No. 1119
C00002794	Naphthazarin	CHEMBL274056	C005503	5 / 0 / 0		No. 1119
C00033638	3-Chloroplumbagin					No. 1119
C00025292	Malvone A / 6-O-Demethyl-3-O-methylancistroquinone B	CHEMBL1915229				No. 1119
C00032646	3-Bromoplumbagin					No. 1119
C00033639	Shikonin	CHEMBL9470 CHEMBL29285 CHEMBL28457		16 / 14 / 12		No. 1119
C00002788	juglone / 5-Hydroxy-1,4-naphthoquinone	CHEMBL43612	C005134	31 / 31 / 60	8 / 0	No. 2968
C00000859	Plumbagin / Plumbagine	CHEMBL295316	C014758	28 / 30 / 59	14 / 3	No. 2968
C00002787	Methylnaphthazarin	CHEMBL11475		20 / 15 / 15		No. 2968
C00036899	Lapachol	CHEMBL15193	C008252	13 / 20 / 50		No. 2968
C00002835	Ancistroquinone B	CHEMBL1915228				No. 4183
C00040839	5-Hydroxylapachol	CHEMBL1089642				No. 4183
C00002813	Lawsone	CHEMBL240963	C005090	16 / 12 / 13	1 / 3	No. 4183
C00002802	2-Methoxy-1,4-naphthoquinone	CHEMBL106562	C096118	13 / 5 / 5		No. 4286
C00002859	Droserone	CHEMBL1915212				No. 4286

Human Protein / Gene in interactions

72 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P00352	Retinal dehydrogenase 1	Enzyme	C00000144 C00000859 C00002787 C00002835 C00002837 C00002852 C00043720	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00000144 C00000859 C00002787 C00002835 C00002837 C00002852 C00043720	4 / 3
P11473	Vitamin D3 receptor	NR1I1	C00000144 C00000859 C00002787 C00002835 C00002837 C00002852	2 / 3
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00000144 C00000859 C00002787 C00002835 C00002852 C00043720	0 / 0
P11387	DNA topoisomerase 1	Isomerase	C00000144 C00000859 C00002787 C00002788 C00002846 C00002852	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00000144 C00000859 C00002787 C00002837 C00002852	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00000144 C00000859 C00002787 C00002852 C00043720	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00000144 C00002835 C00002837 C00002852 C00043720	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00000144 C00000859 C00002787 C00002852 C00043720	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00000144 C00002835 C00002852 C00043720	1 / 2
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00000144 C00002835 C00002837 C00002852	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00000144 C00002837 C00002852 C00043720	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00000859 C00002787 C00002835 C00002852	4 / 1
P10828	Thyroid hormone receptor beta	NR1A2	C00000144 C00000859 C00002787 C00043720	3 / 1
O00255	Menin	Unclassified protein	C00000144 C00002835 C00002852 C00043720	2 / 5
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000144 C00002835 C00002837 C00002852	0 / 1
P54132	Bloom syndrome protein	Enzyme	C00000144 C00002852 C00043720	1 / 2
Q13951	Core-binding factor subunit beta	Unclassified protein	C00000144 C00000859 C00002787	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00000144 C00000859 C00002787	1 / 4
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00000144 C00002837 C00002852	2 / 2
P04637	Cellular tumor antigen p53	Transcription Factor	C00000144 C00002835 C00002852	7 / 37
P14902	Indoleamine 2,3-dioxygenase 1	Enzyme	C00000144 C00002837 C00049940	0 / 0
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00000859 C00002787	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000859 C00002787	0 / 0
P35610	Sterol O-acyltransferase 1	Enzyme	C00000859 C00002787	0 / 0
P55210	Caspase-7	C14	C00000144 C00002852	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00000144 C00002852	0 / 0
P30305	M-phase inducer phosphatase 2	Ser_Thr_Tyr	C00000144 C00002846	0 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00000144 C00043720	0 / 0
O75908	Sterol O-acyltransferase 2	Enzyme	C00000859 C00002787	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00000144 C00002852	3 / 3
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00000144 C00002852	1 / 1
P29466	Caspase-1	C14	C00000144 C00002852	0 / 0
Q02750	Dual specificity mitogen-activated protein kinase kinase 1	Ste7	C00002852	1 / 1
Q9Y253	DNA polymerase eta	Enzyme	C00049940	1 / 1
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00043720	0 / 0
Q9UGP5	DNA polymerase lambda	Enzyme	C00000144	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00049940	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00002852	0 / 0
Q04206	Transcription factor p65	Transcription Factor	C00002852	0 / 0
P03956	Interstitial collagenase	M10A	C00002837	0 / 1
P08253	72 kDa type IV collagenase	M10A	C00002837	1 / 3
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00049940	0 / 0
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00000144	4 / 2
O15118	Niemann-Pick C1 protein	Unclassified protein	C00043720	1 / 1
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00049940	0 / 0
P51151	Ras-related protein Rab-9A	Unclassified protein	C00043720	0 / 0
O75496	Geminin	Unclassified protein	C00049940	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00049940	2 / 0
P39748	Flap endonuclease 1	Enzyme	C00049940	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00049940	0 / 0
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00043720	1 / 0
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00000144	0 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00043720	1 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00049940	0 / 0
Q04760	Lactoylglutathione lyase	Enzyme	C00002835	0 / 0
P04049	RAF proto-oncogene serine/threonine-protein kinase	Raf	C00002852	2 / 0
P08254	Stromelysin-1	M10A	C00002837	1 / 0
Q9HC97	G-protein coupled receptor 35	Kynurenic acid receptor	C00002835	0 / 0
Q99558	Mitogen-activated protein kinase kinase kinase 14	Unique STE serine/threonine protein kinase	C00002852	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00002837	2 / 2
P22894	Neutrophil collagenase	M10A	C00002837	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00043720	1 / 1
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00049940	1 / 0
P06746	DNA polymerase beta	Enzyme	C00043720	0 / 0
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00002837	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00043720	0 / 0
Q9NNW7	Thioredoxin reductase 2, mitochondrial	Enzyme	C00002846	0 / 0
Q16881	Thioredoxin reductase 1, cytoplasmic	Oxidoreductase	C00002846	0 / 0
Q86VQ6	Thioredoxin reductase 3	Enzyme	C00002846	0 / 0
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00049940	0 / 3
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00049940	1 / 1

21 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00000144 C00002837
7296	TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR	thioredoxin reductase 1 (EC:1.8.1.9)	C00000144 C00002852
2950	GSTP1, DFN7, FAEES3, GST3, GSTP, PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	C00002852
1874	E2F4, E2F-4	E2F transcription factor 4, p107/p130-binding	C00000144
1958	EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225	early growth response 1	C00000144
81631	MAP1LC3B, ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a	microtubule-associated protein 1 light chain 3 beta	C00000144
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00000144
10587	TXNRD2, SELZ, TR, TR-BETA, TR3, TRXR2	thioredoxin reductase 2 (EC:1.8.1.9)	C00000144
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00002852
2730	GCLM, GLCLR	glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2)	C00002852
1601	DAB2, DOC-2, DOC2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	C00000144
3162	HMOX1, HMOX1D, HO-1, HSP32, bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	C00002852
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00002852
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00002852
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00002852
1728	NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1	NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2)	C00002852
54658	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A	UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)	C00002852
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00002852
54577	UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G	UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17)	C00002852
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00002852
54600	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I	UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17)	C00002852

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions