KCF-S cluster No. 1047 (8 metabolites)

Corresponding Phytochemical cluster No. 80

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (8)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	18
rosids	10
eudicotyledons	9
Liliopsida	3

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Cumulative family count

class name	count
Ebenaceae	16
Juglandaceae	6
Plumbaginaceae	3
Iridaceae	3
Balsaminaceae	2
Droseraceae	2
Proteaceae	2
Lythraceae	2
Nepenthaceae	1
Peraceae	1
Ancistrocladaceae	1
Fabaceae	1
Davidiellaceae	1
Magnaporthaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
alpha-Naphthoquinones	2

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metabolites link (2)

br08003 Category	KEGG ID	KNApSAcK ID
alpha-Naphthoquinones	C03840	C00000144
alpha-Naphthoquinones	C10368	C00002837

Metabolite list (8)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000144	juglone / 5-Hydroxy-1,4-naphthoquinone	CHEMBL43612	C005134	31 / 31 / 60	8 / 0
C00002837	Lawsone	CHEMBL240963	C005090	16 / 12 / 13	1 / 3
C00002846	Naphthazarin	CHEMBL274056	C005503	5 / 0 / 0
C00002852	Plumbagin / Plumbagine	CHEMBL295316	C014758	28 / 30 / 59	14 / 3
C00036496	2-Hydroxyjuglone	CHEMBL1089486	C420979
C00043194	3-Methoxyjuglone / 5-Hydroxy-3-methoxy-1,4-naphthoquinone	CHEMBL2204407
C00043720	Methylnaphthazarin	CHEMBL11475		20 / 15 / 15
C00049940	2-Methoxy-1,4-naphthoquinone	CHEMBL106562	C096118	13 / 5 / 5

Human Protein / Gene in interactions

66 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P28482	Mitogen-activated protein kinase 1	Erk	C00000144 C00002837 C00002852 C00043720	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00000144 C00002837 C00002852 C00043720	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00000144 C00002837 C00002852 C00043720	4 / 3
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00000144 C00002837 C00002852 C00043720	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00000144 C00002837 C00002852	2 / 3
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00000144 C00002837 C00002852	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00000144 C00002837 C00002852	0 / 0
O00255	Menin	Unclassified protein	C00000144 C00002852 C00043720	2 / 5
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00000144 C00002852 C00043720	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00000144 C00002852 C00043720	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00000144 C00002852 C00043720	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00000144 C00002837 C00002852	2 / 2
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000144 C00002837 C00002852	0 / 1
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00000144 C00002852 C00043720	1 / 2
P14902	Indoleamine 2,3-dioxygenase 1	Enzyme	C00000144 C00002837 C00049940	0 / 0
P11387	DNA topoisomerase 1	Isomerase	C00000144 C00002846 C00002852	0 / 0
P54132	Bloom syndrome protein	Enzyme	C00000144 C00002852 C00043720	1 / 2
P30305	M-phase inducer phosphatase 2	Ser_Thr_Tyr	C00000144 C00002846	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00000144 C00002852	0 / 0
P55210	Caspase-7	C14	C00000144 C00002852	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00000144 C00043720	3 / 1
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00000144 C00043720	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00000144 C00002852	3 / 3
P29466	Caspase-1	C14	C00000144 C00002852	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00000144 C00002852	1 / 1
P04637	Cellular tumor antigen p53	Transcription Factor	C00000144 C00002852	7 / 37
Q02750	Dual specificity mitogen-activated protein kinase kinase 1	Ste7	C00002852	1 / 1
P03956	Interstitial collagenase	M10A	C00002837	0 / 1
Q04206	Transcription factor p65	Transcription Factor	C00002852	0 / 0
Q9UGP5	DNA polymerase lambda	Enzyme	C00000144	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00049940	1 / 1
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00043720	0 / 0
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00000144	4 / 2
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00049940	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00002852	0 / 0
P51151	Ras-related protein Rab-9A	Unclassified protein	C00043720	0 / 0
O75496	Geminin	Unclassified protein	C00049940	0 / 0
P08253	72 kDa type IV collagenase	M10A	C00002837	1 / 3
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00049940	2 / 0
P39748	Flap endonuclease 1	Enzyme	C00049940	0 / 0
O15118	Niemann-Pick C1 protein	Unclassified protein	C00043720	1 / 1
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00049940	0 / 0
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00000144	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00049940	0 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00043720	1 / 0
Q99558	Mitogen-activated protein kinase kinase kinase 14	Unique STE serine/threonine protein kinase	C00002852	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00049940	0 / 0
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00043720	1 / 0
P14780	Matrix metalloproteinase-9	M10A	C00002837	2 / 2
P22894	Neutrophil collagenase	M10A	C00002837	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00049940	0 / 0
P04049	RAF proto-oncogene serine/threonine-protein kinase	Raf	C00002852	2 / 0
P08254	Stromelysin-1	M10A	C00002837	1 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00043720	1 / 1
P06746	DNA polymerase beta	Enzyme	C00043720	0 / 0
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00002837	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00043720	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00049940	1 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00002852	4 / 1
Q13951	Core-binding factor subunit beta	Unclassified protein	C00000144	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00000144	1 / 4
Q9NNW7	Thioredoxin reductase 2, mitochondrial	Enzyme	C00002846	0 / 0
Q16881	Thioredoxin reductase 1, cytoplasmic	Oxidoreductase	C00002846	0 / 0
Q86VQ6	Thioredoxin reductase 3	Enzyme	C00002846	0 / 0
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00049940	0 / 3
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00049940	1 / 1

21 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00000144 C00002837
7296	TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR	thioredoxin reductase 1 (EC:1.8.1.9)	C00000144 C00002852
2950	GSTP1, DFN7, FAEES3, GST3, GSTP, PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	C00002852
1874	E2F4, E2F-4	E2F transcription factor 4, p107/p130-binding	C00000144
1958	EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225	early growth response 1	C00000144
81631	MAP1LC3B, ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a	microtubule-associated protein 1 light chain 3 beta	C00000144
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00000144
10587	TXNRD2, SELZ, TR, TR-BETA, TR3, TRXR2	thioredoxin reductase 2 (EC:1.8.1.9)	C00000144
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00002852
2730	GCLM, GLCLR	glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2)	C00002852
1601	DAB2, DOC-2, DOC2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	C00000144
3162	HMOX1, HMOX1D, HO-1, HSP32, bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	C00002852
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00002852
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00002852
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00002852
1728	NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1	NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2)	C00002852
54658	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A	UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)	C00002852
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00002852
54577	UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G	UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17)	C00002852
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00002852
54600	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I	UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17)	C00002852

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions