PCIDB

KNApSAcK Metabolite C00000144

Metabolite

KNApSAcK Entry

id C00000144
Name juglone / 5-Hydroxy-1,4-naphthoquinone
CAS RN 481-39-0
Standard InChI InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H
Standard InChI (Main Layer) InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H

Cluster

Phytochemical cluster No. 80
KCF-S cluster No. 1047

Link

ChEMBL

By standard InChI CHEMBL43612
By standard InChI Main Layer CHEMBL43612

KEGG

By LinkDB C03840

CTD

By CAS RN C005134

Human Protein / Gene in interaction

31 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL43612 CHEMBL1613992 (1) CHEMBL1613995 (1)
7 / 44
P29466 Caspase-1 C14 CHEMBL43612 CHEMBL1614158 (1)
0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL43612 CHEMBL1614331 (1)
0 / 0
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL43612 CHEMBL1614554 (2) CHEMBL1613776 (2)
3 / 1
P54132 Bloom syndrome protein Enzyme CHEMBL43612 CHEMBL1614067 (2)
1 / 2
P11387 DNA topoisomerase 1 Isomerase CHEMBL43612 CHEMBL847689 (1)
0 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL43612 CHEMBL1794311 (2)
2 / 3
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL43612 CHEMBL1613800 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL43612 CHEMBL1614458 (1)
0 / 0
P14902 Indoleamine 2,3-dioxygenase 1 Enzyme CHEMBL43612 CHEMBL935410 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL43612 CHEMBL1738606 (2)
0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme CHEMBL43612 CHEMBL1614303 (1)
4 / 2
Q9UGP5 DNA polymerase lambda Enzyme CHEMBL43612 CHEMBL1921596 (1) CHEMBL1920071 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL43612 CHEMBL1794467 (1)
0 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL43612 CHEMBL1613808 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL43612 CHEMBL1613910 (1)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL43612 CHEMBL1614038 (1)
2 / 2
P30305 M-phase inducer phosphatase 2 Ser_Thr_Tyr CHEMBL43612 CHEMBL965759 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL43612 CHEMBL1614240 (1)
0 / 0
P55210 Caspase-7 C14 CHEMBL43612 CHEMBL1613779 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL43612 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL43612 CHEMBL1614466 (1) CHEMBL1614211 (2)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL43612 CHEMBL1614250 (1) CHEMBL1614421 (1)
CHEMBL1614502 (1)
4 / 3
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL43612 CHEMBL1794536 (2) CHEMBL1921592 (1)
CHEMBL1921595 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL43612 CHEMBL1613914 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL43612 CHEMBL1613829 (2) CHEMBL1613928 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL43612 CHEMBL1614364 (1)
1 / 1
O00255 Menin Unclassified protein CHEMBL43612 CHEMBL1614257 (2) CHEMBL1614531 (2)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL43612 CHEMBL1614257 (2) CHEMBL1614531 (2)
1 / 3
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL43612 CHEMBL1738090 (1) CHEMBL1737904 (1)
CHEMBL1738444 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL43612 CHEMBL1738090 (1) CHEMBL1737904 (1)
CHEMBL1738444 (1)
1 / 6

CTD interaction (8)

compound gene gene name gene description interaction interaction type form reference
pmid
C005134 196 AHR
bHLHe76
aryl hydrocarbon receptor juglone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] decreases reaction
/ increases activity
protein 19269596
C005134 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) juglone results in increased activity of CASP8 protein increases activity
protein 20138029
C005134 1601 DAB2
DOC-2
DOC2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) juglone affects the phosphorylation of DAB2 protein affects phosphorylation
protein 12881709
C005134 1874 E2F4
E2F-4
E2F transcription factor 4, p107/p130-binding juglone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of E2F4 protein] decreases reaction
/ increases expression
protein 20479004
C005134 1958 EGR1
AT225
G0S30
KROX-24
NGFI-A
TIS8
ZIF-268
ZNF225
early growth response 1 juglone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGR1 protein] decreases reaction
/ increases expression
protein 20479004
C005134 81631 MAP1LC3B
ATG8F
LC3B
MAP1A/1BLC3
MAP1LC3B-a
microtubule-associated protein 1 light chain 3 beta juglone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MAP1LC3B protein] decreases reaction
/ increases expression
protein 20479004
C005134 7296 TXNRD1
GRIM-12
TR
TR1
TRXR1
TXNR
thioredoxin reductase 1 (EC:1.8.1.9) TXNRD1 protein results in increased reduction of juglone increases reduction
protein 21172426
C005134 10587 TXNRD2
SELZ
TR
TR-BETA
TR3
TRXR2
thioredoxin reductase 2 (EC:1.8.1.9) TXNRD2 protein results in increased reduction of juglone increases reduction
protein 21172426

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (31)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#210900 Bloom syndrome; blm P54132
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#119900 Digital clubbing, isolated congenital P15428
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#211980 Lung cancer P04637
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (60)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)