Organism name | Juglans mandshurica |
---|---|
Genus | Juglans |
Family | Juglandaceae |
Kingdom | Plantae |
Linked NCBI taxonomy name | Juglans mandshurica |
---|---|
Linked NCBI taxonomy ID | 91218 |
Linked level | species |
Family in NCBI taxonomy | Juglandaceae |
---|---|
ID | 16714 |
Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
---|---|
ID | 33090 |
Plant class | rosids |
---|---|
ID | 71275 |
KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
---|---|---|---|---|---|---|---|---|
C00005140
![]() |
Afzelin
/ Kaempferol 3-O-alpha-rhamnoside / Kaempferol 3-O-alpha-L-rhamnopyranoside |
CHEMBL240528
CHEMBL515798 |
C477954
|
4 / 2 / 2 | No. 2 | No. 15 |
![]() |
|
C00005730
![]() |
Myricitrin
/ Myricetin 3-O-rhamnoside / Myricetin 3-O-alpha-L-rhamnoside / Myricetin 3-O-alpha-L-rhamnopyranoside |
CHEMBL454576
CHEMBL522983 CHEMBL1599224 |
C008577
|
25 / 11 / 11 | No. 2 | No. 15 |
![]() |
|
C00000677
![]() |
Distylin
/ Dihydroquercetin / (2R,3R)-Taxifolin |
CHEMBL66
CHEMBL9249 CHEMBL337309 CHEMBL1492383 |
C003377
|
65 / 41 / 37 | 29 / 1 | No. 42 | No. 14 |
![]() |
C00032577
![]() |
1,2,3,6-Tetra-O-galloyl-beta-D-glucose
|
CHEMBL449947
CHEMBL1159463 |
C060475
|
11 / 2 / 2 | No. 448 | No. 81 |
![]() |
|
C00002647
![]() |
Gallic acid
|
CHEMBL288114
|
D005707
|
42 / 53 / 68 | 52 / 16 | No. 817 | No. 81 |
![]() |
C00000144
![]() |
juglone
/ 5-Hydroxy-1,4-naphthoquinone |
CHEMBL43612
|
C005134
|
31 / 31 / 60 | 8 / 0 | No. 1047 | No. 80 |
![]() |
C00029670
![]() |
alpha-Hydrojuglone-4-glucoside
|
No. 1275 |
![]() |
|||||
C00031926
![]() |
Juglanoside B
/ (-)-Juglanoside B |
No. 2387 |
![]() |
|||||
C00031927
![]() |
Juglanoside C
/ (-)-Juglanoside C |
No. 2387 |
![]() |
|||||
C00031928
![]() |
Juglanoside D
/ (-)-Juglanoside D |
No. 2387 |
![]() |
|||||
C00031929
![]() |
Juglanoside E
/ (-)-Juglanoside E |
No. 2387 |
![]() |
|||||
C00031925
![]() |
Juglanoside A
/ (-)-Juglanoside A |
No. 2387 |
![]() |
|||||
C00050190
![]() |
p-Hydroxymethoxybenzobijuglone
|
No. 6497 |
![]() |
accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
---|---|---|---|---|
P10636 | Microtubule-associated protein tau | Unclassified protein | C00000144 C00000677 C00002647 C00005730 | 4 / 3 |
B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000144 C00000677 C00002647 C00005730 | 0 / 0 |
Q9UBT6 | DNA polymerase kappa | Enzyme | C00000144 C00000677 C00002647 C00005730 | 0 / 0 |
P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000144 C00000677 C00002647 C00005730 | 0 / 0 |
Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00000144 C00000677 C00005730 | 1 / 4 |
P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000144 C00000677 C00005140 | 0 / 1 |
Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000144 C00000677 C00002647 | 3 / 3 |
P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000144 C00000677 C00002647 | 2 / 2 |
P28482 | Mitogen-activated protein kinase 1 | Erk | C00000144 C00000677 C00002647 | 0 / 0 |
P00352 | Retinal dehydrogenase 1 | Enzyme | C00000144 C00002647 C00005730 | 0 / 0 |
P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000144 C00000677 C00005730 | 0 / 0 |
Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000677 C00002647 C00005730 | 0 / 0 |
Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000144 C00002647 C00005730 | 1 / 1 |
Q13951 | Core-binding factor subunit beta | Unclassified protein | C00000144 C00000677 C00005730 | 0 / 1 |
O00255 | Menin | Unclassified protein | C00000144 C00000677 | 2 / 5 |
Q04759 | Protein kinase C theta type | Delta | C00000677 C00032577 | 0 / 1 |
Q05513 | Protein kinase C zeta type | Iota | C00000677 C00032577 | 0 / 0 |
P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000677 C00005140 | 1 / 0 |
O94806 | Serine/threonine-protein kinase D3 | Pkd | C00000677 C00032577 | 0 / 0 |
Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000144 C00000677 | 1 / 2 |
Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00000677 C00005730 | 0 / 0 |
Q02156 | Protein kinase C epsilon type | Eta | C00000677 C00032577 | 0 / 0 |
P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00000677 C00005730 | 1 / 1 |
P06746 | DNA polymerase beta | Enzyme | C00000677 C00005730 | 0 / 0 |
P17252 | Protein kinase C alpha type | Alpha | C00000677 C00032577 | 0 / 0 |
Q05655 | Protein kinase C delta type | Delta | C00000677 C00032577 | 0 / 0 |
P05129 | Protein kinase C gamma type | Alpha | C00000677 C00032577 | 1 / 1 |
P05771 | Protein kinase C beta type | Alpha | C00000677 C00032577 | 0 / 0 |
P24723 | Protein kinase C eta type | Eta | C00000677 C00032577 | 1 / 0 |
Q9UNA4 | DNA polymerase iota | Enzyme | C00000677 C00005730 | 0 / 0 |
P54132 | Bloom syndrome protein | Enzyme | C00000144 C00000677 | 1 / 2 |
P41743 | Protein kinase C iota type | Iota | C00000677 C00032577 | 0 / 0 |
P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00000144 C00000677 | 0 / 0 |
P11473 | Vitamin D3 receptor | NR1I1 | C00000144 C00002647 | 2 / 3 |
Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00000677 C00032577 | 0 / 0 |
Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00000677 C00005730 | 0 / 0 |
Q16637 | Survival motor neuron protein | Unclassified protein | C00000677 C00002647 | 4 / 1 |
P39748 | Flap endonuclease 1 | Enzyme | C00000677 C00005730 | 0 / 0 |
P04637 | Cellular tumor antigen p53 | Transcription Factor | C00000144 C00002647 | 7 / 37 |
P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000677 C00005730 | 0 / 0 |
Q9Y253 | DNA polymerase eta | Enzyme | C00000677 C00005730 | 1 / 1 |
Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00000144 C00002647 | 0 / 0 |
O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002647 C00005730 | 0 / 0 |
P14902 | Indoleamine 2,3-dioxygenase 1 | Enzyme | C00000144 | 0 / 0 |
Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00000677 | 0 / 0 |
P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00000677 | 1 / 1 |
O75496 | Geminin | Unclassified protein | C00000677 | 0 / 0 |
P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00000144 | 4 / 2 |
P41143 | Delta-type opioid receptor | Opioid receptor | C00000677 | 0 / 0 |
P15121 | Aldose reductase | Enzyme | C00002647 | 0 / 0 |
P10145 | Interleukin-8 | Secreted protein | C00002647 | 0 / 0 |
P00915 | Carbonic anhydrase 1 | Lyase | C00002647 | 0 / 0 |
P03956 | Interstitial collagenase | M10A | C00000677 | 0 / 1 |
Q9UGP5 | DNA polymerase lambda | Enzyme | C00000144 | 0 / 0 |
O43570 | Carbonic anhydrase 12 | Lyase | C00002647 | 1 / 2 |
Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00005730 | 0 / 0 |
P16581 | E-selectin | Adhesion | C00002647 | 0 / 0 |
P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00000677 | 0 / 0 |
Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00002647 | 0 / 0 |
P04150 | Glucocorticoid receptor | NR3C1 | C00002647 | 0 / 1 |
P16083 | Ribosyldihydronicotinamide dehydrogenase [quinone] | Enzyme | C00005140 | 0 / 0 |
P45452 | Collagenase 3 | M10A | C00000677 | 1 / 1 |
P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00000677 | 2 / 0 |
P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00002647 | 2 / 3 |
O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00000144 | 0 / 0 |
P56817 | Beta-secretase 1 | A1A | C00000677 | 0 / 0 |
P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000677 | 0 / 0 |
Q16790 | Carbonic anhydrase 9 | Lyase | C00002647 | 0 / 1 |
P08253 | 72 kDa type IV collagenase | M10A | C00000677 | 1 / 3 |
P23280 | Carbonic anhydrase 6 | Lyase | C00002647 | 0 / 0 |
Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00000677 | 1 / 1 |
P41145 | Kappa-type opioid receptor | Opioid receptor | C00000677 | 0 / 0 |
Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00000677 | 5 / 2 |
P03372 | Estrogen receptor | NR3A1 | C00002647 | 1 / 1 |
P12821 | Angiotensin-converting enzyme | M2 | C00002647 | 4 / 2 |
P35372 | Mu-type opioid receptor | Opioid receptor | C00000677 | 0 / 0 |
P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00000677 | 0 / 0 |
P30305 | M-phase inducer phosphatase 2 | Ser_Thr_Tyr | C00000144 | 0 / 0 |
P11387 | DNA topoisomerase 1 | Isomerase | C00000144 | 0 / 0 |
P55210 | Caspase-7 | C14 | C00000144 | 0 / 0 |
P14151 | L-selectin | Adhesion | C00002647 | 0 / 0 |
P16109 | P-selectin | Adhesion | C00002647 | 1 / 0 |
P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000677 | 1 / 1 |
Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00005730 | 1 / 0 |
P98170 | E3 ubiquitin-protein ligase XIAP | Other cytosolic protein | C00005140 | 1 / 1 |
P07237 | Protein disulfide-isomerase | Enzyme | C00005730 | 0 / 0 |
O75164 | Lysine-specific demethylase 4A | Enzyme | C00005730 | 0 / 0 |
P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000677 | 0 / 1 |
P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00002647 | 5 / 1 |
P78536 | Disintegrin and metalloproteinase domain-containing protein 17 | M12B | C00002647 | 1 / 0 |
Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002647 | 0 / 0 |
P07451 | Carbonic anhydrase 3 | Lyase | C00002647 | 0 / 0 |
P08254 | Stromelysin-1 | M10A | C00000677 | 1 / 0 |
P34949 | Mannose-6-phosphate isomerase | Enzyme | C00005730 | 1 / 1 |
P22748 | Carbonic anhydrase 4 | Lyase | C00002647 | 1 / 1 |
P00918 | Carbonic anhydrase 2 | Lyase | C00002647 | 1 / 2 |
P24298 | Alanine aminotransferase 1 | Enzyme | C00000677 | 0 / 0 |
P10828 | Thyroid hormone receptor beta | NR1A2 | C00000144 | 3 / 1 |
P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00000677 | 1 / 1 |
P02545 | Prelamin-A/C | Unclassified protein | C00002647 | 11 / 10 |
O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00000144 | 0 / 0 |
P28907 | ADP-ribosyl cyclase 1 | Enzyme | C00000677 | 0 / 1 |
P14780 | Matrix metalloproteinase-9 | M10A | C00000677 | 2 / 2 |
P39900 | Macrophage metalloelastase | M10A | C00000677 | 0 / 0 |
P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | C00002647 | 0 / 0 |
P29466 | Caspase-1 | C14 | C00000144 | 0 / 0 |
P43166 | Carbonic anhydrase 7 | Lyase | C00002647 | 0 / 0 |
P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00002647 | 0 / 0 |
Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00002647 | 0 / 0 |
Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00002647 | 3 / 0 |
P33765 | Adenosine receptor A3 | Adenosine receptor | C00000677 | 0 / 0 |
P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002647 | 0 / 3 |
P21728 | D(1A) dopamine receptor | Dopamine receptor | C00000677 | 0 / 0 |
P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00000677 | 0 / 0 |
P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00000677 | 2 / 0 |
Q99700 | Ataxin-2 | Unclassified protein | C00005730 | 1 / 1 |
O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000144 | 0 / 0 |
gene | gene name | gene description | KNApSAcK metabolite in interactions |
---|---|---|---|
338 | APOB, FLDB, LDLCQ4 | apolipoprotein B |
C00000677
C00002647
|
841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00000144
C00002647
|
7296 | TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR | thioredoxin reductase 1 (EC:1.8.1.9) |
C00000144
C00000677
|
5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00000677
C00002647
|
4255 | MGMT | O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) |
C00002647
|
1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00000677
|
1630 | DCC, CRC18, CRCR1, IGDCC1, MRMV1 | deleted in colorectal carcinoma |
C00000677
|
1950 | EGF, HOMG4, URG | epidermal growth factor |
C00000677
|
8817 | FGF18, FGF-18, ZFGF5 | fibroblast growth factor 18 |
C00000677
|
2248 | FGF3, HBGF-3, INT2 | fibroblast growth factor 3 |
C00000677
|
2621 | GAS6, AXLLG, AXSF | growth arrest-specific 6 |
C00000677
|
9518 | GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB | growth differentiation factor 15 |
C00000677
|
2944 | GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1 | glutathione S-transferase mu 1 (EC:2.5.1.18) |
C00000677
|
3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00000677
|
3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00000677
|
3458 | IFNG, IFG, IFI | interferon, gamma |
C00000677
|
3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00000677
|
8900 | CCNA1 | cyclin A1 |
C00000677
|
4547 | MTTP, ABL, MTP | microsomal triglyceride transfer protein |
C00000677
|
4780 | NFE2L2, NRF2 | nuclear factor, erythroid 2-like 2 |
C00000677
|
1728 | NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 | NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) |
C00000677
|
5155 | PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis | platelet-derived growth factor beta polypeptide |
C00000677
|
5921 | RASA1, CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120GAP, p120RASGAP | RAS p21 protein activator (GTPase activating protein) 1 |
C00000677
|
6772 | STAT1, CANDF7, ISGF-3, STAT91 | signal transducer and activator of transcription 1, 91kDa |
C00000677
|
7187 | TRAF3, CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1 | TNF receptor-associated factor 3 |
C00000677
|
4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00000677
|
7498 | XDH, XO, XOR | xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) |
C00000677
|
7507 | XPA, XP1, XPAC | xeroderma pigmentosum, complementation group A |
C00000677
|
7518 | XRCC4 | X-ray repair complementing defective repair in Chinese hamster cells 4 |
C00000677
|
196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00000144
|
335 | APOA1 | apolipoprotein A-I |
C00000677
|
1601 | DAB2, DOC-2, DOC2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) |
C00000144
|
1874 | E2F4, E2F-4 | E2F transcription factor 4, p107/p130-binding |
C00000144
|
1958 | EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225 | early growth response 1 |
C00000144
|
81631 | MAP1LC3B, ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a | microtubule-associated protein 1 light chain 3 beta |
C00000144
|
10587 | TXNRD2, SELZ, TR, TR-BETA, TR3, TRXR2 | thioredoxin reductase 2 (EC:1.8.1.9) |
C00000144
|
5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00002647
|
25 | ABL1, ABL, JTK7, bcr/abl, c-ABL, p150, v-abl | c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) |
C00002647
|
207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00002647
|
472 | ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 | ataxia telangiectasia mutated (EC:2.7.11.1) |
C00002647
|
545 | ATR, FCTCS, FRP1, MEC1, SCKL, SCKL1 | ataxia telangiectasia and Rad3 related (EC:2.7.11.1) |
C00002647
|
581 | BAX, BCL2L4 | BCL2-associated X protein |
C00002647
|
596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00002647
|
613 | BCR, ALL, BCR1, CML, D22S11, D22S662, PHL | breakpoint cluster region (EC:2.7.11.1) |
C00002647
|
836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00002647
|
898 | CCNE1, CCNE | cyclin E1 |
C00002647
|
998 | CDC42, CDC42Hs, G25K | cell division cycle 42 |
C00002647
|
1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00002647
|
1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00002647
|
1147 | CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16 | conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) |
C00002647
|
7852 | CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM | chemokine (C-X-C motif) receptor 4 |
C00002647
|
54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00002647
|
356 | FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 | Fas ligand (TNF superfamily, member 6) |
C00002647
|
2551 | GABPA, E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07 | GA binding protein transcription factor, alpha subunit 60kDa |
C00002647
|
2885 | GRB2, ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2 | growth factor receptor-bound protein 2 |
C00002647
|
3551 | IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) |
C00002647
|
3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00002647
|
3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00002647
|
3949 | LDLR, FH, FHC, LDLCQ2 | low density lipoprotein receptor |
C00002647
|
5604 | MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 | mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) |
C00002647
|
5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00002647
|
5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00002647
|
5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) |
C00002647
|
993 | CDC25A, CDC25A2 | cell division cycle 25A (EC:3.1.3.48) |
C00000677
|
4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00002647
|
4316 | MMP7, MMP-7, MPSL1, PUMP-1 | matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23) |
C00002647
|
4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00002647
|
4793 | NFKBIB, IKBB, TRIP9 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta |
C00002647
|
5578 | PRKCA, AAG6, PKC-alpha, PKCA, PRKACA | protein kinase C, alpha (EC:2.7.11.13) |
C00002647
|
5591 | PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350 | protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1) |
C00002647
|
5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00002647
|
5879 | RAC1, Rac-1, TC-25, p21-Rac1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
C00002647
|
19412 |
C00002647
|
||
5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00002647
|
387 | RHOA, ARH12, ARHA, RHO12, RHOH12 | ras homolog family member A |
C00002647
|
388 | RHOB, ARH6, ARHB, MST081, MSTP081, RHOH6 | ras homolog family member B |
C00002647
|
6195 | RPS6KA1, HU-1, MAPKAPK1A, RSK, RSK1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 (EC:2.7.11.1) |
C00002647
|
9252 | RPS6KA5, MSK1, MSPK1, RLPK | ribosomal protein S6 kinase, 90kDa, polypeptide 5 (EC:2.7.11.1) |
C00002647
|
6622 | SNCA, NACP, PARK1, PARK4, PD1 | synuclein, alpha (non A4 component of amyloid precursor) |
C00002647
|
6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00002647
|
7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00002647
|
7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00002647
|
7224 | TRPC5, TRP5 | transient receptor potential cation channel, subfamily C, member 5 |
C00002647
|
7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00002647
|
331 | XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 | X-linked inhibitor of apoptosis |
C00002647
|
OMIM | preferred title | UniProt |
---|---|---|
#300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
#202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
#600807 | Asthma, susceptibility to |
Q13093
|
#614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
#601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
#210900 | Bloom syndrome; blm |
P54132
|
#114480 | Breast cancer |
P38398
|
#604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
#115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
#212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
#118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
#605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
#118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
#114500 | Colorectal cancer; crc |
P18054
|
#602579 | Congenital disorder of glycosylation, type ib; cdg1b |
P34949
|
#614466 | Coronary heart disease, susceptibility to, 6; chds6 |
P08254
|
#218800 | Crigler-najjar syndrome, type i |
P22309
|
#606785 | Crigler-najjar syndrome, type ii |
P22309
|
#119900 | Digital clubbing, isolated congenital |
P15428
|
#609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
#608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
#237500 | Dubin-johnson syndrome; djs |
Q92887
|
#181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
#133239 | Esophageal cancer |
P04637
P18054 |
#615363 | Estrogen resistance; estrr |
P03372
|
#600274 | Frontotemporal dementia; ftd |
P10636
|
#143500 | Gilbert syndrome |
P22309
|
#232300 | Glycogen storage disease ii |
P10253
|
#139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
#605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
#610140 | Heart-hand syndrome, slovenian type |
P02545
|
#614519 | Hemorrhage, intracerebral, susceptibility to; ich |
P12821
|
#114550 | Hepatocellular carcinoma |
P08581
|
#176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
#237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
#143860 | Hyperchlorhidrosis, isolated |
O43570
|
#145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
#145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
#259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
#147050 | Ige responsiveness, atopic; iger |
Q13093
|
#614328 | Inflammatory skin and bowel disease, neonatal; nisbd |
P78536
|
#603932 | Intervertebral disc disease; idd |
P14780
|
#601626 | Leukemia, acute myeloid; aml |
P36888
|
#151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
#151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
#211980 | Lung cancer |
P04637
|
#300635 | Lymphoproliferative syndrome, x-linked, 2; xlp2 |
P98170
|
#248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
#300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
#300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
#613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
#612624 | Microvascular complications of diabetes, susceptibility to, 3; mvcd3 |
P12821
|
#259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
#131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
#613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
#159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
#607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
#160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
#162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
#259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
#167000 | Ovarian cancer |
P38398
|
#614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
#260500 | Papilloma of choroid plexus; cpp |
P04637
|
#260540 | Parkinson-dementia syndrome |
P10636
|
#172700 | Pick disease of brain |
P10636
|
#601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
#614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
#605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
#267430 | Renal tubular dysgenesis; rtd |
P12821
|
#275210 | Restrictive dermopathy, lethal |
P02545
|
#600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
#604906 | Schizophrenia 9; sczd9 |
P49798
|
#181500 | Schizophrenia; sczd |
P49798
|
#253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
#253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
#253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
#271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
#605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
#183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
#607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
#602111 | Spondyloepimetaphyseal dysplasia, missouri type |
P45452
|
#275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
#601367 | Stroke, ischemic |
P12821
P16109 P24723 |
#601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
#188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
#274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
#145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
#277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
#278300 | Xanthinuria, type i |
P47989
|
#278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG | name | UniProt |
---|---|---|
H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
H00034 | Carcinoid |
O00255
(related)
|
H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
H00246 | Primary hyperparathyroidism |
O00255
(related)
|
H01102 | Pituitary adenomas |
O00255
(related)
|
H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
H00021 | Renal cell carcinoma |
O43570
(marker)
P04637 (marker) P08581 (related) Q16790 (marker) |
H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
H00436 | Osteopetrosis |
P00918
(related)
|
H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
H00663 | Restrictive dermopathy |
P02545
(related)
|
H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) |
H00028 | Choriocarcinoma |
P03956
(related)
P04637 (related) P08253 (related) |
H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
P28907 (marker) |
H00006 | Hairy-cell leukemia |
P04637
(related)
|
H00008 | Burkitt lymphoma |
P04637
(related)
|
H00009 | Adult T-cell leukemia |
P04637
(related)
|
H00010 | Multiple myeloma |
P04637
(related)
|
H00013 | Small cell lung cancer |
P04637
(related)
|
H00014 | Non-small cell lung cancer |
P04637
(related)
|
H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
H00018 | Gastric cancer |
P04637
(related)
P08581 (related) |
H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
H00022 | Bladder cancer |
P04637
(related)
|
H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P08253 (related) P14780 (related) P35354 (related) |
H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
H00029 | Vulvar cancer |
P04637
(related)
|
H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
H00032 | Thyroid cancer |
P04637
(related)
|
H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
H00038 | Malignant melanoma |
P04637
(related)
|
H00039 | Basal cell carcinoma |
P04637
(related)
|
H00040 | Squamous cell carcinoma |
P04637
(related)
|
H00041 | Kaposi's sarcoma |
P04637
(related)
|
H00042 | Glioma |
P04637
(related)
P04637 (marker) |
H00044 | Cancer of the anal canal |
P04637
(related)
|
H00046 | Cholangiocarcinoma |
P04637
(related)
P08581 (related) P35354 (related) |
H00047 | Gallbladder cancer |
P04637
(related)
|
H00048 | Hepatocellular carcinoma |
P04637
(related)
|
H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
H01007 | Choroid plexus papilloma |
P04637
(related)
|
H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
Q99700 (related) Q9NUW8 (related) |
H00472 | Torg-Winchester syndrome |
P08253
(related)
|
H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
H00342 | Tuberculosis |
P11473
(related)
|
H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
H01205 | Coumarin resistance |
P11712
(related)
|
H00083 | Allograft rejection |
P12821
(related)
|
H00575 | Renal tubular dysgenesis |
P12821
(related)
|
H00479 | Metaphyseal dysplasias |
P14780
(related)
P45452 (related) |
H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
H00208 | Hyperbilirubinemia |
P22309
(related)
Q92887 (related) |
H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
H00118 | Congenital disorders of glycosylation (CDG) type I |
P34949
(related)
|
H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
Q01196 (related) Q01196 (marker) Q13951 (marker) |
H00192 | Xanthinuria |
P47989
(related)
|
H00094 | DNA repair defects |
P54132
(related)
|
H00296 | Defects in RecQ helicases |
P54132
(related)
|
H00107 | Other well-defined immunodeficiency syndromes |
P98170
(related)
|
H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
H00408 | Type I diabetes mellitus |
Q04759
(related)
|
H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
MESH or OMIM | name |
KNApSAcK
metabolite |
---|---|---|
D006461 | Hemolysis |
C00000677
|
D003921 | Diabetes Mellitus, Experimental |
C00002647
|
D050171 | Dyslipidemias |
C00002647
|
D005234 | Fatty Liver |
C00002647
|
D018149 | Glucose Intolerance |
C00002647
|
D006937 | Hypercholesterolemia |
C00002647
|
D006943 | Hyperglycemia |
C00002647
|
D006949 | Hyperlipidemias |
C00002647
|
D015228 | Hypertriglyceridemia |
C00002647
|
D015464 | Leukemia, Myelogenous, Chronic, BCR-ABL Positive |
C00002647
|
D008546 | Melanoma, Experimental |
C00002647
|
D009069 | Movement Disorders |
C00002647
|
D009203 | Myocardial Infarction |
C00002647
|
D009361 | Neoplasm Invasiveness |
C00002647
|
D009362 | Neoplasm Metastasis |
C00002647
|
D012516 | Osteosarcoma |
C00002647
|
D010182 | Pancreatic Diseases |
C00002647
|