KCF-S cluster No. 42 (83 metabolites)

Corresponding Phytochemical cluster No. 14

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (83)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	186
asterids	63
Spermatophyta	21
eudicotyledons	16
Liliopsida	10
Magnoliophyta	4
Euphyllophyta	2

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Cumulative family count (Top 20)

class name	count
Fabaceae	97
Asteraceae	40
Pinaceae	15
Anacardiaceae	13
Rhamnaceae	10
Rosaceae	10
Salicaceae	10
Moraceae	8
Myrtaceae	7
Brassicaceae	6
Lamiaceae	6
Ericaceae	5
Iridaceae	4
Rutaceae	4
Platanaceae	3
Malvaceae	3
Betulaceae	3
Podocarpaceae	3
Orchidaceae	3
Polygonaceae	3

KEGG BRITE br08003

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Categories (2)

br08003 Category	# of metabolite
Dihyroflavonols	7
Isoflavanones	1

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metabolites link (8)

br08003 Category	KEGG ID	KNApSAcK ID
Dihyroflavonols	C01617	C00000677
Dihyroflavonols	C02906	C00000938
Dihyroflavonols	C01378	C00000963
Dihyroflavonols	C09751	C00000964
Dihyroflavonols	C09826	C00000991
Dihyroflavonols	C00974	C00007234
Dihyroflavonols	C09770	C00008594
Isoflavanones	C12631	C00034377

Metabolite list (83)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000677	Distylin / Dihydroquercetin / (2R,3R)-Taxifolin	CHEMBL66 CHEMBL9249 CHEMBL337309 CHEMBL1492383	C003377	65 / 41 / 37	29 / 1
C00000938	Ampelopsin / Dihydromyricetin / (2R,3R)-3,5,7,3',4',5'-Hexahydroxyflavanone	CHEMBL2048508	C106407	6 / 5 / 4	1 / 0
C00000963	(2R,3R)-fustin	CHEMBL470267 CHEMBL508731		2 / 3 / 5
C00000964	Garbanzol	CHEMBL254051
C00000991	Pinobanksin	CHEMBL608410 CHEMBL1097926	C108261
C00007234	Katuranin / (+)-Aromadendrin / (+)-Dihydrokaempferol / (2R,3R)-2,3-Dihydro-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one	CHEMBL9323 CHEMBL1933859	C080220	4 / 3 / 3
C00008408	WS 7528 / BE 14348B / 3-Methylnaringenin		C066794
C00008409	8-Chloro-5,7,4'-trihydroxy-3-C-methylflavanone		C067073
C00008546	3,7-dihydroxyflavanone	CHEMBL252667
C00008547	Pinobanksin 3-methyl ether
C00008548	Pinobanksin 5-methyl ether	CHEMBL551582 CHEMBL1096213
C00008549	Alpinone	CHEMBL1081328
C00008550	(2R,3R)-5,7-Di-O-methylpinobanksin / (2R.3R)-3-Hydroxy-5,7-dimethoxyflavanone
C00008551	3,7-Dihydroxy-6-methoxyflavanone	CHEMBL254729
C00008552	Alnustinol	CHEMBL252704
C00008553	3,5,7,2'-Tetrahydroxyflavanone		C061741
C00008554	Aromadendrin 3-methyl ether
C00008555	Aromadendrin 5-methyl ether
C00008556	Aromadendrin 7-methyl ether	CHEMBL491541 CHEMBL452130
C00008557	Aromadendrin 4'-methyl ether	CHEMBL480655 CHEMBL458480
C00008558	Aromadendrin 5,7-dimethyl ether
C00008559	Aromadendrin 7,4'-dimethyl ether
C00008560	7-Hydroxy-3,5,4'-trimethoxyflavanone
C00008561	(2S,3S)-Fustin	CHEMBL470267 CHEMBL508731		2 / 3 / 5
C00008562	3-O-Methyl-2,3-trans-fustin
C00008563	Fustin 3,7-dimethyl ether
C00008564	3,5,7,4'-Tetrahydroxy-6-methoxyflavanone
C00008565	3,5,4'-Trihydroxy-6,7-dimethoxyflavanone
C00008566	3,5,7-Trihydroxy-6,4'-dimethoxyflavanone
C00008567	3,5,2'-Trihydroxy-7,8-dimethoxyflavanone
C00008568	3,5,7,4'-Tetrahydroxy-8-methoxyflavanone
C00008569	3,5,7-Trihydroxy-8,4'-dimethoxyflavanone
C00008570	Dihydromorin	CHEMBL465073 CHEMBL463453		3 / 2 / 5
C00008571	3,5,7,2',5'-Pentahydroxyflavanone
C00008572	3,5,7,2'-Tetrahydroxy-5'-methoxyflavanone
C00008573	3,5,2'-Trihydroxy-7,5'-dimethoxyflavanone
C00008574	3,5,7,2',6'-Pentahydroxyflavanone	CHEMBL465772
C00008575	Taxifolin 3-methyl ether
C00008576	Taxifolin 5-methyl ether
C00008577	Padmatin
C00008578	Epipadmatin / (2R,3S)-3,5,3',4'-Tetrahydroxy-7-methoxyflavanone
C00008579	Dihydroisorhamnetin / (+)-Dihydroisorhamnetin	CHEMBL9353 CHEMBL1822704
C00008580	Taxifolin 4'-methyl ether	CHEMBL451709
C00008581	Taxifolin 7,3'-dimethyl ether
C00008582	Taxifolin 7,4'-dimethyl ether / (2R,3R)-3,5,3'-Trihydroxy-7,4'-dimethoxyflavanone
C00008583	8-Hydroxyfustin
C00008584	(2R,3S)-3,7,8,3',4'-Pentahydroxyflavanone
C00008585	8-Methoxyfustin
C00008586	Dihydrorobinetin	CHEMBL444171 CHEMBL1163000
C00008587	Sepinol
C00008588	Dihydrogossypetin 7,8-dimethyl ether
C00008589	3,5,7,3'-Tetrahydroxy-8,4'-dimethoxyflavanone
C00008590	Pallasiin	CHEMBL484429
C00008591	Dihydrosyringetin
C00008592	3,5,7-Trihydroxy-6-methylflavanone
C00008593	3,7,4'-Trihydroxy-5-methoxy-6-methylflavanone
C00008594	Cedeodarin / 6-Methoxytaxifolin / 3,5,7,3',4'-Pentahydroxy-6-methylflavanone
C00008595	Deodarin
C00008596	Cedrin
C00008601	Peltogynone
C00008602	Mopanone
C00008603	Crombeone
C00008604	5-Methoxypeltogynone
C00008605	5-Methoxymopanone
C00014363	cis-3-Hydroxy-5,7-dimethoxyflavanone / (2R,3S)-3-Hydroxy-5,7-dimethoxyflavanone
C00014364	(2R,3R)-3,5,8-Trihydroxy-7-methoxyflavanone
C00014365	(2R,3R)-3-Hydroxy-5,7,4'-trimethoxyflavanone
C00014366	3,5,2',3'-Tetrahydroxy-7-methoxyflavanone
C00014367	3,5,3'-Trihydroxy-7,2'-dimethoxyflavanone
C00014368	(2R,3S)-3,5,3'-Trihydroxy-7,4'-dimethoxyflavanone
C00014369	Hovenitin III / (2R,3S)-3,5,7,3',4',5'-Hexahydroxyflavanone	CHEMBL2048508		6 / 5 / 4
C00014370	Diosalol / (2R,3R)-3,5,7,2',5'-Pentahydroxy-6-methoxyflavanone
C00014371	Hovenitin I / (2R,3R)-3,5,7,4',5'-Pentahydroxy-3'-methoxyflavanone		C105698
C00014372	Hovenitin II / (2R,3S)-3,5,7,4',5'-Pentahydroxy-3'-methoxyflavanone
C00014378	3,5,7-Trihydroxy-4'-methoxy-6-methylflavanone
C00014379	3,5,7,3',4'-Pentahydroxy- 6'-hydroxymethylflavanone
C00020493	Folerogenin	CHEMBL491541 CHEMBL452130
C00020593	Guarabin
C00020607	Isoguarabin
C00030207	Erycibenin D / (-)-Erycibenin D	CHEMBL241571
C00033753	Dalparvinol C / (+)-Dalparvinol C
C00034377	2',4',5,7-Tetrahydroxyisoflavanone
C00045465	(-)-Alpinone	CHEMBL1081328

Human Protein / Gene in interactions

70 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P39900	Macrophage metalloelastase	M10A	C00000677 C00000938 C00014369	0 / 0
P08254	Stromelysin-1	M10A	C00000677 C00000938 C00014369	1 / 0
P03956	Interstitial collagenase	M10A	C00000677 C00000938 C00014369	0 / 1
P08253	72 kDa type IV collagenase	M10A	C00000677 C00000938 C00014369	1 / 3
P45452	Collagenase 3	M10A	C00000677 C00000938 C00014369	1 / 1
P14780	Matrix metalloproteinase-9	M10A	C00000677 C00000938 C00014369	2 / 2
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00007234 C00008570	2 / 2
P83916	Chromobox protein homolog 1	Unclassified protein	C00000677 C00007234	0 / 0
P10275	Androgen receptor	NR3C4	C00000963 C00008561	3 / 4
O75496	Geminin	Unclassified protein	C00000677 C00007234	0 / 0
P36888	Receptor-type tyrosine-protein kinase FLT3	Pdgfr	C00000677 C00007234	1 / 1
P04150	Glucocorticoid receptor	NR3C1	C00000963 C00008561	0 / 1
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00000677	0 / 0
P28907	ADP-ribosyl cyclase 1	Enzyme	C00000677	0 / 1
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00000677	1 / 1
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000677	0 / 1
P54132	Bloom syndrome protein	Enzyme	C00000677	1 / 2
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00008570	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00000677	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000677	1 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00000677	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00000677	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00000677	1 / 1
P41143	Delta-type opioid receptor	Opioid receptor	C00000677	0 / 0
P06746	DNA polymerase beta	Enzyme	C00000677	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00000677	1 / 1
P33765	Adenosine receptor A3	Adenosine receptor	C00000677	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00000677	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00008570	0 / 3
P21728	D(1A) dopamine receptor	Dopamine receptor	C00000677	0 / 0
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00000677	0 / 0
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00000677	2 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00000677	0 / 0
P56817	Beta-secretase 1	A1A	C00000677	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000677	0 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00000677	2 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00000677	3 / 3
Q92887	Canalicular multispecific organic anion transporter 1	Unclassified protein	C00000677	1 / 1
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00000677	2 / 2
Q01453	Peripheral myelin protein 22	Unclassified protein	C00000677	5 / 2
P35372	Mu-type opioid receptor	Opioid receptor	C00000677	0 / 0
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00000677	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00000677	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000677	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000677	0 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00000677	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00000677	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00000677	4 / 3
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00000677	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00000677	4 / 1
Q9UBT6	DNA polymerase kappa	Enzyme	C00000677	0 / 0
P24298	Alanine aminotransferase 1	Enzyme	C00000677	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00000677	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00000677	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000677	0 / 0
O00255	Menin	Unclassified protein	C00000677	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00000677	1 / 2
Q13951	Core-binding factor subunit beta	Unclassified protein	C00000677	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00000677	1 / 4
Q05513	Protein kinase C zeta type	Iota	C00000677	0 / 0
Q04759	Protein kinase C theta type	Delta	C00000677	0 / 1
Q02156	Protein kinase C epsilon type	Eta	C00000677	0 / 0
O94806	Serine/threonine-protein kinase D3	Pkd	C00000677	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00000677	0 / 0
Q05655	Protein kinase C delta type	Delta	C00000677	0 / 0
P05129	Protein kinase C gamma type	Alpha	C00000677	1 / 1
P05771	Protein kinase C beta type	Alpha	C00000677	0 / 0
P24723	Protein kinase C eta type	Eta	C00000677	1 / 0
P41743	Protein kinase C iota type	Iota	C00000677	0 / 0
Q15139	Serine/threonine-protein kinase D1	Pkd	C00000677	0 / 0

30 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
4363	ABCC1, ABC29, ABCC, GS-X, MRP, MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	C00000677
335	APOA1	apolipoprotein A-I	C00000677
338	APOB, FLDB, LDLCQ4	apolipoprotein B	C00000677
8900	CCNA1	cyclin A1	C00000677
993	CDC25A, CDC25A2	cell division cycle 25A (EC:3.1.3.48)	C00000677
1571	CYP2E1, CPE1, CYP2E, P450-J, P450C2E	cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7)	C00000677
1630	DCC, CRC18, CRCR1, IGDCC1, MRMV1	deleted in colorectal carcinoma	C00000677
1950	EGF, HOMG4, URG	epidermal growth factor	C00000677
8817	FGF18, FGF-18, ZFGF5	fibroblast growth factor 18	C00000677
2248	FGF3, HBGF-3, INT2	fibroblast growth factor 3	C00000677
2621	GAS6, AXLLG, AXSF	growth arrest-specific 6	C00000677
9518	GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB	growth differentiation factor 15	C00000677
2944	GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1	glutathione S-transferase mu 1 (EC:2.5.1.18)	C00000677
3162	HMOX1, HMOX1D, HO-1, HSP32, bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	C00000677
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00000677
3458	IFNG, IFG, IFI	interferon, gamma	C00000677
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00000677
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00000677
4547	MTTP, ABL, MTP	microsomal triglyceride transfer protein	C00000677
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00000677
1728	NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1	NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2)	C00000677
5155	PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis	platelet-derived growth factor beta polypeptide	C00000677
5921	RASA1, CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120GAP, p120RASGAP	RAS p21 protein activator (GTPase activating protein) 1	C00000677
6772	STAT1, CANDF7, ISGF-3, STAT91	signal transducer and activator of transcription 1, 91kDa	C00000677
7187	TRAF3, CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1	TNF receptor-associated factor 3	C00000677
7296	TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR	thioredoxin reductase 1 (EC:1.8.1.9)	C00000677
7498	XDH, XO, XOR	xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2)	C00000677
7507	XPA, XP1, XPAC	xeroderma pigmentosum, complementation group A	C00000677
7518	XRCC4	X-ray repair complementing defective repair in Chinese hamster cells 4	C00000677
8877	SPHK1, SPHK	sphingosine kinase 1 (EC:2.7.1.91)	C00000938

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions