Juglans nigra
Species
KNApSAcK Entry
| Organism name | Juglans nigra |
|---|---|
| Genus | Juglans |
| Family | Juglandaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Juglans nigra |
|---|---|
| Linked NCBI taxonomy ID | 16719 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Juglandaceae |
|---|---|
| ID | 16714 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Natural Activity
List (17)
| Species | Activity |
|---|---|
| Juglans nigra L. | Alterative |
| Juglans nigra L. | Anti-HIV |
| Juglans nigra L. | Antiseptic |
| Juglans nigra L. | Antitumor |
| Juglans nigra L. | Antiviral |
| Juglans nigra L. | Astringent |
| Juglans nigra L. | Depurative |
| Juglans nigra L. | Diaphoretic |
| Juglans nigra L. | Emetic |
| Juglans nigra L. | Fungicide |
| Juglans nigra L. | Hemostat |
| Juglans nigra L. | Herbicide |
| Juglans nigra L. | Insecticide |
| Juglans nigra L. | Laxative |
| Juglans nigra L. | Parasiticide |
| Juglans nigra L. | Vermifuge |
| Juglans nigra L. | Vulnerary |
Metabolite list (3)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00007885
|
Neosakuranin
|
CHEMBL495848
|
No. 36 | No. 13 |
|
|||
|
C00002775
|
Sinapaldehyde
/ Sinapic aldehyde |
CHEMBL225067
|
C075386
|
No. 310 | No. 6 |
|
||
|
C00000144
|
juglone
/ 5-Hydroxy-1,4-naphthoquinone |
CHEMBL43612
|
C005134
|
31 / 31 / 60 | 8 / 0 | No. 1047 | No. 80 |
|
Human Protein / Gene in interactions
31 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00000144 | 7 / 37 |
| P29466 | Caspase-1 | C14 | C00000144 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00000144 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00000144 | 3 / 1 |
| P54132 | Bloom syndrome protein | Enzyme | C00000144 | 1 / 2 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00000144 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000144 | 2 / 3 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00000144 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000144 | 0 / 0 |
| P14902 | Indoleamine 2,3-dioxygenase 1 | Enzyme | C00000144 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00000144 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00000144 | 4 / 2 |
| Q9UGP5 | DNA polymerase lambda | Enzyme | C00000144 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000144 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000144 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000144 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000144 | 2 / 2 |
| P30305 | M-phase inducer phosphatase 2 | Ser_Thr_Tyr | C00000144 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00000144 | 0 / 0 |
| P55210 | Caspase-7 | C14 | C00000144 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000144 | 0 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000144 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000144 | 4 / 3 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000144 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000144 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000144 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000144 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00000144 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000144 | 1 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00000144 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00000144 | 1 / 4 |
8 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00000144
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00000144
|
| 1601 | DAB2, DOC-2, DOC2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) |
C00000144
|
| 1874 | E2F4, E2F-4 | E2F transcription factor 4, p107/p130-binding |
C00000144
|
| 1958 | EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225 | early growth response 1 |
C00000144
|
| 81631 | MAP1LC3B, ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a | microtubule-associated protein 1 light chain 3 beta |
C00000144
|
| 7296 | TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR | thioredoxin reductase 1 (EC:1.8.1.9) |
C00000144
|
| 10587 | TXNRD2, SELZ, TR, TR-BETA, TR3, TRXR2 | thioredoxin reductase 2 (EC:1.8.1.9) |
C00000144
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (31)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #133239 | Esophageal cancer |
P04637
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #211980 | Lung cancer |
P04637
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (60)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|