KCF-S cluster No. 38 (88 metabolites)

Corresponding Phytochemical cluster No. 21

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (88)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
Magnoliophyta	226
asterids	197
rosids	151
Liliopsida	30
Spermatophyta	25
eudicotyledons	22
Embryophyta	4

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Cumulative family count (Top 20)

class name	count
Magnoliaceae	73
Rutaceae	54
Lauraceae	46
Oleaceae	39
Myristicaceae	31
Thymelaeaceae	31
Asteraceae	31
Piperaceae	22
Araliaceae	18
Annonaceae	16
Apocynaceae	15
Lamiaceae	13
Hernandiaceae	13
Pinaceae	12
Acanthaceae	11
Aristolochiaceae	11
Orobanchaceae	10
Araceae	10
Malvaceae	9
Fabaceae	8

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Lignans	9

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metabolites link (10)

br08003 Category	KEGG ID	KNApSAcK ID
Lignans	C10561	C00000640
Lignans	C10894	C00000642
Lignans	C10622	C00002607
Lignans	C10879	C00002623
Lignans	C10884	C00002627
Lignans	C10889	C00002631
Lignans	C10892	C00002633
Lignans	C05366	C00007190
Lignans	C16957	C00030244
Lignans	C10889	C00044152

Metabolite list (88)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000587	(-)-Pinoresinol	CHEMBL267963 CHEMBL487611 CHEMBL460862		7 / 5 / 6
C00000625	(-)-Lirioresinol A / (-)-Episyringaresinol	CHEMBL361362 CHEMBL402653		1 / 0 / 0
C00000627	(-)-Lirioresinol B / (-)-Syringaresinol	CHEMBL361362 CHEMBL402653		1 / 0 / 0
C00000638	(+)-Piperitol	CHEMBL1688935 CHEMBL1688938 CHEMBL2011539 CHEMBL2011540 CHEMBL2136585		7 / 13 / 7
C00000640	(+)-Eudesmin	CHEMBL519099 CHEMBL512865 CHEMBL523743 CHEMBL464352 CHEMBL1726879	C105875	2 / 0 / 0
C00000641	Magnolin / (+)-Magnolin	CHEMBL453302 CHEMBL519926	C094148
C00000642	(+)-Yangambin	CHEMBL510536 CHEMBL454592 CHEMBL1412125		4 / 2 / 0
C00000643	Kobusin / (+)-Kobusin / (+)-Spinescin / Methylpiperitol	CHEMBL462822
C00000644	Kobusinol A
C00000645	Kobusinol B
C00000647	(+)-Phillygenin	CHEMBL457587
C00000659	Medioresinol / (+)-Medioresinol	CHEMBL376507 CHEMBL513023		2 / 1 / 1
C00000697	(-)-Machilusin	CHEMBL471177 CHEMBL469499 CHEMBL559937
C00000698	(+)-Epieudesmin	CHEMBL519099 CHEMBL512865 CHEMBL523743 CHEMBL464352 CHEMBL1726879		2 / 0 / 0
C00002607	Grandisin / (-)-Grandisin	CHEMBL459404 CHEMBL459405 CHEMBL1377609 CHEMBL2204392	C074346	4 / 3 / 7
C00002623	Saucernetin	CHEMBL56800 CHEMBL57542 CHEMBL418309 CHEMBL291515 CHEMBL56856 CHEMBL56917 CHEMBL112481 CHEMBL469500		1 / 0 / 0
C00002627	Sesartemin	CHEMBL453301 CHEMBL1980572 CHEMBL1988515 CHEMBL1990848
C00002631	(+)-Lirioresinol B / (+)-Syringaresinol	CHEMBL361362 CHEMBL402653	C042192	1 / 0 / 0
C00002633	(+)-Veraguensin	CHEMBL56800 CHEMBL57542 CHEMBL418309 CHEMBL291515 CHEMBL56856 CHEMBL56917 CHEMBL112481 CHEMBL469500		1 / 0 / 0
C00007190	(+)-Pinoresinol	CHEMBL267963 CHEMBL487611 CHEMBL460862	C103298	7 / 5 / 6
C00007192	(+)-Epipinoresinol	CHEMBL267963 CHEMBL487611 CHEMBL460862		7 / 5 / 6
C00007193	(+)-Xanthoxylol	CHEMBL1688935 CHEMBL1688938 CHEMBL2011539 CHEMBL2011540 CHEMBL2136585		7 / 13 / 7
C00007195	(+)-Fargesin	CHEMBL462822	C058339
C00007196	(+)-Epimagnolin	CHEMBL453302 CHEMBL519926
C00007197	(+)-Epiyangambin	CHEMBL510536 CHEMBL454592 CHEMBL1412125	C082827	4 / 2 / 0
C00007198	(+)-Lariciresinol 4-methyl ether	CHEMBL483422
C00007199	(+)-Lariciresinol dimethyl ether	CHEMBL1760590
C00007212	Galgravin	CHEMBL56800 CHEMBL57542 CHEMBL418309 CHEMBL291515 CHEMBL56856 CHEMBL56917 CHEMBL112481 CHEMBL469500	C084077	1 / 0 / 0
C00021674	Nectandrin B / Malabaricanol	CHEMBL228326 CHEMBL1170325		1 / 0 / 1
C00024162	Fragransin A2 / (+)-Fragransin A2	CHEMBL228326 CHEMBL1170325		1 / 0 / 1
C00024163	Fragransin B1
C00024164	Fragransin B2
C00024165	Fragransin B3
C00024166	Machilin H / Fragransin C1 / (+)-Fragransin C1	CHEMBL1812793
C00024167	Fragransin C2	CHEMBL1812793
C00024168	Fragransin C3a / (+)-Fragransin C3a	CHEMBL1812793
C00024169	Fragransin C3b	CHEMBL1812793
C00024170	Fragransin D1 / (+)-Fragransin D1
C00024171	Fragransin D2
C00024172	Fragransin D3
C00024173	Fragransin E1
C00029279	(-)-Aschantin	CHEMBL480876 CHEMBL2007286
C00029284	(-)-Medioresinol	CHEMBL376507 CHEMBL513023		2 / 1 / 1
C00029595	7R,8S,7'S.8'R-3,4,3',4'-Tetramethoxy-9,7'-dihydroxy-8,8',7.O.9'-lignan
C00029596	7S,8R,7'S.8'R-3,4,3',4'-Tetramethoxy-9,7'-dihydroxy-8,8',7.O.9'-lignan
C00029744	Aschantin
C00030244	Fargesin	CHEMBL462822
C00030492	Horsfieldin
C00030639	Lariciresinol dimethyl ether / (+)-Lariciresinol dimethyl ether	CHEMBL1760590
C00030703	Machilin I	CHEMBL228326 CHEMBL1170325		1 / 0 / 1
C00030710	Magnostellin A
C00030885	Odoratisol C / (-)-Odoratisol C	CHEMBL228326 CHEMBL1170325		1 / 0 / 1
C00030886	Odoratisol D
C00031445	(-)-Chicanine
C00031449	(-)-Methylpiperitol	CHEMBL462822
C00031455	(+)-Diayangambin	CHEMBL510536 CHEMBL454592 CHEMBL1412125	C472151	4 / 2 / 0
C00031801	Galbelgin	CHEMBL56800 CHEMBL57542 CHEMBL418309 CHEMBL291515 CHEMBL56856 CHEMBL56917 CHEMBL112481 CHEMBL469500		1 / 0 / 0
C00032559	(-)-Fargesol
C00033151	Magnostellin B / (+)-Magnostellin B
C00033950	Icariol A2 / (-)-Icariol A2	CHEMBL466534
C00034730	Tripterygiol / (+)-Tripterygiol
C00036305	(+)-Epiexcelsin
C00037278	Huazhongilexin	CHEMBL466534
C00037984	Verrucosin / (+)-Verrucosin	CHEMBL228326 CHEMBL1170325		1 / 0 / 1
C00037991	Virgatusin
C00038062	(-)-Xanthoxylol	CHEMBL1688935 CHEMBL1688938 CHEMBL2011539 CHEMBL2011540 CHEMBL2136585		7 / 13 / 7
C00038083	(+)-Neoolivil	CHEMBL464631 CHEMBL577783		1 / 0 / 0
C00040828	4,9'-Dihydroxy-3',4',5-trimethoxy-7',9-epoxylignan	CHEMBL483422
C00041994	(+)-Diaeudesmin	CHEMBL519099 CHEMBL512865 CHEMBL523743 CHEMBL464352 CHEMBL1726879		2 / 0 / 0
C00043134	(+)-Epiaschantin	CHEMBL480876 CHEMBL2007286
C00043282	Aristolignin	CHEMBL444025 CHEMBL513705
C00043338	Calopiptin	CHEMBL471177 CHEMBL469499 CHEMBL559937
C00043643	Kusunokinol / (-)-Kusunokinol	CHEMBL514686
C00043690	Machilin G / (+)-Machilin G	CHEMBL471177 CHEMBL469499 CHEMBL559937
C00043755	Nectandrin A / (+)-Nectandrin A	CHEMBL444025 CHEMBL513705
C00043756	Nectandrin C / (+)-Nectandrin C
C00043757	Nectandrin D / (+)-Nectandrin D	CHEMBL444025 CHEMBL513705
C00043758	Nectandrin E / (+)-Nectandrin E	CHEMBL444025 CHEMBL513705
C00043843	Praderin
C00044152	dl-Syringaresinol	CHEMBL361362 CHEMBL402653		1 / 0 / 0
C00044400	(+)-Pinoresinol monomethyl ether	CHEMBL457587
C00045144	(+)-Epimagnolin A	CHEMBL453302 CHEMBL519926
C00045293	Diasesartemin	CHEMBL453301 CHEMBL1980572 CHEMBL1988515 CHEMBL1990848
C00045653	Aristelegin B / (-)-Aristelegin B
C00045654	Aristelegin C / (-)-Aristelegin C
C00045892	Epigrandisin / (-)-Epigrandisin	CHEMBL459404 CHEMBL459405 CHEMBL1377609 CHEMBL2204392		4 / 3 / 7
C00047041	Epigrandisin	CHEMBL459404 CHEMBL459405 CHEMBL1377609 CHEMBL2204392		4 / 3 / 7
C00047400	Austrobailignan 7

Human Protein / Gene in interactions

23 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
O75496	Geminin	Unclassified protein	C00000638 C00000642 C00002607 C00007193 C00007197 C00031455 C00038062 C00045892 C00047041	0 / 0
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00000587 C00000638 C00007190 C00007192 C00007193 C00038062	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00000587 C00000642 C00007190 C00007192 C00007197 C00031455	0 / 0
Q07869	Peroxisome proliferator-activated receptor alpha	NR1C1	C00000587 C00000638 C00007190 C00007192 C00007193 C00038062	0 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00000587 C00000638 C00007190 C00007192 C00007193 C00038062	5 / 3
Q9UBT6	DNA polymerase kappa	Enzyme	C00000640 C00000642 C00000698 C00007197 C00031455 C00041994	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00021674 C00024162 C00030703 C00030885 C00037984	0 / 1
P11387	DNA topoisomerase 1	Isomerase	C00000625 C00000627 C00002631 C00044152	0 / 0
P25105	Platelet-activating factor receptor	PAF receptor	C00002623 C00002633 C00007212 C00031801	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00000587 C00007190 C00007192	0 / 3
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00000638 C00007193 C00038062	7 / 3
O00255	Menin	Unclassified protein	C00002607 C00045892 C00047041	2 / 5
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00000642 C00007197 C00031455	2 / 0
Q9H0H5	Rac GTPase-activating protein 1	Unclassified protein	C00000587 C00007190 C00007192	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00000640 C00000698 C00041994	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002607 C00045892 C00047041	1 / 2
Q9UNA4	DNA polymerase iota	Enzyme	C00002607 C00045892 C00047041	0 / 0
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00000587 C00007190 C00007192	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00000638 C00007193 C00038062	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00000638 C00007193 C00038062	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000659 C00029284	0 / 1
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000659 C00029284	1 / 0
P04278	Sex hormone-binding globulin	Secreted protein	C00038083	0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions