phytochemical cluster No. 21 (379 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• KCF-S cluster (19)
• Metabolite list (379)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
Magnoliophyta	539
asterids	515
rosids	398
Spermatophyta	214
eudicotyledons	93
Liliopsida	41
Embryophyta	8
Euphyllophyta	2

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Cumulative family count (Top 20)

class name	count
Schisandraceae	160
Rutaceae	144
Cupressaceae	113
Asteraceae	107
Magnoliaceae	101
Oleaceae	75
Lauraceae	71
Thymelaeaceae	70
Acanthaceae	62
Myristicaceae	57
Pinaceae	54
Piperaceae	54
Berberidaceae	51
Lamiaceae	49
Apocynaceae	43
Aristolochiaceae	37
Phyllanthaceae	37
Araliaceae	35
Taxaceae	35
Apiaceae	26

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Lignans	52

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metabolites link (56)

br08003 Category	KEGG ID	KNApSAcK ID
Lignans	C10725	C00000599
Lignans	C10891	C00000600
Lignans	C10882	C00000601
Lignans	C10646	C00000602
Lignans	C18167	C00000604
Lignans	C10682	C00000606
Lignans	C10545	C00000609
Lignans	C10874	C00000610
Lignans	C10886	C00000612
Lignans	C10873	C00000634
Lignans	C10561	C00000640
Lignans	C10894	C00000642
Lignans	C10719	C00000693
Lignans	C10633	C00000700
Lignans	C10636	C00000701
Lignans	C10547	C00000705
Lignans	C10746	C00000706
Lignans	C10658	C00000725
Lignans	C10877	C00000727
Lignans	C10544	C00002588
Lignans	C10546	C00002589
Lignans	C10551	C00002593
Lignans	C10552	C00002594
Lignans	C10553	C00002595
Lignans	C10555	C00002596
Lignans	C10556	C00002597
Lignans	C10557	C00002598
Lignans	C10558	C00002599
Lignans	C10559	C00002600
Lignans	C10616	C00002605
Lignans	C10621	C00002606
Lignans	C10622	C00002607
Lignans	C10627	C00002608
Lignans	C10657	C00002612
Lignans	C10707	C00002613
Lignans	C10728	C00002614
Lignans	C10729	C00002615
Lignans	C10730	C00002616
Lignans	C10737	C00002617
Lignans	C10871	C00002619
Lignans	C10875	C00002620
Lignans	C10879	C00002623
Lignans	C10880	C00002624
Lignans	C10883	C00002626
Lignans	C10884	C00002627
Lignans	C10887	C00002629
Lignans	C10889	C00002631
Lignans	C10892	C00002633
Lignans	C10893	C00002634
Lignans	C05366	C00007190
Lignans	C10555	C00007216
Lignans	C17814	C00007217
Lignans	C16957	C00030244
Lignans	C10871	C00033300
Lignans	C10558	C00039028
Lignans	C10889	C00044152

KCF-S cluster (19)

KCF-S ID	# of metabolite
No. 38	88
No. 105	46
No. 147	36
No. 223	29
No. 216	29
No. 282	24
No. 285	24
No. 427	18
No. 621	13
No. 629	13
No. 700	12
No. 951	10
No. 1029	9
No. 1142	8
No. 1232	8
No. 2159	5
No. 1938	5
No. 7343	1
No. 7392	1

Metabolite list (379)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	figure
C00000587	(-)-Lirioresinol B / (-)-Syringaresinol	CHEMBL361362 CHEMBL402653		1 / 0 / 0		No. 38
C00040828	Picropodophyllone	CHEMBL82303 CHEMBL1778160				No. 38
C00041994	7beta,7beta-Epoxyzuonin A					No. 38
C00043134	Heliobuphthalmin lactone	CHEMBL180970 CHEMBL182073 CHEMBL242011		2 / 1 / 1		No. 38
C00043282	Hinokinin / Hinoquinin / (-)-Hinokinin / (-)-Hinoquinin	CHEMBL180970 CHEMBL182073 CHEMBL242011	C475934	2 / 1 / 1		No. 38
C00038083	Sauriol B / (-)-Sauriol B					No. 38
C00038062	Sauriol A / (-)-Sauriol A					No. 38
C00037991	(+)-Secoisolariciresinol	CHEMBL368347		2 / 1 / 1		No. 38
C00037984	(-)-Secoisolariciresinol	CHEMBL368347	C060283	2 / 1 / 1	1 / 0	No. 38
C00043338	(+)-Hinokinin	CHEMBL180970 CHEMBL182073 CHEMBL242011		2 / 1 / 1		No. 38
C00037278	Oleiferin F / (+)-Oleiferin F					No. 38
C00043643	(-)-Cubebin / beta-Cubebin / (-)-beta-Cubebin / (8R,8'R,9S)-Cubebin	CHEMBL182001 CHEMBL399831	C433065	2 / 1 / 1	0 / 2	No. 38
C00043690	beta-Methylcubebin	CHEMBL520915		2 / 1 / 1		No. 38
C00043755	Dehydroxycubebin / (-)-Dehydroxycubebin	CHEMBL487394				No. 38
C00043756	Dihydrocubebin / (-)-Dihydrocubebin	CHEMBL486597 CHEMBL1477391	C011228	4 / 8 / 4		No. 38
C00043757	(-)-Dihydrocubebin	CHEMBL486597 CHEMBL1477391	C011228	4 / 8 / 4		No. 38
C00000625	Aschantin					No. 38
C00000627	Sesartemin	CHEMBL453301 CHEMBL1980572 CHEMBL1988515 CHEMBL1990848				No. 38
C00043758	3,4 / 3',4'-Bismethylenedioxybibenzyl					No. 38
C00043843	(+)-Lariciresinol	CHEMBL518421		2 / 1 / 1		No. 38
C00036305	(+)-Arctigenin	CHEMBL369142 CHEMBL435734 CHEMBL1966556		13 / 7 / 6		No. 38
C00000638	(-)-Xanthoxylol	CHEMBL1688935 CHEMBL1688938 CHEMBL2011539 CHEMBL2011540 CHEMBL2136585		7 / 13 / 7		No. 38
C00044152	(8R,8'R,9R)-4,4',9-trihydroxy-3,3'-dimethoxy-9,9'-epoxylignan	CHEMBL514546 CHEMBL575225 CHEMBL584197				No. 38
C00000640	Horsfieldin					No. 38
C00000641	Kobusin / (+)-Kobusin / (+)-Spinescin / Methylpiperitol	CHEMBL462822				No. 38
C00000642	(+)-Fargesin	CHEMBL462822	C058339			No. 38
C00000643	Fargesin	CHEMBL462822				No. 38
C00000644	(-)-Methylpiperitol	CHEMBL462822				No. 38
C00000645	(+)-Phillygenin	CHEMBL457587				No. 38
C00000647	(+)-Pinoresinol monomethyl ether	CHEMBL457587				No. 38
C00044400	(+)-Taxiresinol	CHEMBL1668114		2 / 1 / 1		No. 38
C00045144	Lariciresinol acetate / (+)-Lariciresinol acetate	CHEMBL464991 CHEMBL1406708		18 / 6 / 8		No. 38
C00000659	(-)-Pinoresinol	CHEMBL267963 CHEMBL487611 CHEMBL460862		7 / 5 / 6		No. 38
C00045293	Renealtin A / (+)-Renealtin A					No. 38
C00045653	1-Acetoxypinoresinol					No. 38
C00045654	Acoradin	CHEMBL345432 CHEMBL156339	C069674	2 / 1 / 1		No. 38
C00045892	Magnosalin	CHEMBL345432 CHEMBL156339		2 / 1 / 1		No. 38
C00000697	Fragransin C3b	CHEMBL1812793				No. 38
C00000698	Fragransin C3a / (+)-Fragransin C3a	CHEMBL1812793				No. 38
C00034730	(+)-Matairesinol	CHEMBL425148		1 / 0 / 0		No. 38
C00033950	Kadsuphilol L					No. 38
C00033151	Kadangustin E	CHEMBL435985				No. 38
C00032559	Kadsuphilol D	CHEMBL376401				No. 38
C00031801	Tiegusanin C	CHEMBL563213				No. 38
C00047041	Pachypostaduin A / Pachypostaudin A					No. 38
C00031455	Kadsuphilol K					No. 38
C00031449	Kadsuphilin F					No. 38
C00031445	Schisantherin D	CHEMBL475880	C082093			No. 38
C00047400	Magnoshinin		C069675			No. 38
C00030886	Kadsuralignan B					No. 38
C00030885	Schisantherin G					No. 38
C00030710	Kadangustin F	CHEMBL465516 CHEMBL465863				No. 38
C00030703	Tiegusanin J	CHEMBL2012544 CHEMBL2012546				No. 38
C00030639	Tigloylgomisin H	CHEMBL479287 CHEMBL1092320 CHEMBL1093179		1 / 0 / 0		No. 38
C00030492	Angeloylisogomisin O					No. 38
C00030244	Arisanschinin I					No. 38
C00029744	Angeloylgomisin P	CHEMBL253687 CHEMBL253907 CHEMBL490308 CHEMBL491342 CHEMBL1867703 CHEMBL2313594				No. 38
C00029596	Kadsuphilin D					No. 38
C00029595	Kadsuphilol I					No. 38
C00029284	Kadsurin	CHEMBL559796 CHEMBL1460441	C075123	4 / 3 / 1		No. 38
C00029279	Longipedunin B					No. 38
C00024173	Gomisin R	CHEMBL465720 CHEMBL1237139				No. 38
C00024172	Tiegusanin M					No. 38
C00024171	Rubriflorin B					No. 38
C00024170	Schizandrin / Schisandrol A / Wuweizichun A / (+)-Schizandrin	CHEMBL253688	C011105	2 / 0 / 0		No. 38
C00024169	Gomisin A	CHEMBL403578 CHEMBL1159658 CHEMBL1834755	C033585	5 / 0 / 0	2 / 2	No. 38
C00024168	(+)-Gomisin A	CHEMBL403578 CHEMBL1159658 CHEMBL1834755		5 / 0 / 0		No. 38
C00024167	Deangeloylschisantherin F	CHEMBL465892				No. 38
C00002607	Magnostellin A					No. 38
C00024166	(-)-Gomisin J	CHEMBL251864	C082091			No. 38
C00024165	Rubrisandrin B					No. 38
C00024164	Arisanschinin F	CHEMBL1080599 CHEMBL1080600				No. 38
C00024163	Arisanschinin G	CHEMBL1080599 CHEMBL1080600				No. 38
C00024162	Rubrisandrin A	CHEMBL1080599 CHEMBL1080600				No. 38
C00021674	Schisandrin A / Deoxyschisandrin	CHEMBL253908 CHEMBL490126 CHEMBL479898	C034734	4 / 1 / 4	2 / 0	No. 38
C00007212	Kadsulignan N	CHEMBL517461				No. 38
C00007199	Pyramidatin H					No. 38
C00007198	Pyramidatin G					No. 38
C00002623	Grandisin / (-)-Grandisin	CHEMBL459404 CHEMBL459405 CHEMBL1377609 CHEMBL2204392	C074346	4 / 3 / 7		No. 38
C00007197	Pyramidatin F					No. 38
C00007196	Kadsuralignan A					No. 38
C00007195	Kadsuphilol A	CHEMBL447240 CHEMBL518555				No. 38
C00002627	Fragransin B2					No. 38
C00007193	Methylisogomisin O					No. 38
C00002631	Icariol A2 / (-)-Icariol A2	CHEMBL466534				No. 38
C00002633	Huazhongilexin	CHEMBL466534				No. 38
C00007192	Gomisin O	CHEMBL522973 CHEMBL521975				No. 38
C00007190	Epigomisin O	CHEMBL522973 CHEMBL521975				No. 38
C00038952	Phyllanthusmin A					No. 105
C00041561	Burseranin / (+)-Burseranin					No. 105
C00002634	Tripterygiol / (+)-Tripterygiol					No. 105
C00041495	alpha-Peltatin	CHEMBL95972 CHEMBL368930 CHEMBL1591274	C049798	6 / 2 / 0		No. 105
C00000712	Odoratisol C / (-)-Odoratisol C	CHEMBL228326 CHEMBL1170325		1 / 0 / 1		No. 105
C00048444	Ethoxyclusin / (-)-Ethoxyclusin					No. 105
C00030770	Kadsuphilol J					No. 105
C00046205	Moslolignan A					No. 105
C00041224	Picropolygamain	CHEMBL465763 CHEMBL478942 CHEMBL1976899	C080237			No. 105
C00041563	(+)-Pinoresinolin					No. 105
C00041802	(+)-Sesamin	CHEMBL43469 CHEMBL252915 CHEMBL1572261 CHEMBL1591714 CHEMBL1708854 CHEMBL1904496 CHEMBL1968861	C054125	20 / 24 / 15	0 / 5	No. 105
C00041803	L-Sesamin / (-)-Sesamin	CHEMBL43469 CHEMBL252915 CHEMBL1572261 CHEMBL1591714 CHEMBL1708854 CHEMBL1904496 CHEMBL1968861		20 / 24 / 15		No. 105
C00033990	Kadangustin C	CHEMBL450645				No. 105
C00040254	4'-Demethylpodophyllotoxin	CHEMBL28941 CHEMBL31929 CHEMBL290640 CHEMBL172476 CHEMBL172001 CHEMBL1514122 CHEMBL1723729		6 / 4 / 2		No. 105
C00040253	Picropodophyllotoxin / (+)-Picropodophyllotoxin	CHEMBL61 CHEMBL273648 CHEMBL21260 CHEMBL282256 CHEMBL283120 CHEMBL24706 CHEMBL310129 CHEMBL1330659		132 / 81 / 78		No. 105
C00030688	Rubriflorin A	CHEMBL488100 CHEMBL1782120				No. 105
C00040177	(-)-Podophyllotoxin	CHEMBL61 CHEMBL273648 CHEMBL21260 CHEMBL282256 CHEMBL283120 CHEMBL24706 CHEMBL310129 CHEMBL1330659	D011034	132 / 81 / 78	1 / 5	No. 105
C00034219	Kadangustin D	CHEMBL499278				No. 105
C00030579	Methyl schisantherin F	CHEMBL558251				No. 105
C00029632	Kadangustin B	CHEMBL457477				No. 105
C00039539	Taiwanin C	CHEMBL65755		1 / 0 / 0		No. 105
C00007216	(+)-Gomisin M2	CHEMBL518108 CHEMBL1426408		7 / 4 / 2		No. 105
C00030576	Angeloylgomisin R	CHEMBL489960				No. 105
C00030530	Ananosin A	CHEMBL1782123				No. 105
C00039537	Justicidin E	CHEMBL304236		1 / 0 / 0		No. 105
C00039536	Prostalidin C					No. 105
C00037700	Macelignan	CHEMBL254071		8 / 10 / 9		No. 105
C00047597	(-)-Aristotetralone	CHEMBL486295 CHEMBL484086				No. 105
C00047725	Urinatetralin					No. 105
C00047726	Cagayanin	CHEMBL407726				No. 105
C00002606	7S,8R,7'S.8'R-3,4,3',4'-Tetramethoxy-9,7'-dihydroxy-8,8',7.O.9'-lignan					No. 105
C00037701	Sphenanlignan					No. 105
C00037702	Pregomisin	CHEMBL1081697				No. 105
C00030418	Arisanschinin J	CHEMBL2313595				No. 105
C00039511	Retrojusticidin B	CHEMBL292540		1 / 0 / 0		No. 105
C00039510	Justicidin B					No. 105
C00002596	Calopiptin	CHEMBL471177 CHEMBL469499 CHEMBL559937				No. 105
C00030417	Interiotherin B	CHEMBL490161 CHEMBL1669434				No. 105
C00037703	Kadangustin H / (-)-Kadangustin H	CHEMBL458390				No. 105
C00030191	Arisanschinin H					No. 105
C00029829	Gomisin B	CHEMBL253687 CHEMBL253907 CHEMBL490308 CHEMBL491342 CHEMBL1867703 CHEMBL2313594	C082090			No. 105
C00037707	Mesodihydroguaiaretic acid	CHEMBL430464 CHEMBL375927 CHEMBL1976696		16 / 18 / 12		No. 105
C00037704	Kadangustin J / (+)-Kadangustin J					No. 105
C00037706	meso-Dihydroguaiaretic acid	CHEMBL430464 CHEMBL375927 CHEMBL1976696		16 / 18 / 12		No. 105
C00037705	Kadangustin K					No. 105
C00000670	(+)-Epipinoresinol	CHEMBL267963 CHEMBL487611 CHEMBL460862		7 / 5 / 6		No. 105
C00029688	Arisanschinin L	CHEMBL253687 CHEMBL253907 CHEMBL490308 CHEMBL491342 CHEMBL1867703 CHEMBL2313594				No. 147
C00029689	Gomisin F					No. 147
C00047729	Tiegusanin N	CHEMBL556989				No. 147
C00047585	Alflabene					No. 147
C00041921	Asarinin		C006637			No. 147
C00024178	Acetyl-binankadsurin A					No. 147
C00024177	Schisantherin Q	CHEMBL517629				No. 147
C00024176	Schisantherin P	CHEMBL517654				No. 147
C00047728	Otobaphenol					No. 147
C00039515	Chaihunaphthone					No. 147
C00047727	Otobain					No. 147
C00039516	Dehydropodophyllotoxin / Tetradehydropodophyllotoxin	CHEMBL487214				No. 147
C00047586	Savinin / (-)-Savinin / (-)-Hibalactone	CHEMBL395263 CHEMBL459851		7 / 10 / 5		No. 147
C00036723	(-)-(3S,4R,6S)-3-(3',4'-Methylenedioxy-alpha-hydroxybenzyl)-4-(3'',4''-dimethoxybenzyl)butyrolactone					No. 147
C00007217	Wuweizisu C / (-)-Wuweizisu C	CHEMBL437412	C031409			No. 147
C00039541	Taiwanin E methyl ether	CHEMBL495475				No. 147
C00045635	Prinsepiol / (-)-Prinsepiol	CHEMBL470456				No. 147
C00039550	Prostalidin A					No. 147
C00030580	Schisantherin F	CHEMBL465865				No. 147
C00030582	Angeloylgomisin H	CHEMBL479287 CHEMBL1092320 CHEMBL1093179		1 / 0 / 0		No. 147
C00046028	Andamanicin	CHEMBL345432 CHEMBL156339		2 / 1 / 1		No. 147
C00040176	5-Methoxyjusticidin A					No. 147
C00040252	Picropodophyllin	CHEMBL61 CHEMBL273648 CHEMBL21260 CHEMBL282256 CHEMBL283120 CHEMBL24706 CHEMBL310129 CHEMBL1330659		132 / 81 / 78		No. 147
C00041920	4-Hydroxysesamin	CHEMBL1380003 CHEMBL1641633		3 / 11 / 6		No. 147
C00047594	Neoboutonin					No. 147
C00047731	(-)-Burseran	CHEMBL157013				No. 147
C00048445	(-)-Dihydroclusin	CHEMBL469916		2 / 1 / 1		No. 147
C00041338	Austrobailignan 1	CHEMBL509850 CHEMBL455113	C093023			No. 147
C00047512	(+/-)-trans-3-(2,4,5-Trimethoxyphenyl)-4-[(E)-2,4,5-trimethoxystyryl]-cyclohexene					No. 147
C00047904	Clusin / (-)-Clusin	CHEMBL479701 CHEMBL476708		2 / 1 / 1		No. 147
C00047593	Isochaihulactone / (-)-Isochaihulactone					No. 147
C00041339	5'-Demethoxydeoxypodophyllotoxin					No. 147
C00031315	Schisantherin A	CHEMBL404875 CHEMBL1704343		2 / 0 / 1		No. 147
C00031314	Arisanschinin K	CHEMBL404875 CHEMBL1704343		2 / 0 / 1		No. 147
C00031087	Gomisin G	CHEMBL515928				No. 147
C00031086	Tiegusanin B					No. 147
C00047596	(-)-Cagayanone B					No. 216
C00047590	Kaerophyllin					No. 216
C00047592	Acutissimalignan B / (+)-Acutissimalignan B	CHEMBL460247				No. 216
C00000718	Fragransin A2 / (+)-Fragransin A2	CHEMBL228326 CHEMBL1170325		1 / 0 / 1		No. 216
C00000717	Verrucosin / (+)-Verrucosin	CHEMBL228326 CHEMBL1170325		1 / 0 / 1		No. 216
C00041374	4'-Demethyldeoxypodophyllotoxin	CHEMBL89905 CHEMBL141117 CHEMBL1707682 CHEMBL1969951		27 / 14 / 4		No. 216
C00047589	4'-O-Demethylsuchilactone					No. 216
C00047591	Piperphilippinin IV / (-)-Piperphilippinin IV					No. 216
C00002625	Epigrandisin / (-)-Epigrandisin	CHEMBL459404 CHEMBL459405 CHEMBL1377609 CHEMBL2204392		4 / 3 / 7		No. 216
C00039512	Justicidin A	CHEMBL508532	C049719			No. 216
C00047588	(-)-Isohibalactone	CHEMBL395263 CHEMBL459851		7 / 10 / 5		No. 216
C00039513	Neojusticin B	CHEMBL455623				No. 216
C00039514	Chinensinaphthol methyl ether	CHEMBL510411				No. 216
C00029810	Tigloylgomisin P	CHEMBL253687 CHEMBL253907 CHEMBL490308 CHEMBL491342 CHEMBL1867703 CHEMBL2313594				No. 216
C00047730	(-)-Cubebinin	CHEMBL480296		2 / 1 / 1		No. 216
C00030575	Kadsuralignan I	CHEMBL400291				No. 216
C00039540	Neojusticin A	CHEMBL455369				No. 216
C00039542	Helioxanthin	CHEMBL436474				No. 216
C00048446	Niranthin		C475932			No. 216
C00041562	beta-Apopicropodophyllin	CHEMBL330498 CHEMBL330639				No. 216
C00041854	(+)-Episesamin	CHEMBL43469 CHEMBL252915 CHEMBL1572261 CHEMBL1591714 CHEMBL1708854 CHEMBL1904496 CHEMBL1968861		20 / 24 / 15		No. 216
C00030689	Tiegusanin I					No. 216
C00030687	Angeloyl-(+)-gomisin K3					No. 216
C00047587	(E)-Gadain	CHEMBL395263 CHEMBL459851		7 / 10 / 5		No. 216
C00030577	Schisantherin L	CHEMBL465719				No. 216
C00030578	Propinquanin F	CHEMBL558251				No. 216
C00039551	Prostalidin B					No. 216
C00048447	Phyllanthin	CHEMBL453568 CHEMBL1253999		3 / 9 / 9		No. 216
C00047595	(-)-Cagayanone A					No. 216
C00043617	alpha-Cubebin / (-)-alpha-Cubebin	CHEMBL182001 CHEMBL399831		2 / 1 / 1		No. 223
C00007203	Pyramidatin E					No. 223
C00007202	Pyramidatin B					No. 223
C00034633	Tiegusanin F					No. 223
C00000599	(-)-Lirioresinol A / (-)-Episyringaresinol	CHEMBL361362 CHEMBL402653		1 / 0 / 0		No. 223
C00034967	7-Hydroxymatairesinol / (-)-7-Hydroxymatairesinol	CHEMBL470875 CHEMBL513565				No. 223
C00000606	(+)-Epimagnolin	CHEMBL453302 CHEMBL519926				No. 223
C00002598	(-)-Machilusin	CHEMBL471177 CHEMBL469499 CHEMBL559937				No. 223
C00040853	beta-Peltatin / (-)-beta-Peltatin	CHEMBL97543 CHEMBL443566 CHEMBL1435754		9 / 16 / 14		No. 223
C00034632	Tiegusanin D					No. 223
C00034417	Tiegusanin H					No. 223
C00034356	Tiegusanin G					No. 223
C00035775	(8S,8'S)-(+)-8-Hydroxy-oxomatairesinol					No. 223
C00034355	Tiegusanin K					No. 223
C00007201	Pyramidatin D					No. 223
C00032428	Tiegusanin L	CHEMBL564434				No. 223
C00000653	Medioresinol / (+)-Medioresinol	CHEMBL376507 CHEMBL513023		2 / 1 / 1		No. 223
C00000600	(+)-Lirioresinol B / (+)-Syringaresinol	CHEMBL361362 CHEMBL402653	C042192	1 / 0 / 0		No. 223
C00036280	Piperphilippinin II / (-)-Piperphilippinin II					No. 223
C00043489	Meridinol					No. 223
C00043571	8'beta-Hydroxyhinokinin / (-)-8'beta-Hydroxyhinokinin					No. 223
C00036353	(-)-Arcitin / Arctigenin methyl ether	CHEMBL476709				No. 223
C00046327	Moslolignan B					No. 223
C00000607	Praderin					No. 223
C00000608	(+)-Diayangambin	CHEMBL510536 CHEMBL454592 CHEMBL1412125	C472151	4 / 2 / 0		No. 223
C00000609	(+)-Epiyangambin	CHEMBL510536 CHEMBL454592 CHEMBL1412125	C082827	4 / 2 / 0		No. 223
C00037045	Piperphilippinin I					No. 223
C00036847	(-)-5'-Methoxyyatein	CHEMBL490527				No. 223
C00038321	2,3-bis[(4-hydroxy-3,5-dimethoxyphenyl)-methyl]-1,4-butanediol					No. 223
C00039520	Taiwanin E	CHEMBL468453				No. 282
C00030746	Kadangustin G	CHEMBL465516 CHEMBL465863				No. 282
C00007215	Deoxygomisin A	CHEMBL402435 CHEMBL479488 CHEMBL513752		6 / 6 / 13		No. 282
C00034637	(-)-Matairesinol	CHEMBL425148	C068935	1 / 0 / 0		No. 282
C00049246	Hirsutanone	CHEMBL464274		1 / 0 / 0		No. 282
C00049245	1,7-bis(3,4-Dihydroxyphenyl)-5-hydroxy-3-heptanone	CHEMBL455297		1 / 0 / 0		No. 282
C00039518	Cilinaphthalide A	CHEMBL491523				No. 282
C00030517	Heteroclitin B					No. 282
C00039517	Cleistanone / (+)-Cleistanone					No. 282
C00049244	Gingerenone A	CHEMBL1086746				No. 282
C00007214	Gomisin N	CHEMBL402435 CHEMBL479488 CHEMBL513752		6 / 6 / 13		No. 282
C00032176	Longipedunin A / 1-Demethylkadsuphilin A	CHEMBL526170				No. 282
C00032046	Benzoylgomisin H	CHEMBL519932				No. 282
C00031992	Schisandrene	CHEMBL479899				No. 282
C00034970	(-)-Wikstromol / (-)-Nortrachelogenin	CHEMBL453799 CHEMBL1483370	C020436	3 / 2 / 2		No. 282
C00034969	Isohydroxymatairesinol / (+)-Isohydroxymatairesinol	CHEMBL513566 CHEMBL471075				No. 282
C00034968	epi-Isohydroxymatairesinol / (+)-epi-Isohydroxymatairesinol	CHEMBL513566 CHEMBL471075				No. 282
C00000605	(+)-Epimagnolin A	CHEMBL453302 CHEMBL519926				No. 282
C00000604	Magnolin / (+)-Magnolin	CHEMBL453302 CHEMBL519926	C094148			No. 282
C00031533	Longipedunin C					No. 282
C00038929	Diphyllin	CHEMBL221190	C010130	24 / 43 / 38		No. 282
C00049243	Hexahydrocurcumin	CHEMBL479650		1 / 2 / 0		No. 282
C00039519	Cilinaphthalide B	CHEMBL521623				No. 282
C00031082	Tiegusanin A	CHEMBL550112				No. 282
C00049576	(-)-Steganacin	CHEMBL152898 CHEMBL357525 CHEMBL347475 CHEMBL154064 CHEMBL157001	C002858			No. 285
C00049575	Steganone	CHEMBL436025				No. 285
C00049574	Neoisostegane	CHEMBL483208	C043524			No. 285
C00031016	Kadsuphilol C	CHEMBL228431				No. 285
C00000720	(+)-Neoolivil	CHEMBL464631 CHEMBL577783		1 / 0 / 0		No. 285
C00037881	(-)-Dihydroguaiaretic acid	CHEMBL430464 CHEMBL375927 CHEMBL1976696		16 / 18 / 12		No. 285
C00000711	Machilin I	CHEMBL228326 CHEMBL1170325		1 / 0 / 1		No. 285
C00031681	Kadsuralignan K	CHEMBL250234				No. 285
C00000721	Fragransin D1 / (+)-Fragransin D1					No. 285
C00002600	(-)-Fargesol					No. 285
C00030455	Heteroclitin C					No. 285
C00000729	(+)-Veraguensin	CHEMBL56800 CHEMBL57542 CHEMBL418309 CHEMBL291515 CHEMBL56856 CHEMBL56917 CHEMBL112481 CHEMBL469500		1 / 0 / 0		No. 285
C00000727	Nectandrin C / (+)-Nectandrin C					No. 285
C00049959	Steganangin	CHEMBL516305 CHEMBL514914	C002859			No. 285
C00000611	(-)-Aschantin	CHEMBL480876 CHEMBL2007286				No. 285
C00000701	Nectandrin A / (+)-Nectandrin A	CHEMBL444025 CHEMBL513705				No. 285
C00000728	Galbelgin	CHEMBL56800 CHEMBL57542 CHEMBL418309 CHEMBL291515 CHEMBL56856 CHEMBL56917 CHEMBL112481 CHEMBL469500		1 / 0 / 0		No. 285
C00049572	10-Demethoxystegane					No. 285
C00049571	Nordihydroguaiaretic acid	CHEMBL52 CHEMBL313972 CHEMBL185893		70 / 73 / 92		No. 285
C00000700	Aristolignin	CHEMBL444025 CHEMBL513705				No. 285
C00007211	Neokadsuranin	CHEMBL464848 CHEMBL485477 CHEMBL1310734		7 / 1 / 1		No. 285
C00036091	Kusunokinin / (-)-Kusunokinin					No. 285
C00007210	Kadsulignan L	CHEMBL464848 CHEMBL485477 CHEMBL1310734		7 / 1 / 1		No. 285
C00036092	Dextrobursehernin / (+)-Dextrobursehernin					No. 285
C00000695	Fragransin C2	CHEMBL1812793				No. 427
C00034971	(+)-Wikstromol / (+)-Nortrachelogenin	CHEMBL453799 CHEMBL1483370		3 / 2 / 2		No. 427
C00007208	Pyramidatin A					No. 427
C00000654	(-)-Medioresinol	CHEMBL376507 CHEMBL513023		2 / 1 / 1		No. 427
C00002616	Kusunokinol / (-)-Kusunokinol	CHEMBL514686				No. 427
C00002615	(+)-Lariciresinol dimethyl ether	CHEMBL1760590				No. 427
C00000610	(+)-Yangambin	CHEMBL510536 CHEMBL454592 CHEMBL1412125		4 / 2 / 0		No. 427
C00043449	Aristelegin A / (-)-Aristelegin A					No. 427
C00002589	Saucernetin	CHEMBL56800 CHEMBL57542 CHEMBL418309 CHEMBL291515 CHEMBL56856 CHEMBL56917 CHEMBL112481 CHEMBL469500		1 / 0 / 0		No. 427
C00002593	(-)-Chicanine					No. 427
C00002619	Aristelegin C / (-)-Aristelegin C					No. 427
C00002620	Magnostellin B / (+)-Magnostellin B					No. 427
C00031640	Interiotherin A	CHEMBL484669				No. 427
C00002594	Fragransin E1					No. 427
C00002597	Machilin G / (+)-Machilin G	CHEMBL471177 CHEMBL469499 CHEMBL559937				No. 427
C00002595	Austrobailignan 7					No. 427
C00031027	Heteroclitin A / (+)-Heteroclitin A					No. 427
C00033300	Kadsuphilol B	CHEMBL426357				No. 427
C00002605	7R,8S,7'S.8'R-3,4,3',4'-Tetramethoxy-9,7'-dihydroxy-8,8',7.O.9'-lignan					No. 621
C00035530	(-)-Trachelogenin	CHEMBL491178				No. 621
C00040830	Podophyllotoxone	CHEMBL82303 CHEMBL1778160				No. 621
C00000601	(+)-Epieudesmin	CHEMBL519099 CHEMBL512865 CHEMBL523743 CHEMBL464352 CHEMBL1726879		2 / 0 / 0		No. 621
C00032674	Kadsuphilin C					No. 621
C00029287	Kadangustin A / Kadsuphilin K	CHEMBL459243				No. 621
C00007213	Gomisin L1 methyl ether	CHEMBL402435 CHEMBL479488 CHEMBL513752	C049013	6 / 6 / 13		No. 621
C00000636	(+)-Piperitol	CHEMBL1688935 CHEMBL1688938 CHEMBL2011539 CHEMBL2011540 CHEMBL2136585		7 / 13 / 7		No. 621
C00000639	(+)-Xanthoxylol	CHEMBL1688935 CHEMBL1688938 CHEMBL2011539 CHEMBL2011540 CHEMBL2136585		7 / 13 / 7		No. 621
C00007194	Binankadsurin A	CHEMBL447240 CHEMBL518555				No. 621
C00037601	Isoanwulignan					No. 621
C00002626	Fragransin B1					No. 621
C00002629	Fragransin B3					No. 621
C00002591	Odoratisol D					No. 629
C00045652	(-)-Olivil / Vladinol C	CHEMBL517144		1 / 1 / 1		No. 629
C00002599	Kobusinol B					No. 629
C00042729	Styraxin					No. 629
C00002608	4,9'-Dihydroxy-3',4',5-trimethoxy-7',9-epoxylignan	CHEMBL483422				No. 629
C00039028	Haplomyrtin					No. 629
C00042458	Sesamolinol					No. 629
C00015304	Gomisin K3 / Schisanhenol	CHEMBL490125 CHEMBL520939	C045309	7 / 10 / 8		No. 629
C00037251	Kadangustin I / (-)-Kadangustin I					No. 629
C00036801	Yatein / (-)-Yatein / (-)-Deoxypodorhizone / Dihydroanhydropodorhizol	CHEMBL345590 CHEMBL471067 CHEMBL2021357	C452802	2 / 1 / 1		No. 629
C00036311	(-)-Arctigenin	CHEMBL369142 CHEMBL435734 CHEMBL1966556	C071942	13 / 7 / 6		No. 629
C00036711	Tupichilignan A					No. 629
C00032678	Kadsuphilin E					No. 629
C00000682	(+)-Pinoresinol	CHEMBL267963 CHEMBL487611 CHEMBL460862	C103298	7 / 5 / 6		No. 700
C00043847	(-)-Lariciresinol	CHEMBL518421	C060282	2 / 1 / 1		No. 700
C00007200	Pyramidatin C					No. 700
C00000603	(+)-Eudesmin	CHEMBL519099 CHEMBL512865 CHEMBL523743 CHEMBL464352 CHEMBL1726879	C105875	2 / 0 / 0		No. 700
C00007191	Isogomisin O	CHEMBL506792 CHEMBL1782124				No. 700
C00002588	Galgravin	CHEMBL56800 CHEMBL57542 CHEMBL418309 CHEMBL291515 CHEMBL56856 CHEMBL56917 CHEMBL112481 CHEMBL469500	C084077	1 / 0 / 0		No. 700
C00045390	Renealtin B / (+)-Renealtin B					No. 700
C00045391	1alpha-Hydroxy-2alpha,4alpha-guaicyl-3,7-dioxabicyclo[3.3.0]octane					No. 700
C00000602	(+)-Diaeudesmin	CHEMBL519099 CHEMBL512865 CHEMBL523743 CHEMBL464352 CHEMBL1726879		2 / 0 / 0		No. 700
C00050143	Phrymarolin I					No. 700
C00038101	Daphneresinol / (-)-Daphneresinol	CHEMBL574120				No. 700
C00036424	Hernanol / (-)-Hernanol	CHEMBL472017				No. 700
C00040868	(-)-5-Methoxypodophyllotoxin	CHEMBL292945 CHEMBL398327	C074971			No. 951
C00037519	Myristargenol B / (+)-Myristargenol B					No. 951
C00037518	Oleiferin H / (-)-Oleiferin H					No. 951
C00002612	(+)-Lariciresinol 4-methyl ether	CHEMBL483422				No. 951
C00000598	dl-Syringaresinol	CHEMBL361362 CHEMBL402653		1 / 0 / 0		No. 951
C00040748	Deoxypicropodophyllin	CHEMBL63970 CHEMBL149525 CHEMBL152144 CHEMBL255919 CHEMBL519603 CHEMBL476679 CHEMBL1736070		7 / 4 / 2		No. 951
C00036725	(-)-Podorhizol	CHEMBL512541 CHEMBL1629990				No. 951
C00000633	Diasesartemin	CHEMBL453301 CHEMBL1980572 CHEMBL1988515 CHEMBL1990848				No. 951
C00000725	Fragransin D3					No. 951
C00000726	Fragransin D2					No. 951
C00036126	Bursehernin / (-)-Bursehernin		C023816			No. 1029
C00036130	Haplomyrfolin / (-)-Haplomyrfolin					No. 1029
C00036171	(-)-Pluviatolide	CHEMBL63962	C016678			No. 1029
C00040740	Deoxypodophyllotoxin / (-)-Deoxypodophyllotoxin	CHEMBL63970 CHEMBL149525 CHEMBL152144 CHEMBL255919 CHEMBL519603 CHEMBL476679 CHEMBL1736070		7 / 4 / 2		No. 1029
C00038358	Piperphilippinin VI					No. 1029
C00002624	Epigrandisin	CHEMBL459404 CHEMBL459405 CHEMBL1377609 CHEMBL2204392		4 / 3 / 7		No. 1029
C00040833	beta-Peltatin A methyl ether	CHEMBL483004	C010499			No. 1029
C00034635	Tiegusanin E					No. 1029
C00050316	Plicatic acid		C008938			No. 1029
C00034750	Prestegane B		C053360			No. 1142
C00002614	Lariciresinol dimethyl ether / (+)-Lariciresinol dimethyl ether	CHEMBL1760590				No. 1142
C00038679	Chinensinaphthol	CHEMBL495476				No. 1142
C00034752	Hydroxymatairesinol / (-)-Hydroxymatairesinol	CHEMBL470875 CHEMBL513565				No. 1142
C00037423	Oleiferin G / (+)-Oleiferin G					No. 1142
C00030902	Propinquanin E					No. 1142
C00034751	7'-hydroxymatairesinol	CHEMBL470875 CHEMBL513565				No. 1142
C00037977	Dihydroguaiaretic acid	CHEMBL430464 CHEMBL375927 CHEMBL1976696	C015816	16 / 18 / 12		No. 1142
C00047598	Lintetralin / (+)-Lintetralin					No. 1232
C00042499	(+)-Sesamolin	CHEMBL2059646	C054124			No. 1232
C00041985	(-)-Galbacin	CHEMBL1980140 CHEMBL2151191		2 / 0 / 0		No. 1232
C00030823	Kadsurarin / Kadsurarin II	CHEMBL464501				No. 1232
C00041984	(+)-Galbacin	CHEMBL1980140 CHEMBL2151191		2 / 0 / 0		No. 1232
C00000705	Nectandrin E / (+)-Nectandrin E	CHEMBL444025 CHEMBL513705				No. 1232
C00041986	Paulownin / (+)-Paulownin	CHEMBL479911	C008773			No. 1232
C00000706	Nectandrin B / Malabaricanol	CHEMBL228326 CHEMBL1170325		1 / 0 / 1		No. 1232
C00000693	Machilin H / Fragransin C1 / (+)-Fragransin C1	CHEMBL1812793				No. 1938
C00031488	Benzoylgomisin O / 6-O-Benzoylgomisin O					No. 1938
C00035640	8-Hydroxypluviatolide / (3S,4S)-8-Hydroxypluviatolide					No. 1938
C00037272	Oleiferin B					No. 1938
C00002747	Virgatusin					No. 1938
C00000612	(+)-Epiaschantin	CHEMBL480876 CHEMBL2007286				No. 2159
C00002613	Kobusinol A					No. 2159
C00045505	(+)-8(1)-Hydroxypinoresinol	CHEMBL471274				No. 2159
C00046416	Magnosalicin	CHEMBL2088629	C074501			No. 2159
C00000704	Nectandrin D / (+)-Nectandrin D	CHEMBL444025 CHEMBL513705				No. 2159
C00002617	Aristelegin B / (-)-Aristelegin B					No. 7343
C00000634	(+)-Epiexcelsin					No. 7392

Human Protein / Gene in interactions

200 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000601 C00000602 C00000603 C00000604 C00000605 C00000608 C00000609 C00000610 C00000633 C00000659 C00000693 C00000726 C00002591 C00002595 C00002597 C00002598 C00002599 C00002608 C00002619 C00002625 C00007194 C00007200 C00007208 C00029284 C00029287 C00033300 C00036311 C00036711 C00036725 C00036801 C00037251 C00039028 C00041984 C00041985 C00041986 C00043449 C00047730	0 / 1
O75496	Geminin	Unclassified protein	C00000601 C00000610 C00000638 C00000642 C00000670 C00000693 C00002594 C00002597 C00002600 C00002607 C00002619 C00007193 C00007194 C00007197 C00007208 C00007214 C00007215 C00029287 C00030746 C00031455 C00031992 C00033300 C00033990 C00034968 C00038062 C00039536 C00040830 C00041224 C00041495 C00041561 C00041563 C00043449 C00045892 C00046205 C00047041	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000601 C00000602 C00000603 C00000604 C00000605 C00000608 C00000609 C00000610 C00000633 C00000659 C00000693 C00000726 C00002591 C00002598 C00002599 C00002608 C00002619 C00007194 C00007200 C00029284 C00029287 C00033300 C00036311 C00036711 C00036725 C00036801 C00037251 C00039028 C00041984 C00041985 C00041986	1 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00000601 C00000608 C00000609 C00000610 C00000642 C00000693 C00002594 C00002597 C00002600 C00002615 C00002619 C00007194 C00007197 C00007208 C00007214 C00007215 C00029287 C00030746 C00031455 C00031992 C00033300 C00033990 C00034968 C00041224 C00043449	2 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00000601 C00000608 C00000609 C00000638 C00002594 C00002597 C00002600 C00002624 C00007193 C00007194 C00007214 C00007215 C00029287 C00030746 C00033990 C00034968 C00038062 C00040740 C00041224 C00041495 C00041563 C00043449 C00050316	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00000601 C00000610 C00000693 C00002594 C00002595 C00002597 C00002600 C00002615 C00002619 C00002624 C00007194 C00007208 C00007214 C00007215 C00029287 C00030746 C00033300 C00034968 C00040740 C00043449 C00050316	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00000599 C00000608 C00000609 C00000610 C00000693 C00002597 C00002600 C00002619 C00002624 C00007203 C00007208 C00007214 C00007215 C00030746 C00031992 C00033300 C00034968 C00040740 C00041563 C00043449 C00050316	1 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00000601 C00000608 C00000609 C00000610 C00000693 C00002594 C00002607 C00002615 C00002619 C00002624 C00007194 C00007208 C00029287 C00033300 C00040740 C00045892 C00047041 C00050143 C00050316	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00000601 C00000638 C00000693 C00002599 C00002600 C00002624 C00007193 C00007194 C00007214 C00007215 C00029287 C00030746 C00034968 C00038062 C00039028 C00040740 C00040830 C00041563 C00050316	7 / 3
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00000587 C00000599 C00000601 C00000610 C00000642 C00000693 C00002599 C00002600 C00002619 C00007190 C00007192 C00007194 C00007197 C00007203 C00029287 C00031455 C00033300 C00039028	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00000601 C00000638 C00000693 C00002624 C00007193 C00007194 C00007214 C00007215 C00029287 C00030746 C00031992 C00034968 C00038062 C00040740 C00041224 C00050316	1 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00000601 C00000610 C00000670 C00000693 C00002619 C00007194 C00029287 C00033300 C00039536 C00041561 C00046205 C00050143	0 / 0
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00000587 C00000611 C00000670 C00000693 C00000711 C00007190 C00007192 C00034219 C00037881 C00041338 C00041561 C00041920	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00000610 C00002619 C00007214 C00007215 C00021674 C00024162 C00030703 C00030746 C00030885 C00033300 C00034968 C00037984	0 / 1
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00000610 C00002594 C00002597 C00002600 C00002619 C00002624 C00007208 C00033300 C00040740 C00043449 C00050316	1 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00000601 C00000610 C00000693 C00002600 C00002619 C00007194 C00029287 C00031992 C00033300 C00040830	4 / 3
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000601 C00000608 C00000609 C00000610 C00000693 C00002619 C00007194 C00029287 C00033300	0 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000601 C00000608 C00000609 C00000610 C00000693 C00002619 C00007194 C00029287 C00033300	1 / 1
P28482	Mitogen-activated protein kinase 1	Erk	C00000601 C00000608 C00000609 C00000610 C00000693 C00002619 C00007194 C00029287 C00033300	0 / 0
O00255	Menin	Unclassified protein	C00000693 C00002596 C00002600 C00002606 C00002607 C00007216 C00045892 C00047041	2 / 5
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00000693 C00002595 C00007214 C00007215 C00030746 C00031992 C00034968 C00050143	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00000693 C00002594 C00007214 C00007215 C00030746 C00034968 C00041224 C00050143	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00000640 C00000642 C00000693 C00000698 C00007197 C00031455 C00041994 C00050143	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00000693 C00002596 C00002600 C00002606 C00002607 C00007216 C00045892 C00047041	1 / 2
P25105	Platelet-activating factor receptor	PAF receptor	C00000610 C00002619 C00002623 C00002633 C00007212 C00031801 C00033300	0 / 0
P00918	Carbonic anhydrase 2	Lyase	C00000610 C00002619 C00007214 C00007215 C00030746 C00033300 C00034968	1 / 2
P33527	Multidrug resistance-associated protein 1	drugs	C00000670 C00002596 C00002606 C00007216 C00034219 C00041495 C00041561	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00000601 C00000610 C00002595 C00002619 C00007194 C00029287 C00033300	4 / 1
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00000601 C00000610 C00000693 C00002619 C00007194 C00029287 C00033300	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00000640 C00000693 C00000698 C00002625 C00041563 C00041994 C00047730	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00000587 C00000610 C00000693 C00002619 C00007190 C00007192 C00033300	0 / 3
P11388	DNA topoisomerase 2-alpha	Isomerase	C00000610 C00002594 C00002595 C00002600 C00002615 C00002619 C00033300	0 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00000587 C00000638 C00007190 C00007192 C00007193 C00038062	5 / 3
Q13315	Serine-protein kinase ATM	Atypical serine/threonine protein kinase PIKK subfamily	C00002596 C00002606 C00007216 C00031992 C00041495 C00041563	1 / 4
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00000587 C00000638 C00007190 C00007192 C00007193 C00038062	0 / 0
Q02880	DNA topoisomerase 2-beta	Isomerase	C00000610 C00002594 C00002595 C00002615 C00002619 C00033300	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00000610 C00000693 C00002600 C00002619 C00007208 C00033300	11 / 10
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00000670 C00000693 C00039536 C00041561 C00046205 C00050143	0 / 0
Q07869	Peroxisome proliferator-activated receptor alpha	NR1C1	C00000587 C00000638 C00007190 C00007192 C00007193 C00038062	0 / 0
P51151	Ras-related protein Rab-9A	Unclassified protein	C00000608 C00000609 C00000610 C00000693 C00002619 C00033300	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000608 C00000609 C00000610 C00000693 C00002619 C00033300	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00000610 C00002619 C00033300 C00039536 C00046205	0 / 0
Q16539	Mitogen-activated protein kinase 14	p38	C00000610 C00002605 C00002619 C00007213 C00033300	0 / 0
O15118	Niemann-Pick C1 protein	Unclassified protein	C00000608 C00000609 C00000610 C00002619 C00033300	1 / 1
Q9Y253	DNA polymerase eta	Enzyme	C00000693 C00002594 C00033990 C00041224 C00050143	1 / 1
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00000610 C00000693 C00002619 C00033300 C00050143	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00000601 C00000693 C00002600 C00007194 C00029287	2 / 2
P37840	Alpha-synuclein	Unclassified protein	C00000693 C00007214 C00007215 C00030746 C00034968	4 / 2
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00002600 C00007214 C00007215 C00030746 C00034968	2 / 2
P00352	Retinal dehydrogenase 1	Enzyme	C00000610 C00000693 C00002600 C00002619 C00033300	0 / 0
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00000601 C00000693 C00002600 C00007194 C00029287	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00000610 C00002619 C00033300 C00039536 C00046205	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00000610 C00002619 C00031488 C00033300 C00037272	0 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00000610 C00002619 C00033300 C00039536 C00046205	0 / 0
P35218	Carbonic anhydrase 5A, mitochondrial	Lyase	C00007214 C00007215 C00030746 C00034968	0 / 0
P11387	DNA topoisomerase 1	Isomerase	C00000625 C00000627 C00002631 C00044152	0 / 0
Q9BUF5	Tubulin beta-6 chain	Structural	C00000610 C00002594 C00002619 C00033300	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00000601 C00000693 C00007194 C00029287	2 / 3
Q9BQE3	Tubulin alpha-1C chain	Unclassified protein	C00000610 C00002594 C00002619 C00033300	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00000610 C00000693 C00002619 C00033300	0 / 0
Q6PEY2	Tubulin alpha-3E chain	Unclassified protein	C00000610 C00002594 C00002619 C00033300	0 / 0
Q13885	Tubulin beta-2A chain	Structural	C00000610 C00002594 C00002619 C00033300	0 / 0
P68363	Tubulin alpha-1B chain	Unclassified protein	C00000610 C00002594 C00002619 C00033300	0 / 0
P42345	Serine/threonine-protein kinase mTOR	Enzyme	C00000610 C00000693 C00002619 C00033300	0 / 0
Q06710	Paired box protein Pax-8	Unclassified protein	C00000610 C00002619 C00007208 C00033300	1 / 2
Q13509	Tubulin beta-3 chain	Structural	C00000610 C00002594 C00002619 C00033300	2 / 1
P68371	Tubulin beta-4B chain	Structural	C00000610 C00002594 C00002619 C00033300	0 / 0
Q71U36	Tubulin alpha-1A chain	Structural	C00000610 C00002594 C00002619 C00033300	1 / 1
P07437	Tubulin beta chain	Structural	C00000610 C00002594 C00002619 C00033300	0 / 0
Q3ZCM7	Tubulin beta-8 chain	Structural	C00000610 C00002594 C00002619 C00033300	0 / 0
P04350	Tubulin beta-4A chain	Structural	C00000610 C00002594 C00002619 C00033300	2 / 0
Q9H4B7	Tubulin beta-1 chain	Structural	C00000610 C00002594 C00002619 C00033300	1 / 0
P68366	Tubulin alpha-4A chain	Structural	C00000610 C00002594 C00002619 C00033300	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00000610 C00000693 C00002619 C00033300	0 / 0
Q13748	Tubulin alpha-3C/D chain	Structural	C00000610 C00002594 C00002619 C00033300	0 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00000610 C00000693 C00002619 C00033300	7 / 37
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000610 C00000693 C00002619 C00033300	0 / 0
P40225	Thrombopoietin	Unclassified protein	C00000610 C00000693 C00002619 C00033300	1 / 1
P21728	D(1A) dopamine receptor	Dopamine receptor	C00000610 C00000693 C00002619 C00033300	0 / 0
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00000610 C00000693 C00002619 C00033300	2 / 2
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00000610 C00002600 C00002619 C00033300	1 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00000599 C00007203 C00031992 C00050143	1 / 1
P03372	Estrogen receptor	NR3A1	C00000610 C00000693 C00002619 C00033300	1 / 1
Q9Y2D0	Carbonic anhydrase 5B, mitochondrial	Lyase	C00007214 C00007215 C00030746 C00034968	0 / 0
P06280	Alpha-galactosidase A	Enzyme	C00000610 C00000693 C00002619 C00033300	1 / 1
P51843	Nuclear receptor subfamily 0 group B member 1	Nuclear hormone receptor subfamily 0 group B member 1	C00000610 C00002600 C00002619 C00033300	2 / 2
P00915	Carbonic anhydrase 1	Lyase	C00007214 C00007215 C00030746 C00034968	0 / 0
P25101	Endothelin-1 receptor	Endothelin receptor	C00000610 C00000706 C00002619 C00033300	0 / 0
Q9BVA1	Tubulin beta-2B chain	Structural	C00000610 C00002594 C00002619 C00033300	1 / 0
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00000610 C00002619 C00033300	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00000610 C00002619 C00033300	0 / 1
P25021	Histamine H2 receptor	Histamine receptor	C00000610 C00002619 C00033300	0 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00000610 C00002619 C00033300	1 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00000610 C00002619 C00033300	1 / 0
P32238	Cholecystokinin receptor type A	Cholecystokinin receptor	C00000610 C00002619 C00033300	0 / 0
P08311	Cathepsin G	S1A	C00000610 C00002619 C00033300	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00000610 C00002619 C00033300	1 / 0
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00000610 C00002619 C00033300	1 / 1
P03956	Interstitial collagenase	M10A	C00000610 C00002619 C00033300	0 / 1
Q13535	Serine/threonine-protein kinase ATR	Atypical serine/threonine protein kinase PIKK subfamily	C00002596 C00002606 C00007216	2 / 2
P32241	Vasoactive intestinal polypeptide receptor 1	Vasoactive intestinal peptide receptor	C00000610 C00002619 C00033300	0 / 0
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00000610 C00002619 C00033300	0 / 1
P14416	D(2) dopamine receptor	Dopamine receptor	C00000610 C00002619 C00033300	2 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00000610 C00002619 C00033300	3 / 2
P37288	Vasopressin V1a receptor	Vasopressin and oxytocin receptor	C00000610 C00002619 C00033300	0 / 0
P30988	Calcitonin receptor	Calcitonin receptor	C00000610 C00002619 C00033300	0 / 0
Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Ser_Thr	C00000610 C00002619 C00033300	0 / 0
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00000610 C00002619 C00033300	2 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00000610 C00002619 C00033300	0 / 0
Q9Y271	Cysteinyl leukotriene receptor 1	Leukotriene receptor	C00000610 C00002619 C00033300	0 / 0
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00000610 C00002619 C00033300	0 / 0
P31645	Sodium-dependent serotonin transporter	Serotonin	C00000610 C00002619 C00033300	2 / 0
P14780	Matrix metalloproteinase-9	M10A	C00000610 C00002619 C00033300	2 / 2
P04626	Receptor tyrosine-protein kinase erbB-2	TK tyrosine-protein kinase EGFR subfamily	C00000610 C00002619 C00033300	5 / 9
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00000610 C00002619 C00033300	1 / 0
P21452	Substance-K receptor	Neurokinin receptor	C00000610 C00002619 C00033300	0 / 0
P29274	Adenosine receptor A2a	Adenosine receptor	C00000610 C00002619 C00033300	0 / 0
P51679	C-C chemokine receptor type 4	CC chemokine receptor	C00000610 C00002619 C00033300	0 / 0
P51681	C-C chemokine receptor type 5	CC chemokine receptor	C00000610 C00002619 C00033300	3 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00000610 C00002619 C00033300	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00000610 C00002619 C00033300	0 / 0
P25929	Neuropeptide Y receptor type 1	Neuropeptide Y receptor	C00000610 C00002619 C00033300	0 / 0
P41597	C-C chemokine receptor type 2	CC chemokine receptor	C00000610 C00002619 C00033300	1 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00000610 C00002619 C00033300	0 / 0
P08575	Receptor-type tyrosine-protein phosphatase C	Enzyme	C00000610 C00002619 C00033300	2 / 1
P29466	Caspase-1	C14	C00000610 C00002619 C00033300	0 / 0
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00000693 C00002594 C00050143	2 / 1
Q9H0H5	Rac GTPase-activating protein 1	Unclassified protein	C00000587 C00007190 C00007192	0 / 0
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00000610 C00002619 C00033300	1 / 8
P50052	Type-2 angiotensin II receptor	Angiotensin receptor	C00000610 C00002619 C00033300	1 / 1
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00000610 C00002619 C00033300	0 / 0
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00000610 C00002619 C00033300	0 / 0
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Oxidoreductase	C00000610 C00002619 C00033300	0 / 0
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00000610 C00002619 C00033300	1 / 0
P22303	Acetylcholinesterase	Hydrolase	C00000610 C00002619 C00033300	1 / 0
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00000610 C00002619 C00033300	0 / 0
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00000610 C00002619 C00033300	0 / 0
P06241	Tyrosine-protein kinase Fyn	Src	C00000610 C00002619 C00033300	0 / 0
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00000610 C00002619 C00033300	0 / 0
P25103	Substance-P receptor	Neurokinin receptor	C00000610 C00002619 C00033300	0 / 0
P49146	Neuropeptide Y receptor type 2	Neuropeptide Y receptor	C00000610 C00002619 C00033300	0 / 0
P17948	Vascular endothelial growth factor receptor 1	Vegfr	C00000610 C00002619 C00033300	0 / 0
P33032	Melanocortin receptor 5	Melanocortin receptor	C00000610 C00002619 C00033300	0 / 0
P41968	Melanocortin receptor 3	Melanocortin receptor	C00000610 C00002619 C00033300	1 / 0
P25024	C-X-C chemokine receptor type 1	CXC chemokine receptor	C00000610 C00002619 C00033300	0 / 0
P06746	DNA polymerase beta	Enzyme	C00000693 C00041224 C00050143	0 / 0
P78527	DNA-dependent protein kinase catalytic subunit	Atypical serine/threonine protein kinase PIKK subfamily	C00002596 C00002606 C00007216	0 / 0
P05181	Cytochrome P450 2E1	Cytochrome P450 2E1	C00000610 C00002619 C00033300	0 / 0
P33765	Adenosine receptor A3	Adenosine receptor	C00000610 C00002619 C00033300	0 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00000610 C00002619 C00033300	0 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00000610 C00002619 C00033300	0 / 0
P08246	Neutrophil elastase	S1A	C00000610 C00002619 C00033300	2 / 1
P04278	Sex hormone-binding globulin	Secreted protein	C00000606 C00000607 C00038083	0 / 0
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00000610 C00002619 C00033300	0 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00000610 C00002619 C00033300	1 / 0
P39748	Flap endonuclease 1	Enzyme	C00000693 C00002615 C00050143	0 / 0
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00000610 C00002619 C00033300	1 / 1
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00000610 C00002619 C00033300	0 / 0
P30542	Adenosine receptor A1	Adenosine receptor	C00000610 C00002619 C00033300	0 / 0
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00000610 C00002619 C00033300	0 / 0
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00000610 C00002619 C00033300	0 / 0
P24557	Thromboxane-A synthase	Cytochrome P450 5A1	C00000610 C00002619 C00033300	1 / 1
P06239	Tyrosine-protein kinase Lck	Src	C00000610 C00002619 C00033300	0 / 1
P25025	C-X-C chemokine receptor type 2	CXC chemokine receptor	C00000610 C00002619 C00033300	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00000610 C00002619 C00033300	0 / 0
P42858	Huntingtin	Unclassified protein	C00002600 C00039536 C00046205	1 / 1
P30411	B2 bradykinin receptor	Bradykinin receptor	C00000610 C00002619 C00033300	0 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00000693 C00002594	2 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00000693 C00002600	0 / 0
P54132	Bloom syndrome protein	Enzyme	C00000693 C00050143	1 / 2
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00000693 C00041563	1 / 1
P45984	Mitogen-activated protein kinase 9	Jnk	C00002605 C00007213	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00000693 C00050143	0 / 0
Q02750	Dual specificity mitogen-activated protein kinase kinase 1	Ste7	C00000608 C00000609	1 / 1
Q13951	Core-binding factor subunit beta	Unclassified protein	C00000693 C00050143	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00000693 C00050143	1 / 4
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00000693	0 / 0
P07900	Heat shock protein HSP 90-alpha	Other cytosolic protein	C00000693	0 / 0
P08238	Heat shock protein HSP 90-beta	Other cytosolic protein	C00000693	0 / 0
P10275	Androgen receptor	NR3C4	C00000693	3 / 4
Q99549	M-phase phosphoprotein 8	Unclassified protein	C00000693	0 / 0
P08069	Insulin-like growth factor 1 receptor	TK tyrosine-protein kinase INSR subfamily	C00000693	1 / 3
P24530	Endothelin B receptor	Endothelin receptor	C00000706	4 / 4
O14746	Telomerase reverse transcriptase	Enzyme	C00000706	5 / 5
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00000693	0 / 0
P26358	DNA (cytosine-5)-methyltransferase 1	Transferase	C00035640	2 / 0
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00002600	4 / 2
Q01453	Peripheral myelin protein 22	Unclassified protein	C00000693	5 / 2
P61981	14-3-3 protein gamma	Unclassified protein	C00000693	0 / 0
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00002600	0 / 3
P14618	Pyruvate kinase PKM	Enzyme	C00050143	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00000693	3 / 3
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00000693	2 / 0
Q15722	Leukotriene B4 receptor 1	Leukotriene receptor	C00000693	0 / 0
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00000693	2 / 2
Q9Y5X4	Photoreceptor-specific nuclear receptor	NR2E3	C00002600	2 / 2
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00000693	0 / 0
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00000682	1 / 1
P11413	Glucose-6-phosphate 1-dehydrogenase	Enzyme	C00000693	1 / 2
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00050143	0 / 0

3 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
8856	NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR	nuclear receptor subfamily 1, group I, member 2	C00000604 C00041495 C00041561
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00041495 C00041561
4137	MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU	microtubule-associated protein tau	C00000610