KCF-S cluster No. 1938 (5 metabolites)

Corresponding Phytochemical cluster No. 21

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (5)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	5
Liliopsida	2
eudicotyledons	1

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Cumulative family count

class name	count
Zygophyllaceae	4
Zingiberaceae	2
Betulaceae	1
Viscaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Lignans	1

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metabolites link (1)

br08003 Category	KEGG ID	KNApSAcK ID
Lignans	C10719	C00000693

Metabolite list (5)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000693	Nordihydroguaiaretic acid	CHEMBL52 CHEMBL313972 CHEMBL185893		70 / 73 / 92
C00002747	Gingerenone A	CHEMBL1086746
C00031488	1,7-bis(3,4-Dihydroxyphenyl)-5-hydroxy-3-heptanone	CHEMBL455297		1 / 0 / 0
C00035640	Hexahydrocurcumin	CHEMBL479650		1 / 2 / 0
C00037272	Hirsutanone	CHEMBL464274		1 / 0 / 0

Human Protein / Gene in interactions

72 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P17252	Protein kinase C alpha type	Alpha	C00031488 C00037272	0 / 0
Q99549	M-phase phosphoprotein 8	Unclassified protein	C00000693	0 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00000693	7 / 37
P61981	14-3-3 protein gamma	Unclassified protein	C00000693	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00000693	1 / 1
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00000693	2 / 0
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00000693	0 / 0
P21728	D(1A) dopamine receptor	Dopamine receptor	C00000693	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00000693	0 / 3
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00000693	2 / 2
P08069	Insulin-like growth factor 1 receptor	TK tyrosine-protein kinase INSR subfamily	C00000693	1 / 3
P06746	DNA polymerase beta	Enzyme	C00000693	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000693	1 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00000693	0 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00000693	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00000693	11 / 10
P37840	Alpha-synuclein	Unclassified protein	C00000693	4 / 2
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000693	0 / 1
P54132	Bloom syndrome protein	Enzyme	C00000693	1 / 2
P11473	Vitamin D3 receptor	NR1I1	C00000693	2 / 3
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00000693	0 / 0
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00000693	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00000693	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00000693	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00000693	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00000693	0 / 0
P11413	Glucose-6-phosphate 1-dehydrogenase	Enzyme	C00000693	1 / 2
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00000693	2 / 0
O75496	Geminin	Unclassified protein	C00000693	0 / 0
P51151	Ras-related protein Rab-9A	Unclassified protein	C00000693	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00000693	7 / 3
Q9Y253	DNA polymerase eta	Enzyme	C00000693	1 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00000693	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00000693	0 / 0
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00000693	2 / 2
Q15722	Leukotriene B4 receptor 1	Leukotriene receptor	C00000693	0 / 0
P06280	Alpha-galactosidase A	Enzyme	C00000693	1 / 1
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00000693	2 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00000693	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000693	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00000693	3 / 3
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00000693	2 / 2
Q01453	Peripheral myelin protein 22	Unclassified protein	C00000693	5 / 2
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00000693	0 / 0
P03372	Estrogen receptor	NR3A1	C00000693	1 / 1
P26358	DNA (cytosine-5)-methyltransferase 1	Transferase	C00035640	2 / 0
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00000693	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00000693	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000693	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000693	0 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00000693	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00000693	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00000693	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00000693	4 / 3
P42345	Serine/threonine-protein kinase mTOR	Enzyme	C00000693	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00000693	0 / 0
P10275	Androgen receptor	NR3C4	C00000693	3 / 4
Q9UBT6	DNA polymerase kappa	Enzyme	C00000693	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00000693	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00000693	0 / 0
P40225	Thrombopoietin	Unclassified protein	C00000693	1 / 1
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000693	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00000693	1 / 1
O00255	Menin	Unclassified protein	C00000693	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00000693	1 / 2
Q13951	Core-binding factor subunit beta	Unclassified protein	C00000693	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00000693	1 / 4
P07900	Heat shock protein HSP 90-alpha	Other cytosolic protein	C00000693	0 / 0
P08238	Heat shock protein HSP 90-beta	Other cytosolic protein	C00000693	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00000693	0 / 0
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00000693	2 / 1
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00000693	1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions