KCF-S cluster No. 223 (29 metabolites)

Corresponding Phytochemical cluster No. 21

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (29)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	92
Spermatophyta	57
rosids	37
Magnoliophyta	17
eudicotyledons	4
Embryophyta	3
Euphyllophyta	1
Liliopsida	1

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Cumulative family count (Top 20)

class name	count
Asteraceae	49
Cupressaceae	29
Apocynaceae	20
Pinaceae	19
Thymelaeaceae	19
Rutaceae	9
Oleaceae	9
Taxaceae	8
Apiaceae	7
Hernandiaceae	6
Piperaceae	6
Convolvulaceae	3
Selaginellaceae	3
Burseraceae	3
Lamiaceae	2
Polygonaceae	2
Aristolochiaceae	2
Menispermaceae	2
Linaceae	2
Polygalaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Lignans	5

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metabolites link (5)

br08003 Category	KEGG ID	KNApSAcK ID
Lignans	C10725	C00000599
Lignans	C10891	C00000600
Lignans	C10682	C00000606
Lignans	C10545	C00000609
Lignans	C10557	C00002598

Metabolite list (29)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000599	(-)-Wikstromol / (-)-Nortrachelogenin	CHEMBL453799 CHEMBL1483370	C020436	3 / 2 / 2
C00000600	(-)-Trachelogenin	CHEMBL491178
C00000606	(-)-Matairesinol	CHEMBL425148	C068935	1 / 0 / 0
C00000607	(+)-Matairesinol	CHEMBL425148		1 / 0 / 0
C00000608	(+)-Arctigenin	CHEMBL369142 CHEMBL435734 CHEMBL1966556		13 / 7 / 6
C00000609	(-)-Arctigenin	CHEMBL369142 CHEMBL435734 CHEMBL1966556	C071942	13 / 7 / 6
C00000653	7'-hydroxymatairesinol	CHEMBL470875 CHEMBL513565
C00002598	Yatein / (-)-Yatein / (-)-Deoxypodorhizone / Dihydroanhydropodorhizol	CHEMBL345590 CHEMBL471067 CHEMBL2021357	C452802	2 / 1 / 1
C00007201	(-)-Pluviatolide	CHEMBL63962	C016678
C00007202	(-)-Podorhizol	CHEMBL512541 CHEMBL1629990
C00007203	(+)-Wikstromol / (+)-Nortrachelogenin	CHEMBL453799 CHEMBL1483370		3 / 2 / 2
C00032428	Tupichilignan A
C00034355	Haplomyrfolin / (-)-Haplomyrfolin
C00034356	Kusunokinin / (-)-Kusunokinin
C00034417	(-)-Arcitin / Arctigenin methyl ether	CHEMBL476709
C00034632	Piperphilippinin I
C00034633	Piperphilippinin II / (-)-Piperphilippinin II
C00034967	(-)-(3S,4R,6S)-3-(3',4'-Methylenedioxy-alpha-hydroxybenzyl)-4-(3'',4''-dimethoxybenzyl)butyrolactone
C00035775	(-)-5'-Methoxyyatein	CHEMBL490527
C00036280	Hydroxymatairesinol / (-)-Hydroxymatairesinol	CHEMBL470875 CHEMBL513565
C00036353	(8S,8'S)-(+)-8-Hydroxy-oxomatairesinol
C00036847	Bursehernin / (-)-Bursehernin		C023816
C00037045	Dextrobursehernin / (+)-Dextrobursehernin
C00038321	7-Hydroxymatairesinol / (-)-7-Hydroxymatairesinol	CHEMBL470875 CHEMBL513565
C00040853	8-Hydroxypluviatolide / (3S,4S)-8-Hydroxypluviatolide
C00043489	epi-Isohydroxymatairesinol / (+)-epi-Isohydroxymatairesinol	CHEMBL513566 CHEMBL471075
C00043571	Hernanol / (-)-Hernanol	CHEMBL472017
C00043617	Isohydroxymatairesinol / (+)-Isohydroxymatairesinol	CHEMBL513566 CHEMBL471075
C00046327	Prestegane B		C053360

Human Protein / Gene in interactions

16 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q99700	Ataxin-2	Unclassified protein	C00000599 C00000608 C00000609 C00007203	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000608 C00000609 C00002598	0 / 1
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000608 C00000609 C00002598	1 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00000608 C00000609	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000608 C00000609	0 / 1
P04278	Sex hormone-binding globulin	Secreted protein	C00000606 C00000607	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00000608 C00000609	2 / 0
P51151	Ras-related protein Rab-9A	Unclassified protein	C00000608 C00000609	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00000599 C00007203	1 / 1
P28482	Mitogen-activated protein kinase 1	Erk	C00000608 C00000609	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000608 C00000609	0 / 0
O15118	Niemann-Pick C1 protein	Unclassified protein	C00000608 C00000609	1 / 1
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00000599 C00007203	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000608 C00000609	1 / 1
Q02750	Dual specificity mitogen-activated protein kinase kinase 1	Ste7	C00000608 C00000609	1 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00000608 C00000609	0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions