KCF-S cluster No. 105 (46 metabolites)

Corresponding Phytochemical cluster No. 21

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (46)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
Magnoliophyta	66

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Cumulative family count

class name	count
Schisandraceae	58
Magnoliaceae	8

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Lignans	3

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metabolites link (4)

br08003 Category	KEGG ID	KNApSAcK ID
Lignans	C10555	C00002596
Lignans	C10621	C00002606
Lignans	C10893	C00002634
Lignans	C10555	C00007216

Metabolite list (46)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000670	(+)-Gomisin A	CHEMBL403578 CHEMBL1159658 CHEMBL1834755		5 / 0 / 0
C00000712	(-)-Gomisin J	CHEMBL251864	C082091
C00002596	Deoxygomisin A	CHEMBL402435 CHEMBL479488 CHEMBL513752		6 / 6 / 13
C00002606	Gomisin L1 methyl ether	CHEMBL402435 CHEMBL479488 CHEMBL513752	C049013	6 / 6 / 13
C00002634	Wuweizisu C / (-)-Wuweizisu C	CHEMBL437412	C031409
C00007216	Gomisin N	CHEMBL402435 CHEMBL479488 CHEMBL513752		6 / 6 / 13
C00029632	Acetyl-binankadsurin A
C00029829	Binankadsurin A	CHEMBL447240 CHEMBL518555
C00030191	Epigomisin O	CHEMBL522973 CHEMBL521975
C00030417	Gomisin O	CHEMBL522973 CHEMBL521975
C00030418	Gomisin R	CHEMBL465720 CHEMBL1237139
C00030530	Isogomisin O	CHEMBL506792 CHEMBL1782124
C00030576	Kadsuphilin D
C00030579	Kadsuralignan A
C00030688	Longipedunin B
C00030770	Methylisogomisin O
C00033990	Kadsurin	CHEMBL559796 CHEMBL1460441	C075123	4 / 3 / 1
C00034219	Schizandrin / Schisandrol A / Wuweizichun A / (+)-Schizandrin	CHEMBL253688	C011105	2 / 0 / 0
C00037700	Pyramidatin A
C00037701	Pyramidatin B
C00037702	Pyramidatin C
C00037703	Pyramidatin D
C00037704	Pyramidatin E
C00037705	Pyramidatin F
C00037706	Pyramidatin G
C00037707	Pyramidatin H
C00038952	Deangeloylschisantherin F	CHEMBL465892
C00039510	Kadangustin A / Kadsuphilin K	CHEMBL459243
C00039511	Kadangustin B	CHEMBL457477
C00039536	Kadsulignan L	CHEMBL464848 CHEMBL485477 CHEMBL1310734		7 / 1 / 1
C00039537	Kadsulignan N	CHEMBL517461
C00039539	Kadsuphilol A	CHEMBL447240 CHEMBL518555
C00040177	Rubriflorin B
C00040253	Schisantherin P	CHEMBL517654
C00040254	Schisantherin Q	CHEMBL517629
C00041224	(+)-Gomisin M2	CHEMBL518108 CHEMBL1426408		7 / 4 / 2
C00041495	Schisandrin A / Deoxyschisandrin	CHEMBL253908 CHEMBL490126 CHEMBL479898	C034734	4 / 1 / 4	2 / 0
C00041561	Gomisin A	CHEMBL403578 CHEMBL1159658 CHEMBL1834755	C033585	5 / 0 / 0	2 / 2
C00041563	Gomisin K3 / Schisanhenol	CHEMBL490125 CHEMBL520939	C045309	7 / 10 / 8
C00041802	Rubrisandrin A	CHEMBL1080599 CHEMBL1080600
C00041803	Rubrisandrin B
C00046205	Neokadsuranin	CHEMBL464848 CHEMBL485477 CHEMBL1310734		7 / 1 / 1
C00047597	Tiegusanin M
C00047725	Arisanschinin F	CHEMBL1080599 CHEMBL1080600
C00047726	Arisanschinin G	CHEMBL1080599 CHEMBL1080600
C00048444	Kadsuphilol I

Human Protein / Gene in interactions

24 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
O75496	Geminin	Unclassified protein	C00000670 C00033990 C00039536 C00041224 C00041495 C00041561 C00041563 C00046205	0 / 0
P33527	Multidrug resistance-associated protein 1	drugs	C00000670 C00002596 C00002606 C00007216 C00034219 C00041495 C00041561	0 / 0
Q13315	Serine-protein kinase ATM	Atypical serine/threonine protein kinase PIKK subfamily	C00002596 C00002606 C00007216 C00041495 C00041563	1 / 4
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00000670 C00039536 C00041561 C00046205	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00000670 C00039536 C00041561 C00046205	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00033990 C00041224 C00041495 C00041563	0 / 0
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00000670 C00034219 C00041561	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002596 C00002606 C00007216	1 / 2
Q13535	Serine/threonine-protein kinase ATR	Atypical serine/threonine protein kinase PIKK subfamily	C00002596 C00002606 C00007216	2 / 2
P78527	DNA-dependent protein kinase catalytic subunit	Atypical serine/threonine protein kinase PIKK subfamily	C00002596 C00002606 C00007216	0 / 0
O00255	Menin	Unclassified protein	C00002596 C00002606 C00007216	2 / 5
P41143	Delta-type opioid receptor	Opioid receptor	C00039536 C00046205	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00033990 C00041224	2 / 0
P42858	Huntingtin	Unclassified protein	C00039536 C00046205	1 / 1
P35372	Mu-type opioid receptor	Opioid receptor	C00039536 C00046205	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00039536 C00046205	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00033990 C00041224	1 / 1
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00041563	7 / 3
O75164	Lysine-specific demethylase 4A	Enzyme	C00041224	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00041563	1 / 1
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00041563	1 / 1
P06746	DNA polymerase beta	Enzyme	C00041224	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00041563	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00041224	1 / 1

2 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00041495 C00041561
8856	NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR	nuclear receptor subfamily 1, group I, member 2	C00041495 C00041561

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions