KNApSAcK Metabolite C00041495
Metabolite
KNApSAcK Entry
| id | C00041495 |
|---|---|
| Name | Schisandrin A / Deoxyschisandrin |
| CAS RN | 61281-38-7 |
| Standard InChI | InChI=1S/C24H32O6/c1-13-9-15-11-17(25-3)21(27-5)23(29-7)19(15)20-16(10-14(13)2)12-18(26-4)22(28-6)24(20)30-8/h11-14H,9-10H2,1-8H3 |
| Standard InChI (Main Layer) | InChI=1S/C24H32O6/c1-13-9-15-11-17(25-3)21(27-5)23(29-7)19(15)20-16(10-14(13)2)12-18(26-4)22(28-6)24(20)30-8/h11-14H,9-10H2,1-8H3 |
Cluster
| Phytochemical cluster | No. 21 |
|---|---|
| KCF-S cluster | No. 105 |
Link
ChEMBL
| By standard InChI | CHEMBL479898 |
|---|---|
| By standard InChI Main Layer | CHEMBL253908 CHEMBL490126 CHEMBL479898 |
KEGG
| By LinkDB | C16951 |
|---|
CTD
| By CAS RN | C034734 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| Magnoliophyta | 2 |
Family
| family name | count |
|---|---|
| Schisandraceae | 2 |
List (2)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Schisandra chinensis | 50507 | Schisandraceae | Magnoliophyta | Viridiplantae |
| Schisandra rubriflora | 124791 | Schisandraceae | Magnoliophyta | Viridiplantae |
Human Protein / Gene in interaction
4 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P33527 | Multidrug resistance-associated protein 1 | drugs | CHEMBL253908 |
CHEMBL2077105
(1)
CHEMBL2077106
(1)
CHEMBL2077107 (1) CHEMBL2077108 (1) CHEMBL2077109 (1) CHEMBL2077838 (1) |
0 / 0 |
| Q13315 | Serine-protein kinase ATM | Atypical serine/threonine protein kinase PIKK subfamily | CHEMBL253908 |
CHEMBL1614153
(1)
|
1 / 4 |
| O75496 | Geminin | Unclassified protein | CHEMBL253908 |
CHEMBL2114843
(1)
CHEMBL2114780
(1)
|
0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | CHEMBL253908 |
CHEMBL2114788
(1)
|
0 / 0 |
CTD interaction (2)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C034734 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | schizandrin A results in increased expression of CYP3A4 mRNA |
increases expression
|
mRNA |
16267138
|
| C034734 | 8856 |
NR1I2
BXR ONR1 PAR PAR1 PAR2 PARq PRR PXR SAR SXR |
nuclear receptor subfamily 1, group I, member 2 | schizandrin A binds to and results in increased activity of NR1I2 protein |
affects binding
/ increases activity |
protein |
16267138
|