PCIDB

Schisandra chinensis

Species

KNApSAcK Entry

Organism name Schisandra chinensis
Genus Schisandra
Family Schisandraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Schisandra chinensis
Linked NCBI taxonomy ID 50507
Linked level species

Family

Family in NCBI taxonomy Schisandraceae
ID 16733

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Natural Activity

List (47)

Species Activity
Schisandra chinensis (Turcz.) Baill. Adaptogen
Schisandra chinensis (Turcz.) Baill. Anorectic
Schisandra chinensis (Turcz.) Baill. Antacid
Schisandra chinensis (Turcz.) Baill. Antiaging
Schisandra chinensis (Turcz.) Baill. Antibacterial
Schisandra chinensis (Turcz.) Baill. Anticonvulsant
Schisandra chinensis (Turcz.) Baill. Antidepressant
Schisandra chinensis (Turcz.) Baill. Antifatigue
Schisandra chinensis (Turcz.) Baill. Antiinflammatory
Schisandra chinensis (Turcz.) Baill. Antimutagenic
Schisandra chinensis (Turcz.) Baill. Antinecrotic
Schisandra chinensis (Turcz.) Baill. Antineurotic
Schisandra chinensis (Turcz.) Baill. Antioxidant
Schisandra chinensis (Turcz.) Baill. Antiradicular
Schisandra chinensis (Turcz.) Baill. Antiseptic
Schisandra chinensis (Turcz.) Baill. Antisialagogue
Schisandra chinensis (Turcz.) Baill. Antitumor
Schisandra chinensis (Turcz.) Baill. Antitussive
Schisandra chinensis (Turcz.) Baill. Aphrodisiac
Schisandra chinensis (Turcz.) Baill. Astringent
Schisandra chinensis (Turcz.) Baill. Bitter
Schisandra chinensis (Turcz.) Baill. Cardiotonic
Schisandra chinensis (Turcz.) Baill. Cerebrotonic
Schisandra chinensis (Turcz.) Baill. Choleretic
Schisandra chinensis (Turcz.) Baill. CNS Depressant
Schisandra chinensis (Turcz.) Baill. CNS Stimulant
Schisandra chinensis (Turcz.) Baill. Digestive
Schisandra chinensis (Turcz.) Baill. Expectorant
Schisandra chinensis (Turcz.) Baill. Gonadotropic
Schisandra chinensis (Turcz.) Baill. Hepatoprotective
Schisandra chinensis (Turcz.) Baill. Immunodepressant
Schisandra chinensis (Turcz.) Baill. Immunostimulant
Schisandra chinensis (Turcz.) Baill. Memorigenic
Schisandra chinensis (Turcz.) Baill. Myorelaxant
Schisandra chinensis (Turcz.) Baill. Nephrotonic
Schisandra chinensis (Turcz.) Baill. Nervine
Schisandra chinensis (Turcz.) Baill. Neuroleptic
Schisandra chinensis (Turcz.) Baill. Pectoral
Schisandra chinensis (Turcz.) Baill. Respirastimulant
Schisandra chinensis (Turcz.) Baill. Sedative
Schisandra chinensis (Turcz.) Baill. Sialagogue Potentiator
Schisandra chinensis (Turcz.) Baill. Spermagenic
Schisandra chinensis (Turcz.) Baill. Tonic
Schisandra chinensis (Turcz.) Baill. Tranquilizer
Schisandra chinensis (Turcz.) Baill. Uterotonic
Schisandra chinensis (Turcz.) Baill. Vasodilator
Schisandra chinensis (Turcz.) Baill. Vermifuge

Metabolite list (21)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00000712 External link 512 (-)-Gomisin J
CHEMBL251864
C082091
No. 105 No. 21
C00002596 External link 512 Deoxygomisin A
CHEMBL402435
CHEMBL479488
CHEMBL513752
6 / 6 / 13 No. 105 No. 21
C00002606 External link 512 Gomisin L1 methyl ether
CHEMBL402435
CHEMBL479488
CHEMBL513752
C049013
6 / 6 / 13 No. 105 No. 21
C00041563 External link 512 Gomisin K3
/ Schisanhenol
CHEMBL490125
CHEMBL520939
C045309
7 / 10 / 8 No. 105 No. 21
C00002634 External link 512 Wuweizisu C
/ (-)-Wuweizisu C
CHEMBL437412
C031409
No. 105 No. 21
C00007216 External link 512 Gomisin N
CHEMBL402435
CHEMBL479488
CHEMBL513752
6 / 6 / 13 No. 105 No. 21
C00041495 External link 512 Schisandrin A
/ Deoxyschisandrin
CHEMBL253908
CHEMBL490126
CHEMBL479898
C034734
4 / 1 / 4 2 / 0 No. 105 No. 21
C00041561 External link 512 Gomisin A
CHEMBL403578
CHEMBL1159658
CHEMBL1834755
C033585
5 / 0 / 0 2 / 2 No. 105 No. 21
C00041338 External link 512 Angeloylgomisin H
CHEMBL479287
CHEMBL1092320
CHEMBL1093179
1 / 0 / 0 No. 147 No. 21
C00007217 External link 512 Gomisin B
CHEMBL253687
CHEMBL253907
CHEMBL490308
CHEMBL491342
CHEMBL1867703
CHEMBL2313594
C082090
No. 147 No. 21
C00041920 External link 512 Tigloylgomisin H
CHEMBL479287
CHEMBL1092320
CHEMBL1093179
1 / 0 / 0 No. 147 No. 21
C00041562 External link 512 Gomisin G
CHEMBL515928
No. 216 No. 21
C00041854 External link 512 Schisandrene
CHEMBL479899
No. 216 No. 21
C00002625 External link 512 Schisantherin A
CHEMBL404875
CHEMBL1704343
2 / 0 / 1 No. 216 No. 21
C00041374 External link 512 Benzoylgomisin H
CHEMBL519932
No. 216 No. 21
C00003116 External link 512 beta-Chamigrene
No. 451 No. 38
C00021610 External link 512 Chamigrenal
No. 451 No. 38
C00003115 External link 512 alpha-Chamigrene
No. 451 No. 38
C00011965 External link 512 Sesquicarene
/ [1R-(1a,6a,7a)]-3,7-Dimethyl-7-(4-methyl-3-pentenyl)-bicyclo[4.1.0]hept-2-ene
No. 699 No. 38
C00021850 External link 512 alpha-Santalene
No. 992 No. 38
C00003182 External link 512 alpha-Santalol
CHEMBL512210
No. 992 No. 38

Human Protein / Gene in interactions

16 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P33527 Multidrug resistance-associated protein 1 drugs C00002596 C00002606 C00007216 C00041495 C00041561 0 / 0
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily C00002596 C00002606 C00007216 C00041495 C00041563 1 / 4
Q13535 Serine/threonine-protein kinase ATR Atypical serine/threonine protein kinase PIKK subfamily C00002596 C00002606 C00007216 2 / 2
P78527 DNA-dependent protein kinase catalytic subunit Atypical serine/threonine protein kinase PIKK subfamily C00002596 C00002606 C00007216 0 / 0
O00255 Menin Unclassified protein C00002596 C00002606 C00007216 2 / 5
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00041338 C00041561 C00041920 0 / 0
O75496 Geminin Unclassified protein C00041495 C00041561 C00041563 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002596 C00002606 C00007216 1 / 2
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00041495 C00041563 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002625 C00041563 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00041561 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002625 0 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00041561 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00041563 1 / 1
Q99700 Ataxin-2 Unclassified protein C00041563 1 / 1
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00041563 7 / 3

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00041495 C00041561
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00041495 C00041561

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (15)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#208900 Ataxia-telangiectasia; at Q13315
#614564 Cutaneous telangiectasia and cancer syndrome, familial; fctcs Q13535
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#166350 Osseous heteroplasia, progressive; poh P63092
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#210600 Seckel syndrome 1; sckl1 Q13535
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8

KEGG DISEASE (18)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00005 Chronic lymphocytic leukemia (CLL) Q13315 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00094 DNA repair defects Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00037 Alveolar rhabdomyosarcoma Q13535 (related)
H00992 Seckel syndrome Q13535 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)

Diseases related to CTD interactions

2 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000647 Amnesia C00041561
D011230 Precancerous Conditions C00041561