PCIDB

KNApSAcK Metabolite C00002600

Metabolite

KNApSAcK Entry

id C00002600
Name Diphyllin
CAS RN 22055-22-7
Standard InChI InChI=1S/C21H16O7/c1-24-15-6-11-12(7-16(15)25-2)20(22)13-8-26-21(23)19(13)18(11)10-3-4-14-17(5-10)28-9-27-14/h3-7,22H,8-9H2,1-2H3
Standard InChI (Main Layer) InChI=1S/C21H16O7/c1-24-15-6-11-12(7-16(15)25-2)20(22)13-8-26-21(23)19(13)18(11)10-3-4-14-17(5-10)28-9-27-14/h3-7,22H,8-9H2,1-2H3

Cluster

Phytochemical cluster No. 21
KCF-S cluster No. 285

Link

ChEMBL

By standard InChI CHEMBL221190
By standard InChI Main Layer CHEMBL221190

KEGG

By LinkDB C10559

CTD

By CAS RN C010130

Species

Summary

Plant class

class name count
rosids 12
asterids 5
eudicotyledons 4
Spermatophyta 1

Family

family name count
Rutaceae 8
Acanthaceae 5
Berberidaceae 4
Phyllanthaceae 3
Cupressaceae 1
Salicaceae 1

List (22)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Cleistanthus collinus 1357584 Phyllanthaceae rosids Viridiplantae
Cleistanthus patulus 283089 Phyllanthaceae rosids Viridiplantae
Diphylleia grayi 153727 Berberidaceae eudicotyledons Viridiplantae
Diphylleia sinensis 382113 Berberidaceae eudicotyledons Viridiplantae
Dysosma majorensis 153728 Berberidaceae eudicotyledons Viridiplantae
Flacourtia ramontchi 210376 Salicaceae rosids Viridiplantae
Haplophyllum buxbaumii 452771 Rutaceae rosids Viridiplantae
Haplophyllum cappadocicum 1006070 Rutaceae rosids Viridiplantae
Haplophyllum hispanicum 266078 Rutaceae rosids Viridiplantae
Haplophyllum obtusifolium 452779 Rutaceae rosids Viridiplantae
Haplophyllum patavinum 452780 Rutaceae rosids Viridiplantae
Haplophyllum telephioides 1006081 Rutaceae rosids Viridiplantae
Haplophyllum tuberculatum 452784 Rutaceae rosids Viridiplantae
Haplophyllum vulcanicum 266078 Rutaceae rosids Viridiplantae
Justicia ciliata 4190 Acanthaceae asterids Viridiplantae
Justicia hayatai 4190 Acanthaceae asterids Viridiplantae
Justicia neesii 4190 Acanthaceae asterids Viridiplantae
Justicia procumbens L. var. leucantha 4190 Acanthaceae asterids Viridiplantae
Mananthes patentiflora 4185 Acanthaceae asterids Viridiplantae
Sauropus quadrangularis 545005 Phyllanthaceae rosids Viridiplantae
Sinopodophyllum hexandrum 93608 Berberidaceae eudicotyledons Viridiplantae
Taiwania cryptomerioides 50187 Cupressaceae Spermatophyta Viridiplantae

Human Protein / Gene in interaction

24 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q99700 Ataxin-2 Unclassified protein CHEMBL221190 CHEMBL2114784 (1)
1 / 1
Q9Y5X4 Photoreceptor-specific nuclear receptor NR2E3 CHEMBL221190 CHEMBL2114728 (1)
2 / 2
P02545 Prelamin-A/C Unclassified protein CHEMBL221190 CHEMBL1614544 (1)
11 / 10
P11388 DNA topoisomerase 2-alpha Isomerase CHEMBL221190 CHEMBL1930896 (1)
0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL221190 CHEMBL1613800 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL221190 CHEMBL1614458 (1)
0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme CHEMBL221190 CHEMBL1794495 (1)
2 / 2
P42858 Huntingtin Unclassified protein CHEMBL221190 CHEMBL1613918 (1)
1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL221190 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL221190 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme CHEMBL221190 CHEMBL2114807 (1)
4 / 2
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL221190 CHEMBL2114788 (1)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL221190 CHEMBL2114810 (1)
7 / 3
P51843 Nuclear receptor subfamily 0 group B member 1 Nuclear hormone receptor subfamily 0 group B member 1 CHEMBL221190 CHEMBL2354292 (1)
2 / 2
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL221190 CHEMBL1614038 (1)
2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL221190 CHEMBL1738588 (1)
0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor CHEMBL221190 CHEMBL1614052 (1)
1 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL221190 CHEMBL1614502 (1)
4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL221190 CHEMBL1738184 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL221190 CHEMBL1613914 (1)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL221190 CHEMBL1964082 (1) CHEMBL1963857 (1)
CHEMBL1964002 (1) CHEMBL2354311 (1)
1 / 0
O00255 Menin Unclassified protein CHEMBL221190 CHEMBL1614257 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL221190 CHEMBL1614257 (1)
1 / 3
P01215 Glycoprotein hormones alpha chain Unclassified protein CHEMBL221190 CHEMBL2114913 (1)
0 / 3

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (43)

OMIM preferred title UniProt
#300018 46,xy sex reversal 2; srxy2 P51843
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#300200 Adrenal hypoplasia, congenital; ahc P51843
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#119900 Digital clubbing, isolated congenital P15428
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#268100 Enhanced s-cone syndrome; escs Q9Y5X4
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#611131 Retinitis pigmentosa 37; rp37 Q9Y5X4
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (38)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00027 Ovarian cancer P38398 (related)
H00031 Breast cancer P38398 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00552 Glycerol kinase deficiency (GKD) P51843 (related)
H00607 46,XY disorders of sex development (Disorders of gonadal development) P51843 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00527 Retinitis pigmentosa (RP) Q9Y5X4 (related)
H00805 Vitreoretinal degeneration Q9Y5X4 (related)