Cleistanthus patulus
Species
KNApSAcK Entry
| Organism name | Cleistanthus patulus |
|---|---|
| Genus | Cleistanthus |
| Family | Phyllanthaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Cleistanthus |
|---|---|
| Linked NCBI taxonomy ID | 283089 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Phyllanthaceae |
|---|---|
| ID | 233880 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (3)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002600
|
Diphyllin
|
CHEMBL221190
|
C010130
|
24 / 43 / 38 | No. 285 | No. 21 |
|
|
|
C00002590
|
Cleistanthin A
|
C010088
|
No. 509 | No. 22 |
|
|||
|
C00000601
|
(+)-Sesamin
|
CHEMBL43469
CHEMBL252915 CHEMBL1572261 CHEMBL1591714 CHEMBL1708854 CHEMBL1904496 CHEMBL1968861 |
C054125
|
20 / 24 / 15 | 0 / 5 | No. 621 | No. 21 |
|
Human Protein / Gene in interactions
35 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00000601 C00002600 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000601 C00002600 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000601 C00002600 | 4 / 3 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00000601 C00002600 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000601 C00002600 | 2 / 2 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00000601 C00002600 | 7 / 3 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00000601 C00002600 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00000601 C00002600 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000601 C00002600 | 2 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000601 | 0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00002600 | 2 / 2 |
| P42858 | Huntingtin | Unclassified protein | C00002600 | 1 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000601 | 1 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000601 | 2 / 3 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00002600 | 4 / 2 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00002600 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000601 | 0 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002600 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000601 | 0 / 0 |
| P51843 | Nuclear receptor subfamily 0 group B member 1 | Nuclear hormone receptor subfamily 0 group B member 1 | C00002600 | 2 / 2 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000601 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002600 | 11 / 10 |
| Q9Y5X4 | Photoreceptor-specific nuclear receptor | NR2E3 | C00002600 | 2 / 2 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000601 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000601 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000601 | 0 / 0 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00002600 | 1 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002600 | 1 / 1 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00000601 | 4 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002600 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00002600 | 1 / 0 |
| O00255 | Menin | Unclassified protein | C00002600 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002600 | 1 / 2 |
| P01215 | Glycoprotein hormones alpha chain | Unclassified protein | C00002600 | 0 / 3 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00000601 | 1 / 1 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (52)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300018 | 46,xy sex reversal 2; srxy2 |
P51843
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #300200 | Adrenal hypoplasia, congenital; ahc |
P51843
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #268100 | Enhanced s-cone syndrome; escs |
Q9Y5X4
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #611131 | Retinitis pigmentosa 37; rp37 |
Q9Y5X4
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (45)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00081 | Hashimoto's thyroiditis |
P01215
(marker)
|
| H00082 | Graves' disease |
P01215
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P01215
(marker)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00027 | Ovarian cancer |
P38398
(related)
|
| H00031 | Breast cancer |
P38398
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00552 | Glycerol kinase deficiency (GKD) |
P51843
(related)
|
| H00607 | 46,XY disorders of sex development (Disorders of gonadal development) |
P51843
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
Q9Y5X4
(related)
|
| H00805 | Vitreoretinal degeneration |
Q9Y5X4
(related)
|