Haplophyllum patavinum
Species
KNApSAcK Entry
| Organism name | Haplophyllum patavinum |
|---|---|
| Genus | Haplophyllum |
| Family | Rutaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Haplophyllum patavinum |
|---|---|
| Linked NCBI taxonomy ID | 452780 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Rutaceae |
|---|---|
| ID | 23513 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (18)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00000609
|
(-)-Arctigenin
|
CHEMBL369142
CHEMBL435734 CHEMBL1966556 |
C071942
|
13 / 7 / 6 | No. 223 | No. 21 |
|
|
|
C00002600
|
Diphyllin
|
CHEMBL221190
|
C010130
|
24 / 43 / 38 | No. 285 | No. 21 |
|
|
|
C00000701
|
Justicidin B
|
No. 285 | No. 21 |
|
||||
|
C00033152
|
Majidine
|
CHEMBL508105
|
No. 509 | No. 22 |
|
|||
|
C00033456
|
Tuberculatin
|
No. 509 | No. 22 |
|
||||
|
C00033292
|
Patavine
/ (-)-Patavine |
No. 509 | No. 22 |
|
||||
|
C00032712
|
Arabelline
|
No. 509 | No. 22 |
|
||||
|
C00026351
|
Ribalinine
/ (-)-Ribalinine / (S)-(-)-Ribalinine |
CHEMBL279711
|
No. 816 | No. 7 |
|
|||
|
C00026352
|
Isoplatydesmine
/ 6-Deoxyribaline / (+)-Isoplatydesmine |
CHEMBL21394
|
No. 816 | No. 7 |
|
|||
|
C00002499
|
Scopoletin
|
CHEMBL71851
|
D012603
|
48 / 37 / 34 | 9 / 0 | No. 864 | No. 25 |
|
|
C00002503
|
Umbelliferon
/ Umbelliferone / 7-Hydroxycoumarin |
CHEMBL51628
|
C031477
|
39 / 33 / 32 | 9 / 0 | No. 1030 | No. 25 |
|
|
C00000297
|
Psoralen
|
CHEMBL164660
|
D005363
|
12 / 6 / 6 | 0 / 5 | No. 1282 | No. 25 |
|
|
C00002450
|
Angelicin
|
CHEMBL53569
|
C011659
|
2 / 0 / 0 | 0 / 3 | No. 1282 | No. 25 |
|
|
C00029297
|
Columbianetin
/ (+)-Columbianetin |
CHEMBL201152
|
7 / 12 / 8 | No. 1336 | No. 25 |
|
||
|
C00026346
|
(-)-Edulinine
/ (S)-(-)-Edulinine |
No. 1903 | No. 7 |
|
||||
|
C00034737
|
Umbelliprenin
|
CHEMBL156127
|
8 / 3 / 3 | No. 2038 |
|
|||
|
C00030900
|
Osthenol
|
CHEMBL350475
|
C114745
|
2 / 0 / 0 | No. 2087 |
|
||
|
C00030143
|
Diphyllin
|
CHEMBL1752
CHEMBL1488819 |
D004400
|
93 / 51 / 42 | 0 / 1 | No. 7304 |
|
Human Protein / Gene in interactions
163 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| O75496 | Geminin | Unclassified protein | C00002499 C00002503 C00002600 C00030143 C00034737 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000297 C00002499 C00002503 C00002600 C00029297 | 0 / 0 |
| P56817 | Beta-secretase 1 | A1A | C00000297 C00002450 C00002503 C00029297 C00030900 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000297 C00000609 C00002499 C00030143 | 0 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000297 C00000609 C00002499 C00030143 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000297 C00000609 C00002499 C00030143 | 0 / 1 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002499 C00002503 C00002600 C00029297 | 2 / 2 |
| Q99700 | Ataxin-2 | Unclassified protein | C00000609 C00002499 C00002503 C00002600 | 1 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000297 C00000609 C00002499 C00030143 | 1 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002499 C00002503 C00002600 C00029297 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002499 C00002503 C00030143 | 0 / 3 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00002600 C00029297 C00034737 | 2 / 2 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002499 C00002503 C00002600 | 1 / 2 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00002499 C00002600 C00029297 | 7 / 3 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000297 C00002503 C00034737 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00002499 C00002503 C00030143 | 1 / 2 |
| P22303 | Acetylcholinesterase | Hydrolase | C00002499 C00002503 C00030143 | 1 / 0 |
| O00255 | Menin | Unclassified protein | C00002499 C00002503 C00002600 | 2 / 5 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00002499 C00002503 C00029297 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000609 C00002499 C00030143 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00002499 C00002503 C00030143 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000297 C00002499 C00002503 | 3 / 3 |
| P06280 | Alpha-galactosidase A | Enzyme | C00002499 C00002503 | 1 / 1 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | C00002499 C00002503 | 0 / 0 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00002499 C00002503 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002503 C00034737 | 1 / 1 |
| Q9Y4X1 | UDP-glucuronosyltransferase 2A1 | Enzyme | C00002499 C00002503 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00002499 C00002503 | 6 / 4 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000609 C00030143 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002600 C00030143 | 11 / 10 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00002499 C00002503 | 0 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00002499 C00002503 | 1 / 1 |
| Q00796 | Sorbitol dehydrogenase | Enzyme | C00002499 C00002503 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00000297 C00002450 | 0 / 0 |
| P55210 | Caspase-7 | C14 | C00002499 C00002503 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00000609 C00002600 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00002499 C00002503 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00002499 C00002503 | 0 / 0 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00002499 C00002503 | 0 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00002499 C00002503 | 3 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000609 C00002600 | 2 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002499 C00002503 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00002503 C00034737 | 0 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00000297 C00030143 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00002499 C00002503 | 5 / 1 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00002499 C00002503 | 1 / 2 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00000297 C00002600 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000609 C00034737 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00030143 C00030900 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00002499 C00002503 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00030143 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00030143 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00030143 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00030143 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00030143 | 1 / 1 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00002600 | 0 / 0 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00030143 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00030143 | 1 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00030143 | 0 / 0 |
| P28845 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Enzyme | C00002503 | 1 / 1 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00030143 | 2 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00030143 | 1 / 8 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00030143 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00002499 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00030143 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00030143 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00002600 | 1 / 1 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00030143 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00030143 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00000609 | 0 / 0 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00002499 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00002600 | 4 / 2 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00030143 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00030143 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00030143 | 0 / 0 |
| P18405 | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | Oxidoreductase | C00002503 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00030143 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00030143 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00030143 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00030143 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00030143 | 0 / 1 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00030143 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00030143 | 1 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00030143 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00030143 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00030143 | 1 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00030143 | 0 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00030143 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00030143 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00030143 | 1 / 0 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00030143 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00030143 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00030143 | 0 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00030143 | 1 / 1 |
| Q04206 | Transcription factor p65 | Transcription Factor | C00002499 | 0 / 0 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00030143 | 0 / 1 |
| P51843 | Nuclear receptor subfamily 0 group B member 1 | Nuclear hormone receptor subfamily 0 group B member 1 | C00002600 | 2 / 2 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00030143 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00030143 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00030143 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00002503 | 4 / 2 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00030143 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00030143 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00030143 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00030143 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00030143 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00030143 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00030143 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00030143 | 0 / 0 |
| P55789 | FAD-linked sulfhydryl oxidase ALR | Enzyme | C00002499 | 1 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00030143 | 1 / 0 |
| Q9Y5X4 | Photoreceptor-specific nuclear receptor | NR2E3 | C00002600 | 2 / 2 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00030143 | 2 / 1 |
| P20813 | Cytochrome P450 2B6 | Cytochrome P450 2B6 | C00000297 | 1 / 0 |
| Q8N1Q1 | Carbonic anhydrase 13 | Lyase | C00002499 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00002499 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00030143 | 2 / 2 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00030143 | 0 / 0 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00000609 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00002600 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00030143 | 0 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00002499 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00030143 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00030143 | 1 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00030143 | 1 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00030143 | 0 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00030143 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00030143 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00030143 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00030143 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00030143 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00030143 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00030143 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00030143 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00030143 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00034737 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00030143 | 0 / 0 |
| P08246 | Neutrophil elastase | S1A | C00030143 | 2 / 1 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00030143 | 2 / 2 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00030143 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00030143 | 0 / 0 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00002600 | 1 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00034737 | 0 / 0 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00002499 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002600 | 4 / 3 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002600 | 0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00030143 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00030143 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00030143 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00030143 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00030143 | 1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00030143 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00030143 | 0 / 0 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00002503 | 1 / 1 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00030143 | 4 / 1 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00002499 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002499 | 0 / 0 |
| O75795 | UDP-glucuronosyltransferase 2B17 | Enzyme | C00002499 | 1 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00002600 | 1 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00002499 | 0 / 0 |
| Q02750 | Dual specificity mitogen-activated protein kinase kinase 1 | Ste7 | C00000609 | 1 / 1 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002503 | 0 / 0 |
| P01215 | Glycoprotein hormones alpha chain | Unclassified protein | C00002600 | 0 / 3 |
16 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 7366 | UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 | UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) |
C00002499
C00002503
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00002499
C00002503
|
| 8644 | AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS | aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) |
C00002503
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00002503
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00002503
|
| 1548 | CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB | cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) |
C00002503
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00002503
|
| 8574 | AKR7A2, AFAR, AFAR1, AFB1-AR1, AKR7 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) (EC:1.1.1.n11) |
C00002503
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00002503
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00002499
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002499
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00002499
|
| 54578 | UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT_1-6, UGT1, UGT1A6S, UGT1F | UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) |
C00002499
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002499
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002499
|
| 7508 | XPC, RAD4, XP3, XPCC | xeroderma pigmentosum, complementation group C |
C00002499
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (111)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #300018 | 46,xy sex reversal 2; srxy2 |
P51843
|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #300200 | Adrenal hypoplasia, congenital; ahc |
P51843
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #612560 | Bone mineral density quantitative trait locus 12; bmnd12 |
O75795
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #300615 | Brunner syndrome |
P21397
|
| #615279 | Cardiofaciocutaneous syndrome 3; cfc3 |
Q02750
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #604931 | Cortisone reductase deficiency 1; cortrd1 |
P28845
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #614546 | Efavirenz, poor metabolism of |
P20813
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #268100 | Enhanced s-cone syndrome; escs |
Q9Y5X4
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 |
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #159900 | Myoclonic dystonia |
P14416
|
| #613076 | Myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay |
P55789
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
P38398 |
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #611131 | Retinitis pigmentosa 37; rp37 |
Q9Y5X4
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #278300 | Xanthinuria, type i |
P47989
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (86)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
Q16790 (marker) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00081 | Hashimoto's thyroiditis |
P01215
(marker)
|
| H00082 | Graves' disease |
P01215
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P01215
(marker)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
P38398 (related) |
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) P38398 (related) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01111 | Cortisone reductase deficiency (CRD) |
P28845
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
Q99714 (related) |
| H00552 | Glycerol kinase deficiency (GKD) |
P51843
(related)
|
| H00607 | 46,XY disorders of sex development (Disorders of gonadal development) |
P51843
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00523 | Noonan syndrome and related disorders |
Q02750
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
Q9Y5X4
(related)
|
| H00805 | Vitreoretinal degeneration |
Q9Y5X4
(related)
|
Diseases related to CTD interactions
7 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D000647 | Amnesia |
C00002450
C00000297 |
| D056486 | Drug-Induced Liver Injury |
C00002450
C00000297 |
| D006973 | Hypertension |
C00030143
|
| D010787 | Photosensitivity Disorders |
C00002450
|
| D002280 | Carcinoma, Basal Cell |
C00000297
|
| D017484 | Dermatitis, Phototoxic |
C00000297
|
| D011565 | Psoriasis |
C00000297
|