Species

KNApSAcK Entry

Organism name Taiwania cryptomerioides
Genus Taiwania
Family Taxodiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Taiwania cryptomerioides
Linked NCBI taxonomy ID 50187
Linked level species

Family

Family in NCBI taxonomy Cupressaceae
ID 3367

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Spermatophyta
ID 58024

Metabolite list (52)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00006447 External link 512 Taiwaniaflavone 7''-O-methyl ether
No. 34 No. 18
C00006487 External link 512 Sequoiaflavone
CHEMBL255493
1 / 0 / 0 No. 34 No. 18
C00006448 External link 512 Taiwaniaflavone 4',7''-dimethyl ether
No. 34 No. 18
C00006446 External link 512 Taiwaniaflavone
CHEMBL272861
1 / 1 / 3 No. 34 No. 18
C00035971 External link 512 7beta-Hydroxymanoyl oxide
/ (+)-7beta-Hydroxymanoyl oxide
No. 70
C00031641 External link 512 Cadin-10(14)-ene-4beta,5alpha-diol
/ (-)-Cadin-10(14)-ene-4beta,5alpha-diol
No. 205 No. 38
C00020150 External link 512 (-)-Torreyol
/ delta-Cadinol
CHEMBL486795
No. 205 No. 38
C00031907 External link 512 Isokhusinodiol
/ (-)-Isokhusinodiol
No. 205 No. 38
C00020154 External link 512 T-Muurolol
/ epi-alpha-Muurolol
CHEMBL486795
No. 205 No. 38
C00031954 External link 512 Khusinodiol
No. 205 No. 38
C00020066 External link 512 T-Cadinol
/ epi-alpha-Cadinol
CHEMBL486795
C072576
No. 205 No. 38
C00020139 External link 512 1beta,10betaH-Cadin-4-ene-3beta,10-diol
CHEMBL462895
No. 205 No. 38
C00020065 External link 512 alpha-Cadinol
/ (-)-alpha-Cadinol
CHEMBL486795
No. 205 No. 38
C00020137 External link 512 (-)-1beta,10betaH-Cadin-4-ene-3alpha,10-diol
CHEMBL462895
No. 205 No. 38
C00007203 External link 512 (+)-Wikstromol
/ (+)-Nortrachelogenin
CHEMBL453799
CHEMBL1483370
3 / 2 / 2 No. 223 No. 21
C00000606 External link 512 (-)-Matairesinol
CHEMBL425148
C068935
1 / 0 / 0 No. 223 No. 21
C00007201 External link 512 (-)-Pluviatolide
CHEMBL63962
C016678
No. 223 No. 21
C00000604 External link 512 (-)-Secoisolariciresinol
CHEMBL368347
C060283
2 / 1 / 1 1 / 0 No. 282 No. 21
C00000721 External link 512 Taiwanin E
CHEMBL468453
No. 285 No. 21
C00007211 External link 512 Helioxanthin
CHEMBL436474
No. 285 No. 21
C00002600 External link 512 Diphyllin
CHEMBL221190
C010130
24 / 43 / 38 No. 285 No. 21
C00032036 External link 512 Muurolane-4beta,5beta,10beta-triol
/ (-)-Muurolane-4beta,5beta,10beta-triol
No. 351
C00031642 External link 512 Cadinane-4beta,5alpha,10beta-triol
/ (-)-Cadinane-4beta,5alpha,10beta-triol
No. 351
C00032274 External link 512 Taiwaniaquinol B
CHEMBL1087912
CHEMBL1088043
No. 355
C00031493 External link 512 11-Hydroxyabieta-8,11,13-trien-7-one
/ (-)-11-Hydroxyabieta-8,11,13-trien-7-one
No. 355
C00031492 External link 512 11,12,14-Trihydroxyabieta-8,11,13-trien-7-one
CHEMBL479312
No. 355
C00003426 External link 512 Ferruginol
CHEMBL197308
No. 359 No. 40
C00002608 External link 512 Hinokinin
/ Hinoquinin
/ (-)-Hinokinin
/ (-)-Hinoquinin
CHEMBL180970
CHEMBL182073
CHEMBL242011
C475934
2 / 1 / 1 No. 629 No. 21
C00032277 External link 512 Taiwaniaquinone A
CHEMBL1087802
No. 792 No. 40
C00032282 External link 512 Taiwaniaquinone F
/ (-)-Taiwaniaquinone F
CHEMBL1088627
No. 792 No. 40
C00032279 External link 512 Taiwaniaquinone C
No. 792 No. 40
C00032278 External link 512 Taiwaniaquinone B
No. 792 No. 40
C00032281 External link 512 Taiwaniaquinone E
/ (-)-Taiwaniaquinone E
CHEMBL1088482
No. 792 No. 40
C00035958 External link 512 6beta,7alpha-Diacetoxyroyleanone
/ (-)-6beta,7alpha-Diacetoxyroyleanone
No. 792 No. 40
C00035940 External link 512 3-Oxo-isotaxodione
/ (-)-3-Oxo-isotaxodione
No. 1020 No. 40
C00002624 External link 512 Savinin
/ (-)-Savinin
/ (-)-Hibalactone
CHEMBL395263
CHEMBL459851
7 / 10 / 5 No. 1029 No. 21
C00044340 External link 512 Taiwaniasterol B
/ (+)-Taiwaniasterol B
No. 1390
C00044341 External link 512 Taiwaniasterol C
/ (+)-Taiwaniasterol C
No. 1390
C00044339 External link 512 Taiwaniasterol A
/ (+)-Taiwaniasterol A
No. 1390
C00044342 External link 512 Taiwaniasterol D
/ (+)-Taiwaniasterol D
No. 1390
C00035983 External link 512 9alpha-Hydroxyisopimara-8(14),15-dien-7-one
/ (-)-9alpha-Hydroxyisopimara-8(14),15-dien-7-one
No. 1841 No. 41
C00020109 External link 512 10-Hydroxy-cadin-4-en-3-one
CHEMBL412697
CHEMBL509233
No. 1872
C00020138 External link 512 10-Hydroxy-4-muurolen-3-one
CHEMBL412697
CHEMBL509233
No. 1872
C00035943 External link 512 3-Oxosapriparaquinone
No. 2154
C00035944 External link 512 Salvisyrianone
/ 3-Oxosaprorthoquinone
CHEMBL328722
No. 2154
C00035941 External link 512 3-Oxomicrostegiol
/ (+)-3-Oxomicrostegiol
No. 2796
C00032280 External link 512 Taiwaniaquinone D
/ (-)-Taiwaniaquinone D
CHEMBL1087925
No. 2989
C00031505 External link 512 15-Acetoxy-T-muurolol
No. 3512
C00032275 External link 512 Taiwaniaquinol C
/ (-)-Taiwaniaquinol C
No. 4279
C00032273 External link 512 Taiwaniaquinol A
CHEMBL1088069
No. 4279
C00031400 External link 512 Taiwaninal
/ (-)-Taiwaninal
No. 4532
C00032276 External link 512 Taiwaniaquinol D
/ (-)-Taiwaniaquinol D
CHEMBL1088042
No. 4669

Human Protein / Gene in interactions

32 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q99700 Ataxin-2 Unclassified protein C00002600 C00002624 C00007203 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000604 C00002608 0 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002600 C00002624 1 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002600 C00002624 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000604 C00002608 1 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002600 C00007203 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00002600 C00002624 7 / 3
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002600 C00002624 0 / 0
P51843 Nuclear receptor subfamily 0 group B member 1 Nuclear hormone receptor subfamily 0 group B member 1 C00002600 2 / 2
P04278 Sex hormone-binding globulin Secreted protein C00000606 0 / 0
P42858 Huntingtin Unclassified protein C00002600 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00002600 2 / 0
O75496 Geminin Unclassified protein C00002600 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00002600 4 / 2
P00352 Retinal dehydrogenase 1 Enzyme C00002600 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00002600 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00002600 2 / 2
P56817 Beta-secretase 1 A1A C00006487 0 / 0
P08253 72 kDa type IV collagenase M10A C00006446 1 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002600 2 / 2
P11388 DNA topoisomerase 2-alpha Isomerase C00002600 0 / 0
P02545 Prelamin-A/C Unclassified protein C00002600 11 / 10
Q9UNA4 DNA polymerase iota Enzyme C00002624 0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00002600 1 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002600 4 / 3
Q9Y5X4 Photoreceptor-specific nuclear receptor NR2E3 C00002600 2 / 2
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002600 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00007203 1 / 1
O00255 Menin Unclassified protein C00002600 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002600 1 / 2
P01215 Glycoprotein hormones alpha chain Unclassified protein C00002600 0 / 3
Q13148 TAR DNA-binding protein 43 Unclassified protein C00002624 1 / 1

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00000604

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (47)

OMIM preferred title UniProt
#300018 46,xy sex reversal 2; srxy2 P51843
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#300200 Adrenal hypoplasia, congenital; ahc P51843
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#119900 Digital clubbing, isolated congenital P15428
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#268100 Enhanced s-cone syndrome; escs Q9Y5X4
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#611131 Retinitis pigmentosa 37; rp37 Q9Y5X4
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (43)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00025 Penile cancer P08253 (related)
H00028 Choriocarcinoma P08253 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00027 Ovarian cancer P38398 (related)
H00031 Breast cancer P38398 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00552 Glycerol kinase deficiency (GKD) P51843 (related)
H00607 46,XY disorders of sex development (Disorders of gonadal development) P51843 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00527 Retinitis pigmentosa (RP) Q9Y5X4 (related)
H00805 Vitreoretinal degeneration Q9Y5X4 (related)