KCF-S cluster No. 34 (97 metabolites)

Corresponding Phytochemical cluster No. 18

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (97)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
Spermatophyta	281
rosids	64
Embryophyta	43
Magnoliophyta	6
asterids	5
Euphyllophyta	4
eudicotyledons	3
Liliopsida	1

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Cumulative family count (Top 20)

class name	count
Cupressaceae	102
Araucariaceae	58
Podocarpaceae	52
Zamiaceae	27
Taxaceae	20
Ochnaceae	15
Cycadaceae	9
Selaginellaceae	9
Bartramiaceae	8
Calophyllaceae	8
Clusiaceae	7
Mniaceae	6
Anacardiaceae	6
Aristolochiaceae	6
Hypericaceae	5
Ginkgoaceae	5
Euphorbiaceae	5
Cephalotaxaceae	5
Hylocomiaceae	4
Dicranaceae	4

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Biflavonoids and polyflavonoids	7

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metabolites link (8)

br08003 Category	KEGG ID	KNApSAcK ID
Biflavonoids and polyflavonoids	C10017	C00001014
Biflavonoids and polyflavonoids	C10018	C00001015
Biflavonoids and polyflavonoids	C10034	C00001034
Biflavonoids and polyflavonoids	C10048	C00001044
Biflavonoids and polyflavonoids	C10057	C00001049
Biflavonoids and polyflavonoids	C10179	C00001094
Biflavonoids and polyflavonoids	C10182	C00001098
Biflavonoids and polyflavonoids	C10018	C00042224

Metabolite list (97)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001014	Agathisflavone	CHEMBL65320	C079168
C00001015	Amentoflavone	CHEMBL63354	C011164	50 / 39 / 29	5 / 0
C00001034	Cupressuflavone	CHEMBL1208973		6 / 1 / 1
C00001044	Ginkgetin / 7,4'-Dimethylamentoflavone / Amentoflavone 7'',4'''-dimethyl ether	CHEMBL377324	C077458	1 / 0 / 0
C00001049	Hinokiflavone	CHEMBL291426	C060299	2 / 1 / 2
C00001094	Robustaflavone	CHEMBL63677		2 / 1 / 3
C00001098	Sciadopitysin	CHEMBL208908	C086243	3 / 3 / 7
C00006431	3,8''-Biapigenin	CHEMBL515252		21 / 16 / 12
C00006446	Taiwaniaflavone	CHEMBL272861		1 / 1 / 3
C00006447	Taiwaniaflavone 7''-O-methyl ether
C00006448	Taiwaniaflavone 4',7''-dimethyl ether
C00006452	7-O-Methylagathisflavone
C00006453	7,7''-Di-O-methylagathisflavone
C00006454	7,4'''-Di-O-Methylagathisflavone
C00006455	7,7'',4'''-Tri-O-methylagathisflavone
C00006456	Agathisflavone tetramethyl ether
C00006459	7-O-Methylcupressuflavone
C00006460	4'-O-Methylcupressuflavone
C00006461	7,7''-Di-O-methylcupressuflavone
C00006462	4',4'''-Di-O-methylcupressuflavone
C00006463	Cupressuflavone 7,4',7''-trimethyl ether
C00006464	Cupressuflavone tetramethyl ether
C00006465	8,'8''-Bibaicalein
C00006468	Dicranolomin		C421171
C00006472	Philonotisflavone
C00006473	Strychnobiflavone
C00006475	5'-Hydroxyrobustaflavone
C00006476	5',3'''-Dihydroxyrobustaflavone	CHEMBL1990497
C00006477	Robustaflavone 7''-methyl ether
C00006478	Abiesin
C00006483	5'-Hydroxyamentoflavone
C00006484	Sumaflavone	CHEMBL270509		1 / 1 / 3
C00006485	3'''-Hydroxyamentoflavone
C00006486	5',8''-Biluteolin
C00006487	Sequoiaflavone	CHEMBL255493		1 / 0 / 0
C00006488	Bilobetin	CHEMBL378188		2 / 1 / 2
C00006489	Sotetsuflavone	CHEMBL450522		1 / 0 / 0
C00006490	Podocarpusflavone A	CHEMBL220745	C094150	2 / 1 / 2
C00006491	7,7''-Di-O-methylamentoflavone	CHEMBL1208793		1 / 0 / 0
C00006492	Putraflavone / Podocarpusflavone B	CHEMBL144630		1 / 0 / 0
C00006493	4',7''-Di-O-methylamentoflavone / Amentoflavone 4',7''-dimethyl ether	CHEMBL208988		1 / 0 / 0
C00006494	Isoginkgetin	CHEMBL1208903		10 / 32 / 61
C00006495	Amentoflavone 7'',4'''-dimethyl ether	CHEMBL374055		2 / 1 / 2
C00006496	7-O-Methyl-6-C-methylamentoflavone
C00006497	5'-Methoxybilobetin
C00006498	Heveaflavone	CHEMBL1208904		1 / 0 / 0
C00006499	4',7,7''-Tri-O-methylamentoflavone / 7,4',7''-Tri-O-methylamentoflavone	CHEMBL208578		1 / 0 / 0
C00006500	Kayaflavone	CHEMBL453479		1 / 0 / 0
C00006501	Amentoflavone 7,4',7'',4'''-tetramethyl ether	CHEMBL378516		1 / 0 / 0
C00006502	Olivieriflavone
C00006503	Dioonflavone
C00006507	Pyranoamentoflavone
C00006534	Neocryptomerin
C00006535	Isocryptomerin
C00006536	Cryptomerin A
C00006537	Chamaecyparin
C00006538	Cryptomerin B
C00006541	Lanaroflavone	CHEMBL2172395
C00006542	Ochnaflavone	CHEMBL187504	C090940	3 / 0 / 0
C00006543	Ochnaflavone 4'-methyl ether	CHEMBL188147
C00006544	7''-O-Methylochnaflavone
C00006545	Ochnaflavone 7,4'-dimethyl ether
C00006564	Bryoflavone
C00006565	Heterobryoflavone
C00006566	Kudzuisoflavone A
C00006585	Anhydrobartramiaflavone
C00006598	Pentagrametin
C00014534	4''',5,5'',7''-Tetrahydroxy-3'',3''',4'-trimethoxy-6-O-alpha,7- beta-flavone-chalcone
C00014535	4',5,5'',7''-Tetrahydroxy-3',3'',4'''-trimethoxy-6-O-alpha,7-beta-flavone-chalcone
C00014536	3''',5,5'',7''-Tetrahydroxy-3'',4',4'''-trimethoxy-6-O-alpha,7-beta-flavone-chalcone
C00014537	4',5,5'',7''-Tetrahydroxy-3',3'',4'''-trimethoxy-6-O-beta,7-alpha-flavone-chalcone
C00014538	Cissampeloflavone
C00014681	7''-Methylagathisflavone
C00014683	Pyranoamentoflavone 7,4'''-dimethyl ether
C00014684	Pyranoamentoflavone 7,4'-dimethyl ether
C00014685	Pyranoamentoflavone 7,4',4'''-Trimethyl ether
C00014687	6''-(3-Methyl-2-butenyl)amentoflavone
C00014688	6''-(2-Hydroxy-3-methyl-3-butenyl)amentoflavone
C00014693	Stephaflavone A / 5,5'-Dihydroxy-7,7'-dimethoxy-2,2'-bis(4-methoxyphenyl)-[3,6'-bi-4H-1-benzopyran]-4,4'-dione
C00014694	Stephaflavone B / 5,5'-Dihydroxy-2-(4-hydroxyphenyl)-7,7'-dimethoxy-2'-(4-methoxyphenyl)-[3,6'-bi-4H-1-benzopyran]-4,4'-dione
C00014695	5-Hydroxy-7-methoxyflavone-(4' ->O -> 8'')-4''',5'',7''-trihydroxyflavone
C00014696	5-Hydroxy-7-methoxyflavone-(4' ->O-> 8'')-5'',7''-dihydroxy-4'''-methoxyflavone
C00014697	Delicaflavone / 3-[4-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenoxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
C00014700	3''-Desoxydicranolomin / 6-[6-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2,3-dihydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
C00014707	Moghatin / (+)-2-(3,4-Dihydroxyphenyl)-5,5',7,7'-tetrahydroxy-2'-(4-hydroxyphenyl)-[8,8'-bi-4H-1-benzopyran]-4,4'-dione
C00014728	Robustaflavone 4'-methyl ether	CHEMBL451902
C00014729	Robustaflavone 7,4'-dimethyl ether	CHEMBL453554
C00014732	Robustaflavone 4',7''-dimethyl ether
C00014733	6,6''-Bigenkwanin / 5,5'-Dihydroxy-2,2'-bis(4-hydroxyphenyl)-7,7'-dimethoxy-[6,6'-bi-4H-1-benzopyran]-4,4'-dione
C00019201	Philonotisflavone-4'''-methyl ether
C00020669	Santarubin C
C00034199	Ridiculuflavone C / (+)-Ridiculuflavone C
C00034200	Ridiculuflavone D
C00035677	Loniflavone
C00037185	Globulixanthone E
C00041635	Lophirone L
C00042224	Amenthoflavone	CHEMBL63354		50 / 39 / 29

Human Protein / Gene in interactions

67 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P56817	Beta-secretase 1	A1A	C00001015 C00001034 C00001044 C00001049 C00001094 C00001098 C00006487 C00006488 C00006489 C00006490 C00006491 C00006492 C00006493 C00006494 C00006495 C00006498 C00006499 C00006500 C00006501 C00042224	0 / 0
P43235	Cathepsin K	C1A	C00001015 C00001049 C00006488 C00006490 C00006495 C00042224	1 / 2
P08253	72 kDa type IV collagenase	M10A	C00001015 C00001094 C00006446 C00006484 C00042224	1 / 3
O00255	Menin	Unclassified protein	C00001015 C00001098 C00006494 C00042224	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00001015 C00001098 C00006494 C00042224	1 / 2
Q9UBT6	DNA polymerase kappa	Enzyme	C00001015 C00001034 C00006431 C00042224	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00001015 C00001034 C00006431 C00042224	1 / 1
P10636	Microtubule-associated protein tau	Unclassified protein	C00001015 C00006431 C00006494 C00042224	4 / 3
Q9UNA4	DNA polymerase iota	Enzyme	C00001015 C00001034 C00006431 C00042224	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00001015 C00001034 C00006431 C00042224	0 / 0
O15496	Group 10 secretory phospholipase A2	Enzyme	C00001015 C00006542 C00042224	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00001015 C00006431 C00042224	0 / 0
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00001015 C00006431 C00042224	2 / 1
P14555	Phospholipase A2, membrane associated	Enzyme	C00001015 C00006542 C00042224	0 / 0
Q07820	Induced myeloid leukemia cell differentiation protein Mcl-1	Other cytosolic protein	C00001015 C00006431 C00042224	0 / 0
P47712	Cytosolic phospholipase A2	Enzyme	C00001015 C00006542 C00042224	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00001015 C00006431 C00042224	0 / 0
P14867	Gamma-aminobutyric acid receptor subunit alpha-1	GABA-A alpha	C00001015 C00042224	1 / 1
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00001015 C00042224	2 / 2
P00352	Retinal dehydrogenase 1	Enzyme	C00001015 C00042224	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00001015 C00042224	2 / 0
O75496	Geminin	Unclassified protein	C00001034 C00006431	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00001015 C00042224	1 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00001015 C00042224	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00001015 C00042224	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00001015 C00042224	7 / 3
P47870	Gamma-aminobutyric acid receptor subunit beta-2	GABA-A beta	C00001015 C00042224	0 / 0
O00591	Gamma-aminobutyric acid receptor subunit pi	GABA-A pi	C00001015 C00042224	0 / 0
P15692	Vascular endothelial growth factor A	Secreted protein	C00001015 C00042224	1 / 2
P41145	Kappa-type opioid receptor	Opioid receptor	C00001015 C00042224	0 / 0
P49763	Placenta growth factor	Unclassified protein	C00001015 C00042224	0 / 0
P34903	Gamma-aminobutyric acid receptor subunit alpha-3	GABA-A alpha	C00001015 C00042224	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00001015 C00042224	2 / 2
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00001015 C00042224	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00001015 C00042224	0 / 0
P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	Enzyme	C00001015 C00042224	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00006431 C00006494	0 / 1
P18507	Gamma-aminobutyric acid receptor subunit gamma-2	GABA-A gamma	C00001015 C00042224	4 / 2
P10828	Thyroid hormone receptor beta	NR1A2	C00001015 C00042224	3 / 1
Q8N1C3	Gamma-aminobutyric acid receptor subunit gamma-1	GABA-A gamma	C00001015 C00042224	0 / 0
P18505	Gamma-aminobutyric acid receptor subunit beta-1	GABA-A beta	C00001015 C00042224	0 / 0
Q16445	Gamma-aminobutyric acid receptor subunit alpha-6	GABA-A alpha	C00001015 C00042224	0 / 0
P78334	Gamma-aminobutyric acid receptor subunit epsilon	GABA-A epsilon	C00001015 C00042224	0 / 0
Q99928	Gamma-aminobutyric acid receptor subunit gamma-3	GABA-A gamma	C00001015 C00042224	0 / 0
P55072	Transitional endoplasmic reticulum ATPase	Unclassified protein	C00001015 C00042224	2 / 1
P47869	Gamma-aminobutyric acid receptor subunit alpha-2	GABA-A alpha	C00001015 C00042224	1 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00001015 C00042224	0 / 0
Q9UN88	Gamma-aminobutyric acid receptor subunit theta	GABA-A theta	C00001015 C00042224	0 / 0
P28472	Gamma-aminobutyric acid receptor subunit beta-3	GABA-A beta	C00001015 C00042224	1 / 0
P31644	Gamma-aminobutyric acid receptor subunit alpha-5	GABA-A alpha	C00001015 C00042224	0 / 0
P48169	Gamma-aminobutyric acid receptor subunit alpha-4	GABA-A alpha	C00001015 C00042224	0 / 0
O14764	Gamma-aminobutyric acid receptor subunit delta	GABA-A delta	C00001015 C00042224	1 / 1
P04637	Cellular tumor antigen p53	Transcription Factor	C00006494	7 / 37
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00006431	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00006431	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00006431	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00006494	3 / 3
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00006494	0 / 0
P68871	Hemoglobin subunit beta	Secreted protein	C00006494	4 / 4
P54132	Bloom syndrome protein	Enzyme	C00006431	1 / 2
P02545	Prelamin-A/C	Unclassified protein	C00006494	11 / 10
P04062	Glucosylceramidase	Enzyme	C00006431	6 / 4
P06746	DNA polymerase beta	Enzyme	C00006431	0 / 0
P63165	Small ubiquitin-related modifier 1	Unclassified protein	C00006431	1 / 1
P14618	Pyruvate kinase PKM	Enzyme	C00006431	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00006431	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00006431	1 / 1

5 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00001015
1638	DCT, TRP-2, TYRP2	dopachrome tautomerase (EC:5.3.3.12)	C00001015
4843	NOS2, HEP-NOS, INOS, NOS, NOS2A	nitric oxide synthase 2, inducible (EC:1.14.13.39)	C00001015
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00001015
7299	TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3	tyrosinase (EC:1.14.18.1)	C00001015

Related Diseases

Diseases related to proteins in ChEMBL interactions