KCF-S cluster No. 282 (24 metabolites)

Corresponding Phytochemical cluster No. 21

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (24)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
Magnoliophyta	35
Spermatophyta	22
rosids	19
asterids	15
eudicotyledons	4
Liliopsida	1

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Cumulative family count (Top 20)

class name	count
Schisandraceae	17
Myristicaceae	9
Taxaceae	7
Pinaceae	7
Cupressaceae	6
Lauraceae	5
Thymelaeaceae	5
Lamiaceae	4
Asteraceae	3
Linaceae	3
Plantaginaceae	3
Apocynaceae	2
Santalaceae	2
Oleaceae	2
Zygophyllaceae	2
Saururaceae	2
Urticaceae	1
Rhamnaceae	1
Enterococcaceae	1
Araucariaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Lignans	1

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metabolites link (1)

br08003 Category	KEGG ID	KNApSAcK ID
Lignans	C18167	C00000604

Metabolite list (24)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000604	(-)-Secoisolariciresinol	CHEMBL368347	C060283	2 / 1 / 1	1 / 0
C00000605	(+)-Secoisolariciresinol	CHEMBL368347		2 / 1 / 1
C00007214	Dihydroguaiaretic acid	CHEMBL430464 CHEMBL375927 CHEMBL1976696	C015816	16 / 18 / 12
C00007215	Mesodihydroguaiaretic acid	CHEMBL430464 CHEMBL375927 CHEMBL1976696		16 / 18 / 12
C00030517	Isoanwulignan
C00030746	meso-Dihydroguaiaretic acid	CHEMBL430464 CHEMBL375927 CHEMBL1976696		16 / 18 / 12
C00031082	Pregomisin	CHEMBL1081697
C00031533	2,3-bis[(4-hydroxy-3,5-dimethoxyphenyl)-methyl]-1,4-butanediol
C00031992	Macelignan	CHEMBL254071		8 / 10 / 9
C00032046	Myristargenol B / (+)-Myristargenol B
C00032176	Sphenanlignan
C00034637	Piperphilippinin VI
C00034968	(-)-Dihydroguaiaretic acid	CHEMBL430464 CHEMBL375927 CHEMBL1976696		16 / 18 / 12
C00034969	Sauriol A / (-)-Sauriol A
C00034970	Sauriol B / (-)-Sauriol B
C00038929	Daphneresinol / (-)-Daphneresinol	CHEMBL574120
C00039517	Kadangustin H / (-)-Kadangustin H	CHEMBL458390
C00039518	Kadangustin I / (-)-Kadangustin I
C00039519	Kadangustin J / (+)-Kadangustin J
C00039520	Kadangustin K
C00049243	Oleiferin B
C00049244	Oleiferin F / (+)-Oleiferin F
C00049245	Oleiferin G / (+)-Oleiferin G
C00049246	Oleiferin H / (-)-Oleiferin H

Human Protein / Gene in interactions

21 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00007214 C00007215 C00030746 C00031992 C00034968	1 / 1
Q99700	Ataxin-2	Unclassified protein	C00007214 C00007215 C00030746 C00031992 C00034968	1 / 1
O75496	Geminin	Unclassified protein	C00007214 C00007215 C00030746 C00031992 C00034968	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00007214 C00007215 C00030746 C00031992 C00034968	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00007214 C00007215 C00030746 C00031992 C00034968	2 / 0
P35218	Carbonic anhydrase 5A, mitochondrial	Lyase	C00007214 C00007215 C00030746 C00034968	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00007214 C00007215 C00030746 C00034968	0 / 0
P37840	Alpha-synuclein	Unclassified protein	C00007214 C00007215 C00030746 C00034968	4 / 2
P00918	Carbonic anhydrase 2	Lyase	C00007214 C00007215 C00030746 C00034968	1 / 2
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00007214 C00007215 C00030746 C00034968	2 / 2
Q9Y2D0	Carbonic anhydrase 5B, mitochondrial	Lyase	C00007214 C00007215 C00030746 C00034968	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00007214 C00007215 C00030746 C00034968	0 / 0
P00915	Carbonic anhydrase 1	Lyase	C00007214 C00007215 C00030746 C00034968	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00007214 C00007215 C00030746 C00034968	0 / 1
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00007214 C00007215 C00030746 C00034968	7 / 3
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00007214 C00007215 C00030746 C00034968	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000604 C00000605	0 / 1
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000604 C00000605	1 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00031992	1 / 1
Q13315	Serine-protein kinase ATM	Atypical serine/threonine protein kinase PIKK subfamily	C00031992	1 / 4
P10636	Microtubule-associated protein tau	Unclassified protein	C00031992	4 / 3

1 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
8856	NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR	nuclear receptor subfamily 1, group I, member 2	C00000604

Related Diseases

Diseases related to proteins in ChEMBL interactions