PCIDB

KNApSAcK Metabolite C00007215

Metabolite

KNApSAcK Entry

id C00007215
Name Mesodihydroguaiaretic acid
CAS RN
Standard InChI InChI=1S/C20H26O4/c1-13(9-15-5-7-17(21)19(11-15)23-3)14(2)10-16-6-8-18(22)20(12-16)24-4/h5-8,11-14,21-22H,9-10H2,1-4H3/t13-,14+
Standard InChI (Main Layer) InChI=1S/C20H26O4/c1-13(9-15-5-7-17(21)19(11-15)23-3)14(2)10-16-6-8-18(22)20(12-16)24-4/h5-8,11-14,21-22H,9-10H2,1-4H3

Cluster

Phytochemical cluster No. 21
KCF-S cluster No. 282

Link

ChEMBL

By standard InChI CHEMBL430464
By standard InChI Main Layer CHEMBL430464 CHEMBL375927 CHEMBL1976696

KEGG

By LinkDB

CTD

By CAS RN

Human Protein / Gene in interaction

16 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q99700 Ataxin-2 Unclassified protein CHEMBL430464 CHEMBL2114784 (1)
1 / 1
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase CHEMBL375927 CHEMBL1068063 (1)
0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase CHEMBL375927 CHEMBL1068062 (1)
0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL430464 CHEMBL1794585 (1)
0 / 0
P37840 Alpha-synuclein Unclassified protein CHEMBL430464 CHEMBL2354282 (1)
4 / 2
P00918 Carbonic anhydrase 2 Lyase CHEMBL375927 CHEMBL1068060 (1) CHEMBL1695108 (1)
1 / 2
P17405 Sphingomyelin phosphodiesterase Enzyme CHEMBL430464 CHEMBL1794495 (1)
2 / 2
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL430464 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL430464 CHEMBL2114843 (1)
0 / 0
P00915 Carbonic anhydrase 1 Lyase CHEMBL375927 CHEMBL1068061 (1) CHEMBL1695107 (1)
0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL430464 CHEMBL2114788 (1)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL430464 CHEMBL2114810 (1)
7 / 3
P04150 Glucocorticoid receptor NR3C1 CHEMBL375927 CHEMBL890266 (1)
0 / 1
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL430464 CHEMBL1737991 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL430464 CHEMBL1738184 (1)
0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL430464 CHEMBL2354287 (1)
1 / 1

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (18)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#114500 Colorectal cancer; crc P84022
#127750 Dementia, lewy body; dlb P37840
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (12)

KEGG disease name UniProt
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)