| Organism name | Dysosma majorensis | 
|---|---|
| Genus | Dysosma | 
| Family | Berberidaceae | 
| Kingdom | Plantae | 
| Linked NCBI taxonomy name | Dysosma majorensis | 
|---|---|
| Linked NCBI taxonomy ID | 153728 | 
| Linked level | species | 
| Family in NCBI taxonomy | Berberidaceae | 
|---|---|
| ID | 41773 | 
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae | 
|---|---|
| ID | 33090 | 
| Plant class | eudicotyledons | 
|---|---|
| ID | 71240 | 
| KNApSAcK ID | name | ChEMBL link | CTD link | # of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE | # of genes in CTD interaction / related diseases | KCF-S cluster | phytochemical cluster | figure | 
|---|---|---|---|---|---|---|---|---|
| C00007210   | Dehydropodophyllotoxin / Tetradehydropodophyllotoxin | CHEMBL487214 | No. 285 | No. 21 |   | |||
| C00002600   | Diphyllin | CHEMBL221190 | C010130 | 24 / 43 / 38 | No. 285 | No. 21 |   | |
| C00002595   | 4'-Demethylpodophyllotoxin | CHEMBL28941 CHEMBL31929 CHEMBL290640 CHEMBL172476 CHEMBL172001 CHEMBL1514122 CHEMBL1723729 | 6 / 4 / 2 | No. 427 | No. 21 |   | ||
| C00002620   | Podophyllotoxone | CHEMBL82303 CHEMBL1778160 | No. 427 | No. 21 |   | |||
| C00000610   | (-)-Podophyllotoxin | CHEMBL61 CHEMBL273648 CHEMBL21260 CHEMBL282256 CHEMBL283120 CHEMBL24706 CHEMBL310129 CHEMBL1330659 | D011034 | 132 / 81 / 78 | 1 / 5 | No. 427 | No. 21 |   | 
| accession | description | class description | KNApSAcK metabolite in interactions | # of diseases (OMIM / KEGG) | 
|---|---|---|---|---|
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000610 C00002595 C00002600 | 0 / 0 | 
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00000610 C00002595 C00002600 | 0 / 0 | 
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000610 C00002595 | 0 / 1 | 
| Q16637 | Survival motor neuron protein | Unclassified protein | C00000610 C00002595 | 4 / 1 | 
| Q99700 | Ataxin-2 | Unclassified protein | C00000610 C00002600 | 1 / 1 | 
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000610 C00002600 | 4 / 3 | 
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00000610 C00002600 | 1 / 0 | 
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00000610 C00002600 | 1 / 0 | 
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00000610 C00002600 | 0 / 0 | 
| P51843 | Nuclear receptor subfamily 0 group B member 1 | Nuclear hormone receptor subfamily 0 group B member 1 | C00000610 C00002600 | 2 / 2 | 
| O75496 | Geminin | Unclassified protein | C00000610 C00002600 | 0 / 0 | 
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000610 C00002600 | 2 / 0 | 
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000610 C00002600 | 0 / 0 | 
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00000610 C00002595 | 0 / 0 | 
| P02545 | Prelamin-A/C | Unclassified protein | C00000610 C00002600 | 11 / 10 | 
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00000610 | 0 / 0 | 
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00002595 | 0 / 0 | 
| Q9Y5X4 | Photoreceptor-specific nuclear receptor | NR2E3 | C00002600 | 2 / 2 | 
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00000610 | 0 / 0 | 
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000610 | 3 / 2 | 
| P00918 | Carbonic anhydrase 2 | Lyase | C00000610 | 1 / 2 | 
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00000610 | 0 / 1 | 
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00000610 | 1 / 1 | 
| P25021 | Histamine H2 receptor | Histamine receptor | C00000610 | 0 / 0 | 
| P35367 | Histamine H1 receptor | Histamine receptor | C00000610 | 0 / 0 | 
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00000610 | 1 / 0 | 
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00000610 | 0 / 0 | 
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00000610 | 0 / 0 | 
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00000610 | 0 / 0 | 
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00000610 | 0 / 0 | 
| P06241 | Tyrosine-protein kinase Fyn | Src | C00000610 | 0 / 0 | 
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00000610 | 0 / 0 | 
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000610 | 0 / 1 | 
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00000610 | 1 / 8 | 
| P17252 | Protein kinase C alpha type | Alpha | C00000610 | 0 / 0 | 
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00000610 | 2 / 0 | 
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000610 | 0 / 0 | 
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00000610 | 0 / 0 | 
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00000610 | 0 / 0 | 
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00000610 | 0 / 0 | 
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00000610 | 0 / 0 | 
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00000610 | 0 / 0 | 
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00000610 | 1 / 1 | 
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00002600 | 0 / 0 | 
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00000610 | 0 / 0 | 
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00000610 | 1 / 0 | 
| P29466 | Caspase-1 | C14 | C00000610 | 0 / 0 | 
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00002600 | 2 / 2 | 
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00000610 | 0 / 0 | 
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00000610 | 0 / 0 | 
| P42858 | Huntingtin | Unclassified protein | C00002600 | 1 / 1 | 
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00000610 | 0 / 0 | 
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00000610 | 0 / 0 | 
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00000610 | 0 / 0 | 
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00002600 | 4 / 2 | 
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00000610 | 0 / 0 | 
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00000610 | 0 / 0 | 
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00000610 | 0 / 0 | 
| P30988 | Calcitonin receptor | Calcitonin receptor | C00000610 | 0 / 0 | 
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00000610 | 1 / 0 | 
| P41143 | Delta-type opioid receptor | Opioid receptor | C00000610 | 0 / 0 | 
| Q92731 | Estrogen receptor beta | NR3A2 | C00000610 | 0 / 1 | 
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00000610 | 0 / 0 | 
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00000610 | 0 / 0 | 
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00000610 | 0 / 0 | 
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00000610 | 1 / 0 | 
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00000610 | 0 / 0 | 
| P08311 | Cathepsin G | S1A | C00000610 | 0 / 0 | 
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00000610 | 1 / 0 | 
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00002600 | 0 / 0 | 
| P03956 | Interstitial collagenase | M10A | C00000610 | 0 / 1 | 
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00000610 | 0 / 0 | 
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00002600 | 7 / 3 | 
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000610 | 0 / 0 | 
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000610 | 0 / 0 | 
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00000610 | 0 / 0 | 
| P04150 | Glucocorticoid receptor | NR3C1 | C00000610 | 0 / 1 | 
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00000610 | 2 / 0 | 
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00000610 | 0 / 0 | 
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00000610 | 0 / 0 | 
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00000610 | 2 / 0 | 
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00000610 | 5 / 9 | 
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00000610 | 1 / 0 | 
| P21452 | Substance-K receptor | Neurokinin receptor | C00000610 | 0 / 0 | 
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00000610 | 0 / 0 | 
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00000610 | 3 / 0 | 
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00000610 | 0 / 0 | 
| P06280 | Alpha-galactosidase A | Enzyme | C00000610 | 1 / 1 | 
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00000610 | 1 / 0 | 
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000610 | 0 / 0 | 
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00000610 | 2 / 1 | 
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000610 | 0 / 0 | 
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002600 | 2 / 2 | 
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00000610 | 1 / 1 | 
| P08246 | Neutrophil elastase | S1A | C00000610 | 2 / 1 | 
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00000610 | 0 / 0 | 
| P03372 | Estrogen receptor | NR3A1 | C00000610 | 1 / 1 | 
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00000610 | 1 / 0 | 
| P22303 | Acetylcholinesterase | Hydrolase | C00000610 | 1 / 0 | 
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00000610 | 0 / 0 | 
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00000610 | 0 / 0 | 
| P35372 | Mu-type opioid receptor | Opioid receptor | C00000610 | 0 / 0 | 
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00000610 | 0 / 0 | 
| P25103 | Substance-P receptor | Neurokinin receptor | C00000610 | 0 / 0 | 
| P25105 | Platelet-activating factor receptor | PAF receptor | C00000610 | 0 / 0 | 
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00000610 | 0 / 0 | 
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000610 | 1 / 1 | 
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00000610 | 2 / 2 | 
| P14780 | Matrix metalloproteinase-9 | M10A | C00000610 | 2 / 2 | 
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000610 | 0 / 0 | 
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000610 | 0 / 3 | 
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000610 | 0 / 0 | 
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00000610 | 0 / 0 | 
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000610 | 1 / 0 | 
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00000610 | 1 / 1 | 
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00000610 | 0 / 0 | 
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00000610 | 0 / 0 | 
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00000610 | 0 / 0 | 
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00000610 | 1 / 1 | 
| P06239 | Tyrosine-protein kinase Lck | Src | C00000610 | 0 / 1 | 
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00000610 | 0 / 0 | 
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002600 | 0 / 0 | 
| P40225 | Thrombopoietin | Unclassified protein | C00000610 | 1 / 1 | 
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000610 | 0 / 0 | 
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00000610 | 7 / 37 | 
| O00255 | Menin | Unclassified protein | C00002600 | 2 / 5 | 
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002600 | 1 / 2 | 
| P42345 | Serine/threonine-protein kinase mTOR | Enzyme | C00000610 | 0 / 0 | 
| Q13748 | Tubulin alpha-3C/D chain | Structural | C00000610 | 0 / 0 | 
| P68366 | Tubulin alpha-4A chain | Structural | C00000610 | 0 / 0 | 
| Q9H4B7 | Tubulin beta-1 chain | Structural | C00000610 | 1 / 0 | 
| P04350 | Tubulin beta-4A chain | Structural | C00000610 | 2 / 0 | 
| Q3ZCM7 | Tubulin beta-8 chain | Structural | C00000610 | 0 / 0 | 
| P07437 | Tubulin beta chain | Structural | C00000610 | 0 / 0 | 
| Q71U36 | Tubulin alpha-1A chain | Structural | C00000610 | 1 / 1 | 
| P68371 | Tubulin beta-4B chain | Structural | C00000610 | 0 / 0 | 
| Q13509 | Tubulin beta-3 chain | Structural | C00000610 | 2 / 1 | 
| P01215 | Glycoprotein hormones alpha chain | Unclassified protein | C00002600 | 0 / 3 | 
| Q06710 | Paired box protein Pax-8 | Unclassified protein | C00000610 | 1 / 2 | 
| P68363 | Tubulin alpha-1B chain | Unclassified protein | C00000610 | 0 / 0 | 
| Q13885 | Tubulin beta-2A chain | Structural | C00000610 | 0 / 0 | 
| Q6PEY2 | Tubulin alpha-3E chain | Unclassified protein | C00000610 | 0 / 0 | 
| Q9BQE3 | Tubulin alpha-1C chain | Unclassified protein | C00000610 | 0 / 0 | 
| Q9BUF5 | Tubulin beta-6 chain | Structural | C00000610 | 0 / 0 | 
| Q9BVA1 | Tubulin beta-2B chain | Structural | C00000610 | 1 / 0 | 
| gene | gene name | gene description | KNApSAcK metabolite in interactions | 
|---|---|---|---|
| 4137 | MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU | microtubule-associated protein tau | C00000610 | 
| OMIM | preferred title | UniProt | 
|---|---|---|
| #300018 | 46,xy sex reversal 2; srxy2 | P51843 | 
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism | P20309 | 
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah | P63092 | 
| #300200 | Adrenal hypoplasia, congenital; ahc | P51843 | 
| #202300 | Adrenocortical carcinoma, hereditary; adcc | P04637 | 
| #103780 | Alcohol dependence | P08172 P14416 P31645 | 
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 | Q99720 | 
| #608584 | Asthma-related traits, susceptibility to, 2 | Q6W5P4 | 
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 | P04637 | 
| #602025 | Body mass index quantitative trait locus 9; bmiq9 | P41968 | 
| #114480 | Breast cancer | P38398 | 
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 | P38398 | 
| #300615 | Brunner syndrome | P21397 | 
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a | P02545 | 
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism | P02545 | 
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 | P02545 | 
| #114500 | Colorectal cancer; crc | P84022 | 
| #614039 | Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 | Q13509 | 
| #162800 | Cyclic neutropenia | P08246 | 
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 | P51681 | 
| #119900 | Digital clubbing, isolated congenital | P15428 | 
| #609535 | Drug metabolism, poor, cyp2c19-related | P33261 | 
| #608902 | Drug metabolism, poor, cyp2d6-related | P10635 | 
| #128101 | Dystonia 4, torsion, autosomal dominant; dyt4 | P04350 | 
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 | P02545 | 
| #268100 | Enhanced s-cone syndrome; escs | Q9Y5X4 | 
| #133239 | Esophageal cancer | P04637 | 
| #615363 | Estrogen resistance; estrr | P03372 | 
| #301500 | Fabry disease | P06280 | 
| #600638 | Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a | Q13509 | 
| #600274 | Frontotemporal dementia; ftd | P10636 | 
| #613659 | Gastric cancer | P04626 | 
| #137215 | Gastric cancer, hereditary diffuse; hdgc | P04626 | 
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd | P24557 | 
| #137800 | Glioma susceptibility 1; glm1 | O75874 P04626 | 
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay | Q03164 | 
| #610140 | Heart-hand syndrome, slovenian type | P02545 | 
| #609423 | Human immunodeficiency virus type 1, susceptibility to | P41597 P51681 | 
| #143100 | Huntington disease; hd | P42858 | 
| #176670 | Hutchinson-gilford progeria syndrome; hgps | P02545 | 
| #145000 | Hyperparathyroidism 1; hrpt1 | O00255 | 
| #603373 | Hyperthyroidism, familial gestational | P16473 | 
| #609152 | Hyperthyroidism, nonautoimmune | P16473 | 
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 | P15428 | 
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 | P16473 | 
| #218700 | Hypothyroidism, congenital, nongoitrous, 2; chng2 | Q06710 | 
| #603932 | Intervertebral disc disease; idd | P14780 | 
| #612438 | Leukodystrophy, hypomyelinating, 6; hld6 | P04350 | 
| #151623 | Li-fraumeni syndrome 1; lfs1 | P04637 | 
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 | P02545 | 
| #611603 | Lissencephaly 3; lis3 | Q71U36 | 
| #613795 | Loeys-dietz syndrome, type 3; lds3 | P84022 | 
| #613688 | Long qt syndrome 2; lqt2 | Q12809 | 
| #211980 | Lung cancer | P00533 P04626 P04637 | 
| #613112 | Macrothrombocytopenia, autosomal dominant, tubb1-related | Q9H4B7 | 
| #608516 | Major depressive disorder; mdd | P08172 | 
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada | P02545 | 
| #174800 | Mccune-albright syndrome; mas | P63092 | 
| %300852 | Mental retardation, x-linked 88; mrx88 | P50052 | 
| #613073 | Metaphyseal anadysplasia 2; mandp2 | P14780 | 
| #131100 | Multiple endocrine neoplasia, type i; men1 | O00255 | 
| #126200 | Multiple sclerosis, susceptibility to; ms | P08575 | 
| #613205 | Muscular dystrophy, congenital, lmna-related | P02545 | 
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b | P02545 | 
| #159900 | Myoclonic dystonia | P14416 | 
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 | P08246 | 
| #257200 | Niemann-pick disease, type a | P17405 | 
| #607616 | Niemann-pick disease, type b | P17405 | 
| #257220 | Niemann-pick disease, type c1; npc1 | O15118 | 
| #601665 | Obesity | P32245 | 
| #164230 | Obsessive-compulsive disorder; ocd | P31645 | 
| #604715 | Orthostatic intolerance | P23975 | 
| #166350 | Osseous heteroplasia, progressive; poh | P63092 | 
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 | P00918 | 
| #167000 | Ovarian cancer | P04626 P38398 | 
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 | P38398 | 
| #260500 | Papilloma of choroid plexus; cpp | P04637 | 
| #260540 | Parkinson-dementia syndrome | P10636 | 
| #613135 | Parkinsonism-dystonia, infantile; pkdys | Q01959 | 
| #172700 | Pick disease of brain | P10636 | 
| #102200 | Pituitary adenoma, growth hormone-secreting | P63092 | 
| #610031 | Polymicrogyria, symmetric or asymmetric; pmgysa | Q9BVA1 | 
| #103580 | Pseudohypoparathyroidism, type ia; php1a | P63092 | 
| #603233 | Pseudohypoparathyroidism, type ib; php1b | P63092 | 
| #612462 | Pseudohypoparathyroidism, type ic; php1c | P63092 | 
| #607276 | Resting heart rate, variation in | P08588 | 
| #275210 | Restrictive dermopathy, lethal | P02545 | 
| #611131 | Retinitis pigmentosa 37; rp37 | Q9Y5X4 | 
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive | P08575 | 
| #609620 | Short qt syndrome 1; sqt1 | Q12809 | 
| #253300 | Spinal muscular atrophy, type i; sma1 | Q16637 | 
| #253550 | Spinal muscular atrophy, type ii; sma2 | Q16637 | 
| #253400 | Spinal muscular atrophy, type iii; sma3 | Q16637 | 
| #271150 | Spinal muscular atrophy, type iv; sma4 | Q16637 | 
| #183090 | Spinocerebellar ataxia 2; sca2 | Q99700 | 
| #275355 | Squamous cell carcinoma, head and neck; hnscc | P04637 | 
| #601104 | Supranuclear palsy, progressive, 1; psnp1 | P10636 | 
| #187950 | Thrombocythemia 1; thcyt1 | P40225 | 
| #190300 | Tremor, hereditary essential, 1; etm1 | P35462 | 
| #610379 | West nile virus, susceptibility to | P51681 | 
| #112100 | Yt blood group antigen | P22303 | 
| KEGG | name | UniProt | 
|---|---|---|
| H00033 | Adrenal carcinoma | O00255
                            (related) P04637 (related) | 
| H00034 | Carcinoid | O00255
                            (related) | 
| H00045 | Malignant islet cell carcinoma | O00255
                            (related) | 
| H00246 | Primary hyperparathyroidism | O00255
                            (related) | 
| H01102 | Pituitary adenomas | O00255
                            (related) | 
| H00136 | Niemann-Pick disease type C (NPC) | O15118
                            (related) | 
| H00016 | Oral cancer | P00533
                            (related) P00533 (marker) P04637 (related) P04637 (marker) | 
| H00017 | Esophageal cancer | P00533
                            (related) P04637 (related) P04637 (marker) P35354 (related) | 
| H00018 | Gastric cancer | P00533
                            (related) P04626 (related) P04637 (related) | 
| H00022 | Bladder cancer | P00533
                            (related) P04626 (related) P04637 (related) | 
| H00028 | Choriocarcinoma | P00533
                            (related) P03956 (related) P04626 (related) P04637 (related) | 
| H00030 | Cervical cancer | P00533
                            (related) P04626 (related) | 
| H00042 | Glioma | P00533
                            (related) P00533 (marker) P04637 (related) P04637 (marker) | 
| H00055 | Laryngeal cancer | P00533
                            (related) P00533 (marker) P04637 (related) P04637 (marker) | 
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) | P00918
                            (related) | 
| H00436 | Osteopetrosis | P00918
                            (related) | 
| H00081 | Hashimoto's thyroiditis | P01215
                            (marker) | 
| H00082 | Graves' disease | P01215
                            (marker) | 
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) | P01215
                            (marker) P16473 (related) Q06710 (related) | 
| H00264 | Charcot-Marie-Tooth disease (CMT) | P02545
                            (related) | 
| H00294 | Dilated cardiomyopathy (DCM) | P02545
                            (related) | 
| H00420 | Familial partial lipodystrophy (FPL) | P02545
                            (related) | 
| H00563 | Emery-Dreifuss muscular dystrophy | P02545
                            (related) | 
| H00590 | Congenital muscular dystrophies (CMD/MDC) | P02545
                            (related) | 
| H00593 | Limb-girdle muscular dystrophy (LGMD) | P02545
                            (related) | 
| H00601 | Hutchinson-Gilford progeria syndrome | P02545
                            (related) | 
| H00663 | Restrictive dermopathy | P02545
                            (related) | 
| H00665 | Mandibuloacral dysplasia | P02545
                            (related) | 
| H01216 | Left ventricular noncompaction (LVNC) | P02545
                            (related) | 
| H00026 | Endometrial Cancer | P03372
                            (marker) P04626 (related) P04637 (related) Q92731 (marker) | 
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) | P04150
                            (related) | 
| H00019 | Pancreatic cancer | P04626
                            (related) P04637 (related) P04637 (marker) | 
| H00027 | Ovarian cancer | P04626
                            (related) P04637 (related) P38398 (related) | 
| H00031 | Breast cancer | P04626
                            (related) P04626 (marker) P04637 (related) P38398 (related) | 
| H00046 | Cholangiocarcinoma | P04626
                            (related) P04637 (related) P35354 (related) | 
| H00004 | Chronic myeloid leukemia (CML) | P04637
                            (related) | 
| H00005 | Chronic lymphocytic leukemia (CLL) | P04637
                            (related) | 
| H00006 | Hairy-cell leukemia | P04637
                            (related) | 
| H00008 | Burkitt lymphoma | P04637
                            (related) | 
| H00009 | Adult T-cell leukemia | P04637
                            (related) | 
| H00010 | Multiple myeloma | P04637
                            (related) | 
| H00013 | Small cell lung cancer | P04637
                            (related) | 
| H00014 | Non-small cell lung cancer | P04637
                            (related) | 
| H00015 | Malignant pleural mesothelioma | P04637
                            (related) | 
| H00020 | Colorectal cancer | P04637
                            (related) P04637 (marker) | 
| H00025 | Penile cancer | P04637
                            (related) P04637 (marker) P14780 (related) P35354 (related) | 
| H00029 | Vulvar cancer | P04637
                            (related) | 
| H00032 | Thyroid cancer | P04637
                            (related) Q06710 (related) | 
| H00036 | Osteosarcoma | P04637
                            (related) P08684 (marker) | 
| H00038 | Malignant melanoma | P04637
                            (related) | 
| H00039 | Basal cell carcinoma | P04637
                            (related) | 
| H00040 | Squamous cell carcinoma | P04637
                            (related) | 
| H00041 | Kaposi's sarcoma | P04637
                            (related) | 
| H00044 | Cancer of the anal canal | P04637
                            (related) | 
| H00047 | Gallbladder cancer | P04637
                            (related) | 
| H00048 | Hepatocellular carcinoma | P04637
                            (related) | 
| H00881 | Li-Fraumeni syndrome | P04637
                            (related) | 
| H01007 | Choroid plexus papilloma | P04637
                            (related) | 
| H00021 | Renal cell carcinoma | P04637
                            (marker) | 
| H00093 | Combined immunodeficiencies (CIDs) | P06239
                            (related) | 
| H00125 | Fabry disease | P06280
                            (related) | 
| H00079 | Asthma | P07550
                            (related) | 
| H00100 | Neutropenic disorders | P08246
                            (related) | 
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) | P08575
                            (related) | 
| H00058 | Amyotrophic lateral sclerosis (ALS) | P10636
                            (related) | 
| H00077 | Progressive supranuclear palsy (PSP) | P10636
                            (related) | 
| H00078 | Frontotemporal lobar degeneration (FTLD) | P10636
                            (related) | 
| H01205 | Coumarin resistance | P11712
                            (related) | 
| H00479 | Metaphyseal dysplasias | P14780
                            (related) | 
| H00457 | Primary hypertrophic osteoarthropathy (PHO) | P15428
                            (related) | 
| H01246 | Isolated congenital nail clubbing (ICNC) | P15428
                            (related) | 
| H01269 | Congenital hyperthyroidism | P16473
                            (related) | 
| H00137 | Niemann-Pick disease (NPD) typeA and B | P17405
                            (related) | 
| H00424 | Defects in the degradation of sphingomyelin | P17405
                            (related) | 
| H00548 | Brunner syndrome | P21397
                            (related) | 
| H01031 | Orthostatic intolerance (OI) | P23975
                            (related) | 
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) | P24557
                            (related) | 
| H01171 | Poor drug metabolism (PM) | P33261
                            (related) | 
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) | P40225
                            (marker) | 
| H00059 | Huntington's disease (HD) | P42858
                            (related) | 
| H00480 | Non-syndromic X-linked mental retardation | P50052
                            (related) | 
| H00552 | Glycerol kinase deficiency (GKD) | P51843
                            (related) | 
| H00607 | 46,XY disorders of sex development (Disorders of gonadal development) | P51843
                            (related) | 
| H00244 | Pseudohypoparathyroidism | P63092
                            (related) | 
| H00441 | Progressive osseous heteroplasia (POH) | P63092
                            (related) | 
| H00501 | Fibrous dysplasia, polyostotic | P63092
                            (related) | 
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) | Q03164
                            (related) Q03164 (marker) | 
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) | Q03164
                            (related) | 
| H00720 | Long QT syndrome | Q12809
                            (related) | 
| H00725 | Short QT syndrome | Q12809
                            (related) | 
| H00838 | Congenital fibrosis of the extraocular muscles (CFEOM) | Q13509
                            (related) | 
| H00455 | Spinal muscular atrophy (SMA) | Q16637
                            (related) | 
| H00268 | Lissencephaly (LIS) | Q71U36
                            (related) | 
| H00063 | Spinocerebellar ataxia (SCA) | Q99700
                            (related) | 
| H00527 | Retinitis pigmentosa (RP) | Q9Y5X4
                            (related) | 
| H00805 | Vitreoretinal degeneration | Q9Y5X4
                            (related) | 
| MESH or OMIM | name | KNApSAcK metabolite | 
|---|---|---|
| D002295 | Carcinoma, Transitional Cell | C00000610 | 
| D003218 | Condylomata Acuminata | C00000610 | 
| D010523 | Peripheral Nervous System Diseases | C00000610 | 
| D054198 | Precursor Cell Lymphoblastic Leukemia-Lymphoma | C00000610 | 
| D012678 | Sensation Disorders | C00000610 |