PCIDB

KCF-S cluster No. 427 (18 metabolites)

Corresponding Phytochemical cluster No. 21

Metabolite list (18)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		figure
C00000610 External link 512 (-)-Podophyllotoxin
CHEMBL61
CHEMBL273648
CHEMBL21260
CHEMBL282256
CHEMBL283120
CHEMBL24706
CHEMBL310129
CHEMBL1330659
D011034
132 / 81 / 78 1 / 5
C00000654 External link 512 (-)-5-Methoxypodophyllotoxin
CHEMBL292945
CHEMBL398327
C074971
C00000695 External link 512 Picropodophyllone
CHEMBL82303
CHEMBL1778160
C00002589 External link 512 Austrobailignan 1
CHEMBL509850
CHEMBL455113
C093023
C00002593 External link 512 5'-Demethoxydeoxypodophyllotoxin
C00002594 External link 512 4'-Demethyldeoxypodophyllotoxin
CHEMBL89905
CHEMBL141117
CHEMBL1707682
CHEMBL1969951
27 / 14 / 4
C00002595 External link 512 4'-Demethylpodophyllotoxin
CHEMBL28941
CHEMBL31929
CHEMBL290640
CHEMBL172476
CHEMBL172001
CHEMBL1514122
CHEMBL1723729
6 / 4 / 2
C00002597 External link 512 Deoxypodophyllotoxin
/ (-)-Deoxypodophyllotoxin
CHEMBL63970
CHEMBL149525
CHEMBL152144
CHEMBL255919
CHEMBL519603
CHEMBL476679
CHEMBL1736070
7 / 4 / 2
C00002615 External link 512 alpha-Peltatin
CHEMBL95972
CHEMBL368930
CHEMBL1591274
C049798
6 / 2 / 0
C00002616 External link 512 beta-Peltatin A methyl ether
CHEMBL483004
C010499
C00002619 External link 512 Picropodophyllin
CHEMBL61
CHEMBL273648
CHEMBL21260
CHEMBL282256
CHEMBL283120
CHEMBL24706
CHEMBL310129
CHEMBL1330659
132 / 81 / 78
C00002620 External link 512 Podophyllotoxone
CHEMBL82303
CHEMBL1778160
C00007208 External link 512 beta-Peltatin
/ (-)-beta-Peltatin
CHEMBL97543
CHEMBL443566
CHEMBL1435754
9 / 16 / 14
C00031027 External link 512 Picropolygamain
CHEMBL465763
CHEMBL478942
CHEMBL1976899
C080237
C00031640 External link 512 Burseranin
/ (+)-Burseranin
C00033300 External link 512 Picropodophyllotoxin
/ (+)-Picropodophyllotoxin
CHEMBL61
CHEMBL273648
CHEMBL21260
CHEMBL282256
CHEMBL283120
CHEMBL24706
CHEMBL310129
CHEMBL1330659
132 / 81 / 78
C00034971 External link 512 beta-Apopicropodophyllin
CHEMBL330498
CHEMBL330639
C00043449 External link 512 Deoxypicropodophyllin
CHEMBL63970
CHEMBL149525
CHEMBL152144
CHEMBL255919
CHEMBL519603
CHEMBL476679
CHEMBL1736070
7 / 4 / 2

Human Protein / Gene in interactions

139 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000610 C00002594 C00002595 C00002597 C00002615 C00002619 C00007208 C00033300 C00043449 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000610 C00002594 C00002597 C00002615 C00002619 C00007208 C00033300 C00043449 2 / 0
O75496 Geminin Unclassified protein C00000610 C00002594 C00002597 C00002619 C00007208 C00033300 C00043449 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00000610 C00002594 C00002597 C00002619 C00007208 C00033300 C00043449 1 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000610 C00002595 C00002597 C00002619 C00007208 C00033300 C00043449 0 / 1
Q99700 Ataxin-2 Unclassified protein C00000610 C00002597 C00002619 C00007208 C00033300 C00043449 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00000610 C00002594 C00002615 C00002619 C00007208 C00033300 0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00000610 C00002594 C00002595 C00002615 C00002619 C00033300 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00000610 C00002594 C00002595 C00002615 C00002619 C00033300 0 / 0
Q13509 Tubulin beta-3 chain Structural C00000610 C00002594 C00002619 C00033300 2 / 1
P68371 Tubulin beta-4B chain Structural C00000610 C00002594 C00002619 C00033300 0 / 0
Q71U36 Tubulin alpha-1A chain Structural C00000610 C00002594 C00002619 C00033300 1 / 1
P07437 Tubulin beta chain Structural C00000610 C00002594 C00002619 C00033300 0 / 0
Q06710 Paired box protein Pax-8 Unclassified protein C00000610 C00002619 C00007208 C00033300 1 / 2
P04350 Tubulin beta-4A chain Structural C00000610 C00002594 C00002619 C00033300 2 / 0
Q9H4B7 Tubulin beta-1 chain Structural C00000610 C00002594 C00002619 C00033300 1 / 0
P68366 Tubulin alpha-4A chain Structural C00000610 C00002594 C00002619 C00033300 0 / 0
Q13748 Tubulin alpha-3C/D chain Structural C00000610 C00002594 C00002619 C00033300 0 / 0
P02545 Prelamin-A/C Unclassified protein C00000610 C00002619 C00007208 C00033300 11 / 10
P68363 Tubulin alpha-1B chain Unclassified protein C00000610 C00002594 C00002619 C00033300 0 / 0
Q13885 Tubulin beta-2A chain Structural C00000610 C00002594 C00002619 C00033300 0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein C00000610 C00002594 C00002619 C00033300 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00000610 C00002595 C00002619 C00033300 4 / 1
Q9BQE3 Tubulin alpha-1C chain Unclassified protein C00000610 C00002594 C00002619 C00033300 0 / 0
Q9BUF5 Tubulin beta-6 chain Structural C00000610 C00002594 C00002619 C00033300 0 / 0
Q3ZCM7 Tubulin beta-8 chain Structural C00000610 C00002594 C00002619 C00033300 0 / 0
Q9BVA1 Tubulin beta-2B chain Structural C00000610 C00002594 C00002619 C00033300 1 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00000610 C00002619 C00033300 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00000610 C00002619 C00033300 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00000610 C00002619 C00033300 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00000610 C00002619 C00033300 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00000610 C00002619 C00033300 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000610 C00002619 C00033300 0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000610 C00002619 C00033300 1 / 8
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00000610 C00002619 C00033300 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00000610 C00002619 C00033300 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000610 C00002619 C00033300 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00000610 C00002619 C00033300 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000610 C00002619 C00033300 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00000610 C00002619 C00033300 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00000610 C00002619 C00033300 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00000610 C00002619 C00033300 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00000610 C00002619 C00033300 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00000610 C00002619 C00033300 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00000610 C00002619 C00033300 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000610 C00002619 C00033300 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000610 C00002619 C00033300 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00000610 C00002619 C00033300 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000610 C00002619 C00033300 1 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00000610 C00002619 C00033300 1 / 0
P35367 Histamine H1 receptor Histamine receptor C00000610 C00002619 C00033300 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00000610 C00002619 C00033300 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00000610 C00002619 C00033300 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00000610 C00002619 C00033300 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00000610 C00002619 C00033300 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00000610 C00002619 C00033300 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00000610 C00002619 C00033300 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000610 C00002619 C00033300 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00000610 C00002619 C00033300 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00000610 C00002619 C00033300 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00000610 C00002619 C00033300 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00000610 C00002619 C00033300 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00000610 C00002619 C00033300 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00000610 C00002619 C00033300 0 / 0
P08311 Cathepsin G S1A C00000610 C00002619 C00033300 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00000610 C00002619 C00033300 1 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002594 C00002597 C00043449 0 / 0
P03956 Interstitial collagenase M10A C00000610 C00002619 C00033300 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00000610 C00002619 C00033300 0 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme C00000610 C00002619 C00033300 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00000610 C00002619 C00033300 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000610 C00002619 C00033300 0 / 0
P51843 Nuclear receptor subfamily 0 group B member 1 Nuclear hormone receptor subfamily 0 group B member 1 C00000610 C00002619 C00033300 2 / 2
P04150 Glucocorticoid receptor NR3C1 C00000610 C00002619 C00033300 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00000610 C00002619 C00033300 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00000610 C00002619 C00033300 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00000610 C00002619 C00033300 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00000610 C00002619 C00033300 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00000610 C00002619 C00033300 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00000610 C00002619 C00033300 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00000610 C00002619 C00033300 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00000610 C00002619 C00033300 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00000610 C00002619 C00033300 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00000610 C00002619 C00033300 0 / 0
P06280 Alpha-galactosidase A Enzyme C00000610 C00002619 C00033300 1 / 1
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00000610 C00002619 C00033300 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000610 C00002619 C00033300 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00000610 C00002619 C00033300 2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000610 C00002619 C00033300 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00000610 C00002619 C00033300 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00000610 C00002619 C00033300 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00000610 C00002619 C00033300 0 / 0
P03372 Estrogen receptor NR3A1 C00000610 C00002619 C00033300 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00000610 C00002619 C00033300 1 / 0
P22303 Acetylcholinesterase Hydrolase C00000610 C00002619 C00033300 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00000610 C00002619 C00033300 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00000610 C00002619 C00033300 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00000610 C00002619 C00033300 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00000610 C00002619 C00033300 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00000610 C00002619 C00033300 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00000610 C00002619 C00033300 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00000610 C00002619 C00033300 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000610 C00002619 C00033300 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00000610 C00002619 C00033300 0 / 0
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00000610 C00002619 C00033300 0 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00000610 C00002619 C00033300 1 / 1
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00000610 C00002619 C00033300 1 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00000610 C00002619 C00033300 7 / 37
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000610 C00002619 C00033300 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000610 C00002619 C00033300 4 / 3
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00000610 C00002619 C00033300 0 / 1
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000610 C00002619 C00033300 2 / 2
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00000610 C00002619 C00033300 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00000610 C00002619 C00033300 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00000610 C00002619 C00033300 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00000610 C00002619 C00033300 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00000610 C00002619 C00033300 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00000610 C00002619 C00033300 0 / 0
P40225 Thrombopoietin Unclassified protein C00000610 C00002619 C00033300 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000610 C00002619 C00033300 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00000610 C00002619 C00033300 1 / 2
P16473 Thyrotropin receptor Glycohormone receptor C00000610 C00002619 C00033300 3 / 2
P21728 D(1A) dopamine receptor Dopamine receptor C00000610 C00002619 C00033300 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00000610 C00002619 C00033300 2 / 2
P27361 Mitogen-activated protein kinase 3 Erk C00000610 C00002619 C00033300 0 / 0
P17252 Protein kinase C alpha type Alpha C00000610 C00002619 C00033300 0 / 0
P29466 Caspase-1 C14 C00000610 C00002619 C00033300 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00000610 C00002619 C00033300 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00000610 C00002619 C00033300 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00000610 C00002619 C00033300 0 / 0
P08246 Neutrophil elastase S1A C00000610 C00002619 C00033300 2 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000610 C00002619 C00033300 0 / 3
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00000610 C00002619 C00033300 1 / 1
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00002594 2 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00002595 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00002594 2 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00002594 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00002594 1 / 1
P39748 Flap endonuclease 1 Enzyme C00002615 0 / 0

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4137 MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU microtubule-associated protein tau C00000610

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (85)

OMIM preferred title UniProt
#300018 46,xy sex reversal 2; srxy2 P51843
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#300200 Adrenal hypoplasia, congenital; ahc P51843
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
Q14191
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 O75874
P04626
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#218700 Hypothyroidism, congenital, nongoitrous, 2; chng2 Q06710
#603932 Intervertebral disc disease; idd P14780
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#611603 Lissencephaly 3; lis3 Q71U36
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277700 Werner syndrome; wrn Q14191
#610379 West nile virus, susceptibility to P51681
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (80)

KEGG name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
Q06710 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00125 Fabry disease P06280 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
Q06710 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00552 Glycerol kinase deficiency (GKD) P51843 (related)
H00607 46,XY disorders of sex development (Disorders of gonadal development) P51843 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

5 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002295 Carcinoma, Transitional Cell C00000610
D003218 Condylomata Acuminata C00000610
D010523 Peripheral Nervous System Diseases C00000610
D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma C00000610
D012678 Sensation Disorders C00000610