KCF-S cluster No. 700 (12 metabolites)

Corresponding Phytochemical cluster No. 21

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (12)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	63
rosids	27
Spermatophyta	18
eudicotyledons	7
Magnoliophyta	3
Liliopsida	3
Euphyllophyta	1

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Cumulative family count (Top 20)

class name	count
Oleaceae	24
Thymelaeaceae	14
Pinaceae	8
Taxaceae	7
Lamiaceae	7
Fabaceae	5
Apocynaceae	5
Caprifoliaceae	5
Asteraceae	4
Acanthaceae	3
Magnoliaceae	3
Rubiaceae	2
Lardizabalaceae	2
Solanaceae	2
Icacinaceae	2
Ranunculaceae	2
Rosaceae	2
Balanophoraceae	2
Gentianaceae	2
Bignoniaceae	2

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Lignans	2

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metabolites link (2)

br08003 Category	KEGG ID	KNApSAcK ID
Lignans	C10646	C00000602
Lignans	C10544	C00002588

Metabolite list (12)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000602	(+)-Lariciresinol	CHEMBL518421		2 / 1 / 1
C00000603	(-)-Lariciresinol	CHEMBL518421	C060282	2 / 1 / 1
C00000682	(-)-Olivil / Vladinol C	CHEMBL517144		1 / 1 / 1
C00002588	1-Acetoxypinoresinol
C00007191	(+)-8(1)-Hydroxypinoresinol	CHEMBL471274
C00007200	(+)-Taxiresinol	CHEMBL1668114		2 / 1 / 1
C00036424	1alpha-Hydroxy-2alpha,4alpha-guaicyl-3,7-dioxabicyclo[3.3.0]octane
C00038101	(8R,8'R,9R)-4,4',9-trihydroxy-3,3'-dimethoxy-9,9'-epoxylignan	CHEMBL514546 CHEMBL575225 CHEMBL584197
C00043847	Prinsepiol / (-)-Prinsepiol	CHEMBL470456
C00045390	Renealtin A / (+)-Renealtin A
C00045391	Renealtin B / (+)-Renealtin B
C00050143	Lariciresinol acetate / (+)-Lariciresinol acetate	CHEMBL464991 CHEMBL1406708		18 / 6 / 8

Human Protein / Gene in interactions

21 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000602 C00000603 C00007200	1 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000602 C00000603 C00007200	0 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00050143	0 / 0
P06746	DNA polymerase beta	Enzyme	C00050143	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00050143	1 / 1
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00050143	0 / 0
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00000682	1 / 1
P54132	Bloom syndrome protein	Enzyme	C00050143	1 / 2
P39748	Flap endonuclease 1	Enzyme	C00050143	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00050143	1 / 1
P14618	Pyruvate kinase PKM	Enzyme	C00050143	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00050143	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00050143	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00050143	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00050143	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00050143	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00050143	0 / 0
Q13951	Core-binding factor subunit beta	Unclassified protein	C00050143	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00050143	1 / 4
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00050143	0 / 0
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00050143	2 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions