PCIDB

KNApSAcK Metabolite C00002669

Metabolite

KNApSAcK Entry

id C00002669
Name Pyrocatechuic acid / o-Pyrocatechuic acid / 2,3-Dihydroxybenzoic acid
CAS RN 303-38-8
Standard InChI InChI=1S/C7H6O4/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3,8-9H,(H,10,11)
Standard InChI (Main Layer) InChI=1S/C7H6O4/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3,8-9H,(H,10,11)

Cluster

Phytochemical cluster No. 81
KCF-S cluster No. 817

Link

ChEMBL

By standard InChI CHEMBL1432
By standard InChI Main Layer CHEMBL1432

KEGG

By LinkDB C00196

CTD

By CAS RN C009135

Human Protein / Gene in interaction

12 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q99700 Ataxin-2 Unclassified protein CHEMBL1432 CHEMBL2114784 (1)
1 / 1
P09917 Arachidonate 5-lipoxygenase Oxidoreductase CHEMBL1432 CHEMBL1664429 (1)
0 / 0
P22894 Neutrophil collagenase M10A CHEMBL1432 CHEMBL1664434 (1)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL1432 CHEMBL1664435 (1)
2 / 2
P02768 Serum albumin Secreted protein CHEMBL1432 CHEMBL1177441 (1)
0 / 0
P16581 E-selectin Adhesion CHEMBL1432 CHEMBL917094 (1)
0 / 0
P03956 Interstitial collagenase M10A CHEMBL1432 CHEMBL1664431 (1)
0 / 1
P08253 72 kDa type IV collagenase M10A CHEMBL1432 CHEMBL1664432 (1)
1 / 3
P14151 L-selectin Adhesion CHEMBL1432 CHEMBL917098 (1)
0 / 0
P16109 P-selectin Adhesion CHEMBL1432 CHEMBL917096 (1)
1 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL1432 CHEMBL1737991 (1)
0 / 0
P08254 Stromelysin-1 M10A CHEMBL1432 CHEMBL1664433 (1)
1 / 0

CTD interaction (3)

compound gene gene name gene description interaction interaction type form reference
pmid
C009135 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) 2,3-dihydroxybenzoic acid results in decreased activity of MMP2 protein decreases activity
protein 10086886
C009135 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) Calcium Chloride inhibits the reaction [2,3-dihydroxybenzoic acid results in decreased activity of MMP2 protein] decreases activity
/ decreases reaction
protein 10086886
C009135 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) ferric chloride inhibits the reaction [2,3-dihydroxybenzoic acid results in decreased activity of MMP2 protein] decreases activity
/ decreases reaction
protein 10086886

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (6)

OMIM preferred title UniProt
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#603932 Intervertebral disc disease; idd P14780
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601367 Stroke, ischemic P16109

KEGG DISEASE (5)

KEGG disease name UniProt
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

4 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D058186 C009135 Acute Kidney Injury therapeutic
3123518
D034381 C009135 Hearing Loss therapeutic
9223576
D007674 C009135 Kidney Diseases therapeutic
17296255
D015837 C009135 Vestibular Diseases therapeutic
9223576